• Geotechnical Engineering
• /
• v.11 no.2
• /
• pp.71-78
• /
• 1995

In this paper, a study was performed on classifying a rock mass into multiple classes as in rock mass classification systems, such as RMR system and Q system etc. In a situation with only limited quantitative data available, it was sought to employ a way of incorporating qualitative data in a systematical and reasonable manner. It is based on the realm of Geostatistics. In particular, indicator kriging technique, which is one of non-parametric approaches, was used. As a selection criterion for an optimal classification, the cost of errors was adopted. As a result, the binary rock classification method developed before was extended and generalized for multiple rock classification with its total number of classes unlimited.

• The KIPS Transactions:PartB
• /
• v.16B no.2
• /
• pp.165-172
• /
• 2009

According to the American Cancer Society, breast cancer is the second largest cause of cancer deaths and most frequently diagnosed cancer in women. The currently most popular method for early detection of breast cancer is the digital mammography. A mass or calcification lesion has been known as the most important clue for the diagnosis. In this paper, we propose a diagnosis approach based on fuzzy cluster knowledge base. We combine different two sources of feature data in duel OFUN-NET and produce the diagnosis result with possibility degree. We also present the experimental results on the dataset of mass and calcification lesions extracted from the public real world mammogram database DDSM. These results show higher classification accuracy than conventional methods and the feasibility as a decision supporting tool for diagnosis of digital mammogram.

• KSBB Journal
• /
• v.11 no.6
• /
• pp.704-711
• /
• 1996

An optimal process design of a foreign protein production system was carried out using a bioprocess flowsheeting software, BioPro Designer, with a capability of economic analysis. The flowsheeting program was applied to a production system of the tailspike protein of Salmonella phage P22, and helped save time and efforts in selecting an optimal process. A wild type tailspike and two types of mutant tailspikes, tsf G244\longrightarrow,R and Su A334\longrightarrowV, were considered in this study to show that the folding characteristics of foreign protein produced inside host influenced the selection of the best production system. An optimal production system for mature tailspike was chosen under the criterion of capital investment per unit mass of mature protein recovered.

• Structural Engineering and Mechanics
• /
• v.10 no.6
• /
• pp.517-532
• /
• 2000

A direct output feedback control scheme was recently proposed by the authors for single-story building structures resting on flexible soil body. In this paper, the control scheme is extended to mitigate the seismic responses of multi-story buildings. Soil-structure interaction is taken into account in two parts: input at the soil-structure interface/foundation and control algorithm. The former reflects the effect on ground motions and is monitored in real time with accelerometers at foundation. The latter includes the effect on the dynamic characteristics of structures, which is formulated by modifying the classical linear quadratic regulator based on the fundamental mode shape of the soil-structure system. Numerical result on the study of a $\frac{1}{4}$-scale three-story structure, supported by a viscoelastic half-space of soil mass, have demonstrated that the proposed algorithm is robust and very effective in suppressing the earthquake-induced vibration in building structures even supported on a flexible soil mass. Parametric studies are performed to understand how soil damping and flexibility affect the effectiveness of active tendon control. The selection of weighting matrix and effect of soil property uncertainty are investigated in detail for practical applications.

• Biomolecules & Therapeutics
• /
• v.29 no.6
• /
• pp.582-595
• /
• 2021

Researchers have endeavored to identify the etiology of inflammatory bowel diseases, including Crohn's disease and ulcerative colitis. Though the pathogenesis of inflammatory bowel diseases remains unknown, dysregulation of the immune system in the host gastrointestinal tract is believed to be the major causative factor. Omics is a powerful methodological tool that can reveal biochemical information stored in clinical samples. Lipidomics is a subset of omics that explores the lipid classes associated with inflammation. One objective of the present systematic review was to facilitate the identification of biochemical targets for use in future lipidomic studies on inflammatory bowel diseases. The use of high-resolution mass spectrometry to observe alterations in global lipidomics might help elucidate the immunoregulatory mechanisms involved in inflammatory bowel diseases and discover novel biomarkers for them. Assessment of the characteristics of previous clinical trials on inflammatory bowel diseases could help researchers design and establish patient selection and analytical method criteria for future studies on these conditions. In this study, we curated literature exclusively from four databases and extracted lipidomics-related data from literature, considering criteria. This paper suggests that the lipidomics approach toward research in inflammatory bowel diseases can clarify their pathogenesis and identify clinically valuable biomarkers to predict and monitor their progression.

• The Bulletin of The Korean Astronomical Society
• /
• v.43 no.2
• /
• pp.35.2-35.2
• /
• 2018

Using the K-band Multi-object Spectrograph (KMOS) at the Very Large Telescope (VLT), the KMOS Redshift One Spectroscopic Survey (KROSS) has gathered integral-field data for ~800 star-forming galaxies at a redshift z~1, when the universe was roughly half its current age and forming the bulk of its stars. With spatially-resolved observations, KROSS reveals galaxies that are both gas-rich and highly turbulent. It is possible to derive the observed and baryonic Tully-Fisher (luminosity - rotation velocity) relations, thus constraining the mass-to-light ratios and total (luminous + dark) masses of the galaxies. This in turn highlights the dependence of the relation zero-point on the degree of rotational support of the galaxies (rotational velocity to velocity dispersion ratio). By degrading and analogously analysing integral-field data of hundreds of local galaxies from the Sydney-AAO Multi-object Integral-field Spectrograph (SAMI) survey, a robust comparison z=0 Tully-Fisher relation can also be derived, thus further constraining the luminous and dark mass growth of disk galaxies over the last 7 billions years. This unique comparison also reveals that systematic effects associated with sample selection and analysis methods are as large as the effects expected from cosmological evolution, and thus that most other comparisons employing heterogeneous data and/or methods can safely be ignored.

• The Journal of Advanced Prosthodontics
• /
• v.11 no.2
• /
• pp.81-87
• /
• 2019

PURPOSE. The purpose of this study was to evaluate the effects of various protocols and systems for finishing and polishing monolithic zirconia on surface topography, phase transformation, and bacterial adhesion. MATERIALS AND METHODS. Three hundred monolithic zirconia specimens were fabricated and then treated with three finishing and polishing systems (Jota [JO], Meisinger [ME], and Edenta [ED]) using four surface treatment protocols: coarse finishing alone (C); coarse finishing and medium polishing (CM); coarse finishing and fine polishing (CF); and coarse finishing, medium polishing, and fine polishing (CMF). Surface roughness, crystal phase transformation, and bacterial adhesion were evaluated using atomic force microscopy, X-ray diffraction, and streptococcal biofilm formation assay, respectively. One-way and two-way analysis of variance with Tukey post hoc tests were used to analyze the results (${\alpha}=.05$). RESULTS. In this study, the surface treatment protocols and systems had significant effects on the resulting roughness. The CMF protocol produced the lowest roughness values, followed by CM and CF. Use of the JO system produced the lowest roughness values and the smallest biofilm mass, while the ME system produced the smallest partial transformation ratio. The ED group exhibited the highest roughness values, biofilm mass, and partial transformation ratio. CONCLUSION. Stepwise surface treatment of monolithic zirconia, combined with careful polishing system selection, is essential to obtaining optimal microstructural and biological surface results.

• Journal of Distribution Science
• /
• v.13 no.6
• /
• pp.71-78
• /
• 2015

Purpose - This study attempts to analyze whether or not there are characteristics among the top management of companies that promote corporate performance at venture companies. It investigates the characteristics of the human and social capital that are inherent in top management at a venture company and conducts an empirical analysis of hypotheses examining if these characteristics will affect utilization of the governmental R&D support system as well as affect the firm's initial success. Research design, data, and methodology - This study conducted theoretical and empirical research together to accomplish the goal of the study. The pilot study researched human capital and social capital as the independent variables; the governmental R&D support system as the parameter; and, the initial success as the dependent variable. The empirical study carried out research on the model, establishment of hypotheses, and the statistical treatment. A survey was conducted targeting top management of high-tech venture companies in Daedeok Innopolis; 500 questionnaires were distributed; and, 222 were collected. Results - The human and social capital inherent in top management at venture companies in the early stages of their existence become good evaluation data for those who are invested in similar resources. If top management includes strong human and social capital, access to external resources will be easier; these will have a positive influence on the selection of overnmental support systems; and, this proper support will also have a positive influence on the initial success of the venture company. The results revealed the following. First, it was found that when the educational level and functional background, (the top management human capital), are the output function, top management human capital had a significant influence on selection of governmental R&D support funds. Second, it was found that the internal social capital and external social capital, (the top management social capital), had a significant influence on selection of governmental R&D support tasks. Third, it was found that selection of the governmental R&D support tasks at the start of the venture company had a positive influence on the corporate financial performance such as sales, business profits, and the increase in workers; and, had a significant influence on nonfinancial performance such as market share, competitive position, product competitiveness, and the future product development. Conclusions - Selection of the governmental R&D support system is not recognized as part of the direct sales of a venture company in its early stages, but as it can reduce costs for technical development and helps significantly in creating test products and mass production, it has a positive influence on the company's financial performance and nonfinancial performance as a result. Therefore, companies should take great efforts to frequently be selected as a candidate in the governmental R&D support system, as it can help facilitate R&D that requires extensive funds. As a result, companies can expect effects such as job creation and patent applications and they can advance future product sales.

• Journal of Forest and Environmental Science
• /
• v.19 no.1
• /
• pp.48-68
• /
• 2003

There have been some problems of high labor. low productivity in the existing systems of bonsai cultivation. This study was conducted to cultivate a large quantity of hig-quality bonsai through the development of bottom irrigation system and management method. Bonsai placed on the FRP bed were grown very well by bottom irrigation system compared with direct watering and sprinkler system. It was concluded that bottom irrigation system was possible to reduce considerable manual labor and produce mass production of high-quality bonsai within shorter periods. This research was finally found that the growth was significantly better and earlier production was certain in the vinyl house, had another advantage which could cultivate less cold-resistant species and therefore broadened a range of species selection for market supply. Cultivation techniques by the use of vinyl house and bottom irrigation system developed was quite effective for early production of bonsai as well as for high productive and value added. This project developed a new practical techniques and systems which can make mass and early production of bonsai with high quality through input of less labor. Interest in bonsai is now expanding in landscape horticulture and other fields concerned, and bonsai export of our country is also increasing. Results from this research will make a great contribution to enhancing of bonsai cultivator's competitive position in world markets and to improving of their annual income.

• Fisheries and Aquatic Sciences
• /
• v.14 no.4
• /
• pp.323-332
• /
• 2011

To find seasonally optimal microalgae for mass culture of the rotifer Brachionus plicatilis, the growth rates of 12 microalgal species (two marine Chlorella spp., five marine Nannochloris spp., two marine Nannochloropsis spp., one estuarine Nannochloropsis sp., and two estuarine Chlorella spp.) were compared at $25^{\circ}C$ at 15 psu and 30 psu. Among these, six species showing high growth rates were chosen and examined again at high ($30^{\circ}C$ and $32^{\circ}C$) and low ($10^{\circ}C$) temperatures. Their amino and fatty acids and the dietary value of the rotifers that fed on each microalgal species were examined. Nannochloris sp. (KMMCC-119) and Chlorella vulgaris (KMMCC-120) showed the highest growth rates at temperatures over $30^{\circ}C$ and at $10^{\circ}C$, respectively. The growth rate of Nannochloris was higher than those of Chlorella and Nannochloropsis at high temperatures, but lower than those of the latter at low temperatures. The growth rate of rotifers fed on Nannochloropsis was highest and that of those fed on Chlorella was lowest. Levels of eicosapentaenoic acid and docosahexaenoic acid were highest in Nannochloropsis and lowest in Nannochloris. However, total amino acid content was highest in Nannochloris and lowest in Chlorella. In conclusion, Nannochloropsis sp. (KMMCC-33) was the best microalgal species for the mass culture of the rotifer. However, during high- or low-temperature seasons in which Nannochloropsis does not grow well, Nannochloris spp. (KMMCC-119, 395) and C. vulgaris (KMMCC-120) would adequately replace Nannochloropsis sp. (KMMCC-33).