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A Case of Pulmonary Mucormycosis Presenting as an Endobronchial Mass (기관지내 종괴로 발현된 폐모균증 1례)

  • Hwang, Jung-Hye;An, Chang-Hyeok;Yun, Jong-Wook;Roh, Gil-Hwan;Ham, Hyeong-Suk;Kang, Eun-Hae;Suh, Gee-Young;Jeong, Man-Pyo;Kim, Ho-Goong;Kwon, O-Jung;Rhee, Chong-H.
    • Tuberculosis and Respiratory Diseases
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    • v.49 no.5
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    • pp.633-638
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    • 2000
  • Pulmonary mucormycosis is an opportunistic infection in patients with severe underlying illness such as immunocompromised diseases or uncontrolled diabetes mellitus. While patients with leukemia and lymphoma usually present with diffuse parenchymal disease, diabetic patients usually have a localized endobronchial disease involving central airways. We report upon a case of pulmonary mucormycosis in diabetes mellitus patient presenting as an endobronchial mass, which was cured with antifungal therapy, rigid bronchoscopic mass removal and right pneumonectomy.

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Quality Characteristics of Dumpling Shell Containing Pleurotus eryngii Powder (새송이버섯 분말을 첨가한 만두피의 품질 특성)

  • Kang, Bok-Hee;Shin, Eun-Jeong;Lee, Sang-Han;Lee, Dong-Sun;Hur, Sang-Sun;Kim, Seong-Ho;Son, Seok-Min;Lee, Jin-Man
    • Journal of the Korean Society of Food Science and Nutrition
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    • v.40 no.4
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    • pp.570-574
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    • 2011
  • This study was conducted to investigate the quality characteristics of dumpling shells with added Pleurotus eryngii powder (PP) (2%, 4%, 6%). The weight after cooking and volume of the dumpling shells increased with the addition of PP. The water absorption of the dumpling shells was not significantly different by the addition of PP. Turbidity after cooking increased and hardness decreased by adding PP. The L value after cooking decreased with the addition of PP, and the b value was highest when the content of PP was 6%. Adhesiveness increased by adding PP and springiness decreased when PP content was above 4%. Chewiness and gumminess decreased by adding the powder. There were no differences among the control, 2%, and 4% samples in cohesiveness values, but cohesiveness significantly decreased with the addition of 6% of powder. Color characteristics showed low values when PP was added at more than 6% according to sensory characteristics tests. No significant differences were found in flavor, taste, smoothness, moisture, or adhesiveness of the dumpling shells after cooking according to additions of PP. Chewiness was higher by adding PP compared to the control, but no significant differences were found by additions of PP.

In vivo protein expression changes in mouse livers treated with dialyzed coffee extract as determined by IP-HPLC

  • Yoon, Cheol Soo;Kim, Min Keun;Kim, Yeon Sook;Lee, Suk Keun
    • Maxillofacial Plastic and Reconstructive Surgery
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    • v.40
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    • pp.44.1-44.17
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    • 2018
  • Background: Coffee extract has been investigated by many authors, and many minor components of coffee are known, such as polyphenols, diterpenes (kahweol and cafestol), melanoidins, and trigonelline, to have anti-inflammatory, anti-oxidant, anti-angiogenic, anticancer, chemoprotective, and hepatoprotective effects. Therefore, it is necessary to know its pharmacological effect on hepatocytes which show the most active cellular regeneration in body. Methods: In order to determine whether coffee extract has a beneficial effect on the liver, 20 C57BL/6J mice were intraperitoneally injected once with dialyzed coffee extract (DCE)-2.5 (equivalent to 2.5 cups of coffee a day in man), DCE-5, or DCE-10, or normal saline (control), and then followed by histological observation and IP-HPLC (immunoprecipitation high performance liquid chromatography) over 24 h. Results: Mice treated with DCE-2.5 or DCE-5 showed markedly hypertrophic hepatocytes with eosinophilic cytoplasms, while those treated with DCE-10 showed slightly hypertrophic hepatocytes, which were well aligned in hepatic cords with increased sinusoidal spaces. DCE induced the upregulations of cellular proliferation, growth factor/RAS signaling, cellular protection, p53-mediated apoptosis, angiogenesis, and antioxidant and protection-related proteins, and the downregulations of NFkB signaling proteins, inflammatory proteins, and oncogenic proteins in mouse livers. These protein expression changes induced by DCE were usually limited to the range ± 10%, suggesting murine hepatocytes were safely reactive to DCE within the threshold of physiological homeostasis. DCE-2.5 and DCE-5 induced relatively mild dose-dependent changes in protein expressions for cellular regeneration and de novo angiogenesis as compared with non-treated controls, whereas DCE-10 induced fluctuations in protein expressions. Conclusion: These observations suggested that DCE-2.5 and DCE-5 were safer and more beneficial to murine hepatocytes than DCE-10. It was also found that murine hepatocytes treated with DCE showed mild p53-mediated apoptosis, followed by cellular proliferation and growth devoid of fibrosis signaling (as determined by IP-HPLC), and subsequently progressed to rapid cellular regeneration and wound healing in the absence of any inflammatory reaction based on histologic observations.

Health Risk Factors and Ventilation Improvements in Welding Operation at Large-sized Casting Process (대형 주물공정 용접작업장의 건강 위해인자 및 환기 개선)

  • Jung, Jong Hyeon;Jung, Yu Jin;Lee, Sang Man;Lee, Jung Hee;Shon, Byung Hyun;Lim, Hyun Sul
    • Clean Technology
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    • v.20 no.2
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    • pp.171-178
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    • 2014
  • In this study we have examined the health risk factors and analyzing data of laborers working at the welding operation at large-sized casting process. In order to improve the working environment of workplace, an effective ventilation method was proposed after performing CFD (computational fluid dynamics) modeling and measurement of pollutants. As a result of examining the health risk factors of workers, oxidized steel dust is the main pollution source in the company A, welding fume in the companies B and C, and welding fume and oxidized steel dust in the company D. The fume concentration in the workers' breathing zone was $0.05{\sim}4.37mg/m^3$, and the fume concentration in the indoor air at the welding process was $0.13{\sim}7.54mg/m^3$. From a result of CFD, a local exhaust with an exhaust duct adjacent to welding point was found to be most effective in case of the exhaust process. In case of air supply, we found that a desired location of air supply fan would be at the end of the opening. If a standardizing the ventilation system for tunnel-type semi-enclosed space at a large-sized casting process is introduced in welding work places in the future, it would be more effective to protect the health of welding workers working at the casting industry and shipbuilding industry and improve the work environment.

Changes in Quality Characteristics of Garlic Jam during Storage (마늘 잼의 저장과정 중 성상변화)

  • Park, Hye-Min;Kwak, Hyo-Soon;Kim, So-Hee;Moon, Mi-A;Oh, Man-Jin
    • Korean Journal of Agricultural Science
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    • v.35 no.2
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    • pp.183-191
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    • 2008
  • In order to make a functional jam containing garlic, sugar, acid and pectin were mixed with garlic and concentrated by heating the mixture under atmosphere or vacuum conditions. And changes of some physico-chemical properties of the garlic jam(i.e., color, textural properties, vitamin C) were investigated during storage at $30^{\circ}C$. It was found that lightness(L) was higher in sample of vacuum concentration than that in atmosphere concentration and redness(a) and yellowness(b) were higher in sample of atmosphere concentration. During the storage lightness was found to decrease for all samples with more drastic decrease in sample of atmosphere concentration where browning was more severely observed after 8 weeks of storage. In terms of textural properties, hardness, chewiness and gumminess were higher in sample of atmosphere concentration than that in vacuum concentration. And springiness and cohesiveness were higher in sample of vacuum concentration. Although sensory score for garlic jam found to be lower than that for the existing strawberry jam, the present garlic jam might have high marketability if considering its physiological value.

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The distribution of Xive implant patients and the type of implant site and survival rate in mandible (하악에 식립된 Xive implant 환자의 분포 및 식립부 유형과 생존율)

  • Jang, In-Kwon;Jung, Ui-Won;Kim, Chang-Sung;Shim, Joon-Sung;Cho, Kyoo-Sung;Chai, Jung-Kiu;Kim, Chong-Kwan;Choi, Seong-Ho
    • Journal of Periodontal and Implant Science
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    • v.35 no.2
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    • pp.437-448
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    • 2005
  • This study is an analysis of distribution of patients who installed Xive implant in Yonsei University Hospital and types of implant site for about 2 years recall check and cumulative survival rate. 41 implant were used in this study. It shows the conclusion below. 1. Patients at the age of 40s and 50s were 60% of all implant cases and average number of implant was 2.4(man), and 1.9(woman). All cases were operated on mandible, 3 implants on anterior region and 38 implants on posterior region. 2. The major cause of tooth loss is dental caries(48.8%), followed by periodontal disease. 3. Most distribution of bone qaulity for mandibular implant site was type II(65.8%) and bone quantity was type B(75.6%). 4. The majority of implants were those of 11, 13mm in length(95%) and regular diameter in width (64%). 5. The 41(19 persons) Xive implants that were placed in the mandibular anterior and posterior region were all survival and showed a 100% 2 year cumulative survival rate. The results provided us with basic data on patient type, implant distribution, bone condition, and survival rate. We wish that our results coupled with other research data helps assist in the further study for better implant success rates, etc.

Korean molluscs as auxiliary hosts for parasites: A study of implications for pathogen transmission in a changing climate (기생충의 보조숙주로서의 한국산 연체동물 감염 실태: 기후변화에서 병원체 전파의 영향에 대한 고찰)

  • Park, Gab-Man
    • The Korean Journal of Malacology
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    • v.28 no.1
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    • pp.13-19
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    • 2012
  • To determine the status of Korean molluscs infection and relation with climate change of Korean peninsula, references were reviewed. Wild animals serve as intermediate, reservoirs and paratenic hosts to zoonotic parasites of human beings. Trematode are common parasites of molluscs and almost all trematodes infect mollusks as the first host in the life cycle, and most have a complex life cycle involving other hosts. The significance of auxiliary hosts to the ecology of the parasite has not been proper discussion. There is increasing concern as to the impact of climate change on the epidermiology of many parasitic diseases. A total of 21 species for snail transmitted parasites from Korean molluscs has been reviewed. Among them, 15 species was aquatic mollusks and 6 species for marine mollusks. Maximum infections belonged to Semisulcospira livertina had 11 kind of parasite pathogenic organisms, including Paragonimus westermani, Metagonimus yokogawai, Centrocestus armatus, Notocotylus magniovatus, Centrocestus formosanus, incerte cercaria, nipponensis cercaria, Yoshidae cercaria, cristata cercaria, innominatum cercaria and Metagonimus sp. And 11 in Parafossarulus manchouricus including Clonorchis sinensis, Asymphylodora japonica, Cyathocotyle orientalis, Exorchis oviformis, Notocotylus attenuatus, Echinochasmus japonicus, Loxogenes liberum, Cercariae of Loxogenes liberum Type I, Cercariae of Loxogenes liberum Type II, Furcocercus cercariae (Family Sanguincolidae) and Cercaria of Mucobucaris, 10 in Semisulcospira sp. including Paragonimus westermani, Metagonimus yokogawai, Centrocestus armatus, Echinochasmus redioduplicatus, Notocotylus magniovatus, Cercaria incerte, Cercaria nipponensis, Cercaria yoshidae, paludinarum cercaria and Metagonimus sp., 7 in Koreanomelania globus including Pseudexorchis major, Cercaria of parapleurolophocercous type, Metagonimus sp. (A & B), Cercaria nipponensis, Cercaria inserta and Cercaria yoshidae. Also, Tapes philippinarum have 3 pathogenic organisms including Cercariae tapidis, Cercariae furcocercus and Parvatrema sp. In particular, under climatic extremes such as floods and drought, aquatic molluscs may play a more prominent role in parasite transmission in the future.

Sensory Evaluation and Changes in Physicochemical Properties of Gochujang Powder with Different Drying Methods (건조방법에 따른 분말 고추장의 성분변화와 관능적 특성)

  • Kim Cheong-Gyu;Lee Jung-Suk;Oh Kyung-Keun;Yi Sang-Duk;Oh Man-Jin
    • Food Science and Preservation
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    • v.13 no.1
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    • pp.24-29
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    • 2006
  • This study was carried out to promote aspects of preservation and convenience of red pepper paste (r.p.p.). Sample was prepared with spray drying (s.d), vacuum drying (v.d) and freeze drying (f.d) methods. The prepared powdered samples were stored for 90 days at $35^{\circ}C$ in seal condition. After powdered samples were hydrated, the samples were used for analysis such as a sensory test, texture, color and changes of component According to sensory test, quality of dried red pepper paste were better in order to f.d.r.p.p. < s.d.r.p.p. < v.d.r.p.p. Changes of pH, reducing sugar, amino nitrogen and NaCl of dried r.p.p. were not observed compared to control but viscosity decreased by about $15\%$ During the storage, acidity decreased by about $15\%$ and reducing sugar, amino nitrogen and ethanol decreased slightly. Hunter L, a and b values decreased from 24.8-27.3 to 23.6-24.4, from 10.8-12.0 to 8.3-9.3 and from 7.1-7.9 to 4.4-5.5, respectively.

Cloning and Identification of Essential Residues for Thermostable β-glucosidase (BgIB) from Thermotoga maritima (Thermotoga maritima로부터 고온성 β-glucosidase (BgIB)의 클로닝과 필수아미노산 잔기의 확인)

  • Hong, Su-Young;Cho, Kye-Man;Kim, Yong-Hee;Hong, Sun-Joo;Cho, Soo-Jeong;Cho, Yong-Un;Kim, Hoon;Yun, Han-Dae
    • Journal of Life Science
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    • v.16 no.7 s.80
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    • pp.1148-1157
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    • 2006
  • A hyperthermophilic bacterium Thernotoga maritima produced thermostable ${\beta}-glucosidase$. The gene encoding ${\beta}-glucosidase$ from T. maritima MSB8 was cloned and expressed in Escherichia coli. The en-zyme (BgIB) hydrolyzed ${\beta}-glucosidase$ linkages between glucose and alkyl, aryl of saccharide groups such as salicin, arbutin, and $_pNPG$. The insert DNA contained ORF with 2,166 bp encodes a 721 amino acids (calculated molecular mass of 80,964 and pl of 4.93). The amino a.id sequence of BglB showed the similarity to family 3 glycosyl hydrolases. The molecular weight of the enzyme was estimated to be approximately 81kDa by MUG-nondenaturing PAGE (4-methylumbelliferyl 13-D-glucoside-nondenaturing polyacrylamide gel electophoresis) and SDS-PACE. The ${\beta}-glucosidase$ exhibited maximal activity at pH 7.0 and $80^{\circ}C$. By exchanging two possible residues (Glu-232 and Asp-242) to Ala by site-directed mutagenesis method, it was found that these were essential for enzymatic activity.

Pragmatische Analyse sprachlicher $Ausdr\"{u}cke$ der $\"{U}berzeugtheit-Modalit\"{a}t$ in den $Lehrb\"{u}chern\;f\"{u}r$ Deutsch als Fremdsprache (독일어 교재에 등장하는 '확신'-화법어의 양상 고찰)

  • Cho Kuk-Hyun
    • Koreanishche Zeitschrift fur Deutsche Sprachwissenschaft
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    • v.3
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    • pp.253-276
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    • 2001
  • In dieser vorliegenden Arbeit wird. versucht, sprachlicher Ausdrucke der $\"{U}berzeugtheit-Modalit\"{a}t$ in den Lehrblichern $f\"{u}r$ Deutsch als Fremdsprache unter dem Aspekt der Pragmatik zu analysieren. Als Untersuchungsmaterial werden zwei $Lehrb\"{u}cher\;gew\"{a}hlt$, die in einem Deutschunterricht an der Hankuk $Universit\"{a}t\;f\"{u}r$ Fremdsprachen benutzt worden ist oder benutzt wird: Deutsche Sprachlehre $f\"{u}r\;Ausl\"{a}nder$(kurz: DSA) und Aufbaukurs Deutsch (kurz: AD). Das erstere gilt als grammatikbezogen, das zweite als kommunikationsorientiert. In AD kommen dialogische und monologische Texte im $Verh\"{a}ltnis$ 5 zu 3 vor, wahrend in DSA monologische Texte $70\%$ aller Texte betragen. Es ist zu beachten, dass DSA relativ mehr asymmetrische Dialoge enthalt, in denen ein $Gesp\"{a}chsteilnehmer$ auf Kenntnisse, $F\"{a}higkeiten$ oder Hilfe eines anderen angewiesen ist. Jeder $Gesp\"{a}chsteilnehmer\;\"{u}bemimmt$ eine konventionell festgelegte Rolle. Asymmetrische Dialogen sind in der Regel standardisierte Dialogformen wie Wegauskunft oder Verkaufsgesprach. Im Vergleich zu DSA sind 25 von 29 Dialogen in AD symmetrisch. Der symmetrische Dialog ist ein Dialog, dessen Teilnehmer sich in 'gleichberechtigter' Position befinden. In symmetrischen Dialogen versucht z.B. ein $Gesp\"{a}chsteilnehmer$ einen anderen zu $\"{u}berzeugen$, um seine eigenen Interessen durchzusetzen oder zwei (oder mehrere)$Gesp\"{a}chsteilnehmer\;bem\"{u}hen$ sich zusammen, urn ein gemeinsames Ziel zu erreichen. Bei der empirischen Untersuchung von DSA und AD $l\"{a}sst$ sich feststellen, dass modale sprachliche Mittel, die zum Ausdruck der $\"{U}berzeugtheit\;dienen,\;h\"{a}ufig$in symmetrischen Dialogen vorkommen. Ein solcher Ausdruck stellt em kommunikativ relevantes Element spraehlieher Handlung dar. Bei der $\"{U}berzeugtheit-Modalit\"{a}t$ handelt es sich $n\"{a}mlich$ um den Grad der $\"{U}berzeugtheit$ des Spreehers, also um die sprecherseitige $Einsch\"{a}tzung$ des Geltungsgrad des Inhaltes einer spraehliehen $\"{A}u{\ss}erung$ in ihrer Beziehung zur objektiven Realitat. In einer sprachliehen $\"{A}u{\ss}erung\;dr\"{u}ckt$ man seine Gewissheit, Ungewissheit, Vermutung, seinen Zweifel aus. Aus der Analyse dialogiseher Texte ergibt sich, dass sprachliche Ausdrucke der $\"{U}berzeugtheit-Modalit\"{a}t$ in AD viel $h\"{a}ufiger\;und\;vielf\"{a}ltiger$ vorkommen, als in DSA.

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