• Proceedings of the Korean Society of Toxicology Conference
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• 2003.05a
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• pp.39-40
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• 2003

Ochratoxin A (OA), a potent nephrotoxin in several species, is knownto be a renal carcinogen in animals and is implicated in the etiology of Balkan endemic nephropathy (BEN). The NTP (National Toxicology Program) classified Ochratoxin A as having clear evidence of carcinogenic activity, based on uncommon tubular adenomas and tubular cell carcinomas of the kidney and multiple fibroadenomas of the mammary gland, seen in the rat.(omitted)

• Journal of Veterinary Clinics
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• v.14 no.1
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• pp.103-107
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• 1997

The effectiveness of two different methods for the treatment of mammary tumors in bitches was examined in 30 dogs to determine the use of homepathy induction by Phytolacca $D_{2}$ preparations. The animals in group 1 received only Phytolacca $D_{2}$. In group 2the tumors were removed surgically and were treated with Phytolacca $D_{2}$ post operation. For the clinical sigh post treatment the dogs were examined regularly to detect neoplasia, reoccurrences and metastases. Treatment with Phytolacca $D_{2}$ resulted in following effects; In group 1 was not efficient. In group 2 was an inhibition of tumor growth and treated animals appeared to be revitalized.

• Bulletin of Food Technology
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• v.17 no.4
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• pp.117-128
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• 2004

Sulforaphane은 브로컬리나 십자화과 채소중의 glucoraphanin의 가수분해 산물인 isothiocyanate로서 이는 detoxification 효소의 phase II를 일으키는 것으로 나타났고 설치류에서 화학적으로 발생된 유선 종양을 억제하고 최근에는 대장암 세포에서 cell cycle arrest와 apoptosis를 일으킨다고 알려져 왔다. 여기서는 SUL이 Human MammaryMCF-7 adenocarcinoma 세포의 증폭을 억제하는 역할을 제시하였다. MCF-7 cell에 15umol/L SUL을 처리하였을 때 G2/M cell cycle이 arrest를 보였고 cyclin B1 protein이 24시간 이내에 증가하였다. 15umol/L의 SUL은 in vivo 상에서 histon Hl의 인산화를 유도하고, 초기 mitosis에서 cell을block하며 mitotic microtuble의 중합화를 방해하였다. In vitro 상에서 정제된 bovine braintubulin에 대한 SUL을 고농도로 투여했을 때, tubulin의 중합율과 총 tubulin 중합도의 억제를 보였다. 덧붙여서, isothiocyanate를 함유하는 SULanalog로 처리된 정제 tubulin도 비슷하게 저해를 받았다. 본 연구는 SUL이 mitotic cell cyclearrest를 포함한 mammary cancer 억제력을 가진 것과, 이러한 기작으로 정상적인 tubulin 중합화및 microtubule dynamic에 한층 효과적인 영향을 준다는 것을 제시하였다.

• Asian-Australasian Journal of Animal Sciences
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• v.14 no.4
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• pp.564-566
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• 2001

A study was undertaken to record the utilization of some micro-elements during inflammation of the mammary gland. Two groups of twenty five animals each suffering from subclinical and clinical mastitis were selected for the study. All the animals were maintained on identical diets. Blood zinc level in cows with subclinical mastitis ($5.66{\pm}0.52$) was significantly (p<0.05) lower than that of healthy cows ($8.46{\pm}1.10ppm$). No significant difference was, however, recorded in blood copper and cobalt levels between healthy and mastitic cows.

• Journal of Veterinary Clinics
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• v.11 no.2
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• pp.567-572
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• 1994

A 14-year-old virgin, female Yorkshire Terrier showed enlarged abdomen after udderectomy was diagnosed with canine mammary gland tumor accompanied with hydrometra. Gross findings appeared a white-yellowish $l0{\times}7{\times}7cm sized solid mass containing cysts filled with various colored mucoid fluids in the udder. Both uteri were distended greatly with white-yellowish watery fluids and their serosal surfaces were translucent. Characteristic micyoscopic findings in the mass of the udder showed great expansion of the mammary lobule and stroma and complete replacement of the glandular elements by prolifaration of myoepithelial cells. The mucosa of the uterus showed severe atrophy of the uterine epithelium.

• Proceedings of the Korean Society of Veterinary Pathology Conference
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• 2000.09a
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• pp.24-24
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• 2000

A case of mammary gland adenocarcinoma is reported in a 22-year-old female Mandril (Mandrillus sphinix). The veterinarian noted a fast growing mass, which was inflammed and perforated, involving both mammary gland during the last 4 months. Supplement antibiotic and chemotherpay were unsucessful and the monkey was found dead. On necropsy, both right and left mannary gland were replaced by firm, tan, perforating neoplastic mass. (omitted)

• Proceedings of the Korean Society of Toxicology Conference
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• 2001.10a
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• pp.175-175
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• 2001

This experiment tested whether in utero and lactational exposure to 4-nonylphenol (NP) alters mammary gland differentiation in the female offspring rat. Pregnant Sprague Dawley rats were administered NP (l0, 100 mg/kg), atrazine (l00 mg/kg), pesticide demonstrating antiestrogenic activity in mammary gland development, or vehicle (0.5% methyl cellulose) by oral gavage from gestation day 15-19.(omitted)

• Korean Journal of Veterinary Research
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• v.53 no.3
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• pp.185-187
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• 2013

An 11-year-old, toy poodle dog was presented with dermatologic lesions and mammary gland tumor (MGT) evaluation. A solitary, lobulated MGT (size $2.5{\times}3.5$ cm) was affecting the 5th left mammary gland. Firm, oval plaque skin lesions were present on the left dorsal carpal area. The skin lesions were alopecic and salivary staining. The dog had historical separation anxiety and excessive licking of skin lesions were observed. Based on the clinical and histopathologic examinations, MGT was diagnosed with mammary complex adenoma and the skin lesions were diagnosed with acral lick dermatitis. Behavior modification treatment using oral clomipramine was effective.

• Korean Journal of Animal Reproduction
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• v.17 no.4
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• pp.375-383
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• 1994

The human growth hormone (hGH) gene uder the control of the rat $\beta$-casein promoter gene was designed to produce transgenic mouse expressed hGH gene in only mammary gland. One hundred seventy two eggs microinjected were transferred to the oviducts of pseudopregnants and 43 offspring were delivered. By Southern blotting hybridization, 3 were transgenic with rat $\beta$-casein/hGH gene. The copy numbers of three transgenic founder were 1, 5, and 15, respectively. A radioimmunoassay was developed to quantitate the amount of expression of the hGH gene in mammary gland of transgenic mice. The amount of hGH was 13.3ng/ml in the lactating milk of one transgenic line, showing predominantly higher than 3.0ng/ml in milk of control mice. Therefore, our findings suggested that $\beta$-casein promoter may induce the tissue specific expression of structural gene.

• Journal of Veterinary Clinics
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• v.19 no.4
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• pp.440-442
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• 2002

A fourteen-year-old mongrel female dog that was 22 kg and had two large mammary tumor lesions was admitted to the Animal Teaching Hospital of Chonbuk National University. Two large mammary tumor lesions were observed in the right caudal thoracic and the left inguinal mammary glands, which were sized 6 cm and 5 cm in diameter, respectively. These tumor lesions were removed by block mastectomy, then large skin defect of 7 cm diameter in caudal abdominal wall were recoverd by classic Z-plasty in both medial thigh. Classic Z-plasty was designed with 60 in angle and, with 6 cm in length of central limb in right medial thigh and 4 cm in left, respectively. This patient had been recoverd to normal gait and behavior at 20 days after the plastic operation.