• 제목/요약/키워드: main peak

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Structural Identification of a Non-Glycosylated Variant at Ser126 for O-Glycosylation Site from EPO BRP, Human Recombinant Erythropoietin by LC/MS Analysis

  • Byeon, Jaehee;Lim, Yu-Ri;Kim, Hyong-Ha;Suh, Jung-Keun
    • Molecules and Cells
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    • 제38권6호
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    • pp.496-505
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    • 2015
  • A variant peak was detected in the analysis of RP-HPLC of rHu-EPO, which has about 7% relative content. Fractions of the main and the variant peaks were pooled separately and further analyzed to identify the molecular structure of the variant peak. Total mass analysis for each peak fraction using ESI-TOF MS shows differences in molecular mass. The fraction of the main peak tends to result in higher molecular masses than the fraction of the variant. The detected masses for the variant are about 600-1000 Da smaller than those for the main peak. Peptide mapping analysis for each peak fraction using Asp-N and Glu-C shows differences in O-glycopeptide profiles at Ser126. The O-glycopeptides were not detected in the fraction of the variant. It is concluded that the variant peak is non-O-glycosylated rHu-EPO and the main peak is fully O-glycosylated rHu-EPO at Ser126.

뇌경새(腦梗塞) 환자(患者)와 건강인(健康人)의 맥상(脈象)과 사상체질(四象體質)에 관(關)한 연구(硏究) (Comparative Study on the Pulse Wave Variables and Sasang Constitution in Cerebral Infarction Patients and Healthy Subjects)

  • 고기덕;김경요;김종열;이시우;주종천
    • 대한약침학회지
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    • 제10권2호통권23호
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    • pp.119-132
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    • 2007
  • This study was performed to determine whether a pulse analyzer was useful 1) to characterize the variables of pulse wave of cerebral infarction patieno (CI), compared with those of healthy subjects, as well as 2) to determine Sasang Constitution in CI and healthy subjects. 1. Calibrated in Gwan, the amount of energy(Energy), height of main peak(H1), height of aorticvalley(H2), height of aortic peak(H3), total area of pulse wave(At), and area of main peak width(Aw) of the CI group were higher than those of the healthy group. 2. Calibrated in Cheek, Energy, H1, H2, H3, height of valve valley(H4), At, Aw, and main peak angle(MPA) of the CI group were higher than those of the healthy group. 3. Among the healthy (subjects) group, Taeumin showed the highest contact pressure(CP) and height of valve peak(H5) calibrated in Chon. The main peak width divided by whole time of pulse wave(MPW/T) calibrated in Gwan and Cheok, was highest in Soyangin and was lowest in Taeumin. The H3 divided by H1(H3/H1) and the time to valve valley minus the time to main peak and divided by T[(T4-T1)/T] calibrated in Cheek were highest in Soyangin. The time to main peak(T1) was longest in Soumin. 4. Among the CI group, At calibrated in Chon was widest in Taeumin and was narrowest in Soumin The time to aortic peak(T3) calibrated in Cheek was longest in Soumin and was shortest in Soyangin. The time to valve peak(T5) was shortest in Soyangin. 5. There were main effects of cerebral infarction in the area of systolic period(As) and area of diastolic period(Ad) calibrated in Chon, Energy calibrated in Cwan, and Energy, H1, H2, H3, (H4+H5)/Hl, and MPA calibrated in Cheek. 6. There were main effects of Sasang Constitution in (T4-T1)/T, area of systolic period(As), and Ad calibrated in Chon. 7. The interactions between the cerebral infarction and Sasang Constitution were observed in H5/H1 , T, At, As, Ad, and MPA calibrated in Chon, H4, T4, (T4-T1)/T, As, and Ad calibrated in Cwan, and 74,75, and MPW calibrated in Cheok. Therefore, we concluded that pulse analyzer was useful to determine the risk degree of cerebral infarction and Sasang Constitution.

Valence Band Photoemission Study of the Kondo Insulator CeNiSn

  • Kang, J.S.;Olson, C.G.;Ouki, Y.
    • Journal of Magnetics
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    • 제2권4호
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    • pp.111-115
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    • 1997
  • The electronic structure of the Kondo insulator CeNiSn has been investigated by using photoemission spectroscopy. A satellite feature is observed in the valence band spectrum about 6 eV below the Ni 3d main peak, indicating a strong Ni 3d Coulomb correlation in CeNiSn. The Ce 4f partial spectral weight exhibits three peak structures, including one due to the 4f1\longrightarrow4f0 transition, another near EF, and the other which overlaps the Ni 3d main peak. We interpret the peak near EF as reflecting mainly the Ce 4f/Sn 5p hybridization, whereas that around the ni 3d main peak as reflecting both the Ce 4f/Ni 3d and Ce 5d/Ni 3d hybridization. Yield measurements across the 4d\longrightarrow4f threshold indicate the Ce valence to be close to 3+. The prominent Fermi edge suggests a metallic ground state in CeNiSn.

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AlGaAs/GaAs multiple-quantum well에 대한 상온에서의 photoreflectance 특성연구 (A study of room temperature PR(photoreflectance) charicteristics for AlGaAs/GaAs multiple-quantum well)

  • 김동렬;최현태;배인호;김말문;한병국;우덕하;김선호;최상삼
    • 한국진공학회지
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    • 제6권2호
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    • pp.109-113
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    • 1997
  • MBE로 성장한 AlGaAs/GaAs multiple-quantum well(MQW)에 대하여 pump source를 He-Ne laser와 Ar laser를 사용하여 상온에서 PR(photoreflectance)측정을 수행한 결과 여러 subband transition peak을 관찰하였다. PR결과를 standard analytic line shape으 로 fitting하여n=1의 conduction band와 heavy hole 그리고 light hole transition peak인 Cl-Hl, Cl-Ll에 대한 energy값들을 얻었다. 또한 상온에서의 PL(photoluminescence)측정에 서 Cl-Hl, Cl-Ll과 관련된 main peak와 shoulder를 관찰하였다. 이 값은 PR측정값과 잘 일 치함으로써 PL에서의 main peak와 should가 Cl-Hl, Cl-Ll과 관련된 peak임을 확인할 수 있 었다. 또한 envelope function approximation(EFA)을 이용하여 구한 이론값과 PR과 PL에서 측정된 실험값들을 비교하였다.

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한국주요빙계의 소유역에 대한 순간단위권 유도에 관한 연구 (I) (Studies on the Derivation of the Instantaneous Unit Hydrograph for Small Watersheds of Main River Systems in Korea)

  • 이순혁
    • 한국농공학회지
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    • 제19권1호
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    • pp.4296-4311
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    • 1977
  • This study was conducted to derive an Instantaneous Unit Hydrograph for the accurate and reliable unitgraph which can be used to the estimation and control of flood for the development of agricultural water resources and rational design of hydraulic structures. Eight small watersheds were selected as studying basins from Han, Geum, Nakdong, Yeongsan and Inchon River systems which may be considered as a main river systems in Korea. The area of small watersheds are within the range of 85 to 470$\textrm{km}^2$. It is to derive an accurate Instantaneous Unit Hydrograph under the condition of having a short duration of heavy rain and uniform rainfall intensity with the basic and reliable data of rainfall records, pluviographs, records of river stages and of the main river systems mentioned above. Investigation was carried out for the relations between measurable unitgraph and watershed characteristics such as watershed area, A, river length L, and centroid distance of the watershed area, Lca. Especially, this study laid emphasis on the derivation and application of Instantaneous Unit Hydrograph (IUH) by applying Nash's conceptual model and by using an electronic computer. I U H by Nash's conceptual model and I U H by flood routing which can be applied to the ungaged small watersheds were derived and compared with each other to the observed unitgraph. 1 U H for each small watersheds can be solved by using an electronic computer. The results summarized for these studies are as follows; 1. Distribution of uniform rainfall intensity appears in the analysis for the temporal rainfall pattern of selected heavy rainfall event. 2. Mean value of recession constants, Kl, is 0.931 in all watersheds observed. 3. Time to peak discharge, Tp, occurs at the position of 0.02 Tb, base length of hlrdrograph with an indication of lower value than that in larger watersheds. 4. Peak discharge, Qp, in relation to the watershed area, A, and effective rainfall, R, is found to be {{{{ { Q}_{ p} = { 0.895} over { { A}^{0.145 } } }}}} AR having high significance of correlation coefficient, 0.927, between peak discharge, Qp, and effective rainfall, R. Design chart for the peak discharge (refer to Fig. 15) with watershed area and effective rainfall was established by the author. 5. The mean slopes of main streams within the range of 1.46 meters per kilometer to 13.6 meter per kilometer. These indicate higher slopes in the small watersheds than those in larger watersheds. Lengths of main streams are within the range of 9.4 kilometer to 41.75 kilometer, which can be regarded as a short distance. It is remarkable thing that the time of flood concentration was more rapid in the small watersheds than that in the other larger watersheds. 6. Length of main stream, L, in relation to the watershed area, A, is found to be L=2.044A0.48 having a high significance of correlation coefficient, 0.968. 7. Watershed lag, Lg, in hrs in relation to the watershed area, A, and length of main stream, L, was derived as Lg=3.228 A0.904 L-1.293 with a high significance. On the other hand, It was found that watershed lag, Lg, could also be expressed as {{{{Lg=0.247 { ( { LLca} over { SQRT { S} } )}^{ 0.604} }}}} in connection with the product of main stream length and the centroid length of the basin of the watershed area, LLca which could be expressed as a measure of the shape and the size of the watershed with the slopes except watershed area, A. But the latter showed a lower correlation than that of the former in the significance test. Therefore, it can be concluded that watershed lag, Lg, is more closely related with the such watersheds characteristics as watershed area and length of main stream in the small watersheds. Empirical formula for the peak discharge per unit area, qp, ㎥/sec/$\textrm{km}^2$, was derived as qp=10-0.389-0.0424Lg with a high significance, r=0.91. This indicates that the peak discharge per unit area of the unitgraph is in inverse proportion to the watershed lag time. 8. The base length of the unitgraph, Tb, in connection with the watershed lag, Lg, was extra.essed as {{{{ { T}_{ b} =1.14+0.564( { Lg} over {24 } )}}}} which has defined with a high significance. 9. For the derivation of IUH by applying linear conceptual model, the storage constant, K, with the length of main stream, L, and slopes, S, was adopted as {{{{K=0.1197( {L } over { SQRT {S } } )}}}} with a highly significant correlation coefficient, 0.90. Gamma function argument, N, derived with such watershed characteristics as watershed area, A, river length, L, centroid distance of the basin of the watershed area, Lca, and slopes, S, was found to be N=49.2 A1.481L-2.202 Lca-1.297 S-0.112 with a high significance having the F value, 4.83, through analysis of variance. 10. According to the linear conceptual model, Formular established in relation to the time distribution, Peak discharge and time to peak discharge for instantaneous Unit Hydrograph when unit effective rainfall of unitgraph and dimension of watershed area are applied as 10mm, and $\textrm{km}^2$ respectively are as follows; Time distribution of IUH {{{{u(0, t)= { 2.78A} over {K GAMMA (N) } { e}^{-t/k } { (t.K)}^{N-1 } }}}} (㎥/sec) Peak discharge of IUH {{{{ {u(0, t) }_{max } = { 2.78A} over {K GAMMA (N) } { e}^{-(N-1) } { (N-1)}^{N-1 } }}}} (㎥/sec) Time to peak discharge of IUH tp=(N-1)K (hrs) 11. Through mathematical analysis in the recession curve of Hydrograph, It was confirmed that empirical formula of Gamma function argument, N, had connection with recession constant, Kl, peak discharge, QP, and time to peak discharge, tp, as {{{{{ K'} over { { t}_{ p} } = { 1} over {N-1 } - { ln { t} over { { t}_{p } } } over {ln { Q} over { { Q}_{p } } } }}}} where {{{{K'= { 1} over { { lnK}_{1 } } }}}} 12. Linking the two, empirical formulars for storage constant, K, and Gamma function argument, N, into closer relations with each other, derivation of unit hydrograph for the ungaged small watersheds can be established by having formulars for the time distribution and peak discharge of IUH as follows. Time distribution of IUH u(0, t)=23.2 A L-1S1/2 F(N, K, t) (㎥/sec) where {{{{F(N, K, t)= { { e}^{-t/k } { (t/K)}^{N-1 } } over { GAMMA (N) } }}}} Peak discharge of IUH) u(0, t)max=23.2 A L-1S1/2 F(N) (㎥/sec) where {{{{F(N)= { { e}^{-(N-1) } { (N-1)}^{N-1 } } over { GAMMA (N) } }}}} 13. The base length of the Time-Area Diagram for the IUH was given by {{{{C=0.778 { ( { LLca} over { SQRT { S} } )}^{0.423 } }}}} with correlation coefficient, 0.85, which has an indication of the relations to the length of main stream, L, centroid distance of the basin of the watershed area, Lca, and slopes, S. 14. Relative errors in the peak discharge of the IUH by using linear conceptual model and IUH by routing showed to be 2.5 and 16.9 percent respectively to the peak of observed unitgraph. Therefore, it confirmed that the accuracy of IUH using linear conceptual model was approaching more closely to the observed unitgraph than that of the flood routing in the small watersheds.

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텍스트 마이닝과 퓨쳐스 휠 기법을 활용한 정부정책의 미래 성공 예측 : 임금피크제의 미래 정책예측 (Predicting Success of Government Policy in the Future with Futures Wheel and Text Mining : Predicting the Future Policy of Wage Peak System)

  • 김형중;김진화
    • 디지털융복합연구
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    • 제14권12호
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    • pp.141-153
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    • 2016
  • 본 연구의 목적은 다양한 자료를 검토 한 후 텍스트 마이닝 기법과 미래예측기법인 퓨쳐스휠 기법 그리고 극성선택 기법을 활용하여 임금피크제에 대한 미래 모습을 과학적으로 그려보고자 하였다. 이를 위해 논문, 뉴스기사, SNS(트위터, 블로그), 연구보고서 등을 수집하였다. 수집된 자료를 토대로 텍스트 마이닝 기법을 활용하여 메인주제 단어에 대한 키워드를 추출하고 퓨쳐스휠 기법과 극성선택 기법을 활용하여 임금피크제 미래 성공에 대한 최종결론을 도출하였다. 분석결과 임금피크제 미래 예측은 긍정적으로 예측되었다. 총 5가지의 메인 주제 중 임금피크제 찬반논란과 임금피크제 해결과제는 부정적으로 예측되었지만 임금피크제 배경이나 임금피크제의 목적 및 이유, 임금피크제 대안에 대해서는 긍정적으로 예측 되었다. 따라서 최종적으로 5가지 메인 주제 중 3가지가 긍정적으로 예측되어 임금피크제에 대한 미래는 긍정적으로 예측되었다. 임금피크제의 목적은 고령 근로자들의 정년보장과 고용안정일 것이다. 그러나 임금피크제가 성공적으로 실행되기 위해서는 단순히 연령만 고려된 임금삭감이 아니라 근로시간이나 직원의 직무 유형 등 다양한 특성들을 고려하는 지원이 필요할 것이다.

HgTe/Cdte superlattices grown on CdZnTe(211)B by MBE

  • Kang, T.W.;Jeong, C.S.;Leem, J.H.;Ryu, Y.S.;Hyun, J.K.;Jeon, H.C.;Lee, H.Y.;Han, M.S.
    • 한국진공학회지
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    • 제6권S1호
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    • pp.34-42
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    • 1997
  • Hg-Te-CdTe superlattices have received much interests over the last several years as a potential material for its applications for detecting devices and optoelectronics. We have grown the HgTe-CdTe superlattice using MBE. in our lab. We have carried out DCRC spectroscopy after growth of HgTe-CdTe superlattice with varying the superlattice periods and controlling the barrier thickness and we have that the presence of the main peak and the satellite peaks. We obtained 20 arcsec of FWHM over 100 periods of superlattice. We also note that high peak intensity shows the high quality of the sample and each layer of superlattice has abrupt interfaces. The angular separation between the main peak(m=0) and the first satellite peak(m=$\pm$1) is increased when the barrier layer thickness in superlatice layers are decreased. The separation between the first setellite peak(m=$\pm$1) and the second satellite peak(m$\pm$2) is increased similarly. The number of the satellite peak is a qualitative measure of the interfacial abruptness of the superlattice.

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기본 주파수와 고조파 성분을 고려한 악기음의 모델링 (Modeling of Instrumental Tone considering Main frequency and Harmonics)

  • 오복환;이동규;이두수
    • 대한전자공학회:학술대회논문집
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    • 대한전자공학회 1999년도 추계종합학술대회 논문집
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    • pp.1127-1130
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    • 1999
  • In this paper, using one method of Additive Synthesis, Analysis-by-synthesis/Overlap-Add (ABS/OLA) method, analysis and synthesis of musical tones is processed. But peak detection of frequency domain is processed by proposed method considering the view of acoustics. It is that that harmonics frequency is times of main frequency. Using this fact, peak detection of frequency domain is useful for detection of tonal component identified musical note. It is possible to realize high-quality lour bit rate audio.

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도토리묵의 물리적 특성 (Texture Profile Analysis of Acorn Flour Gels)

  • 김영아;이혜수
    • 한국식품과학회지
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    • 제17권5호
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    • pp.345-349
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    • 1985
  • $3^{3}$ 요인배치법에 의하여, 농도 저장시간 저장온도의 차이에 따를 도토리묵의 물리적 특성 변화를, Instron Universal Testing Machine을 사용하여 측정 비교하였다. 도토리묵의TPA curve는 첫 번째 압착에서 두개의 peak를 보이고, negative peak는 나타나지 않았다. 견고성과 절단성은 농도 저장시간 저장온도의 세 인자들의 변화에 대해 매우 유의적인 차이를 보이고, 두 peak의 높이 차이는 농도와 저장온도의 변화에 의해 특히 영향을 받으며 저장시간의 효과도 무시할 수 없었다. Bend는 농도의 변화에 대해서는 민감하게 대응하나 저장온도의 영향은 다소 약하게 작용하며 저장시간에 따른 변화는 무시할 수 있었다. 탄성은 농도의 변화에 대해서만 유의적인 차이를 보였다.

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Generation of Si-O-C Bond without Si-$CH_3$ Bond in Hybrid Type SiOC Film

  • Oh, Teresa
    • 반도체디스플레이기술학회지
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    • 제7권3호
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    • pp.1-4
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    • 2008
  • The chemical shift of SiOC film was observed according to the flow rate ratio. SiOC film had the broad main band of $880\sim1190cm^{-1}$ and the sharp Si-$CH_3$ bond at $1252cm^{-1}$, and the peak position of the main bond in the infrared spectra moved to high frequency according to the increasing of an BTMSM flow rate. So the increment of the alkyl group induced the C-H bond condensation in the film, and shows the blueshift in the infrared spectra. In the case of P5000 system of Applied Materials Corporation, the strong bond of Si-CH3 bond in precursor does not enough to dissociated and ionized, because low plasma energy due to the capactive coupled CVD. Therefore, there was the sharp peak of Si-$CH_3$ bond at $1252cm^{-1}$.

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