• Journal of the Korean Mathematical Society
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• v.59 no.6
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• pp.1067-1082
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• 2022

This paper presents a new optimal three-step eighth-order family of iterative methods for finding multiple roots of nonlinear equations. Different from the all existing optimal methods of the eighth-order, the new iterative scheme is constructed using one function and three derivative evaluations per iteration, preserving the efficiency and optimality in the sense of Kung-Traub's conjecture. Theoretical results are verified through several standard numerical test examples. The basins of attraction for several polynomials are also given to illustrate the dynamical behaviour and the obtained results show better stability compared to the recently developed optimal methods.

• Animal Systematics, Evolution and Diversity
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• v.38 no.1
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• pp.46-49
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• 2022

This study newly records a deep-sea coral, Flabellum (Ulocyathus) deludens from Korea. The specimens were collected by trawling at a depth of 100 m off Jejudo Island in 2019. The newly recorded species is described and compared with the other similar consubgeneric species in detail based on morphological characteristics, including corallum size, calicular diameter, calicular edge, face angle, edge angle, and septal arrangement. Flabellum(Ulocyathus) deludens is characterized by its solitary, highly compressed, wedge-shaped corallite with a small cylindrical pedicel, radiating inverse chevron-patterned lateral stripes on thecal faces, highly jagged calicular edges, and hexameral septal arrangement in five cycles. As a result of this study, five species in the family Flabellidae have been recorded from Korea.

• Korean Journal of Pharmacognosy
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• v.54 no.1
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• pp.16-20
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• 2023

KSM-2690 B (1), a peptide-polyketide hybrid compound, was discovered from an actinomycete strain (CJD 1) isolated from Dong-Baek hill on Jeju Island, Republic of Korea. The chemical structure of 1 was identified by using NMR, MS, and UV spectroscopic analyses. Careful analysis of 1D and 2D NMR data revealed that KSM-2690 (1) has an oxazole ring, a β-lactone-γ-lactam spirocycle ring, and both triene and diene structures. KSM-2690 B (1) showed inhibitory activities against E. coli at 200 ㎍/mL.

• Journal of the Korean Society of School Health
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• v.13 no.2
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• pp.319-329
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• 2000

This study suggestes that the improvement of oral care through on investigation of the effects of oral care on children by parents. This investigation was done on Sep. 29 1999 through Oct. 8 examining 376 of elementary, 1grade, 2grade, 3grade students in Kyunggi-Do. The content of the questions was analzed with a t-test and a one-way ANOVA; the relation to the oral care on children by parents with oral care behavior was analyzed by a Pearson's Correlation Coefficient. The results are as follow; 1) Statistically women were higher(F=-2.675, p<0.01). The average of the oral care of children was 2.34, man averaged 2.29, woman are raged 2.32. Statistically women were also higher(F=4.682, p<0.052). 2) The more educatior the mother had higher, the higher the grade. Statistically there was a difference(F=6.756, p<0.01. The oral care of children above Uni graduate(M=2.38), high (M=2:23), middle graduate(M=2.Z3). Statistically, the higher the academic degree, the more optimistic(F=4.114, p<0.05). 3) In the oral care on children by parents, when the conversation with the family was often 2.17, there was little difference(F=7.343, p<0.01). In the oral care of children was 2.45, there was little difference(F=7.343. p<0.01). As a result, the conversation with family affects the behavior. 4) In the oral care of children, if the food that they like was fruits, vegetables, and fresh food, the average was 2.37, very high. There was little difference in other cases(F=-3.179, p<0.05). We can conclude that fresh food affects the oral care of children. 5) In the oral care on children by parents, when the course of knowledge on the oral care was viewed by a grandfather(M=2.02), grandmother(M=2.05), father(M=2.14), mother(M=2.08). There was little difference(F=2.666, p<0.05). 6) In oral care, if the level of income was viewed high level(M=2.42), middle(M=2.34), 10w(M=1.88), there was a little difference(F=3.300, p<0.05). 7) The relation of the oral care on children by parents and the oral care was normal. In other words, the more management by parents, the more management by children.(p<0.01) Therefore in this study, the oral care on children by parents effect the oral care behavior of children. To improve the mouth health of children, the parents's interest in their children must be constant. Also, it is needed to develope an education program where parents and children can be educated.

• Biomolecules & Therapeutics
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• v.18 no.2
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• pp.166-170
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• 2010

Recently some researches have established that the melatonin, secreted by pineal gland, may evoke the changes of contractile responses on smooth muscles. We examined the effects of melatonin on the motility of rat pyloric antrum and which mechanism might be involved in the effects. Pyloric antral strips from the stomach of 20 Sprague-Dawley rats were prepared for isometric tension recording in organ bath. The strips were precontracted by acetylcholine and high-KCl solutions. In precontracted conditions the tensions were increased by accumulative application of melatonin ($10^{-8}-10^{-4}$ M) dose-dependently, even in resting states. And the effects were almost disappeared when the concentrations of ACh were over than 10 ${\mu}M$. The effects of melatonin were inhibited by pretreatment of 10 mM TEA and/or 10 ${\mu}M$ 4-AP and rarely affected by pretreatment of 1 mM TEA, 10 ${\mu}M$ glibenclamide and 10 ${\mu}M$ verapamil respectively. From these results it is concluded that the contractile responses of smooth muscles of rat pyloric antrum were enhanced by melatonin application and the mechanism might be concerned with the inhibition of some voltage-dependent potassium channels.

• Pediatric Infection and Vaccine
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• v.9 no.1
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• pp.61-66
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• 2002

Purpose : To determine wether varicella can be prevented by administration of oral acyclovir(ACV) during the incubation period of the disease. Methods : Starting 9 days after exposure to the index case in their families, ACV(40 mg/kg/day in four divided doses) was given orally to 20 exposed children for 5 days. Their clinical features was compared with those of 20 control subjects. Antibody titers to VZV were measured in both group 1 week and 4 weeks after finishing the oral ACV administration. Results : The mean age of family members with varicella(51.4 months) were significantly high compared to that of ACV prophylaxis group(28.5 months) and control group(31 months) (P<0.05). Among the 12 children with ACV prophylaxis who completed follow up blood sampling, nine children were diagnosed as VZV infection on the serologic test(75%). Among them six children showed positive VZV IgM on the first blood sample and two children showed serocoversion to positive IgM on the second test after ACV prophylaxis. One child who was negative on both IgM and IgG, showed positive IgG on the second test. The incidence of fever and severity of skin rashes were significantly low in children received oral ACV than in the control group. No or reduced number of maculopapular eruption were observed in the oral ACV group compared to multiple vesicles of the control group. Conclusion : In the present study, we observed that oral ACV prophylaxis to the family contacts is effective in reducing severity of skin lesion. It is likely that oral ACV 9 days after contact prevents or reduces blood dissemination of VZV. Little is known about clinical effect and immunity to the virus in exposed children with no varicella symptom after treatment. We propose the checking up antibody to VZV some period after oral ACV, and considering vaccination to whom with no antibody. But further more studies are needed to practical application of oral ACV for the postexposure prophylaxis of varicella.

• Journal of Microbiology and Biotechnology
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• v.18 no.3
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• pp.404-409
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• 2008

The brown-rot basidiomycete Fomitopsis palustris is known to degrade crystalline cellulose (Avicel) and produce three major cellulases, exoglucanases, endoglucanases, and ${\beta}$-glucosidases. A gene encoding endoglucanase, designated as cel12, was cloned from total RNA prepared from F. palustris grown at the expense of Avicel. The gene encoding Cel12 has an open reading frame of 732 bp, encoding a putative protein of 244 amino acid residues with a putative signal peptide residing at the first 18 amino acid residues of the N-terminus of the protein. Sequence analysis of Cel12 identified three consensus regions, which are highly conserved among fungal cellulases belonging to GH family 12. However, a cellulose-binding domain was not found in Cel12, like other GH family 12 fungal cellulases. Northern blot analysis showed a dramatic increase of cel12 mRNA levels in F. palustris cells cultivated on Avicel from the early to late stages of growth and the maintenance of a high level of expression in the late stage, suggesting that Cel12 takes a significant part in endoglucanase activity throughout the growth of F. palustris. Adventitious expression of cel12 in the yeast Pichia pastoris successfully produced the recombinant protein that exhibited endoglucanase activity with carboxymethyl cellulose, but not with crystalline cellulose, suggesting that the enzyme is not a processive endoglucanase unlike two other endoglucanases previously identified in F. palustris.

• Parasites, Hosts and Diseases
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• v.54 no.3
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• pp.375-380
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• 2016

Angiostrongyliasis is difficult to be diagnosed for the reason that no ideal method can be used. Serologic tests require specific equipment and are not always available in poverty-stricken zone and are time-consuming. A lateral flow immunoassay (LFIA) may be useful for angiostrongyliasis control. We established a LFIA for the diagnosis of angiostrongyliasis based on 2 monoclonal antibodies (mAbs) against antigens of Angiostrongylus cantonensis adults. The sensitivity and specificity were 91.1% and 100% in LFIA, while those of commercial ELISA kit was 97.8% and 86.3%, respectively. Youden index was 0.91 in LFIA and 0.84 in commercial ELISA kit. LFIA showed detection limit of 1 ng/ml of A. cantonensis ES antigens. This LFIA was simple, rapid, highly sensitive and specific, which opened an alternative approach for the diagnosis of human angiostrongyliasis.

• The Korean Journal of Malacology
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• v.29 no.2
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• pp.155-161
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• 2013

Cathepsins are lysosomal/cysteine proteases belong to papain family (C1 family) that is involved in intracellular protein degradation, antigen processing, hormone maturation, and immune responses. In this study, member of cathepsin family was identified from Manila clam (Mc-Cathepsin D) and investigated the immune response against brown ring disease (BRD) causing Vibrio tapetis challenge. The identified Mc-Cathepsin D gene encodes characteristic features typical for the cathepsin family including eukaryotic and viral aspartyl protease signature domain and two highly conserved active sites ($^{84}VVFDTGSSNLWV^{95}$ and $^{270}IADTGTSLLAG^{281}$). Moreover, MC-Cathepsin D shows higher identity values (-50-70%) and conserved amino acids with known cathepsin D members. Transcriptional results (by quantitative real-time RT-PCR) showed that Mc-Cathepsin D was expressed at higher levels in gills and hemocytes than mantle, adductor muscle, foot, and siphon. After the V. tapetis challenge under laboratory conditions, Mc-Cathepsin D mRNA was up-regulated in gills and hemocytes. Present study indicates that Mc-Cathepsin D is constitutively expressed in different tissues and potentially inducible when infecting BRD by V. tapetis. It is further suggesting that Mc-Cathepsin D may be involved in multiple role including immune response reactions against BRD.

• Journal of Korean Academy of Nursing
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• v.30 no.2
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• pp.259-271
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• 2000

This study was attempted to explore meaning in life and it's relationship to problematic life events, health status and depression among older people. 198samples of elderly were over the age 60 (mean age=70.06) conveniently selected in Seoul, Korea. The data were collected through questionaires by interview with subjects from April, 1, 1999 to May 30, 1999. The research instuments were the main framework in the experiment. They involved meaning fulfillment and problematic life events which were developed by Burbank (1988) and short form geriatric depression scale(Sheikh & Yesavage, 1986). The data were analysed by SAS Program. The results are followed; 1. 172 lists were given out and had objects that would bring meaning to one's life. They were categrized as wishing for offsprings' prosperity, their relation with their grand-children, marriage of their offspring, health of family members, strong family ties, caring for the family, relation with husband, health for self, religious activity, helping others, individual hobbies, needs for growth such as writing, education, relationships with friends and personal achievements. In the end, 50% of total list dealt with in the relationship with their family members. 2. The mean fulfillment of the subjects was 38.31(SD=13.58) with a range of 12-60. The degree fulfillment varied according to the subjects' characteristics such as age group(F=4.44, 0P=.0008), education status (F=6.44, P=.0001), economic status (F=10.27, P=.0001), marrital status (F=9.12, P=.0002) and religious background (F=3.68, P=.006). 3. According to the pearson correlation, analysis significant variables were found between meaning fulfillment and health(r=.47, P=.0001), depression and the number of problematic life events for a life time (r=.147, P=.04), the stress score of problamatic life events for the past one year and the stress score of problematic life events for a life time was r=.43, P=.002, meaning fulfillment and the stress score of problamatic life events r=-.26, P=.04, depression and meaning fulfillment r=-.70, P=.0001 and depression and health r=-.521, P=.0001. 4. According to multiful regression analysis, depression was found as a most predictable variable for health(F=12.51, P=.001).