• KSBB Journal
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• v.21 no.5
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• pp.371-375
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• 2006

Frontal analysis(FA) and Pulsed input method(PIM) have been frequently utilized to measure isotherm of single solute, as well as non-competitive isotherms of two solutes in chromatography(1). FA and PIM were used in this study as complementary methods to measure adsorption isotherms of loxoprofen racemate in HPLC. Prior to FA and PIM experiments, measurements of loxoprofen solubility were made at hexane/ethanol=50/50, 80/20, 95/5(v/v) with acetic acid(0.5%) for adjusting pH. The last composition(95/5) of hexane/ethanol allows us to separate loxoprofen racemate into two forms(retentate, extract). PIM and FA were used to determine the isotherms of re-and ex-loxoprofen.

• Asian Pacific Journal of Cancer Prevention
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• v.16 no.8
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• pp.3325-3331
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• 2015

Pim kinase-3(Pim-3), a member of serine/threonine protein kinases, has been implicated in multiple human cancers and involved in Myc-induced tumorigenesis. However, little is known regarding its expression and biological function in human ovarian cancer. In this study we showed that the clinical significance and biological functions of Pim-3 in ovarian cancer and found that higher Pim-3 mRNA level are detected in ovarian cancer tissues than those in normal ovarian tissues. There are significant correlations between higher Pim-3 expression levels with the FIGO stage, histopathological subtypes, and distant metastasis in ovarian cancer patients. Lentivirus-mediated gene overexpression of Pim-3 significantly promotes the proliferation and migration of SKOV3 cell lines. Furthermore, MACC1 and Pim-3 expression were significantly correlated in human ovarian cancer cells, and overexpression of Pim-3 in ovary cancer cells increased MACC1 mRNA and protein expression. The data indicate that Pim-3 acts as a putative oncogene in ovary cancer and could be a viable diagnostic and therapeutic target for ovarian cancer.

• Proceedings of the Korea Information Processing Society Conference
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• 2022.11a
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• pp.147-149
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• 2022

PIM은 CPU와 메모리 간의 데이터 버스 오버헤드를 완화하기 위해서 메모리 내부에 프로세서를 가지며 낮은 데이터 재사용성을 가지는 데이터 집약형 워크로드에서 지연과 에너지 관점에서 장점을 가진다. 본 논문은 UPMEM사의 PIM을 이용하여 HPC분야에서 자주 사용되는 행렬 연산인 GEMV, SpMV의 벤치마크 구현을 분석하고 성능 분석을 통해 CPU 대비 가지는 장단점에 대해서 논하였다.

• Journal of Microbiology and Biotechnology
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• v.26 no.2
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• pp.241-247
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• 2016

Natamycin is a widely used antifungal antibiotic. For natamycin biosynthesis, the gene pimE encodes cholesterol oxidase, which acts as a signalling protein. To confirm the positive effect of the gene pimE on natamycin biosynthesis, an additional copy of the gene pimE was inserted into the genome of Streptomyces gilvosporeus 712 under the control of the ermE* promoter (p_ermE*) using intergeneric conjugation. Overexpression of the target protein engendered 72% and 81% increases in the natamycin production and cell productivity, respectively, compared with the control strain. Further improvement in the antibiotic production was achieved in a 1 L fermenter to 7.0 g/l, which was a 153% improvement after 120 h cultivation. Exconjugants highly expressing pimE and pimM were constructed to investigate the effects of both genes on the increase of natamycin production. However, the co-effect of pimE and pimM did not enhance the antibiotic production obviously, compared with the exconjugants highly expressing pimE only. These results suggest not only a new application of cholesterol oxidase but also a useful strategy to genetically engineer natamycin production.

• Proceedings of the Korea Information Processing Society Conference
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• 2024.05a
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• pp.65-68
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• 2024

이 연구는 PIM(Processing-in-Memory) 아키텍처를 활용하여 General Matrix Multiplication(GEMM)의 최적화 기법을 UPMEM PIM 을 통해 탐구한다. 본 연구는 CPU 에서 경험하는 메모리 대역폭의 제한을 극복하고 병렬 처리 구조를 활용함으로써 GEMM 연산에서 PIM 의 잠재적 이점을 확인한다. 또한 연속된 세 개의 행렬 곱셈에 대한 효율성을 평가하고, 데이터 전송 시간이 성능 최적화의 주요병목 현상으로 작용하는 것을 확인한다. CPU 에서 UPMEM 커널로 전송되는 데이터의 양을 한 번에 늘리면서 전송 횟수를 줄이는 방법을 사용하여 CPU 에 비해 성능을 최대 6.57 배 향상시켰다.

• Proceedings of the Korea Information Processing Society Conference
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• 2024.05a
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• pp.57-60
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• 2024

오늘날 데이터 보안이 점점 중요한 요소로 강조되고 있으며, 기술의 발전에 따라 데이터 중심의 워크로드 증가로 인해 메모리 대역폭의 병목 현상의 문제로 데이터 처리 속도의 제약이 발생하고 있다. 이에 따라 Processing-In-Memory(PIM) 라는 새로운 형태의 메모리가 연구 및 개발되고 있다. 본 논문은 새로운 메모리인 PIM 의 취약점을 파악하고 안전하게 데이터를 처리할 수 있도록 TEE(Trusted Execution Environment) 환경을 적용하여 PIM 의 보안성을 강화하는 새로운 보호 체계를 제안한다.

• Proceedings of the Korea Information Processing Society Conference
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• 2023.11a
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• pp.27-29
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• 2023

폰노이만 구조를 따르는 기존의 컴퓨터 시스템은 프로세서와 메모리의 역할이 구분되어 있으며 프로세서는 메모리에 저장된 명령어와 데이터를 불러와 실행한다. 이 과정에서 메모리와 프로세서 간에 발생하는 데이터 이동은 메모리 집약적인 응용을 처리하는데 있어서 심각한 오버헤드를 야기할수 있다. PIM(Processing-In-Memory)은 데이터 이동 병목을 해결하기 위해서 메모리에 프로세서의 능력을 통합하는 기술로서 최근의 메모리 기술의 발전으로 주목받고 있다. 본 논문에서는 UPMEM사의 상용 PIM 제품을 기반으로 몬테카를로 방법을 이용한 원주율 추정을 구현하고 성능 확장성을 분석하였다.

• Design & Manufacturing
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• v.11 no.3
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• pp.29-34
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• 2017

Increased demand for parts with micro-pattern structure made of metals, ceramics, and composites in various fields such as medical ultrasonic sensors, CT collimators, and ultra-small actuator parts. Micro powder injection molding (PIM) is a technology for manufacturing micro size, high volume, complex, precision, net-shape components from either metal or ceramic powder. In the present study, a standard mold with a variable insert core capable of producing various micro patterns was investigated. An injection molding test was performed on a standard mold using a line type micro-pattern core having an aspect ratio of 2, a slenderness ratio of 70, a pattern size of $200{\mu}m$, and a pattern spacing of $150{\mu}m$. During the filling process, the deformation of the mold with large aspect ratio and slenderness ratio was analyzed by the experiment and the numerical simulation according to the position of the gate. We proposed a mold structure that minimizes mold deformation by gate modification and enables uniform pattern filling behavior.

• Structural Engineering and Mechanics
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• v.60 no.5
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• pp.891-902
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• 2016

The beam structure with breathing cracks subjected to harmonic excitations was modeled by FEM based on Euler-Bernoulli theory, and a piecewise dynamical system was deduced. The precise integration method (PIM) was employed to propose an algorithm for analyzing the dynamic responses of the deduced system. This system was first divided into linear sub-systems, between which there are switching points resulted from the breathing cracks. The inhomogeneous terms due to the external excitations were tackled by introducing auxiliary variables to express the harmonic functions, hence the sub-systems are homogeneous. The PIM was then applied to solve the homogeneous sub-systems one by one. During the procedures, a predictor-corrector algorithm was presented to determine the switching points accurately. The presented method can provide solutions with an accuracy to a magnitude of $10^{-12}$ compared with exact solutions obtained by the theories of ordinary differential equations. The PIM results are much more accurate than Newmark ones with the same time step. Moreover, it is found that the PIM can maintain a high level of accuracy even when the time step increases within a relatively wide range.

• Journal of Powder Materials
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• v.6 no.1
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• pp.88-95
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• 1999

The purpose of this study is to investigate the manufacturing feasibility of WC-Co milling inserts via Powder Injection Molding (PIM) process. WC-Co is used in a wide variety of cutting tools due to its high hardness, stiffness, compressive strength and wear resistance properties. WC-Co parts for a high stress application were conventionally produced by the press and sinter method, which were Iimited to 2 dimensional shapes. Manufacturing WC-Co parts for a high stress application by PIM implies that tool efficiency can be highly improved due to increased freedom is design. P30 grade WC powder (WC-Co-TiC-TaC system) was mixed with RIST-5B133 binder and injection molded into milling inserts (Taegu Tech. Model WCMX 06T 308). The mean grain size of the powder was about 0.8$\mu$m. Injection molded specimens were debound by solvent extraction and thermal degradation method at various conditions. The specimens were sintered at 140$0^{\circ}C$ for 1 hr in vacuum. Carbon content, weight loss, dimensional change, and macro defects of the specimen were carefully monitored at each stage of the PIM process. PIMed WC-Co milling inserts reached 100% full density after sinteing. Its mechanical properties and micro-structures were comparable with the press and sintered milling insert. Carbon content of the sintered WC-Co insert was mainly determained by the atmosphere of thermal debinding. By controlling powder loading and injection molding condition, dimensional accuracy could be obtained within 0.4%. We confirm that PIM can not only be an alternative manufacturing method for WC-Co parts economically but also provide a design freedom for more effieient cutting tools.