• Nutrition Research and Practice
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• v.12 no.6
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• pp.486-493
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• 2018

BACKGROUND/OBJECTIVE: The honeysuckle berry (HB) contains ascorbic acid and phenolic components, especially anthocyanins, flavonoids, and low-molecular-weight phenolic acids. In order to examine the potential of HB as a hepatoprotective medicinal food, we evaluated the in vitro anti-oxidant and anti-inflammatory activities of Korean HB (HBK) and Chinese HB (HBC). MATERIALS/METHODS: Antioxidant and anti-inflammatory effects of the extracts were examined in HepG2 and RAW 264.7 cells, respectively. The anti-oxidant capacity was determined by DPPH, SOD, CAT, and ARE luciferase activities. The production of nitric oxide (NO) as an inflammatory marker was also evaluated. The Nrf2-mediated mRNA levels of heme oxygenase-1 (HO-1), NAD(P)H dehydrogenase [quinone] 1 (Nqo1), and glutamate-cysteine ligase catalytic subunit (Gclc) were measured. The concentrations of HB extracts used were 3, 10, 30, 100, and $300{\mu}g/mL$. RESULTS: The radical scavenging activity of all HB extracts increased in a concentration-dependent manner (P < 0.01 or P < 0.05). SOD (P < 0.05) and CAT (P < 0.01) activities were increased by treatment with $300{\mu}g/mL$ of each HB extract, when compared to those in the control. NO production was observed in cells pretreated with 100 or $300{\mu}g/mL$ of HBC and HBK (P < 0.01). Treatment with $300{\mu}g/mL$ of HBC significantly increased Nqo1 (P < 0.01) and Gclc (P < 0.05) mRNA levels compared to those in the control. Treatment with $300{\mu}g/mL$ of HBK (P < 0.05) and HBC (P < 0.01) also significantly increased the HO-1 mRNA level compared to that in the control. CONCLUSIONS: Thus, the Korean and Chinese HBs were found to possess favorable in vitro anti-oxidant and anti-inflammatory activities. Nrf2 and its related anti-oxidant genes were associated with both anti-oxidant and anti-inflammatory activities in HB-treated cells. Further studies are needed to confirm these in vivo effects.

• Journal of Industrial Convergence
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• v.20 no.5
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• pp.93-100
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• 2022

This study is a descriptive survey study that applies the planned behavior theory to identify the factors influencing the childbirth intention of unmarried men and women. Data were collected from April 05 to April 23, 2021 for 168 unmarried men and women. As a result of the study, in general characteristics, male, old, highly educated, occupational, and non-regular workers had statistically significantly higher childbirth intentions. As a result of examining the correlation between the variables constituting the theory of planned behavior(TPB), it was found that the more positive the attitude toward childbirth, the greater the subjective norm, and the greater the perceived behavior control, the higher the intention to give birth. Multiple regression analyses showed that the factors affecting fertility intention on men and women. The factors affecting fertility intention in men was attitude, with an explanatory power of 62.2% and the factors affecting fertility intention in women were attitudes and perceived behavioral control, and the explanatory power of these variables on fertility intention was 69.0%. In order to increase the intention to give birth, a comprehensive approach is needed, and the research is meaningful in that the results of this study provided basic data in the development of policies and education programs related to low birth rates in the future.

• Journal of Bio-Environment Control
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• v.31 no.3
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• pp.152-162
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• 2022

This study developed simulation model for predicting the greenhouse interior environment using artificial intelligence machine learning techniques. Various methods have been studied to predict the internal environment of the greenhouse system. But the traditional simulation analysis method has a problem of low precision due to extraneous variables. In order to solve this problem, we developed a model for predicting the temperature inside the greenhouse using machine learning. Machine learning models are developed through data collection, characteristic analysis, and learning, and the accuracy of the model varies greatly depending on parameters and learning methods. Therefore, an optimal model derivation method according to data characteristics is required. As a result of the model development, the model accuracy increased as the parameters of the hidden unit increased. Optimal model was derived from the GRU algorithm and hidden unit 6 (r² = 0.9848 and RMSE = 0.5857℃). Through this study, it was confirmed that it is possible to develop a predictive model for the temperature inside the greenhouse using data outside the greenhouse. In addition, it was confirmed that application and comparative analysis were necessary for various greenhouse data. It is necessary that research for development environmental control system by improving the developed model to the forecasting stage.

• Journal of the Korean Society of Radiology
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• v.18 no.3
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• pp.239-248
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• 2024

Radiation therapy uses high energy, which can have side effects on the human body. Therefore, it is important to ensure that the appropriate dose is set for irradiation and to have confidence in the radiation produced by the generator. The EPR/Alanine dosimetry system is characterized by water equivalence, dose response linearity, and low fading, which makes it useful for quality control of radiation therapy equipment. In this study, we compared the signal and dose response curves of EPR/Alanine dosimetry by mass of alanine using 6 MV energy of a LINAC. An alanine dosimeter and EPR spectrometer from Burker, and a LINAC from Elekta, were used. A dose response curve and a 1st order regression equation were constructed from the irradiated dose and the EPR signal from the alanine dosimeter. We compared the signal magnitude and dose response curve with mass and checked the confidence through the measurement uncertainty of the dose response curve. As a result, it was found that the magnitude of the EPR signal increased by about 1.3 times at 64.5 mg, and the sensitivity of the dose response curve increased as the mass increased. The measurement uncertainty was evaluated to be between 5.84 % and 8.93 %. Through this study, it is expected that the EPR/alanine dosimetry system can be applied to the quality assurance and quality control of a LINAC.

• Journal of Bio-Environment Control
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• v.26 no.4
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• pp.283-290
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• 2017

In this study, the method to attach plastic film on the side vent from inside of greenhouse for the entire length was developed as the way to make crops less stressful while uniformly getting outside air into the greenhouse when ventilating using roof ventilation fans at single-span plastic greenhouse for oriental melon in a low-temperature period. The plastic film was installed from ground to 10cm below from the height where side vent is fully opened. In order to verify that the improved side vent can improve greenhouse environment and fruit yield, it was compared with the control plot of conventional side vent. Both greenhouses were not ventilated until February 25th, 2017. Air temperature in both greenhouses exceeded $40^{\circ}C$ in mid February. Therefore, it is judged that the greenhouse should be ventilated from mid February. Air temperature in the control plot exceeded $30^{\circ}C$ from late April. Therefore, it is judged that the plastic film attached to the inside of side vent should be removed in late April, or in early May at the latest. Soil temperature in the treatment plot in the mid Aril exceeded $20^{\circ}C$, which is suitable for growth, while that in the control plot was still below $20^{\circ}C$. Soil temperature in the control plot finally exceeded $20^{\circ}C$ in late April. The consumption of electricity was 47.2 kWh in the treatment plot, and 48.3 kWh in the control plot, which was no significant difference. The marketable yield of oriental melon in the treatment plot was 5,094kg, which was 23.9% more than that in the control plot, 4,113kg. The marketable fruit ratio was 73.5% in the treatment plot, and that in the control plot was 73.9%, which was no significant difference.

• The korean journal of orthodontics
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• v.26 no.4
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• pp.401-413
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• 1996

Facial vertical dyscrepancies is decided on the relationship between the anterior vertical facial height and posterior vertical facial height. Thus this study was conducted to determine the factors that affect the FHI, and classify the Class II div.1, malocclusion, which success is dependent on the vertical control according to the FHI, which is the ratio of antero-inferior facial height, posterio-inferior facial height ratio, and to use this as a guideline for treatment. Angle between palatal plane and Mandibular plane were in the order of RH, ID. Thus showing that interrelated angle was more inportant than the independent angle of both, palatal plane and Mandibular plane. The tendency of Cl II div.1. Malocclusion according to FHI, showed the Low group to have Mx. protrusion, prominent development of Mn. ramus, and the Mn. body length and ant. post. position was normal. The Normo group showed slight protrusion of the Maxilla,. The development of the ramus was less than normal and the Mn. was in a slight retruded position. The High group showed the Mx. in a normal position, the development of the Mn. ramus and body was the lowest, and the Mn. was in a posterior position. In observation of the factors affecting the FHI between each groups of Cl II div.l, malocclusion; In the Low group the MP- PP angle was very small, the ID was smililar to the normal group, but the RH was very large thus the FHI was increased. In the Normo group, the PP-MP angle was normal, ID was slightly smaller than the normal group and the RH was slightly smaller than the normal group, thus maintaining a normal FHI ratio. In the High group the PP-MP angle was very large, the ID was similar to the normal group, but the RH was smaller than the normal group thus the FHI was small.

• Journal of Bio-Environment Control
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• v.26 no.4
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• pp.340-345
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• 2017

Carrot leaves have many nutrients as well as roots, which will increase the demand for carrot leaves in the future. This study was carried out by dividing into two stages: high temperature and low temperature periods, in order to investigate the possibility of cultivation of carrot leaves and the composition and EC of the nutrient solution for growth and quality of carrot leaves. Composition of nutrient solution($NO_3-N:16.0$, $NH_4-N:1.0$, P: 1.0, K: 11.0, Ca: 2.0, Mg: 1.0, $SO_4-S:1.0mM{\cdot}L^{-1}$) developed by analysis of plant. In the high temperature range (From June $29^{th}$ to Sep. $8^{th}$, 2016), the concentration of the developed nutrient solution (JNU) were 1.0, 2.0, 3.0, and $4.0dS{\cdot}m^{-1}$ and the concentration of nutrient solution of Japanese Horticultural Station(JHS) $2.0dS{\cdot}m^{-1}$ was used for comparison. In the low temperature range (From Dec. $31^{st}$, 2015 to Feb. $29^{th}$, 2016), the concentration of the developed nutrient solution 1.0, 2.0, and $3.0dS{\cdot}m^{-1}$ were used. Growth was investigated in root fresh and dry weights, shoot fresh and dry weights, leaf number, and leaf area of carrot. In the high temperature range, the leaf area and shoot fresh and dry weights were good at 1.0 and $2.0dS{\cdot}m^{-1}$. The sugar content of the root was the highest at the EC $2.0dS{\cdot}m^{-1}$, and the chlorophyll content was the highest at the EC $4.0dS{\cdot}m^{-1}$. In the low temperature range, The shoot fresh and dry weights were the highest at EC 1.0 and $2.0dS{\cdot}m^{-1}$. There was no significant difference in sugar content and chlorophyll content. As a result, from the viewpoint of growth and quality of carrot, it is good to cultivate EC 1.0 and $2.0dS{\cdot}m^{-1}$ in high temperature period and low temperature period, but EC $1.0dS{\cdot}m^{-1}$ is economical perspective such as fertilizer input.

• The Korean Journal of Nuclear Medicine
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• v.39 no.3
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• pp.200-208
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• 2005

Purpose: Tc-99m labeled diethylenetriaminepentaacctic acid (DTPA)-coupled galactosylated human serum albumin (GSA) is a currently used imaging agent for asialoglycoprotein receptor (ASGPR) of the liver, but, it has several shortcomings. Recently a new ASGPR imaging agent, $^{99m}Tc$-lactosylated human serum albumin (LSA), with simple labeling procedure, high labeling efficiency, high stability was developed. In order to assess the feasibility of the $^{99m}Tc$-LSA as a ASGPR imaging radiopharmaceuticals, we performed biodistribution study of the tracer in liver injured mice model and the results were compared with histolgic data. Materals and Methods: To induce hepatic damage in ICR mice, diethylnitrosamine (DEN) ($60mg/kg/week{\times}5time$, low dose or $180mg/kg/week{\times}2times$, high dose) and thioacetamide (TAA) ($50mg/kg{\times}1time$) were administrated intraperitoneally. Degree of liver damage was evaluated by tissue hematoxilin-eosin stain, and expression of asialoglycoprotein receptor (ASGPR) was assessed by immunohistochemistry using ASGPR antibody. $^{99m}Tc$-LSA was intravenously administrated via tail vein in DEN or TAA treated mice, and biodistribution study of the tracer was also performed. Results: DEN treated mice showed ballooning of hepatocyte and inflammatory cell infiltration in low dose group and severe hapatocyte necrosis in high dose group, and low dose group showed higher ASGPR staining than control mice in immunohistochemical staining. TAA treated mice showed severe hepatic necrosis. $^{99m}Tc$-LSA Biodistribution study showed that mice with hepatic necrosis induced by high dose DEN or TAA revealed higher blood activity and lower liver activity than control mice, due to slow clearance of the tracer by the liver. The degree of liver uptake was inversely correlated with the degree of histologic liver damage. But low dose DEN treated mice with mild hepatic injury showed normal blood clearance and hepatic activity, partly due to overexpression of ASGPR in mice with mild degree hepatic injury. Conclusion: Liver uptake of $^{99m}Tc$-LSA was inversely correlated with degree of histologic hepatic injury in DEN and TAA treated mice. These results support that $^{99m}Tc$-LSA can be used to evaluate the liver status in liver disease patients.

• Korean Journal of Environment and Ecology
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• v.34 no.3
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• pp.249-258
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• 2020

This study aims to provide reference material for effective forest management techniques at the catchment scale, based on the field investigation of large woody debris (LWD) in 11 streams within a third-order forest catchment in Gangwon Province, Korea. To achieve this aim, we analyzed the morphological features of LWD pieces, and the storage and distribution status of LWD by stream order throughout the entire investigation. As a result, a total of 1,207 individual pieces of LWD were categorized into three types as follows: (ⅰ) 1,142 pieces (95%) as only trunk and 65 pieces (5%) as a trunk with root wad, (ⅱ) 1,015 pieces (84%) as non-thinned and 192 pieces (16%) as the thinned, and (ⅲ) 1,050 pieces (87%) as conifer and 157 pieces (13%) as broadleaf. Additionally, in-stream LWD loads (㎥/ha) decreased with increasing stream order, yielding 105.4, 71.3, and 35.6 for first-, second-, and third-order streams, respectively. On the other hand, the ratio of LWD jams to the total LWD volume increased with increasing stream order, yielding 11%, 43%, and 49% for first-, second-, and third-order streams, respectively. Finally, a comparison of the in-stream LWD load with previous studies in several countries around the world indicated that in-stream LWD load was positively correlated with forest stand age even though the climate, topography, forest soil type, forest composition, stand growth rate, disturbance regime, and forest management practices were different. These results could contribute to understanding the significance of LWD as a by-product of forest ecosystems and an indicator of riparian forest disturbance. Based on this, we conclude that advanced forest management techniques, including treatment of thinning slash and stand density control of riparian forest by site location (hillslope and riparian zone, or stream order), should be established in the future, taking the forest ecosystem and the aquatic environment from headwater streams to low land rivers into consideration.

• Journal of Preventive Medicine and Public Health
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• v.31 no.4 s.63
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• pp.857-874
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• 1998

The objective of this study is to collect the opinions on the present condition and the improvement directions of urban health centers from and to make a comparison. Samples were drawn from the various sources of a district in seoul. 53 persons involved in district health's administration(the Members of a District Parliament, the senior officials of a District office, village chief) and 84 health center workers were surveyed with anonymous postal questionaires and 427 district private medical personnels with postal questionaires and 625 users of a health center with direct questionaires, from November 18 to 25, 1996. Additionally, 12,151 households were surveyed with self-reported questionaires including priorities on special district health services of health center, from September 1 to 7, 1996. The major findings were as follows : 1) Although the persons involved in district health administration tend to put lower priority on health service over other community activities, they well acknowledged the importance of health center. But health center workers strongly acknowledged the importance of both health service and heath center. 2) As to the level of human resoureces, equipments and ammenities of Health Center commpared with private medical institute, the persons involved in district health's administration and health center workers responded that health center was higher in following order : 54.9%, 41.6%, 36.5% and 88.0%, 80.7%, 44.1%. 3) Concerning the priorities of health center's improvement, the persons involved in district health's administration replied in the order of reinforcement of proffesional health workers (43.3%), improvement of equipments and ammenities(28.3%), and the health center workers replied in the order of reconstruction of organization(24.1%), public health education and promotion(22.8%), reinforcement of proffesional health workers(21.0%). 4) Both the persons involved in district health's administration and health center workers replied that Ministry Health and Welfare, District office, health center were essential as the most critical organizations in the activation of Health Center's Function. 5) Persons involved in district health's administration and health center workers chose, as the most important health center's Function, medical treatment and prevention of infectious disease, and prevention of acute and chrone disease control and special district health service, respectively. Both Groups replied that fammily planning and parasite control are no longer in need. 6) As the future health service requiring reinforcement, every human resources parties considered health conselling, health line, sex education as the most imortant elements in public health education. Concerning the reinforement of other health services such as medical checkup and visiting nurses, every human resources parties showed more than 80% approval rate, but for oriental medical care service, the private medical personels showed relatively low approval rate(52.9%). Therefore the planning for reinforcement of health center's function requires the reflection of human resources party's opinion and the implication of system which can control and combine the differences in party's opinions.