• Title/Summary/Keyword: longitudinal changes

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Characterization of Brain Microstructural Abnormalities in High Myopia Patients: A Preliminary Diffusion Kurtosis Imaging Study

  • Huihui Wang;Hongwei Wen;Jing Li;Qian Chen;Shanshan Li;Yanling Wang;Zhenchang Wang
    • Korean Journal of Radiology
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    • v.22 no.7
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    • pp.1142-1151
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    • 2021
  • Objective: To evaluate microstructural damage in high myopia (HM) patients using 3T diffusion kurtosis imaging (DKI). Materials and Methods: This prospective study included 30 HM patients and 33 age- and sex-matched healthy controls (HCs) with DKI. Kurtosis parameters including kurtosis fractional anisotropy (FA), mean kurtosis (MK), axial kurtosis (AK), and radial kurtosis (RK) as well as diffusion metrics including FA, mean diffusivity, axial diffusivity (AD), and radial diffusivity derived from DKI were obtained. Group differences in these metrics were compared using tract-based spatial statistics. Partial correlation analysis was used to evaluate correlations between microstructural changes and disease duration. Results: Compared to HCs, HM patients showed significantly reduced AK, RK, MK, and FA and significantly increased AD, predominately in the bilateral corticospinal tract, right inferior longitudinal fasciculus, superior longitudinal fasciculus, inferior fronto-occipital fasciculus, and left thalamus (all p < 0.05, threshold-free cluster enhancement corrected). In addition, DKI-derived kurtosis parameters (AK, RK, and MK) had negative correlations (r = -0.448 to -0.376, all p < 0.05) and diffusion parameter (AD) had positive correlations (r = 0.372 to 0.409, all p < 0.05) with disease duration. Conclusion: HM patients showed microstructural alterations in the brain regions responsible for motor conduction and vision-related functions. DKI is useful for detecting white matter abnormalities in HM patients, which might be helpful for exploring and monitoring the pathogenesis of the disease.

A Short-Term Longitudinal Study on Infant and Mother Interaction (영아와 어머니의 상호작용에 관한 단기 종단 연구)

  • Kim, Mi-Ok;Rha, Jong-Hye;Hyun, On-Kang
    • Journal of Families and Better Life
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    • v.25 no.5
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    • pp.167-183
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    • 2007
  • The purpose of this study was to investigate the changes in infant-mother interactions and to measure infant-mother interaction, mutuality, and reciprocity at the 2nd and 6th postnatal monthperiods. Infant-mother interaction was assessed in the mornings, afternoons, and evenings in the 2nd and 6th postnatal months, by filming unstructured free play in the home and analyzing 28 of these infant-mother film recordingsusing two trained observers. This study can be summarized in five points. First, the separate frequency distribution of each category in MIIBR's maternal behavior was as follows: the frequencies of vocalization category, the kinesthetic exercise & physical contact category, the physical caregiving category, and theuse of play tool category. These all showed changes in the 6th postnatal month compared to the 2nd postnatal month. Second, the separate frequency distribution of each category in MIIBR's infant behavior was as follows: the frequencies of physical behavior category, the vocalization category, and the play behavior category. These also all showed changes in the 6th postnatal month compared to the 2nd postnatal month. Third, the mutuality and reciprocity of mother interaction decreased in the 2nd postnatal month compared to the 6th postnatal month. Fourth, mutuality and reciprocity in the infant interaction increased in 2nd postnatal month compared to the 6th postnatal month. Fifth, mutuality and reciprocity in the infant-mother interaction increased in 2nd postnatal month compared to the 6th postnatal month. In conclusion, it is evident that infant-mother interactions change over time. This study bears particular significance in setting a foundation for the theoretical basis of the interaction between infant and mother by observation.

A Longitudinal Study on Maternal Iron and Folate Status During and After Pregnancy in Korean Women (임신기간과 분만 후 모체의 철 및 엽산 영양상태의 종단적 변화)

  • 이종임;임현숙
    • Korean Journal of Community Nutrition
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    • v.6 no.2
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    • pp.182-191
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    • 2001
  • Anemia in women during pregnancy and after delivery has been known to affect the mother, the fetus, and the infant's growth and health status. Studies examining, changes in iron and folate status associated with anemia during pregnancy and during pregnancy, and those supplements are stopped after postpartum. However, the effects of those have not been clearly determined in pregnant and lactating Korea women. Therefore, this study was performed to determine the changes in maternal iron and folate status during pregnancy and six months after delivery longitudinally in six pregnant women who consumed supplements from 20 wk to delivery. We concluded that the iron status deteriorated during pregnancy and especially was weak in the third trimester, but had a tendency to recovery after delivery. On the other hand, the folate status deteriorated in the first and second trimester and was good in the third trimester, but had a tendency to decrease after delivery. These results suggested that the iron status was not improved despite consuming total iron supplements of 50 mg/day through diets and supplements during the second half of the pregnancy. On the other hand, the folate status improved at the end of pregnancy by consuming folate supplements of a total of 800 mg/day through diets and supplements. However, folate status was poor in the first half of the pregnancy, and the tendency of folate status to decrease during postpartum was advanced. At the point in which iron and therefore supplementation is essential. However, the effects of supplement intake time and intake dosage need to be verified and the nutritional status changes of postpartum women should be carefully monitored.

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A STUDY OF MARGINAL BONE RESORPTION AROUND IMPLANTS AFTER IMMEDIATE LOADING (Immediate loading하에서 치근형 임프란트 주위 변연골 흡수에 대한 연구)

  • Kim Sung-Hyen;Han Chong-Hyun
    • The Journal of Korean Academy of Prosthodontics
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    • v.39 no.4
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    • pp.376-390
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    • 2001
  • Alveolar bone changes after immediate loading on implants up to one year were observed by means of standard intraoral X-ray measurement which were taken at 3 month intervals. At the same time, bone density changes were observed according to digital subtraction method which is a becoming a more and more promising diagnostic tool for implants. Following results were obtained ; 1. There was no significant difference in the amount of alveolar bone loss implant type, sex and implant diameter, but there was difference according to case selection. In fully bone anchored prostheses cases, bone loss was $1.16{\pm}0.15m$ whereas, in partial edentulous cases, it was $1.84{\pm}0.08mm$. 2. Alveolar bone loss after immediate loading showed a higher degree of bone loss than after submerged loading in the initial three months. But there were no significant difference at the 12th month. 3. According to the one year bone density change observation at the alveolar bone surrounding the implant, significant change was observed vertically, whereas no significant change could observed horizontally. According to the above mentioned results, we can conclude that immediate loading of implants results in a higher degree of alveolar bone loss in one year than submerged loading. But since alveolar bone loss rate decreases to a reasonable rate after the initial 3 months of rapid bone loss, immediate loading of implants seems to be an acceptable treatment modality for patients with good bone conditions. Fully bone anchored cases showed an favorable outcome, but partial edentulous cases showed more bony resorption. So this cases considered in case selections. Bone density changes observation in the study was performed for only one year therefore a more longitudinal observation may be studied.

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Changes in the Characteristics of Wintertime Climatology Simulation for METRI AGCM Using the Improved Radiation Parameterization (METRI AGCM의 복사 모수화 개선에 따른 겨울철 기후모의의 특징적 변화)

  • Lim, Han-Cheol;Byun, Young-Hwa;Park, Suhee;Kwon, Won-Tae
    • Atmosphere
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    • v.19 no.2
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    • pp.127-143
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    • 2009
  • This study investigates characteristics of wintertime simulation conducted by METRI AGCM utilizing new radiation parameterization scheme. New radiation scheme is based on the method of Chou et al., and is utilized in the METRI AGCM recently. In order to analyze characteristics of seasonal simulation in boreal winter, hindcast dataset from 1979 to 2005 is produced in two experiments - control run (CTRL) and new model's run (RADI). Also, changes in performance skill and predictability due to implementation of new radiation scheme are examined. In the wintertime simulation, the RADI experiment tends to reduce warm bias in the upper troposphere probably due to intensification of longwave radiative cooling over the whole troposphere. The radiative cooling effect is related to weakening of longitudinal temperature gradient, leading to weaker tropospheric jet in the upper troposphere. In addition, changes in vertical thermodynamic structure have an influence on reduction of tropical precipitation. Moreover, the RADI case is less sensitive to variation of tropical sea surface temperature than the CTRL case, even though the RADI case simulates the mean climate pattern well. It implies that the RADI run does not have significant improvement in seasonal prediction point of view.

A Longitudinal Study on the Changes in Individual Local Government's Social Spending in South Korea (기초지방정부 사회복지비 지출비중의 변화요인 탐색)

  • Jang, Dong-Ho
    • Korean Journal of Social Welfare
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    • v.59 no.1
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    • pp.329-351
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    • 2007
  • This study analyzes the changes in individual local government's social spending from 1995 to 2004 in South Korea. Using the pooled time-series and cross-sectional data of 226 basic-level local governments, the resulting analyses of an error correction model are very interesting: First, a rising local population led to an immediate increase in social spending; Secondly, local governments gradually increased social spending when the elderly ratio had been high, but the levels of social spending in the previous year and local economy related spending level had been low. Thirdly, there were no spending changes associated with local elections and partisan politics. Fourthly, both cooperative and competitive intergovernmental relations had the most significant effect on the social spending and reduced geographical disparities in the level of spending across localities. In conclusion, this study suggests that we establish a more comprehensive intergovernmental network which lead to territorial justice in social welfare.

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Changes of Protein Composition and Muscle Tissues in Top Shell Meat during Frozen Storage (바다방석고둥육의 동결저장중 단백질조성과 근육조직의 변화)

  • 송대진;김창용;박환준
    • Journal of the Korean Society of Food Science and Nutrition
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    • v.22 no.6
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    • pp.763-770
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    • 1993
  • To investigate the quality changes during frozen storage, top shell, Omphalius pfeifferi capenteri, was stored at -18$^{\circ}C$, -$25^{\circ}C$ and -3$0^{\circ}C$ immediately after shelling and water holding capacity, protein composition and histological features were examined with the lapsed period of the storage. During the storage period, amount of free drip was increased with higher frozen temperature and longer frozen period, but with the longer storage period, the lower water holding capacity was observed. The extractability and composition of muscle protein, sarcoplasmic protein and stroma protein were rather stable regardless of frozen temperature and frozen storage period. However, the extractability of myofibrillar protein was decreased with higher frozen temperature and longer frozen storage period. On the changes of muscle tissue structure, following points were observed. 1) In the muscle tissue structure of fresh sample, fine muscle fiber was closely distributed all over the tissue regardless of cross and longitudinal section. 2) In tissue structure under frozen state, it was observed that ice crystals apparently grew with the higher storage temperature. Empty spaces between muscle bundles which wee formed by aggregations of muscle fiber were observed after 3 months storage at -18$^{\circ}C$ . 3) Tissue structure in thawed state was restored satisfactorily after 1 month storage regardless of storage temperature. After 3 months storage at -3$0^{\circ}C$, muscle tissue was well restored, but at -18$^{\circ}C$, empty spaces were apparent due to incomplete restoration.

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Microstructural changes of polyacrylonitrile-based carbon fibers (T300 and T700) due to isothermal oxidation (1): focusing on morphological changes using scanning electron microscopy

  • Oh, Seong-Moon;Lee, Sang-Min;Kang, Dong-Su;Roh, Jae-Seung
    • Carbon letters
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    • v.18
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    • pp.18-23
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    • 2016
  • Polyacrylonitrile (PAN)-based carbon fibers have high specific strength, elastic modulus, thermal resistance, and thermal conductivity. Due to these properties, they have been increasingly widely used in various spheres including leisure, aviation, aerospace, military, and energy applications. However, if exposed to air at high temperatures, they are oxidized, thus weakening the properties of carbon fibers and carbon composite materials. As such, it is important to understand the oxidation reactions of carbon fibers, which are often used as a reinforcement for composite materials. PAN-based carbon fibers T300 and T700 were isothermally oxidized in air, and microstructural changes caused by oxidation reactions were examined. The results showed a decrease in the rate of oxidation with increasing burn-off for both T300 and T700 fibers. The rate of oxidation of T300 fibers was two times faster than that of T700 fibers. The diameter of T700 fibers decreased linearly with increasing burn-off. The diameter of T300 also decreased with increasing burn-off but at slower rates over time. Cross-sectional observations after oxidation reactions revealed hollow cores in the longitudinal direction for both T300 and T700 fibers. The formation of hollow cores after oxidation can be traced to differences in the fabrication process such as the starting material and final heat treatment temperature.

Anatomical Changes in the Forming and Germinating Processes of Tobacco (Nicotiana tabacum L.) Seeds (담배종자의 형성과정과 발아과정중의 형태적 변화)

  • ;Byong-Hee Hong;Jae-Young Cho
    • KOREAN JOURNAL OF CROP SCIENCE
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    • v.31 no.2
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    • pp.143-149
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    • 1986
  • Anatomical changes in the forming and germinating processes of tobacco seeds were investigated to obtain basic information on the ecological characteristics of tobacco seeds. Seed development studied through the longitudinal section of the fertilized ovule clarified that the cell division of the zygote was initiated after 7 days of flowering. After 12 days of flowering, perfect seed constituents such as cotyledon, epicotyle and radicle were formed and those were expressed to recognizable level of germinability. After 15 days of flowering germination rate reached higher than 30% and 17 and 21 days after flowering a perfect seed which have 70% or higher germinability were produced. Seed size was ranged between 0.3-0.6 mm and varietal differences were noted in the given seed size range. Under the light treatment, the morphological changes were observed by elongation of radicle after 2 days of imbibition and apparent germination after 3 days of imbibition. But no responses of the seeds imbibed 6 days under the dark condition were observed.

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Comparison of Flatfoot on the Activities of Medial and Lateral Plantar Flexor Muscle During Heel Rising

  • Jung, Hui-won;Yoo, Won-gyu
    • Physical Therapy Korea
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    • v.28 no.2
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    • pp.132-137
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    • 2021
  • Background: Flat feet can be identified by assessing the collapse of the medial longitudinal arch (MLA) and these conditions can trigger epidemiological changes in the feet. Many of previous studies compared the muscle activity of lower body in terms of intervention and dynamics to treat the structural defect of flat feet. However, few studies have investigated or analyzed the muscle activity of gastrocnemius muscle in the subjects with flat feet. Objects: This study investigated the differences in changes of medial and lateral plantar flexors in subjects with flat feet during bipedal heel-rise (BHR) task and analyzed the differences in muscle activity between two groups by measuring the electromyography (EMG) of abductor hallucis (AH), tibialis anterior (TA), medial gastrocnemius (MG), lateral gastrocnemius (LG). Methods: A total of Twenty one adult females participated in this experiment. Subjects were assigned to groups according to the navicular drop test. The task was applied to the leg, where the heel lifting action prevailed. The muscle activity of the medial and lateral feet plantar flexors was evaluated, and the % maximum voluntary isometric contractions (%MVIC) of these were compared. Results: For the difference between groups the muscle activity (%MVIC) of LG muscle was statistically significantly low in flat feet group compared to healthy feet group (flat feet: 64.57, healthy feet: 90.17; p < 0.05). Conclusion: The results of this study will contribute to identifying the muscle activities of medial and lateral feet plantar flexors among subjects with flat feet, which can cause abnormal epidemiological changes in the feet.