• Title/Summary/Keyword: long-term safety

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Estimation of sediment deposition rate in collapsed reservoirs(wetlands) using empirical formulas and multiple regression models (경험공식 및 다중회귀모형을 이용한 붕괴 저수지(습지) 비퇴사량 추정)

  • Kim, Donghyun;Lee, Haneul;Bae, Younghye;Joo, Hongjun;Kim, Deokhwan;Kim, Hung Soo
    • Journal of Wetlands Research
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    • v.23 no.4
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    • pp.287-295
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    • 2021
  • As facilities such as dam reservoir wetlands and agricultural irrigation reservoir wetlands are built, sedimentation occurs over time through erosion, sedimentation transport, and sediment deposition. Sedimentation issues are very important for the maintenance of reservoir wetlands because long-term sedimentation of sediments affects flood and drought control functions. However, research on resignation has been estimated mainly by empirical formulas due to the lack of available data. The purpose of this study was to calculate and compare the sediment deposition rate by developing a multiple regression model along with actual data and empirical formulas. In addition, it was attempted to identify potential causes of collapse by applying it to 64 reservoir wetlands that suffered flood damage due to the long rainy season in 2020 due to reservoir wetland sedimentation and aging. For the target reservoir, 10 locations including the GaGog reservoir located in Miryang city, Gyeongsangnam province in South Korea, where there is actual survey information, were selected. A multiple regression model was developed in consideration of physical and climatic characteristics, and a total of four empirical formulas and sediment deposition rate were calculated. Using this, the error of the sediment deposition rate was compared. As a result of calculating the sediment deposition rate using the multiple regression model, the error was the lowest from 0.21(m3km2/yr) to 2.13(m3km2/yr). Therefore, based on the sediment deposition rate estimated by the multi-regression model, the change in the available capacity of reservoir wetlands was analyzed, and the effective storage capacity was found to have decreased from 0.21(%) to 16.56(%). In addition, the sediment deposition rate of the reservoir where the overflow damage occurred was relatively higher than that of the reservoir where the piping damage occurred. In other words, accumulating sediment deposition rate at the bottom of the reservoir would result in a lack of acceptable effective water capacity and reduced reservoir flood and drought control capabilities, resulting in reservoir collapse damage.

Characterization of Antidiabetic Compounds from Extract of Torreya nucifera (비자나무 추출물의 항당뇨 활성물질의 특성 연구)

  • Kim, Ji Won;Kim, Dong-Seob;Lee, Hwasin;Park, Bobae;Yu, Sun-Nyoung;Hwang, You-Lim;Kim, Sang Hun;Ahn, Soon-Cheol
    • Journal of Life Science
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    • v.32 no.1
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    • pp.1-10
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    • 2022
  • Natural products have gained increasing attention due to their advantage of long-term safety and low toxicity for a very long time. Torreya nucifera is widespread in southern Korea and Jeju Island and its seeds are commonly used as edible food. Oriental ingredients have often been reported for their insecticidal, antioxidant and antibacterial properties, but there have not yet been any studies on their antidiabetic effect. In this study, we investigated several biological activities of T. nucifera pericarp (TNP) and seeds (TNS) extracts and proceeded to characterize the antidiabetic compounds of TNS. The initial results suggested that TNS extract at 15 and 10 ㎍/ml concentration has inhibitory effects on α-glucosidase and protein tyrosine phosphatase 1B, that is 14.5 and 4.35 times higher than TNP, respectively. Thus, the stronger antidiabetic TNS was selected for the subsequent experiments to characterize its active compounds. Ultrafiltration was used to determine the apparent molecular weight of the active compounds, showing 300 kDa or more. Finally the mixture was then partially purified using Diaion HP-20 column chromatography by eluting with 50~100% methanol. Therefore we concluded that the active compounds of TNS have potential as therapeutic agents in functional food or supplemental treatment to improve diabetic diseases.

Estimation of Ecological Carrying Capacity for Oyster Culture by Ecological Indicator in Geoje-Hansan Bay (생태지표를 이용한 거제한산만 굴양식장의 생태학적 수용능력 산정)

  • Lee, Won-Chan;Cho, Yoon-Sik;Hong, Sok-Jin;Kim, Hyung-Chul;Kim, Jeong-Bae;Lee, Suk-Mo
    • Journal of the Korean Society of Marine Environment & Safety
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    • v.17 no.4
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    • pp.315-322
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    • 2011
  • The importance of aquafarming is increasing all over the world, however the coastal environment in the semi-closed inner bay has been aggravated due to the long term production and the high stocking density. For the sustainable aquafarming, there is a requirement for a eco-friendly fishery management by the estimation of ecological carrying capacity. The model development and application is still in the initial step, because it has to consider the whole ecosystem and all culture activities. As an alternative, there is a requirement for ecological indicator to assess the ecological performance. This study tried the estimation of ecological carrying capacity using ecological indicator. The production and the facility of the oyster farms was 4,935M/T, $49ind./m^3$ in Geoje-Hansan Bay(2008). Filtration pressure indicator was 0.203 which could provide a guidance on the present level of culture development. According to the environmental characteristics and the present oyster farms in Geoje-Hansan Bay, the newly assessed filtration pressure for the acceptable ecological carrying capacity was 0.102. Consequently, ecological carrying capacity in Geoje-Hansan Bay was 2,480M/T, $25ind./m^3$ and this represents the level of culture that can be introduced into Geoje-Hansan Bay without leading to significant changes to ecological process, species, populations or communities. Our study utilized the ecological indicator to estimate ecological carrying capacity of oyster farming for sustainable productivity and this could be the scientific basis for the eco-friendly fishery management.

Detection and Measurement of Nuclear Medicine Workers' Internal Radioactive Contamination (핵의학과 종사자의 방사성동위원소 체내오염 측정)

  • Jeong, Gyu-Hwan;Kim, Yong-Jae;Jang, Jeong-Chan;Lee, Jai-Ki
    • The Korean Journal of Nuclear Medicine Technology
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    • v.13 no.3
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    • pp.123-131
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    • 2009
  • Purpose: We tested a sample of nuclear medicine workers at Korean healthcare institutions for internal contamination with radioactive isotopes, measuring concentrations and evaluating doses of individual exposure. Materials and Methods: The detection and measurement was performed on urine samples collected from 25 nuclear medicine workers at three large hospitals located in Seoul. Urine samples were collected once a week, 100~200 mL samples were gathered up to 6~10 times weekly. A high-purity germanium detector was used to measure gamma radiations in urine samples for the presence of radioactive isotopes. Based on the detection results, we estimated the amounts of intake and committed effective doses using IMBA software. In cases where committed effective doses could not be adequately evaluated with IMBA software, we estimated individual committed effective doses for radionuclides with a very short half life such as $^{99m}Tc$ and $^{123}I$, using the methods recommended by International Atomic Energy Agency. Results: Radionuclides detected through the analysis of urine samples included $^{99m}Tc$, $^{123}I$, $^{131}I$ and $^{201}Tl$, as well as $^{18}F$, a nuclide used in Positron Emission Tomography examinations. The committed effective doses, calculated based on the radionuclide concentrations in urine samples, ranged from 0 to 5 mSv, but were, in the majority of cases, less than 1 mSv. The committed effective dose exceeded 1 mSv in three of the samples, and all three were workers directly handling radioactive sources. No nurses were found to have a committed effective dose in excess of 1 mSv. Conclusions: To improve the accuracy of results, it may be necessary to conduct a long-term study, performed over a time span wide enough to allow the clear determination of the influence of seasonal factors. A larger sample should also help increase the reliability of results. However, as most Korean nuclear medicine workers are currently not necessary to monitored routinely for internal contamination with radionuclides. Notwithstanding, a continuous effort is recommended to reduce any unnecessary exposure to radioactive substances, even if in inconsequential amounts, by regularly surveying workplace environments and frequently monitoring atmospheric concentrations of radionuclides.

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Risk Ranking Determination of Combination of Foodborne Pathogens and Livestock or Livestock Products (식중독 세균과 주요 축산식품 및 가공품 조합에 대한 위해순위 결정)

  • Hong, Soo-Hyeon;Park, Na-Yoon;Jo, Hye-Jin;Ro, Eun-Young;Ko, Young-Mi;Na, Yu-Jin;Park, Keun-Cheol;Choi, Bum-Geun;Min, Kyung-Jin;Lee, Jong-Kyung;Moon, Jin-San;Yoon, Ki-Sun
    • Journal of Food Hygiene and Safety
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    • v.30 no.1
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    • pp.1-12
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    • 2015
  • This study was performed to determine risk ranking of the combination of pathogen-livestock or livestock products to identify the most significant public health risks and to prioritize risk management strategies. First, we reviewed foodborne outbreak data related to livestock products and determined main vehicles and pathogens according to the number of outbreak and case. Second, expert's opinion about management priority of pathogen-livestock product pairing was surveyed with 19 livestock experts in the university, research center, and government agency. Lastly, we used the outcome of Risk Ranger (semi-quantitative risk ranking tool) of 14 combinations of pathogen and livestock or livestock products. We have classified the combination of pathogen-livestock products into group I (high risk), II (medium risk), and III (low risk) according to their risk levels and management priority. Group I, which is the highest risk for foodborne outbreak, includes Salmonella spp./egg and egg products, Campylobacter spp./poultry, pathogenic E. coli/meat and processed ground meat. In conclusion, the results of this study will provide the specific guideline of mid- and long-term planning for risk assessment and risk management prioritization of the combination of pathogen and livestock, or livestock product.

Study on Basic Requirements of Geoscientific Area for the Deep Geological Repository of Spent Nuclear Fuel in Korea (사용후핵연료 심지층처분장부지 지질환경 기본요건 검토)

  • Bae, Dae-Seok;Koh, Yong-Kwon;Park, Ju-Wan;Park, Jin-Baek;Song, Jong-Soon
    • Journal of Nuclear Fuel Cycle and Waste Technology(JNFCWT)
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    • v.10 no.1
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    • pp.63-75
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    • 2012
  • This paper gives some basic requirements and preferences of various geological environmental conditions for the final deep geological repository of spent nuclear fuel (SNF). This study also indicates how the requirements and preferences are to be considered prior to the selection of sites for a site investigation as well as the final disposal in Korea. The results of the study are based on the knowledge and experience from the IAEA and NEA/OECD as well as the advanced countries in SNF disposal project. This study discusses and suggests preliminary guideline of the disposal requirements including geological, mechanical, thermal, hydrogeological, chemical and transport properties of host rock with long term geological stabilities which influence the functions of a multi-barrier disposal system. To apply and determine whether requirements and preferences for a given parameter are satisfied at different stages during a site selection and suitability assessment of a final disposal site, the quantitative criteria in each area should be formulated with credibility through relevant research and development efforts for the deep geological environment during the site screening and selection processes as well as specific studies such as productions of safety cases and validation studies using a generic underground research laboratory (URL) in Korea.

Oseltamivir efficacy, side effects, and safety in children with influenza (인플루엔자 바이러스 감염 소아 환아에서 Oseltamivir 약제 효용성과 단기간.장기간 부작용 및 안전성에 관한 임상연구)

  • Seo, Eun Sun;Park, Geun Hwa;Kim, Sung Mi;Kim, Sung Won;Jung, Woo Sik;Cho, Kyung Soon;Park, Yeon Gyeong;Lee, Chang Kyu;Kang, Chun;Lee, Joo Yeon;Choi, Woo Young
    • Clinical and Experimental Pediatrics
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    • v.53 no.1
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    • pp.56-66
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    • 2010
  • Purpose : Although oseltamivir is widely used for treatment of influenza, few clinical studies of its efficacy and resistance have been performed in Korea. We evaluated the safety, side effects, and efficacy of oseltamivir treatment in Korean pediatric patients. Methods : We analyzed 321 children diagnosed with influenza at Busan St. Mary's Medical Center, Korea, between January 2008 and June 2008 (first study period) and November 2008 and January 2009 (second study period). Patients were divided into two groups: those receiving oseltamivir treatment for 5 days and those receiving only symptomatic treatment. We investigated clinical symptoms, side effects, and resistance to oseltamivir. We also identified influenza strains and evaluated resistance to oseltamivir using an influenza virus culture. Results : One hundred eighty-six patients were assigned to the treatment group, and 135 were assigned to the control group. The treatment group showed shorter admission duration (4.4 days) compared with controls (5.0 days) (P =0.000) and had fewer lower respiratory tract complications compared with controls (P <0.05). No significant statistical difference in the virus antigenic type was observed between the groups. In the first study period, virus culture showed influenza B (41.7% vs. 49.6%), A/H3N2 (7.9% vs. 8.4%), and A/H1N1 (9.4% vs. 6.5%). In the second study period, only A/H1N1 (55.3% vs. 50.0%) was isolated, except for one case of A (H3N2) in the treatment group. No differences in short- and long-term side effects, including neuropsychologic side effects, were noted between groups. There was no resistance to oseltamivir before or after treatment in the first study period. Conclusion : Based on our results, we suggest that osetalmivir therapy in pediatric patients is effective.

토양 및 지하수 Investigation 과 Remediation에 대한 현장적용

  • Wallner, Heinz
    • Proceedings of the Korean Society of Soil and Groundwater Environment Conference
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    • 2000.11a
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    • pp.44-63
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    • 2000
  • Situated close to Heathrow Airport, and adjacent to the M4 and M25 Motorways, the site at Axis Park is considered a prime location for business in the UK. In consequnce two of the UK's major property development companies, MEPC and Redrew Homes sought the expertise of Intergeo to remediate the contaminated former industrial site prior to its development. Industrial use of the twenty-six hectare site, started in 1936, when Hawker Aircraft commence aircraft manufacture. In 1963 the Firestone Tyre and Rubber Company purchased part of the site. Ford commenced vehicle production at the site in the mid-1970's and production was continued by Iveco Ford from 1986 to the plant's decommissioning in 1997. Geologically the site is underlain by sand and gravel, deposited in prehistory by the River Thames, with London Clay at around 6m depth. The level of groundwater fluctuates seasonally at around 2.5m depth, moving slowly southwest towards local streams and watercourses. A phased investigation of the site was undertaken, which culminated in the extensive site investigation undertaken by Intergeo in 1998. In total 50 boreholes, 90 probeholes and 60 trial pits were used to investigate the site and around 4000 solid and 1300 liquid samples were tested in the laboratory for chemical substances. The investigations identified total petroleum hydrocarbons in the soil up to 25, 000mg/kg. Diesel oil, with some lubricating oil were the main components. Volatile organic compounds were identified in the groundwater in excess of 10mg/l. Specific substances included trichloromethane, trichloromethane and tetrachloroethene. Both the oil and volatile compounds were widely spread across the site, The specific substances identified could be traced back to industrial processes used at one or other dates in the sites history Slightly elevated levels of toxic metals and polycyclic aromatic hydrocarbons were also identified locally. Prior to remediation of the site and throughout its progress, extensive liaison with the regulatory authorities and the client's professional representatives was required. In addition to meetings, numerous technical documents detailing methods and health and safety issues were required in order to comply with UK environmental and safety legislation. After initially considering a range of options to undertake remediation, the following three main techniques were selected: ex-situ bioremediation of hydrocarbon contaminated soils, skimming of free floating hydrocarbon product from the water surface at wells and excavations and air stripping of volatile organic compounds from groundwater recovered from wells. The achievements were as follows: 1) 350, 000m3 of soil was excavated and 112, 000m3 of sand and gravel was processed to remove gravel and cobble sized particles; 2) 53, 000m3 of hydrocarbon contaminated soil was bioremediated in windrows ; 3) 7000m3 of groundwater was processed by skimming to remove free floating Product; 4) 196, 000m3 of groundwater was Processed by air stripping to remove volatile organic compounds. Only 1000m3 of soil left the site for disposal in licensed waste facilities Given the costs of disposal in the UK, the selected methods represented a considerable cost saving to the Clients. All other soil was engineered back into the ground to a precise geotechnical specification. The following objective levels were achieved across the site 1) By a Risk Based Corrective Action (RBCA) methodology it was demonstrated that soil with less that 1000mg/kg total petroleum hydrocarbons did not pose a hazard to health or water resources and therefore, could remain insitu; 2) Soils destined for the residential areas of the site were remediated to 250mg/kg total petroleum hydrocarbons; in the industrial areas 500mg/kg was proven acceptable. 3) Hydrocarbons in groundwater were remediated to below the Dutch Intervegtion Level of 0.6mg/1; 4) Volatile organic compounds/BTEX group substances were reduced to below the Dutch Intervention Levels; 5) Polycyclic aromatic hydrocarbons and metals were below Inter-departmental Committee for the Redevelopment of Contaminated Land guideline levels for intended enduse. In order to verify the qualify of the work 1500 chemical test results were submitted for the purpose of validation. Quality assurance checks were undertaken by independent consultants and at an independent laboratory selected by Intergeo. Long term monitoring of water quality was undertaken for a period of one year after remediation work had been completed. Both the regulatory authorities and Clients representatives endorsed the quality of remediation now completed at the site. Subsequent to completion of the remediation work Redrew Homes constructed a prestige housing development. The properties at "Belvedere Place" retailed at premium prices. On the MEPC site the Post Office, amongst others, has located a major sorting office for the London area. Exceptionally high standards of remediation, control and documentation were a requirement for the work undertaken here.aken here.

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Survey for contamination and study for reduction of ochratoxin A and aflatoxin in red pepper (고추 중 오크라톡신 A와 아플라톡신의 오염도 조사 및 저감화방안 연구)

  • Kim, Dong-Ho;Jang, Han-Sub;Kim, Yeong-Min;Ahn, Jong-Sung
    • Journal of Food Hygiene and Safety
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    • v.24 no.4
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    • pp.299-306
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    • 2009
  • Aflatoxin (AF) and Ochratoxin A (OTA) are carcinogenic and possible carcinogenic mycotoxins respectively produced by Aspergillus spp or Penicillium spp. The study for contamination survey and proposal for reduction of mycotoxin in red pepper were carried out. 192 samples were collected at such various stages and markets as pre/post-harvest stages, internet shopping mall /super-market and small stakeholder mill/geographically indicated company. As only 2 samples were positive for aflatoxin, so contamination rate was 1.04%. In the meanwhile, contamination rate for ochratoxin A was 21.88% and a various amount of OTA was detected in 42 positive samples. 6 samples were found to be contaminated at higher level than $5\;{\mu}gkg^{-1}$ for ochratoxin A, which was established recently as a maximum permissible limit in korea. There was no difference in degree of contamination with regard to cultivation type because any mycotoxin was not found at all in both organically and conventionally grown red pepper. But, there was statistically significant difference in the process of manufacturing. Finished products were OTA-contaminated at a level of $2.32\;{\pm}\;6.54\;{\mu}gkg^{-1}$(mean ${\pm}$ SD), even though OTA was not detected in deep frozen red peppers right after long term storage. And contamination for OTA was a level of $0.33\;{\pm}\;0.91\;{\mu}gkg^{-1}$(mean ${\pm}$ SD) in red paprika powder after uv sterilization, while the contamination for OTA was $2.78\;{\pm}\;4.49\;{\mu}kg^{-1}$(mean ${\pm}$ SD) in non-uv sterilized powder. In addition, our investigation shows that higher OTA contamination occurred in some of famous brand products sold in super-market and domestic products than products collected through on-line shopping or from small stakeholder mills and imported products respectively, however, difference was not statistically significant.

The Effect of working Noise Exposure and Military Background on the Hearing Threshold (특수병과의 과거 군 소음 노출이 소음 노출 작업자의 청력에 미치는 영향)

  • Chung, Ho-Keun;Kim, Kyoo-Sang
    • Journal of Preventive Medicine and Public Health
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    • v.36 no.2
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    • pp.137-146
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    • 2003
  • Objectives : Impaired hearing is a prevalent occupational hazard, not only in industry, but also in the armed forces. In military life, noise has unusual characteristics, and constitutes a serious hazard to hearing. The aim of this study was to analyze the hearing threshold data in order to compare the hearing loss among shipyard workers, representing different workers, and a military service background. Methods : A cross-sectional audiological survey, combined with a questionnaire study, was conducted on a stratified random sample of 440 shipyard workers, with long-term exposure to noise. The employees were divided into four groups, according to their working and military service backgrounds, in relation to their exposure to noise. Results : As expected, the working and military noise exposure group (Group I) had significantly poorer hearing than the other groups. The high frequencies (2-8 kHz) showed the greatest difference in terms of poorer fearing in both ears. The prevalence of noise-induced hearing loss (NIHL) was highest in Group I. A logistic regression analysis was applied to determine the dependence of the NIHL in relation to age, smoking, drinking, working duration, ear protection, past history of ear diseases, and working and military sonics backgrounds, on the noise exposure The important factors found to be related to the NIHL, in relation to noise exposure were: age, work duration, and working and military service backgrounds. The adjusted odds ratio estimates for NIML in the right ear were 4.5 times greater (95% CI 1.7-11.6) for the military noise exposed group, and 7.9 times greater (95% CI 2.0-31.3) for the working noise exposed group than in the controls. The hearing thresholds at the pure-tone average and 4 kHz were significantly increased with age and work duration with both the working and military service backgrounds. Conclusions : From these results, specific preventive programs were planned, which should be assessed by epidemiological surveillance of the military noise exposed population.