• Title/Summary/Keyword: long-term failure analysis

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Risk Factor Analysis of Endoscopic Dilation Procedure for the Management of Subglottic Stenosis in Pediatric Patients (성문하 협착 소아 환자에 대한 내시경적 기도 확장 시술 후 치료 실패 위험 요인 분석)

  • Park, Min Hae;Choi, Nayeon;Song, Bok Hyun;Jeong, Han-Sin;Son, Young-Ik;Chung, Man Ki
    • Journal of the Korean Society of Laryngology, Phoniatrics and Logopedics
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    • v.31 no.1
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    • pp.19-26
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    • 2020
  • Background and Objective Endoscopic airway dilation is the primary treatment for pediatric subglottic stenosis (SGS) due to its feasibility and non-invasiveness. The aim of this study is to evaluate the risk factors for the failure of endoscopic airway dilation in pediatric patients with SGS. Materials and Methods This study reviewed medical records of 38 pediatric patients had endoscopic dilation from a single and tertiary referral center, retrospectively. The success of the endoscopic dilation procedure was defined as no dyspneic symptom without tracheostomy or laryngotracheal reconstruction. Demographic profiles, underlying disease, and Myer-Cotton SGS severity grade were recorded. Success rates and risk factors for the failure of treatment were analyzed. Results The SGS patients with severity grade I was most common. After mean 1.8 numbers of procedures, there were 23 patients (60.5%) in the success group and 15 patients (39.5%) in the failure group. Age, sex, underlying diseases, and SGS severity grade were not significantly different between two groups. In patients who had multiple endoscopic procedures, the failure group showed SGS deteriorated after procedures in 66.7%, compared to 11.1% of the success group. In multivariable analysis, a long-term intubation (≥1 month) was identified as an independent risk factor for failure of endoscopic dilation procedure. Conclusion Although endoscopic dilation procedure is safe and effective for the management, repetitive endoscopic dilation may not give clinical benefit in patient with long-term intubation. Other airway procedures must be considered in those group of patients.

Time Dependent Extension and Failure Analysis of Structural Adhesive Assemblies Under Static Load Conditions

  • Young, Patrick H.;Miller, Zachary K.;Gwasdacus, Jeffrey M.
    • Journal of Adhesion and Interface
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    • v.21 no.1
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    • pp.6-13
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    • 2020
  • The objective of the current study is to characterize the long-term stability and efficacy of a structural adhesive assembly under static load. An apparatus was designed to be used in the Instron tensile test machine that would allow for real time modeling of the failure characteristics of an assembly utilizing a moisture- cure adhesive which was bonded to concrete. A regression model was developed that followed a linear - natural log function which was used to predict the expected life of the assembly. Evaluations at different curing times confirmed the structure was more robust with longer cure durations prior to loading. Finally, the results show that under the conditions the assembly was tested, there was only a small amount of inelastic creep and the regression models demonstrated the potential for a stable structure lasting several decades.

Factors affecting the survival of implants: a long-term retrospective study (임플란트의 생존에 영향을 미치는 요인에 대한 장기간의 후향적 연구)

  • Song, Susanna;Lee, Jae-Kwan;Um, Heung-Sik;Chang, Beom-Seok
    • Journal of Dental Rehabilitation and Applied Science
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    • v.31 no.1
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    • pp.10-19
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    • 2015
  • Purpose: The aim of the present study was to evaluate the long-term survival of implants retrospectively and determine the risk factors associated with implant failure. Materials and Methods: Of all implants that were placed at the Department of Periodontology of the Dental Hospital of Gangneung-Wonju National University from January 1998 to December 2012, 2265 implants that were followed up until June 2013 were included in this study. Data were collected from clinical and radiographic examinations from previous visits. The information gathered included gender, age, smoking status, implant diameter, implant length, surface of implant, location of implant within the dental arch, surgical techniques and existence of complications. Results: The survival rate before loading was 98.9%. The cumulative survival rate after 5 years of loading was 97.2%, and after 15 years of loading was 95.2%. In a simple logistic regression analysis, gender (P = 0.016), smoking status (P = 0.001), location of implant (P = 0.020) and existence of complications (P = 0.002) were statistically associated with implant failure and included in the multiple regression analysis. As a result of multiple logistic regression analysis, the variables statistically associated with implant failure (P < 0.05) were smoking status (P = 0.049) and existence of complications (P < 0.001). Conclusion: The cumulative survival rate of dental implants after 15 years of loading was 95.2% and that the variables statistically associated with implant failure were smoking status and existence of complications.

Multi-Objective Handover in LTE Macro/Femto-Cell Networks

  • Roy, Abhishek;Shin, Jitae;Saxena, Navrati
    • Journal of Communications and Networks
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    • v.14 no.5
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    • pp.578-587
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    • 2012
  • One of the key elements in the emerging, packet-based long term evolution (LTE) cellular systems is the deployment of multiple femtocells for the improvement of coverage and data rate. However, arbitrary overlaps in the coverage of these femtocells make the handover operation more complex and challenging. As the existing handover strategy of LTE systems considers only carrier to interference plus noise ratio (CINR), it often suffers from resource constraints in the target femtocell, thereby leading to handover failure. In this paper, we propose a new efficient, multi-objective handover solution for LTE cellular systems. The proposed solution considers multiple parameters like signal strength and available bandwidth in the selection of the optimal target cell. This results in a significant increase in the handover success rate, thereby reducing the blocking of handover and new sessions. The overall handover process is modeled and analyzed by a three-dimensional Markov chain. The analytical results for the major performance metrics closely resemble the simulation results. The simulation results show that the proposed multi-objective handover offers considerable improvement in the session blocking rates, session queuing delay, handover latency, and goodput during handover.

Experiments and MAAP4 Assessment for Core Mixture Level Depletion After Safety Injection Failure During Long-Term Cooling of a Cold Leg LB-LOCA

  • Kim, Y. S.;B. U. Bae;Park, G. C.;K. Y. Sub;Lee, U. C .
    • Nuclear Engineering and Technology
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    • v.35 no.2
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    • pp.91-107
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    • 2003
  • Since DBA(Design Basis Accidents) has been studied rather separately from SA(Severe Accidents) in the conventional nuclear reactor safety analysis, the thermal hydraulics during transition between DBA and SA has not been identified so much as each accident itself. Thus, in this study, the thermal hydraulic behavior from DBA to the commencement of SA has been experimentally and analytically investigated for the long-term cooling phase of LB-LOCA(Large-Break Loss-of-Coolant Accident). Experiments were conducted for both cases of the loop seal open and closed in an integral test loop, named as SNUF (Seoul National University Facility), which was scaled down to l/6.4 in length and 1/178 in area of the APR1400 (Advanced Power Reactor 1400MWe). The core mixture level was a main measured value since it took major role in the fuel heat-up rate, the location of fuel melting initiation and the channel blockage by melting material during SA. Experimental results were compared to MAAP4.03 to assess its model of calculating the core mixture level. MAAP4.03 overestimates the core two- phase mixture level because sweep-out and spill-over and the measures to simulate the status of loop seal are not included, which is against the conservatism. Thus, it is recommended that MAAP4.03 should be improved to simulate the thermal hydraulic phenomena, such as sweep-out, spill-over and the status of loop seal.

Long Term Outcomes and Prognostic Factors of N0 Stage Nasopharyngeal Carcinoma: a Single Institutional Experience with 610 Patients

  • Sun, Jian-Da;Chen, Chuang-Zhen;Chen, Jian-Zhou;Li, Dong-Sheng;Chen, Zhi-Jian;Zhou, Ming-Zhen;Li, De-Rui
    • Asian Pacific Journal of Cancer Prevention
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    • v.13 no.5
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    • pp.2101-2107
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    • 2012
  • Treatment responses of $N_0$ stage nasopharyngeal carcinoma were firstly analyzed comprehensively to evaluate long term outcomes of patients and identify prognostic factors. A total of 610 patients with $N_0$ NPC, undergoing definitive radiotherapy to their primary lesion and prophylactic radiation to upper neck, were reviewed retrospectively. Concomitant chemotherapy was administrated to 65 out of the 610. Survival rates of the patients were calculated using the Kaplan-Meier method and compared by log-rank test. Prognostic factors were identified by the Cox regression model. The study revealed the 5-year and 10-year overall, disease-free, disease-specific, local failure-free, regional failure-free, locoregional failure-free and distant metastasis-free survival rates to be 78.7% and 66.8%, 68.8% and 55.8%, 79.9% and 70.4%, 81.2% and 72.5%, 95.8% and 91.8%, 78.3% and 68.5%, 88.5% and 85.5%, respectively. There were 192 patients experiencing failure (31.5%) after radiotherapy or chemoradiotherapy. Of these, local recurrence, regional relapse and distant metastases as the first event of failure occurred in 100 (100/610, 16.4%), 15(15/610, 2.5%) and 52 (52/610, 8.5%), respectively. Multivariate analysis showed that T stage was the only independent prognostic factor for patients with $N_0$ NPC (P=0.000). Late T stage (P=0.000), male (P=0.039) and anemia (P=0.007) were independently unfavorable factors predicting disease-free survival. After treatment, satisfactory outcome wasgenerally achieved in patients with $N_0$ NPC. Local recurrence represented the predominant mode of treatment failure, while T stage was the only independent prognostic factor for overall survival. Late T stage, male gender, and anemia independently predicted lower possibility of the disease-free survival.

Simulation of interface ageing effect of suspension insulator using ANSYS (ANSYS를 이용한 현수애자의 계면팽창거동에 대한 해석)

  • Woo, B.C.;Han, S.W.;Cho, H.G.;Choi, J.H.
    • Proceedings of the KIEE Conference
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    • 2002.11a
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    • pp.74-76
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    • 2002
  • The suspension insulators are subjected to harsh environment in service for a long time. Long term reliability of the insulators is required for both mechanical and electrical performances. We studied an analysing method to find out a deformation of brittle porcelain with a thermal expansion of cement for suspension insulator. These simulation analysis and experimental results show that cement volume growths affect severely to be mechanical failure ageing.

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Long-term tolerance and outcomes for dose escalation in early salvage post-prostatectomy radiation therapy

  • Safdieh, Joseph J.;Schwartz, David;Weiner, Joseph;Weiss, Jeffrey P.;Rineer, Justin;Madeb, Isaac;Rotman, Marvin;Schreiber, David
    • Radiation Oncology Journal
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    • v.32 no.3
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    • pp.179-186
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    • 2014
  • Purpose: To study the long-term outcomes and tolerance in our patients who received dose escalated radiotherapy in the early salvage post-prostatectomy setting. Materials and Methods: The medical records of 54 consecutive patients who underwent radical prostatectomy subsequently followed by salvage radiation therapy (SRT) to the prostate bed between 2003-2010 were analyzed. Patients included were required to have a pre-radiation prostate specific antigen level (PSA) of 2 ng/mL or less. The median SRT dose was 70.2 Gy. Biochemical failure after salvage radiation was defined as a PSA level >0.2 ng/mL. Biochemical control and survival endpoints were analyzed using the Kaplan-Meier method. Univariate and multivariate Cox regression analysis were used to identify the potential impact of confounding factors on outcomes. Results: The median pre-SRT PSA was 0.45 ng/mL and the median follow-up time was 71 months. The 4- and 7-year actuarial biochemical control rates were 75.7% and 63.2%, respectively. The actuarial 4- and 7-year distant metastasis-free survival was 93.7% and 87.0%, respectively, and the actuarial 7-year prostate cancer specific survival was 94.9%. Grade 3 late genitourinary toxicity developed in 14 patients (25.9%), while grade 4 late genitourinary toxicity developed in 2 patients (3.7%). Grade 3 late gastrointestinal toxicity developed in 1 patient (1.9%), and grade 4 late gastrointestinal toxicity developed in 1 patient (1.9%). Conclusion: In this series with long-term follow-up, early SRT provided outcomes and toxicity profiles similar to those reported from the three major randomized trials studying adjuvant radiation therapy.

Evaluation of Long-Term Behaviors of the Cone Nailing System using Geotechnical Centrifuge Guidelines (원심모형실험을 이용한 방추형 콘 네일링 시스템의 장기거동 특성 평가)

  • Park, Si-Sam;Bae, Woo-Seok;Jung, Woo-Chul;Kim, Hong-Taek;Kim, Yong-Kyu
    • Proceedings of the Korean Geotechical Society Conference
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    • 2006.03a
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    • pp.744-751
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    • 2006
  • In case of the Soil Nail System applied to a slope, effects of vibrations from blasting, earthquake and creep of long term behaviors cause reductions of adhesion between grout and soil-nail. There are some reports of nail's pull-out failure by those reasons. In this paper it is suggested that the Cone Nailing System is enable to diminish effects of vibrations and creep. In this study on Cone Nailing System, the cones are installed to each nail by 2m. By such installing cones, the adhesion between nail and grout will increase and the long term creep behavior will decrease. In this study, the centrifuge test is performed to understand the behaviors of the Cone Nail System. For the centrifuge test, the soil tank is 52cm in width, 17cm in length and 35cm in height. In comparison with general soil nail, the centrifuge test of general soil nail(without cone) is performed equally. Additionally, the interface between cone nail and soil through the pull-out test is applied to FLAC 2D version 3.3. and the evaluation of application for the Cone Nail System in slope is performed.

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Mechanical Properties of EPDM Gasket after Long-Term Operations (EPDM 가스켓의 장시간 운전에 따른 기계적 성능변화)

  • Wu, Lan;Kim, Seon-Hak;Cheon, Seung-Ho;Kim, Jin-Su;Hyun, Deok-Su;Kim, Byeong-Heon;Lee, Sung-Kun;Jeong, Jae-Hoon;Ji, Duk-Jin;Oh, Byeong-Soo
    • Journal of Hydrogen and New Energy
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    • v.22 no.4
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    • pp.488-494
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    • 2011
  • Gasket plays an important role on sealing of the polymer electrolyte membrane fuel cell (PEMFC) stack. Stack requires gaskets in each cell to keep the hydrogen and air/oxygen within their respective regions. The failure of the gasket creates the problems of fuel leakage, mixing, damage on parts and can be a direct reason for the degrading the efficiency of fuel cell. The purpose of this paper researches on how mechanical properties of EPDM gasket in PEMFC are changed after long-term operations. The EPDM (ethylenepropylene-diene monomer) gaskets are obtained from the stack after long-term operations. DMA (dynamic mechanical analysis) is conducted to access the change of mechanical properties of the EPDM gasket. SEM/EDS (scanning electron microscope/energy dispersive spectroscopy) was used to show the surface topography and chemical characterization on the sample surface.