• The Korean Journal of Applied Statistics
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• v.32 no.4
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• pp.561-572
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• 2019

We study false discovery rate segmentation (FDRSeg) and simultaneous multiscale change-point estimator (SMUCE) methods for multiscale multiple change-point estimation, and compare empirical behavior via simulation. FSRSeg is based on the control of a false discovery rate while SMUCE used for the multiscale local likelihood ratio tests. FDRSeg seems to work best if the number of change-points is large; however, FDRSeg and SMUCE methods can both provide similar estimation results when there are only a small number of change-points. As a real data application, multiple change-points estimation is done with the well-log data.

• Journal of the Korean Data and Information Science Society
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• v.25 no.5
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• pp.971-986
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• 2014

When thousands of hypotheses are tested simultaneously, the probability of rejecting any true hypotheses increases, and large multiplicity problems are generated. To solve these problems, researchers have proposed different approaches to multiple testing methods, considering family-wise error rate (FWER), false discovery rate (FDR) or false nondiscovery rate (FNR) as a type I error and some test statistics. In this article, we discuss Bonferroni (1960), Holm (1979), Benjamini and Hochberg (1995) and Benjamini and Yekutieli (2001) procedures based on T statistics, modified T statistics or local-pooled-error (LPE) statistics. We also consider Sun and Cai (2007) procedure based on Z statistics. These procedures are compared in the simulation and applied to Arabidopsis microarray gene expression data to identify differentially expressed genes.

• Communications for Statistical Applications and Methods
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• v.29 no.6
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• pp.655-664
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• 2022

On the motivation by an integrative study of multi-omics data, we are interested in estimating the structure of the sparse cross correlation matrix of two high-dimensional random vectors. We rewrite the problem as a multiple testing problem and propose a new method to estimate the sparse structure of the cross correlation matrix. To do so, we test the correlation coefficients simultaneously and threshold the correlation coefficients by controlling FRD at a predetermined level α. Further, we apply the proposed method and an alternative adaptive thresholding procedure by Cai and Liu (2016) to the integrative analysis of the protein expression data (X) and the mRNA expression data (Y) in TCGA breast cancer cohort. By varying the FDR level α, we show that the new procedure is consistently more efficient in estimating the sparse structure of cross correlation matrix than the alternative one.