• Food Science and Biotechnology
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• 제18권4호
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• pp.978-984
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• 2009

An analytical method for the simultaneous determination of 9 quinolones (QNs) in porcine, chicken, and bovine muscles was developed and validated using liquid chromatography-fluorescence detector (LC-FLD). The samples were extracted using a liquid-liquid extraction (LLE) process. Chromatographic separation was achieved on a reverse phase $C_8$ column with a gradient elution using a mobile phase of 200 mM ammonium acetate buffer (pH 4.5) and acetonitrile (ACN). The proposed method was validated according to the Food and Drug Administration (FDA) guideline for bioanalytical assay procedures. Recoveries of QNs were 83.1-111.9% with relative standard deviations (RSDs) below 15%. Linearity within a range of 30-500 ${\mu}g/kg$ was obtained with the correlation coefficient ($R^2$) of 0.9967-0.9999. The limits of detection (LOD) were 1-16 ${\mu}g/kg$. These values were lower than the maximum residues limits (MRLs) established by the European Union (EU). The present method was successfully applied to determine QNs in edible muscles.

• 대한기계학회논문집B
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• 제23권10호
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• pp.1327-1339
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• 1999

Characteristics of two-phase flow and heat transfer were numerically investigated in a submerged gas Injection system. Effects of both the gas flow rate and bubble size were investigated. In addition, heat transfer characteristic and effects of heat transfer were investigated when temperature of the injected gas was different from that of the liquid. The Eulerian approach was used for the formulation of both the continuous and the dispersed phases. The turbulence in the liquid phase was modeled by the use of the standard $k-{\varepsilon}$ turbulence model. The interphase friction and heat transfer coefficient were calculated by means of correlations available in the literature. The turbulent dispersion of the phases was modeled by introducing a "dispersion Prandtl number". The plume region and the axial velocities are increased with increases in the gas flow rate and with decreases in the bubble diameter. The turbulent flow field grows stronger with the increases in the gas flow rate and with the decreases in the bubble diameter. In case that the heat transfer between the liquid and the gas is considered, the axial and the radial velocities are decreased in comparison with the case that there is no temperature difference between the liquid and the gas when the temperature of the injected gas is higher than the mean liquid temperature. The results in the present research are of interest in the design and the operation of a wide variety of material and chemical processes.

• 한국해양공학회지
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• 제35권2호
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• pp.121-130
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• 2021

In this study, a computational fluid dynamics (CFD) simulation based on an Eulerian-Eulerian approach was used to evaluate the mixing performance of a mud agitator through the distribution of bulk particles. Firstly, the commercial CFD software Star-CCM+ was verified by performing numerical simulations of single-phase water mixing problems in an agitator with various turbulence models, and the simulation results were compared with an experiment. The standard model was selected as an appropriate turbulence model, and a grid convergence test was performed. Then, a simulation of the liquid-solid multi-phase mixing in an agitator was simulated with different multi-phase interaction models, and lift and drag models were selected. In the case of the lift model, the results were not significantly affected, but Syamlal and O'Brien's drag model showed more reasonable results with respect to the experiment. Finally, with the properly determined simulation conditions, a multi-phase flow simulation of a mud agitator was performed to predict the mixing time and spatial distribution of solid particles. The applicability of the CFD multi-phase simulation for the practical design of a mud agitator was confirmed.

• 상하수도학회지
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• 제18권2호
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• pp.201-207
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• 2004

Dissolved air flotation (DAF) is a solid-liquid separation process that uses fine rising bubbles to remove particles in water. Most of particle-bubble collision occurs in the DAF contact zone. This initial contact considered by the researchers to play a important role for DAF performance. It is hard to make up conceptual model through simple mass balance for estimating collision efficiency in the contact zone because coupled behavior of the solid-liquid-gas phase in DAF system is 90 complicate. In this study, 2-phase(gas-liquid) flow equations for the conservation of mass, momentum and turbulence quantities were solved using an Eulerian-Eulerian approach based on the assumption that very small particle is applied in the DAF system. For the modeling of turbulent 2-phase flow in the reactor, the standard $k-{\varepsilon}$ mode I(liquid phase) and zero-equation(gas phase) were used in CFD code because it is widely accepted and the coefficients for the model are well established. Particle-bubble collision efficiency was calculated using predicted turbulent energy dissipation rate and gas volume fraction. As the result of this study, the authors concluded that bubble size and recycle ratio play important role for flow pattern change in the reactor. Predicted collision efficiency using CFD showed good agreement with measured removal efficiency in the contact zone. Also, simulation results indicated that collision efficiency at 15% recycle ratio is higher than that of 10% and showed increasing tendency of the collision efficiency according to the decrease of the bubble size.

• 설비공학논문집
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• 제27권11호
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• pp.559-566
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• 2015

The main objective of this work is to experimentally investigate the effect of angle variation on the distribution of two-phase flow at header-channel junctions. The cross-sections of the header and the channels were fixed at $16mm{\times}16mm$ and $12mm{\times}1.8mm$, respectively. Air and water were used as the test fluids. Four different header-channel positions were tested : Vertical header with Horizontal channels (case VM-HC), Horizontal header with Horizontal channels (case HM-HC), Horizontal header with Vertical Downward channels (case HM-VDC), and Horizontal header with Vertical Upward channels (case HM-VUC). In all cases, liquid flow distribution tended to decrease gradually in the upstream header region. However, in the downstream region, different trends could be seen. The reason for these different tendencies were identified by flow visualization in each case. The standard deviations for the liquid and gas flow distribution in each case were calculated, and the case of VM-HC had the lowest values compared to other cases because of the symmetrically distributed liquid film and strong flow recirculation near the end plate.

• 대한화학회지
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• 제37권6호
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• pp.590-598
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• 1993

미국의 환경청이 지정한 129종의 priority pollutants 중 16종의 유기살충제를 대상물질로 선정하여 수질시료 중의 극미량 분석방법을 연구하였다. 분석방법으로는 기체크로마토그래프-전자포획 및 기체크로마토그래프/질량분석기-SIM(selected ion moitoring)법을 검출방법으로 정하고, 시료용액의 추출 및 농축방법으로는 용매추출법(liquid-liquid extraction)과 고체상 추출법(solid-phase extraction)을 비교 연구하였다. 각 화합물들의 회수율, 상대표준편차 및 검출한계 등을 측정하여 EPA 분석법을 대체할 수 있는지의 가능성을 조사하였다.

• 분석과학
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• 제7권4호
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• pp.441-453
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• 1994

수질에서 유해물질을 농축하는 방법으로 액체 추출법과 고체상 추출법을 GC/MS를 검출기로 사용하여 비교하였다. 비휘발성 유해물질 중 11종의 산과 44종의 염기/중성 화합물들을 reagent water에 첨가하여 분석한 결과, 액체추출법은 54종의 화합물에 대해 91%의 평균회수율과 4.6%의 평균상대표준편차를 나타내었으며, 고체상 추출법은 52종의 화합물에 대해 63%의 평균회수율과 8.9%의 평균상대표준편차를 보였다. 두 방법의 검출한계는 $1{\sim}5{\mu}g/l$였다.

• Computers and Concrete
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• 제32권4호
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• pp.399-410
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• 2023

This study proposes a novel use of backpropagated Levenberg-Marquardt neural networks based on computational intelligence heuristics to comprehend the examination of hybrid nanoparticles on the flow of dusty liquid via stretched cylinder. A two-phase model is employed in the present work to describe the fluid flow. The use of desulphated nanoparticles of silver and molybdenum suspended in water as base fluid. The mathematical model represented in terms of partial differential equations, Implementing similarity transformationsis model is converted to ordinary differential equations for the analysis . By adjusting the particle mass concentration and curvature parameter, a unique technique is utilized to generate a dataset for the proposed Levenberg-Marquardt neural networks in various nanoparticle circumstances on the flow of dusty liquid via stretched cylinder. The intelligent solver Levenberg-Marquardt neural networks is trained, tested and verified to identify the nanoparticles on the flow of dusty liquid solution for various situations. The Levenberg-Marquardt neural networks approach is applied for the solution of the hybrid nanoparticles on the flow of dusty liquid via stretched cylinder model. It is validated by comparison with the standard solution, regression analysis, histograms, and absolute error analysis. Strong agreement between proposed results and reference solutions as well as accuracy provide an evidence of the framework's validity.

• 약학회지
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• 제28권6호
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• pp.321-325
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• 1984

A HPLC determination method of xanthinol nicotinate(I) was developed for study of its stability and characteristics in solutions. I was determined using an ${\mu}-Bondapak\;C_{18}$ column with a mobile phase of methanol: $H_2O$ (1 : 1) and UV absorbance detection at 254nm. The results revealed that the method was enough to use as stability indicating determination with the mean of 99.9% and standard deviation of ${\pm}1.42%$ when analyzed 10 times for standard solution.

• 대한약학회:학술대회논문집
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• 대한약학회 2002년도 Proceedings of the Convention of the Pharmaceutical Society of Korea Vol.2
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• pp.395.3-396
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• 2002

A simple, rapid and reliable high performance liquid chromatography (HPLC) method has been developed for the measurement of lansoprazole in human plasma, and the application of pharmacokinetic study has been evaluated. Omeprazole was used as an internal standard. After adding methyl tert-butyl ether, samples were stored at －7$0^{\circ}C$. The extracts were easily obtained only with pouring the organic phase. The mobile phase was prepared using acetonitrile and water at the volume ratio of 38:62. (omitted)