• Nutrition Research and Practice
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• v.8 no.5
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• pp.533-538
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• 2014

BACKGROUND/OBJECTIVES: We investigated the effect of Pycnogenol (Pyc) on survival and immune dysfunction of C57BL/6 mice induced by low micronutrient supplementation. MATERIALS/METHODS: Female C57/BL/6 mice were fed a diet containing 7.5% of the recommended amount of micronutrients for a period of 12 wks (immunological assay) and 18 wks (survival test). For immunological assay, lymphocyte proliferation, cytokine regulation, and hepatic oxidative status were determined. RESLUTS: Pyc supplementation with 50 and $100mg{\cdot}kg^{-1}{\cdot}bw{\cdot}d^{-1}$ resulted in partial extension of the median survival time. Pyc supplementation led to increased T and B cell response against mitogens and recovery of an abnormal shift of cytokine pattern designated by the decreased secretion of Th1 cytokine and increased secretion of Th2 cytokine. Hepatic vitamin E level was significantly decreased by micronutrient deficiency, in accordance with increased hepatic lipid peroxidation level. However, Pyc supplementation resulted in a dose-dependent reduction of hepatic lipid peroxidation, which may result from restoration of hepatic vitamin E level. CONCLUSION: Findings of this study suggest that Pyc supplementation ameliorates premature death by restoring immune dysfunction, such as increasing lymphocyte proliferation and regulation of cytokine release from helper T cells, which may result from the antioxidative ability of Pyc.

• Journal of Nutrition and Health
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• v.30 no.9
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• pp.1095-1101
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• 1997

The present paper resents information on the dietary intake and biochemical status of elderly who are living in different types of residence. On hundred and sixty five women(age 65-80 years old) were divided into three groups ; those who are living alone (LA) , living with family (LF) , and living in institutions (LI) within the same general community. Nutrient intake, body fat content, and biochemical measurements in blood and urine were examined statistically and potential environment-related influence are discussed. Elderly women living alone had significantly lower intake of nutrients than elderly women were not living alone LF group showed significantly higher fat consumption than LA and LI groups. Body fat content, plasma albumin and calcium levels in elderly women who lived with other people were significantly higher than those in elderly women living alone, but fat weights and lean body mass between groups were not different. None of the plasma lipid fractions were significantly different among the three groups except LDL-cholesterol (LDL-C) concentration. In the LI group, LDL-C was lower than that of LF and LA groups. From the above results, serious nutritional deficiency has been shown in elderly women that live alone. Therefore, nutritional education and social help should be carried out to improve these situations for elderly people.

• Journal of Nutrition and Health
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• v.32 no.7
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• pp.781-786
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• 1999

This study was designed to investigate the effects of vitamin E supplementation on radical scavenger activity and immune responses in female judo athletes(n=18). The age and sex matched sedentary students were used as controls(n=15). The initial plasma vitamin E concentration, lipid peroxide level and radical scavenger activity (RSA) were not different between two groups. The supplementation of $\alpha$-tocopheryl acetate(400IU/d) for 4 weeks significantly increased plasma vitamin E concentration of the subjects in both groups. In addition, the decrease in thiobarbituric acid reactive substance(TBARS)(p<0.05) and enhancement of RSA(p<0.05) were observed in both groups. Percentages of total T-cells in the athletic group was lower than that in the control group(p<0.05). However, the ratio of CD4 / CD8(helper T-cal $l^pressor T-cell) was higher in the sports group, due to more decrease in CD8 subset than in CD4 subset. The concentrations of IgG and IgM in the sports group were significantly lower than those in the control group(p<0.05). Therefore, severe training of the athletic group seems to be associated with the changes of supplementation. In conclusion, vitamin E supplementation (400IU/d, 4 weeks) of the female university students improved antioxidative activities of the blood, by decreasing lipid peroxide and enhancing radical scavenger activity. Percentages of T lymphocytes and IgG and IgM concentrations in the athletic group were lower than those in the control group. Meanwhile, vitamin E supplementation had no effects on immune status in both groups.ps.

• Asian Pacific Journal of Cancer Prevention
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• v.13 no.10
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• pp.5273-5279
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• 2012

The aim of the present study was to investigate the chemopreventive effect of coumarin against 7, 12-dimethylbenz[a]anthracene (DMBA)-induced hamster buccal pouch carcinogenesis by monitoring tumor incidence and histopathological changes as well as by analyzing the status of biochemical markers (lipid peroxidation, enzymatic and non-enzymatic antioxidants, phase I and phase II detoxification enzymes). Oral squamous cell carcinomas were induced in the buccal pouch of Syrian golden hamsters by painting with 0.5% DMBA in liquid paraffin three times a week for 14 weeks. We noted 100% tumor formation with marked abnormalities in the biomarkers status in hamsters treated with DMBA alone. Oral administration of coumarin at a dose of 100 mg/kg body weight (bw) to DMBA treated hamsters completely prevented the tumor formation as well as restored the staus of biochemical variables. The results of the present study thus suggest that the chemopreventive effect of coumarin is probably due to its anti-lipid peroxidative potential and modulating effect on carcinogen detoxification agents in favor of the excretion of ultimate carcinogenic metabolites of DMBA during DMBA-induced hamster buccal pouch carcinogenesis.

• Journal of Nutrition and Health
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• v.33 no.8
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• pp.901-908
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• 2000

The study was carried out to assess whether the nutritional management program by dietician at child center can affect nutritional status of children at child care center. The diet intakes were measured by mother\`s record at home and by direct weighing at child care centers, and the hight and weight of children were measured before and after nutritional management program for 3months to see the effects. The energy intakes were significantly increased 56.29 Kcal after program, and protein 3.61g, lipid 3.12 g, calcium 49.71mg, iron 0.39 mg, vitamin B$_1$ 0.084 mg, vitamin B$_2$ 0.116 mg, and vitamin C 10.10 mg, respectively, except vitamin A and niacin. the significant changes of nutrient intakes were more at higher age group compared to at the lower age group, and more at girls compared to boys, Although the significant increase fo nutrient intakes at child care center, most nutrient intakes at home were not significantly changed, except energy, lipid, iron, vitamin A. The changes at changes of fat and calcium intakes for 3 months were positively correlated to the change of Z-score for weight, and the change of A-score for weight was positively correlated to changes of Z-score for height. The results showed that the nutritional management program for 3 month at child care center can increase nutrient intakes significantly and the incresed nutrient intakes can enhance children\`s growth. (Korean J Nutrition 33(8) : 901-908, 2000)

• KOREAN JOURNAL OF CROP SCIENCE
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• v.47
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• pp.140-149
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• 2002

Sesame (Sesamum indicum L.) is probably the most ancient oilseed crop known in the world. Sesame seed is known for its high nutritional value and for having oil (51%) and protein (20%) content. The fatty acid composition of sesame oil is palmitic acid (7.8%), stearic acid (3.6%), oleic acid (45.3%), and linoleic acid (37.7%). Sesame oil is characterized by a very high oxidative stability compared with other vegetable oils. Two lignan-type compounds, sesamin and sesamolin, are the major constituents of sesame oil unsaponifiables. Sesamol (a sesamolin derivative) can be present in sesame seeds and oils in very small amount. Other lignans and sesamol are also present in sesame seeds and oils in very small amount as aglycones. Lipid oxidation activity was significantly lower in the sesamolin-fed rats, which suggests that sesamolin and its metabolites contribute to the antioxidative properties of sesame seeds and oil and support that sesame lignans reduce susceptibility to oxidative stress. Sesaminols strongly inhibit lipid peroxidation related to their ability to scavenge free radical. The sesame seed lignan act synergistically with vitamin I in rats fed a low $\alpha$-tocopherol diet and cause a marked increase in a u-tocopherol concentration in the blood and tissue of rats fed an $\alpha$-tocopherol containing diet with sesame seed or its lignan. The authors are reviewed and discussed for present status and prospects of quality evaluation and researched in sesame seeds to provide and refers the condensed informations on their quality.

• Journal of the East Asian Society of Dietary Life
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• v.12 no.3
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• pp.225-234
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• 2002

This study was designed to determine changes of nutritional status, diabetic indices and serum lipid composition in non-insulin dependent diabetes mellitus patients during intake of diabetic-oriented convenience food prepared from 7 medicinal plants and chicken. We conducted dietary, anthropometric and biochemical assessments before and after the intake of diabetic oriented food. Once a day, in the study, their normal lunch was replaced by the diabetic-oriented convenience food diet for 30 consecutive days. It was found that the nutrients of the diet were well-balanced, and the intake levels nearly approached those of the RDA. Obesity rate, body fat, and body weight were significantly lower than those of a normal diet. The average fasting blood glucose significantly decreased while the insulin level significantly increased after the intake of diabetic meal. Also the total serum cholesterol and triglyceride levels significantly decreased. The above results indicate that diabetic-oriented convenience food prepared from 7 medicinal plants and chicken may be used as a diet regime fer controlling the diabetes mellitus on a regular basis.

• Journal of Community Nutrition
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• v.6 no.2
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• pp.67-77
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• 2004

In order to investigate the differences of nutrient intakes by the economic status and different age groups and to identify the nutritional risk group and its specific nutrition problem, 2001 Korean National Health and Nutrition Survey were analyzed. The subject's numbers of 9,391 were classified into four classes such as low (14.2%), medium (37.2%), high (26.0%), and high above (22.6%) on the basis of the family monthly income and the 2001 Korean minimum cost of living according to the family size. Mean intakes of energy and all nutrients assessed by the RDAs, lipid-energy %, and MAR were increased as the economic status were going up. Na intake expressed per 1,000kcal was in reverse. Nearly a half(45.5%) of the low-income people seemed to take nutritionally inadequate diet in consideration with MAR values. Deficiencies of iron and even energy in the toddlers (1 to 2 years) of low-income class were of great concern. Adolescent age group has been observed that their calcium and iron intakes, and possibly energy, were appeared to be the most deficient among all the age groups regardless of the economic status. For the elderly in all the economic status except high-above class, calcium, vitamin A, and riboflavin were commonly deficient nutrients. Calcium deficiency was appeared throughout nearly all the ages except toddlers and all the economic classes. Even in the high-above class 57.3% took insufficient amount of calcium.

• Journal of Nutrition and Health
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• v.33 no.4
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• pp.454-463
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• 2000

The purpose of this study was to assess the biochemical nutritional status of the long-lived elderly. The subjects of the study were 148 elderly people of age over 85 years living in Kyungpook Sung-Ju area who have no problem in daily living. The anthropometric measurement and biochemical assessment of the blood sample were carried out. The subject group for this study was composed of 25.9% males and 74.1% females, the average age being 87 years old. The mean Body Mass Index(BMI) of the male and female subjects were 20.7 and 21.2 respectively. The average body fat amounts of the male and female were 21.4% and 29.8% respectively, and the average waist/hip ratios were 0.9 and 0.7 respectively. The mean levels of the total blood protein and albumin of the subjects were in the normal ranges. The mean levels of serum cholesterol and triglyceride were 167.9mg /dL and 123.9mg/dL respectively. The mean levels of the subjects below normal range of hemoglobin were 63.5%. Serum levels of antioxidant nutrients were very poor. The mean levels of serum lipid peroxidation products were 3.3nmol/mL. BMI and WHR were positively correlated with the serum cholesterol levels. The resuts showed that the long-lived elderly had good nutritional status except for antioxidant nutrients status. In addition antioxidant supplement for long-lived elderly may be effective to maintain healthy life in later years.

• Korean Journal of Occupational Health Nursing
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• v.25 no.4
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• pp.311-319
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• 2016

Purpose: This study examined association of job stress with health-promoting behaviors and objective health status in 129 clinical nurses working at a university hospital. Methods: A cross-sectional and descriptive design was used. Job stress and health behaviors were measured with Korean Occupational Stress Scale and Heath Promoting Lifestyle Profile-II, respectively. Health status measured with afternoon plasma cortisol, C-peptide, and lipid profiles. Results: The level of job stress among clinical nurses was moderate with 51.41 on average. The mean for health-promoting behavior in the low stress group was significantly higher than that in the high or moderate stress groups (p<.001). The proportions of nurses with high C-peptide and cortisol levels, or low high-density lipoprotein levels, ranged from 14.0% to 35.7%. In particular, the percentage of nurses with high C-peptide levels was significantly higher in moderate and high stress groups than in the low stress group (24.1% versus 11.6%, p<.05). Conclusion: The study findings affirmed the associations of job stress with health-promoting behaviors as well as selected health status indicators such as C-peptide in clinical nurses. Job stress management intervention can help clinical nurses to improve their health-promoting behaviors and health status.