• Journal of Korean Tunnelling and Underground Space Association
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• v.22 no.4
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• pp.401-417
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• 2020

As an increasing demand for rapid railway transportation, the construction of sidetrack is inevitable to operate local and express trains simultaneously. However, the current technologies for the sidetrack construction method require a long construction period by interrupting the operation of the existing subway line, as well as cause a huge economic loss. Thus, it is necessary to study the sidetrack construction method under the special situation that the subway is in operation and to analyze the risk of the existing tunnel enlargement process for the sidetrack construction. Therefore, in this paper, the Government Complex Gwacheon station on Subway Line 4 was considered as a target station for the virtual sidetrack construction and the optimal sidetrack construction plan was derived. Subsequently, the application of risk management process was carried out in the order of identifying risk, risk response planning, performing a risk analysis, risk monitoring and control for potential risk events during the construction of sidetrack under the subway operation. A total of eight potential risk events and risk mitigation methods were selected, and a risk assessment matrix was established using the five-step risk probability and impact level criteria to perform the risk assessment including residual risks. Based on the results of the risk assessment, the risk grade and the reduction effect of each risk mitigation method were confirmed.

• IMMUNE NETWORK
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• v.2 no.1
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• pp.60-64
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• 2002

Background: Chemotherapy with 5-fluorouracil (5-FU) has been one of the mainstay in breast cancer treatment. The effects of high dose 5-FU on cell cycle regulation were studied in breast caner cells. Methods: A breast cancer cell line MCF-7 was used. Protein expressions of G1/S cyclins, $p21^{Waf1/Cip1}$, cdk2, E2F1 and retinoblastoma were tested by western blot analysis. Immunoprecipitation and immune complex kinase assay were done for the assessment of E2F1/RB interacton and the activity of cdk2 respectively. Results: $p21^{Waf1/Cip1}$ expression was barely detectable in control cells. With addition of 5-FU level of $p21^{Waf1/Cip1}$ were induced and cyclin D3 level was decreased as cell growth decreases. In accordance with increased expression of $p21^{Waf1/Cip1}$, cyclin E-associated cdk2 kinase activity was reduced. Retinoblastoma protein (RB) became dephosphorylated and E2F-1 binding activity with RB was increased. Conclusion: In this situation of high concentration of 5-FU breast cancer cells tend to be G1/S cell cycle arrested. Overexpression of $p21^{Waf1/Cip1}$ and dephosphorylation of RB may mediate the effectss of 5-FU by inhibiting E2F-1 activity, which contributes to G1/S cell cycle arrest. These results could be an indicating landmark for further study of high dose chemotherapy with 5-FU.

• Spatial Information Research
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• v.23 no.2
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• pp.1-9
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• 2015

Graphical processing unit (GPU) contains many arithmetic logic units (ALUs). Because many ALUs can be exploited to process parallel processing, GPU provides efficient data processing. The spatial data require many geographic coordinates to represent the shape of them in a map. The coordinates are usually stored as geodetic longitude and latitude. To display a map in 2-dimensional Cartesian coordinate system, the geodetic longitude and latitude should be converted to the Universal Transverse Mercator (UTM) coordinate system. The conversion to the other coordinate system and the rendering process to represent the converted coordinates to screen use complex floating-point computations. In this paper, we propose a parallel processing technique that processes the conversion and the rendering using the GPU to improve the performance. Large spatial data is stored in the disk on files. To process the large amount of spatial data efficiently, we propose a technique that merges the spatial data files to a large file and access the file with the method of memory mapped file. We implement the proposed technique and perform the experiment with the 747,302,971 points of the TIGER/Line spatial data. The result of the experiment is that the conversion time for the coordinate systems with the GPU is 30.16 times faster than the CPU only method and the rendering time is 80.40 times faster than the CPU.

• Tuberculosis and Respiratory Diseases
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• v.83 no.4
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• pp.289-294
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• 2020

Background: Line probe assay (LPA) is standard diagnostic tool to detect multidrug resistant tuberculosis. Non-interpretable (NI) results in LPA (complete missing or light wild-type 3 and 8 bands with no mutation band in rpoB gene region) poses a diagnostic challenge. Methods: Sputum samples obtained between October 2016 and July 2017 at the Intermediate Reference Laboratory, All India Institute of Medical Sciences Hospital, New Delhi, India were screened. Smear-positive and smear-negative culture-positive specimens were subjected to LPA Genotype MTBDRplus Ver 2.0. Smear-negative with culture-negative and culture contamination were excluded. LPA NI samples were subjected to phenotypic drug susceptibility testing (pDST) using MGIT-960 and sequencing. Results: A total of 1,614 sputum specimens were screened and 1,340 were included for the study (smear-positive [n=1,188] and smear-negative culture-positive [n=152]). LPA demonstrated 1,306 (97.5%) valid results with TUB (Mycobacterium tuberculosis) band, 24 (1.8%) NI, three (0.2%) valid results without TUB band, and seven (0.5%) invalid results. Among the NI results, 22 isolates (91.7%) were found to be rifampicin (RIF) resistant and two (8.3%) were RIF sensitive in the pDST. Sequencing revealed that rpoB mutations were noted in all 22 cases with RIF resistance, whereas the remaining two cases had wild-type strains. Of the 22 cases with rpoB mutations, the most frequent mutation was S531W (n=10, 45.5%), followed by S531F (n=6, 27.2%), L530P (n=2, 9.1%), A532V (n=2, 9.1%), and L533P (n=2, 9.1%). Conclusion: The present study showed that the results of the Genotype MTBDRplus assay were NI in a small proportion of isolates. pDST and rpoB sequencing were useful in elucidating the cause and clinical meaning of the NI results.

• Journal of the Korea Institute of Information and Communication Engineering
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• v.8 no.4
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• pp.894-900
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• 2004

There are many types of circularly polarized(CP) microstrip antenna elements, which are used as a good unit radiator. Since an advantage of CP antenna is no strict alignment requirements between Rx and Tx system, the printed antennas with circular polarization are very often used in numerous satellite and mobile radio systems. In order to realize the broad bandwidth of 3 dB axial ratio and impedance of CP microstrip antenna, complex feed structure and tri-plate patch element have been researched. This paper describes a design of wideband microstrip cross slot array antennas with circular polarization. The proposed antenna is composed of an open-ended microstrip feed line as a feeder and a cross slot as a radiator for circular polarization. To realize the wide bandwidth, tri-plate structure are considered and cross slot is electromagnetically coupled with feed line. Optimum parameters of 1-element cross slot antenna are analyzed and designed by method of moments. These parameters are also applied to may antennas design considered the mutual coupling between radiating elements. Right hand circular polarization(RHCP) and left hand circular polarization(LHCP) of the proposed antenna are easily controlled by asymmetrical cross slot structure and slot position. In 1-element and 15-element cross slot array antenna, the good axial ratio of 1 dB below and the broad bandwidth characteristics of antenna are obtained.

• Journal of Korean Society of Environmental Engineers
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• v.38 no.6
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• pp.299-308
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• 2016

Seoul metropolitan has established a vision as 'Healthy water-cycle city' to resolve urban water-environmental deterioration. And it established administrative structure to expand Low Impact Development (LID) facilities to recover aggravated water-cycle and water-environment. Therefore, various LID facilities are constructed and operated, however, benefit analytic plans for systematic valuation are insufficient. In this study, to analyze economic, environmental and social benefits of LID facilities, contents for benefit analysis were selected and categorized as water, energy, air quality and climate changes. As a result of quantification and valuation to the beneficial effects, LID facilities showed the total benefit as 1,191~3,292 won/yr. Characteristics of benefit distribution by analysis contents were various reflecting functional characteristics of each LID facility (Water: 30~90%, Energy: 4~44%, Air quality: <1~2%, Climate change: 5~22%). As a result of Triple Bottom Line analysis, economic benefit showed the greatest portion as 75~90%. As further studies, suggested benefit assessment plans for each LID facility should be applied to inter-connected LID systems on complex-scaled area, and synergy effects by various LID systems would be evaluated such as prevention of heat island and flood disasters.

• The Journal of the Korea Contents Association
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• v.19 no.9
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• pp.666-673
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• 2019

In the immersive virtual reality environment, we can select and manipulate various virtual objects. in order to select a virtual object, we generally use Ray-casting method that fires a virtual line in user's view and selects an object when the line and the object match, or Cone-casting method that is widely used to select multiple objects at the same time. However, since the virtual objects used in CAD are composed of small and complex objects in detail, when selecting an object in the user's view by existing methods, there occurs a ambiguity problem that needs additional realignment operation even though an object is selected as a group. in this paper, even if a virtual object is composed of several small virtual objects, it calculates the spatial and logical relationship among objects and expands or shrinks desired objects, so that the user can quickly and accurately select a desired object. in order to evaluate the proposed method, performance comparison were performed using Our and Ray-Casting and Cone-Casting methods. Experimental results show that the proposed method has the fastest speed and the highest accuracy when selecting the desired objects.

• Journal of The Geomorphological Association of Korea
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• v.18 no.4
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• pp.1-15
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• 2011

This work is to review the granite landforms studies by Korean geographers. It is verified that geomorphlogical characteristics of granite present landscapes characterized by 1) in case of mountains, are difficultly or irregularly weathered, so as to develop rocky forms such as domes, cliffs, and tors ; 2) in case of stream valley that is inter-massif lowland, low relief hills and flood plains with alluvium. All these facts owe to the difference of weathering mode granite properties. The granite hills and alluvial plains of southwestern coastal parts in Korean peninsula is low undulatory and large owing not only to the existence of highly weathered granitic regolith, but also to frequent flooding. Cultivated brownish field, orchard, meadow and forest are located at granite hills. On the other hand paddy rice field at granite alluvial plains. Korean peninsula have endured erodible geomorphlogical processes since Miocene when warping it up. Therefore many intermontane basins are located on the weathered granite areas which are surrounded by mountains composed of much less Precambrian gneiss complex. In fact, intermontane basin is mainly linear fault-line valley. The landforms of the intermontane basins are characterized by gentle piedmont slopes, alluvial fans, fluvial terraces and alluvial plains.

• Journal of Food Hygiene and Safety
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• v.38 no.6
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• pp.464-475
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• 2023

In this study, based on an analysis of two DNA barcode markers (cytochrome c oxidase subunit I and cytochrome b genes), we performed species identification and monitored labeling compliance for 50 commercial pufferfish products sold in on-line markets in Korea. Using these barcode sequences as a query for species identification and phylogenetic analysis, we screened the GenBank database. A total of seven pufferfish species (Takifugu chinensis, T. pseudommus, T. xanthopterus, T. alboplumbeus, T. porphyreus, T. vermicularis, and Lagocephalus cheesemanii) were identified and we detected 35 products (70%) that were non-compliant with the corresponding label information. Moreover, the labels on 12 commercial products contained only the general common name (i.e., pufferfish), although not the scientific or Korean names for the 21 edible pufferfish species. Furthermore, the proportion of mislabeled highly processed products (n = 9, 81.8%) was higher than that of simply processed products (n = 26, 66.7%). With respect to the country of origin, the percentage of mislabeled Chinese products (n = 8, 80%) was higher than that of Korean products (n = 26, 66.7%). In addition, the market and dialect names of different pufferfish species were labeled only as Jolbok or Milbok, whereas two non-edible pufferfish species (T. vermicularis and T. pseudommus) were used in six commercial pufferfish products described as JolboK and Gumbok on their labels, which could be attributable to the complex classification system used for pufferfish. These monitoring results highlight the necessity to develop genetic methods that can be used to identify the 21 edible pufferfish species, as well as the need for regulatory monitoring of commercial pufferfish products.

• Journal of the Korean earth science society
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• v.30 no.6
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• pp.744-758
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• 2009

The characteristics of brightness temperature (BT) of infrared and water vapor channels from MTSAT-1R have been investigated using 12 persistent and frequent lightning cases selected from the summer lightnings of 2006-2008. The infrared (IR1, 10.3-11.3 ${\mu}M$) and water vapor (WV, 6.5-7.0 ${\mu}M$) channels from the MTSAT-1R and the lightning observation data from Korea Meteorological Administration are used. When there is no lightning, the BTs of the IR1 and WV channels show the largest frequency at around 290-295K and 245K, respectively. On the other hand, the BTs of two channels show the largest frequency at 215K caused by strong convection when there is lightning. As a result, the WV-IR1 difference (BTDWI) sharply increases from -50K to 0K. Although it depends on the evolution stage of thunderstorms, the lightning mainly occurs at the core of circular convection in the mesoscale convective complex (MCC), whereas the lightning occurs by concentrated line-shape in the squall line. A strong positive correlation exists between the lightning frequency and the BT in the MCC regardless of the BT, but only at the very cold BT in the squall line. In general, the characteristics of BT are well defined for the lightning occurring in the concentrated line, but they are not well defined in the MCC, especially during the decaying stage of MCC. When they are defined well, the lightning occurs when the BTs of IR1 and WV are lower than 215K, BTDWI is near -3 to 1K, and local standard deviation of IR1 decreases to around 1K.