• Maxillofacial Plastic and Reconstructive Surgery
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• v.40
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• pp.44.1-44.17
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• 2018

Background: Coffee extract has been investigated by many authors, and many minor components of coffee are known, such as polyphenols, diterpenes (kahweol and cafestol), melanoidins, and trigonelline, to have anti-inflammatory, anti-oxidant, anti-angiogenic, anticancer, chemoprotective, and hepatoprotective effects. Therefore, it is necessary to know its pharmacological effect on hepatocytes which show the most active cellular regeneration in body. Methods: In order to determine whether coffee extract has a beneficial effect on the liver, 20 C57BL/6J mice were intraperitoneally injected once with dialyzed coffee extract (DCE)-2.5 (equivalent to 2.5 cups of coffee a day in man), DCE-5, or DCE-10, or normal saline (control), and then followed by histological observation and IP-HPLC (immunoprecipitation high performance liquid chromatography) over 24 h. Results: Mice treated with DCE-2.5 or DCE-5 showed markedly hypertrophic hepatocytes with eosinophilic cytoplasms, while those treated with DCE-10 showed slightly hypertrophic hepatocytes, which were well aligned in hepatic cords with increased sinusoidal spaces. DCE induced the upregulations of cellular proliferation, growth factor/RAS signaling, cellular protection, p53-mediated apoptosis, angiogenesis, and antioxidant and protection-related proteins, and the downregulations of NFkB signaling proteins, inflammatory proteins, and oncogenic proteins in mouse livers. These protein expression changes induced by DCE were usually limited to the range ± 10%, suggesting murine hepatocytes were safely reactive to DCE within the threshold of physiological homeostasis. DCE-2.5 and DCE-5 induced relatively mild dose-dependent changes in protein expressions for cellular regeneration and de novo angiogenesis as compared with non-treated controls, whereas DCE-10 induced fluctuations in protein expressions. Conclusion: These observations suggested that DCE-2.5 and DCE-5 were safer and more beneficial to murine hepatocytes than DCE-10. It was also found that murine hepatocytes treated with DCE showed mild p53-mediated apoptosis, followed by cellular proliferation and growth devoid of fibrosis signaling (as determined by IP-HPLC), and subsequently progressed to rapid cellular regeneration and wound healing in the absence of any inflammatory reaction based on histologic observations.

• Journal of Periodontal and Implant Science
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• v.37 no.2
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• pp.277-286
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• 2007

The edentulous posterior maxilla generally provides a limited amount of bone height because of atrophy of the ridge and pneumatization of the maxillary sinus, Maxillary sinus augmentation is one of the surgical techniques for reconstruction of the severely resorbed posterior maxilla. The purpose of this study was to evaluate the survival rate of implants and the long-term changes of graft height after maxillary sinus augmentation by lateral window approach. From September 1996 to July 2004, maxillary sinus augmentation with mixed grafts of autograft, allograft, xenograft and alloplast were performed on 45 patients and 100 implants were placed. We evaluated the survival rate of implants and the changes of BL(bone length)/IL(implant length) according to time using panoramic radiographs. The survival rate of implants was 91.0% for follow-up period. The mean reduction of graft heights was 0.34mm(3.0%) for 6 months and 1.22mm(1O.66%) for 3 years after augmentation. The total mean BL/IL was $1.34{\pm}0.21$ during 5 year observation period after augmentation and decreased slightly over time. The result means that graft materials were stable above the implant apex. BL/ILs of 1stage procedure were significantly decreased at 1-2 year, 3-4 year after augmentation and no statistically significant changes were observed in those of 2 stage procedure. The graft materials of both procedures were stable above the implant apex. No statistically significant changes of BL/IL were observed in the grafts combined with low amount of autogenous bone or without autogenous bone. The graft materials of both groups were stable above the implant apex. The results indicated that the placement of dental implants with maxillary sinus augmentation showed predictable clinical results and the grafts combined with low amount of autogenous bone or without autogenous bone had long-term resistance to resorption in maxillary sinus.

• Conservation Science in Museum
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• v.4
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• pp.71-78
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• 2003

The wooden striker on the Divine Bell of King Seongdeok was examined to identify the species of the wood and the outdoor wood weathering caused by solar light, moisture, temperature and air. The species of the wooden striker was identified to Zelkova serrata. When observed the striker with naked eyes, the results were surface discoloration (graying), cracking and roughness. In order to examine the morphological changes according to deterioration type, the specimen were separated to three part(I, II,III-spot). The I-spot was discolored to gray and at the same time entirely covered with dust. So the observation was impossible. The II-spot was also discolored but its texture could be observed. On it could observe numerous fungal hypae and dirts like dust flown into the cell lumens. The cell wall has been so weakened by weathering that it lost the physical intensity. This have made microchecks and splits on the cell wall. Although fungal hypae covered the cell, they did not result in wood decay. The III-spot, located just 0.5 mm below the surface, was maintaining the natural red-brown color of the wood. Its cell wall was similar to that of sound wood. These changes are different from wood decay, and limited only to the surface of the striker-less than or equal to 0.5 mm below.

• The KIPS Transactions:PartD
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• v.11D no.6
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• pp.1259-1268
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• 2004

To organize training in limited training area for an actuai combat, realistic training simulation plugged in by various battle conditions is essential. In this paper, we propose a virtual target overlay technique which does not use a virtual image, but Projects a virtual target on ground-based CCD image by appointed scenario for a realistic training simulation. In the proposed method, we create a realistic 3D model (for an instructor) by using high resolution Geographic Tag Image File Format(GeoTIFF) satellite image and Digital Terrain Elevation Data (DTED), and extract the road area from a given CCD image (for both an instructor and a trainee). Satellite images and ground-based sensor images have many differences in observation position, resolution, and scale, thus yielding many difficulties in feature-based matching. Hence, we propose a moving synchronization technique that projects the target on the sensor image according to the marked moving path on 3D satellite image by applying Thin-Plate Spline(TPS) interpolation function, which is an image warping function, on the two given sets of corresponding control point pair. To show the experimental result of the proposed method, we employed two Pentium4 1.8MHz personal computer systems equipped with 512MBs of RAM, and the satellite and sensor images of Daejoen area are also been utilized. The experimental result revealed the effective-ness of proposed algorithm.

• KSBB Journal
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• v.10 no.3
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• pp.241-248
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• 1995

For the treatment of poorly biodegradable polyvinyl alcohol(PVA) in dye-processing wastewater, immobilized microbial beads were prepared by uslng agar-acrylamide method. PVA removal efficiency for the synthetic wastewater was 85% at the PVA volume loading rate of $3.1g/\ell$.day. In case of real desizing wastewater, PVA removal efficiency was 81.3% at the PVA volume loading rate of $3.25g/\ell$.day. In observation of cross section of immobilized bead passed 5 months with diameter of 2.4mm, the growth of cell was limited by the resistance of substrate and oxygen transfer for the inners region of more than 48% of bead radius from the surface. It was estimated that 70% of total removed PVA was degraded by the immobilized cells in the continuous immobilized reactor. Substrate utilization rate in the suspended reactor was decreased with increasing dilution rates above 0.083 hr-1, but that in the immobilized reactor was increased with increasing dilution rates up to 0.125hr-1. The substrate removal efficiency of immobilized reactor was much superior to that of suspended reactor with increasing dilution rates. Saturation constant of substrate utilization rate equation, Ks was $6.6 g PVA/\ell$, and maximum specific substrate utilization. k was 0.175g PVA/g cell.hr

• Journal of the Korea institute for structural maintenance and inspection
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• v.22 no.2
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• pp.105-114
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• 2018

Modular system can be divided into two types based on the methods of resisting load. The one is the open-sided modular system composed of beams and columns. The other is the enclosed modular system composed of panels and studs. Of the Modular systems, the use of open-sided modular system is limited because it consists of closed member sections. In order to solve this problem, Choi et al.(2017) proposed a composite modular system with folded steel members filled with concrete. However, it was assumed in the previous study that the connections between modules are composed of rigid joint. Therefore it didn't identify the effect of connection behavior in structure. This study used finite element analysis to calculate stiffness of the connections in the proposed modular system. The linearization method presented in FEMA 440 is used for seismic performance assessment of structures, considering the connection stiffness computed in this study. The result of analysis shows that the capacity and story drift ratio obtained in the model considering stiffness of connection are less than those in the model not considering connection stiffness. Based on this observation, it is concluded that the stiffness of connection has a considerable effect on structural behavior.

• Informatization Policy
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• v.24 no.3
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• pp.67-90
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• 2017

This study is conducted to find out problems in the implementation system of regional informatization policies in Korea and solutions to enhance the effectiveness in policy execution. The study uses research methodologies such as participant observation, interview and AHP for experts and employees of public organizations for regional informatization policies. Many implications were found in the analysis, including that policy relations, structure of the policy implementation system, and environment and contents of regional informatization policiesin Korea have to be innovated and re-organized. Especially, this paper emphasizes the horizontal and cooperative relationship between the central and local governments and redesigning of the legal system on the regional informatization. This paper also shows expectations on reshaping of the regional informatization policies with the paradigm shift of the government power toward decentralization. This paper also finds diverse views on the problems and solutions for the regional informatization policy implementation system based on different characteristics and interests of policy participants. This paper finds the possibility of applying the policy network model to regional informatization policy implementation, which can be supported by Rhodes & Marsh(1992)'s theory. Therefore, this paper shows the change of regional informatization policies can be expected through application of the policy network. Although the paper draws many academic and policy implications, they are limited to the implementation system of regional informatization policies only.

• Korean Journal of Remote Sensing
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• v.21 no.3
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• pp.189-211
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• 2005

This paper makes an effort to compare the recently evolved soft classification method based on Linear Spectral Mixture Modeling (LSMM) with the traditional hard classification methods based on Iterative Self-Organizing Data Analysis (ISODATA) and Maximum Likelihood Classification (MLC) algorithms in order to achieve appropriate results for mapping, monitoring and preserving valuable coastal wetland ecosystems of southern India using Indian Remote Sensing Satellite (IRS) 1C/1D LISS-III and Landsat-5 Thematic Mapper image data. ISODATA and MLC methods were attempted on these satellite image data to produce maps of 5, 10, 15 and 20 wetland classes for each of three contrast coastal wetland sites, Pitchavaram, Vedaranniyam and Rameswaram. The accuracy of the derived classes was assessed with the simplest descriptive statistic technique called overall accuracy and a discrete multivariate technique called KAPPA accuracy. ISODATA classification resulted in maps with poor accuracy compared to MLC classification that produced maps with improved accuracy. However, there was a systematic decrease in overall accuracy and KAPPA accuracy, when more number of classes was derived from IRS-1C/1D and Landsat-5 TM imagery by ISODATA and MLC. There were two principal factors for the decreased classification accuracy, namely spectral overlapping/confusion and inadequate spatial resolution of the sensors. Compared to the former, the limited instantaneous field of view (IFOV) of these sensors caused occurrence of number of mixture pixels (mixels) in the image and its effect on the classification process was a major problem to deriving accurate wetland cover types, in spite of the increasing spatial resolution of new generation Earth Observation Sensors (EOS). In order to improve the classification accuracy, a soft classification method based on Linear Spectral Mixture Modeling (LSMM) was described to calculate the spectral mixture and classify IRS-1C/1D LISS-III and Landsat-5 TM Imagery. This method considered number of reflectance end-members that form the scene spectra, followed by the determination of their nature and finally the decomposition of the spectra into their endmembers. To evaluate the LSMM areal estimates, resulted fractional end-members were compared with normalized difference vegetation index (NDVI), ground truth data, as well as those estimates derived from the traditional hard classifier (MLC). The findings revealed that NDVI values and vegetation fractions were positively correlated ($r^2$= 0.96, 0.95 and 0.92 for Rameswaram, Vedaranniyam and Pitchavaram respectively) and NDVI and soil fraction values were negatively correlated ($r^2$ =0.53, 0.39 and 0.13), indicating the reliability of the sub-pixel classification. Comparing with ground truth data, the precision of LSMM for deriving moisture fraction was 92% and 96% for soil fraction. The LSMM in general would seem well suited to locating small wetland habitats which occurred as sub-pixel inclusions, and to representing continuous gradations between different habitat types.

• Journal of The Korean Association For Science Education
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• v.41 no.4
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• pp.311-324
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• 2021

In this study, we analyzed the process of pre-service science teachers' designing and implementation of lessons in teaching practice from the perspective of CHAT. Five pre-service teachers attending the Department of Chemistry Education at the College of Education in Seoul participated in this study. We observed their teaching practice, collected documentary data, and conducted in-depth interviews. The data were analyzed using the constant comparative method based on grounded theory. The analyses of the results reveal that, due to the lack of authority to make decisions for lesson design, pre-service teachers faced difficulties and had direct conflict with teachers. In addition, it was difficult for them to obtain sufficient contextual information for lesson design even through subject orientation and classroom observation, which made it difficult for them to design lessons. When consecutive lessons were taken by several pre-service teachers, there were many problems such as poor continuity of lessons. Given limited authority to assess students, they conducted additional assessments. They showed a lack of professionalism when conducting assessments. The cause of this could be found in the curriculum of the College of Education. Some ways to provide better teaching practice based on the results are discussed.

• Journal of the Korea institute for structural maintenance and inspection
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• v.23 no.1
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• pp.9-18
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• 2019

Modular system can be divided into two types based on the methods of resisting load. The one is the open-sided modular system composed of beams and columns. The other is the enclosed modular system composed of panels and studs. Of the Modular systems, the use of open-sided modular system is limited because it consists of closed member sections. In order to solve this problem, Choi et al.(2017) proposed a composite modular system with folded steel members filled with concrete. However, it was assumed in the previous study that the connections between modules are composed of rigid joint. Therefore it didn't identify the effect of connection behavior in structure. This study used finite element analysis to calculate stiffness of the connections in the proposed modular system. The linearization method presented in FEMA 440 is used for seismic performance assessment of structures, considering the connection stiffness computed in this study. The result of analysis shows that the capacity and story drift ratio obtained in the model considering stiffness of connection are less than those in the model not considering connection stiffness. Based on this observation, it is concluded that the stiffness of connection has a considerable effect on structural behavior.