• Title/Summary/Keyword: life history research

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Emerging signals modulating potential of ginseng and its active compounds focusing on neurodegenerative diseases

  • Jakaria, Md.;Kim, Joonsoo;Karthivashan, Govindarajan;Park, Shin-Young;Ganesan, Palanivel;Choi, Dong-Kug
    • Journal of Ginseng Research
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    • v.43 no.2
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    • pp.163-171
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    • 2019
  • Common features of neurodegenerative diseases (NDDs) include progressive dysfunctions and neuronal injuries leading to deterioration in normal brain functions. At present, ginseng is one of the most frequently used natural products. Its use has a long history as a cure for various diseases because its extracts and active compounds exhibit several pharmacological properties against several disorders. However, the pathophysiology of NDDs is not fully clear, but researchers have found that various ion channels and specific signaling pathways might have contributed to the disease pathogenesis. Apart from the different pharmacological potentials, ginseng and its active compounds modulate various ion channels and specific molecular signaling pathways related to the nervous system. Here, we discuss the signal modulating potential of ginseng and its active compounds mainly focusing on those relevant to NDDs.

Perspectives on Functional Genomics

  • Song, Kyuyoung
    • Biotechnology and Bioprocess Engineering:BBE
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    • v.5 no.5
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    • pp.307-312
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    • 2000
  • As the first assembly of the human genome was announced on June 26, 2000, we have entered post genome era. The genome sequence represents a new starting point for science and medicine with possible impact on research across the life sciences. In this review I tried to offer brief summaries of history and progress of the Human Genome Project and two major challenges ahead, functional genomics and DNA sequence variation research.

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Development of User Based Recommender System using Social Network for u-Healthcare (사회 네트워크를 이용한 사용자 기반 유헬스케어 서비스 추천 시스템 개발)

  • Kim, Hyea-Kyeong;Choi, Il-Young;Ha, Ki-Mok;Kim, Jae-Kyeong
    • Journal of Intelligence and Information Systems
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    • v.16 no.3
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    • pp.181-199
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    • 2010
  • As rapid progress of population aging and strong interest in health, the demand for new healthcare service is increasing. Until now healthcare service has provided post treatment by face-to-face manner. But according to related researches, proactive treatment is resulted to be more effective for preventing diseases. Particularly, the existing healthcare services have limitations in preventing and managing metabolic syndrome such a lifestyle disease, because the cause of metabolic syndrome is related to life habit. As the advent of ubiquitous technology, patients with the metabolic syndrome can improve life habit such as poor eating habits and physical inactivity without the constraints of time and space through u-healthcare service. Therefore, lots of researches for u-healthcare service focus on providing the personalized healthcare service for preventing and managing metabolic syndrome. For example, Kim et al.(2010) have proposed a healthcare model for providing the customized calories and rates of nutrition factors by analyzing the user's preference in foods. Lee et al.(2010) have suggested the customized diet recommendation service considering the basic information, vital signs, family history of diseases and food preferences to prevent and manage coronary heart disease. And, Kim and Han(2004) have demonstrated that the web-based nutrition counseling has effects on food intake and lipids of patients with hyperlipidemia. However, the existing researches for u-healthcare service focus on providing the predefined one-way u-healthcare service. Thus, users have a tendency to easily lose interest in improving life habit. To solve such a problem of u-healthcare service, this research suggests a u-healthcare recommender system which is based on collaborative filtering principle and social network. This research follows the principle of collaborative filtering, but preserves local networks (consisting of small group of similar neighbors) for target users to recommend context aware healthcare services. Our research is consisted of the following five steps. In the first step, user profile is created using the usage history data for improvement in life habit. And then, a set of users known as neighbors is formed by the degree of similarity between the users, which is calculated by Pearson correlation coefficient. In the second step, the target user obtains service information from his/her neighbors. In the third step, recommendation list of top-N service is generated for the target user. Making the list, we use the multi-filtering based on user's psychological context information and body mass index (BMI) information for the detailed recommendation. In the fourth step, the personal information, which is the history of the usage service, is updated when the target user uses the recommended service. In the final step, a social network is reformed to continually provide qualified recommendation. For example, the neighbors may be excluded from the social network if the target user doesn't like the recommendation list received from them. That is, this step updates each user's neighbors locally, so maintains the updated local neighbors always to give context aware recommendation in real time. The characteristics of our research as follows. First, we develop the u-healthcare recommender system for improving life habit such as poor eating habits and physical inactivity. Second, the proposed recommender system uses autonomous collaboration, which enables users to prevent dropping and not to lose user's interest in improving life habit. Third, the reformation of the social network is automated to maintain the quality of recommendation. Finally, this research has implemented a mobile prototype system using JAVA and Microsoft Access2007 to recommend the prescribed foods and exercises for chronic disease prevention, which are provided by A university medical center. This research intends to prevent diseases such as chronic illnesses and to improve user's lifestyle through providing context aware and personalized food and exercise services with the help of similar users'experience and knowledge. We expect that the user of this system can improve their life habit with the help of handheld mobile smart phone, because it uses autonomous collaboration to arouse interest in healthcare.

The contact fatigue life estimation between Rough surfaces by using mesoscopic fatigue criterion (Mesoscopic 피로이론을 이용한 거친 표면의 접촉피로 수명예측)

  • Chu Hyojun;Kim Taewan;Lee Sangdon;Cho Youngjoo
    • Proceedings of the Korean Society of Tribologists and Lubrication Engineers Conference
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    • 2004.11a
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    • pp.53-59
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    • 2004
  • Rough surfaces are taking into account to estimate the contact fatigue life. A computational methodology and the theoretical basis in this case is presented in this paper. Displacement solution technique by Cho and Love is applied to calculate the stress history beneath the surface subjected to loading. Mesoscopic multiaxial fatigue criterion is then applied to predict fatigue life. This fatigue criterion yields satisfactory results for non-proportional loading and can satisfactorily describe the physical mechanisms of crack initiation as well. As a result of analysis the relation between the life and the roughness as well as the most probable depth of the crack nucleation is discussed.

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Analysis of in planta Expressed Orphan Genes in the Rice Blast Fungus Magnaporthe oryzae

  • Sadat, Md. Abu;Jeon, Junhyun;Mir, Albely Afifa;Kim, Seongbeom;Choi, Jaeyoung;Lee, Yong-Hwan
    • The Plant Pathology Journal
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    • v.30 no.4
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    • pp.367-374
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    • 2014
  • Genomes contain a large number of unique genes which have not been found in other species. Although the origin of such "orphan" genes remains unclear, they are thought to be involved in species-specific adaptive processes. Here, we analyzed seven orphan genes (MoSPC1 to MoSPC7) prioritized based on in planta expressed sequence tag data in the rice blast fungus, Magnaporthe oryzae. Expression analysis using qRT-PCR confirmed the expression of four genes (MoSPC1, MoSPC2, MoSPC3 and MoSPC7) during plant infection. However, individual deletion mutants of these four genes did not differ from the wild-type strain for all phenotypes examined, including pathogenicity. The length, GC contents, codon adaptation index and expression during mycelial growth of the four genes suggest that these genes formed during the evolutionary history of M. oryzae. Synteny analyses using closely related fungal species corroborated the notion that these genes evolved de novo in the M. oryzae genome. In this report, we discuss our inability to detect phenotypic changes in the four deletion mutants. Based on these results, the four orphan genes may be products of de novo gene birth processes, and their adaptive potential is in the course of being tested for retention or extinction through natural selection.

The life and scholastic career of a New Math campaigner, Zoltan P. Dienes (새수학 운동가 Zoltan P. Dienes의 생애 및 연구 업적)

  • Kim, Soo-Mi
    • Journal for History of Mathematics
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    • v.22 no.3
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    • pp.153-170
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    • 2009
  • Zoltan, P. Dienes is a famous researcher and practitioner who has tried to teach mathematical structures to children for about 50 years. Even though his ideas of teaching mathematics and materials including MAB have been well known in Korea, they are only a part of his achievement he has developed for his whole life. So this article is designed for taking an overview of his whole life and achievement and getting some implications for today's mathematics education. In this article, his life story could be divided by five periods in terms of a scholastic career and his research achievement could be reorganized with respect to five theses: psychology of learning mathematics, mathematical curriculum, teacher education, games and material for mathematical learning. As a result, it is found that there is a deep connection between his personal life and his scholastic career.

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Use of Housing through Oral Life History of Korean Chineses in Harbin, China - Focused on use of housing, cultural assimilation and acculturation - (생애구술을 통해 본 중국 할빈지역 조선족의 주거의 사용 - 주거의 사용과 생활문화의 동화 및 문화접변을 중심으로 -)

  • Hong, Hyung-Ock
    • Journal of Families and Better Life
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    • v.28 no.6
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    • pp.81-94
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    • 2010
  • This qualitative research was designed to explore the use of housing among Korean Chinese people in Harbin, China. Focusing on the use which based on the epistemology of housing adjustment, this was particularly designed to examine its cultural assimilation and acculturation on the way of life course, it employed the in-depth interview on the oral history of 5 interviewees in their 60s and 70s, individualized interviews were conducted from May 28 to 31 in 2010. Key findings were summarized as follows; 1. The free market reform in China resulted in privatization that allowed respondents to become homeowners, and the ownership was viewed as part of family asset centered upon a sense of solidarity. 2. Although homeowners in multi-story houses were responsible to decorate interior spaces, the common features in using interior spaces were found: entrance had no thresholds; kitchen was small, lack of storage cabinets, tile-flooring; washers were installed inside bathroom; and newly built apartment didn't have proper space to store Korean fermented foods. It was observed that housing adaptation outweighed housing adjustment. Those who used to live in Chinese houses with indoor-wearing-shoes or Russian houses with indoor-wearing-slippers were receptive to the use of dining table and bed, and the community heating system discouraged the use of individual electric water heater because of high electricity cost. 3. In daily life, eating habit wasn't much changed to the Chinese style, meals were shared, dish sterilizer was popular, and Kimchi fridge wasn't used. Because of the influence of the Chinese culture, such Korean traditions as ancestral rites and bedroom allocation tradition faded away, but traditional family values remained unchanged. In conclusion, Korean Chinese people experience normative housing deficits and adaptation selectively incurred. It's implied that residential design meets the needs resulting from the dual culture in terms of cultural assimilation and acculturation.

『Yeongchu·Ohseak(靈樞·五色)』 and Physiognomy - Focused on Inspecting Colors - (『영추(靈樞)·오색(五色)』에 대한 상학적(相學的) 고찰(考察) - 오색편(五色篇)과 인상고전(人相古典)에 나오는 찰색(察色) 중심으로 -)

  • Joo, Sun-Hee
    • The Journal of Korean Medical History
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    • v.26 no.1
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    • pp.55-71
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    • 2013
  • Objectives : In physiognomy, human emotion such as joy, anger, sorrow, and pleasure in social relation is one of important factors for impression formation. Various emotional feelings exert significant influence on the endocrine action and the muscle activities as well as changes of one's impression, which results in changes of one's life. On the other hand, such alterations in life may also bring changes of one's impression. The method of physiognomic examination is not different from the inspecting colors that makes a diagnosis of physical conditions. Thus, based on "Yeongchu Ohseak(靈樞 五色)", the present study compares similarities and differences between the two views of the physiognomy and the Korean medicine. Methods : The similarities and differences between the two approaches will be compared to each other and analysed with the respect to inspecting colors suggested by preceding research in physiognomy and "Yeongchu Ohseak(靈樞 五色)". Results & Conclusions : From this study, we found physiognomy and the Korean medicine shares the same theoretical background. The differences that we found in the present study are as follow. The inspection diagnosis in the Korean medicine focuses on the prevention and treatment of diseases; however, physiognomy focuses on the prognostication of one's life in order to lead a happy life. As the ultimate goals of the two approaches differ with each other, it is peculiarly challenging to compare these two in detail. Therefore, the future study should address physiognomy as a part of the Korean medicine so that the Korean medicine can contribute to mankind for a better and healthy human life.

Egg Development and Early Life History of Zacco koreanus (Pisces: Cyprinidae) (참갈겨니 Zacco koreanus (Pisces: Cyprinidae)의 난 발생과 초기생활사)

  • Lee, Wan-Ok;Kim, Kyeong-Hwan;Back, Jae-Min;Song, Mi-Young
    • Korean Journal of Ichthyology
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    • v.25 no.4
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    • pp.200-207
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    • 2013
  • We investigated developmental stages of egg and early life history of the Korean indigenous fish, Korean Chub Zacco koreanus from the South Han River in 2011 for phylogenetic study and conservation of this species. Eggs of Zacco koreanus were artificially fertilized by the dry method in the laboratory. The fertilized eggs were demersal, almost spherical in shape, transparent and unpigmented, with a pale yellow yolk, and no oil globule and average $3.09{\pm}0.07$ mm (n=10) in diameter. The hatching of the embryo took place in about 68 hrs after fertilization under water temperature of $20.0{\sim}23.0^{\circ}C$ and the newly hatched larvae were average $10.30{\pm}0.40$ mm (n=10) in total length (TL). Six days after hatching, the larvae grew up to $16.12{\pm}0.42$ mm (n=8) in TL and york sac absorption, mouth and anus opening were shown postflexion larvae stage. 17 days after hatching, most of fin-rays appeared at $18.21{\pm}0.38$ mm (n=6) in TL and brown spot appeared on the abdomen. 27 days after hatching, the larvae were brought up to $20.01{\pm}1.12$ mm(n=5) in TL and all their fin-rays were formed. 120 days after hatching, the larvae (juvenile) were $23.29{\pm}3.12$ mm (n=10) in TL and their body shape and color pattern were similar to the adult fish.

Phenological Studies of Deciduous Trees in the Cool Temperate Region of Japan

  • Jun, Kala;Hayashi, Ichiroku
    • Journal of Ecology and Environment
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    • v.31 no.3
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    • pp.193-200
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    • 2008
  • We obtained quantitative information on leaf unfolding and leaf shedding by observing 45 species of cool temperate deciduous trees in an arboretum over 5 growing seasons. These trees were in leaf (the foliage period) for 207 days on average after 1 April; 50% of leaves had been shed by 192 days after 1 April. Duration from the start of leaf unfolding to 50% leaf shedding was 157 days on average. Leaf unfolding began 35 days on average after 1 April. For leaf unfolding to begin, a$ 51^{\circ}C{\cdot}day$ of cumulated daily mean air temperature above $5^{\circ}C$ from 1 January (modified Kira's warmth index) was needed. Fifty-nine days elapsed between initiation and the final stage of leaf unfolding. The period of net photosynthetic assimilation was 157 days. The species with succeeding- type leaf unfolding associated with the anemochore seed type dominated the early stage of succession, while the species with flush-type leaf unfolding tended to dominate the late stage of succession. Few species were found in regions where late frosts occur after the day when the cumulative temperature for leaf unfolding is achieved. Biological characteristics include time of leaf unfolding, which affects the life history of each species, so that each species occupies its own niche in the stand. We conclude that that leaf phenology, such as timing of leaf unfolding and leaf shedding, is one of the components of each species' ecological characteristics.