• Molecules and Cells
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• v.41 no.9
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• pp.818-829
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• 2018

Significant research efforts are ongoing to elucidate the complex molecular mechanisms underlying amyotrophic lateral sclerosis (ALS), which may in turn pinpoint potential therapeutic targets for treatment. The ALS research field has evolved with recent discoveries of numerous genetic mutations in ALS patients, many of which are in genes encoding RNA binding proteins (RBPs), including TDP-43, FUS, ATXN2, TAF15, EWSR1, hnRNPA1, hnRNPA2/B1, MATR3 and TIA1. Accumulating evidence from studies on these ALS-linked RBPs suggests that dysregulation of RNA metabolism, cytoplasmic mislocalization of RBPs, dysfunction in stress granule dynamics of RBPs and increased propensity of mutant RBPs to aggregate may lead to ALS pathogenesis. Here, we review current knowledge of the biological function of these RBPs and the contributions of ALS-linked mutations to disease pathogenesis.

• Structural Engineering and Mechanics
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• v.57 no.2
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• pp.265-280
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• 2016

A NLFE model was proposed to investigate the mechanical behavior of short columns, cast using plain or fibrous lightweight aggregate concrete (LWAC), and subjected to elevated temperatures of up to $700^{\circ}C$. The model was validated, before its predictions were extended to study the effect of other variables, not studied experimentally. The three-dimensional NLFE model was developed using ANSYS software and involved rational simulation of thermal mechanical behavior of plain and fibrous LWAC as well as longitudinal and lateral steel reinforcement. The prediction from the NLFE model of columns' mechanical behavior, as represented by the stress-strain diagram and its characteristics, compared well with the experimental results. The predictions of the proposed models, considering wide range of lateral reinforcement ratios, confirmed the behaviors observed experimentally and stipulated the importance of steel confinement in preserving post-heating mechanical properties of plain and fibrous LWAC columns, being subjected to high temperature.

• Structural Engineering and Mechanics
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• v.55 no.1
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• pp.205-228
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• 2015

The results of a numerical investigation pertaining to the hysteretic behaviour of concrete filled steel tubular (CFT) column to I-beam connections are discussed in detail. Following the verification of the numerical results against the available experimental tests, the nonlinear finite element (FE) analysis was implemented to evaluate the effects of different parameters including the column axial load, beam lateral support, shape and arrangement of stiffeners, stiffness of T-stiffeners, and the number of shear stiffeners. Pursuing this objective, an external CFT column to beam connection, tested previously, was selected as the case-study. The lateral forces on the structure were simulated, albeit approximately, using an incremental cyclic loading reversal applied at the beam tip. The results were compared in terms of hysteretic load-displacement curves, stress distributions in connection, strength, rotation, and energy dissipation capacity. It was shown that external T-stiffeners combined with internal shear stiffeners play an important role in the hysteretic performance of CFT columns to I-beam connections.

• Steel and Composite Structures
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• v.11 no.1
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• pp.21-38
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• 2011

This study examines the influence of curved, steel, I-girder bridge configuration on girder end reactions and cross frame member forces during seismic events. Simply-supported bridge finite element models were created and examined under seismic events mimicking what could be experienced in AASHTO Seismic Zone 2. Bridges were analyzed using practical ranges of: radius of curvature; girder and cross frame spacings; and lateral bracing configuration. Results from the study indicated that: (1) radius of curvature had the greatest influence on seismic response; (2) interior (lowest radius) girder reactions were heavily influenced by parameter variations and, in certain instances, uplift at their bearings could be a concern; (3) vertical excitation more heavily influenced bearing and cross frame seismic response; and (4) lateral bracing helped reduce seismic effects but using bracing along the entire span did not provide additional benefit over placing bracing only in bays adjacent to the supports.

• Proceedings of the Earthquake Engineering Society of Korea Conference
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• 2006.03a
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• pp.589-596
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• 2006

Torsional behavior of eccentric structures under seismic loading may cause stress and/or strain concentration, which result in the failure of the structures in an unexpected manner. This study propose how to assess the seismic capacity of plan-irregular RC wall structures. The seismic capacities ate expressed in terms of lateral displacement capacity of each wall. The seismic demands for displacement are assessed by so called displacement-based design approach. Those seismic capacity and demands are combined D-R coordinate, which is made up of lateral displacement and rotation angle. To expand these concepts to the inelastic region the adaptive modal analysis method is used. In addition, the failure mechanisms including torsional failure are defined on D-R coordinate. Finally, seismic assessments of two 3-story plan-irregular wall structures ate presented.

• Geomechanics and Engineering
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• v.6 no.2
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• pp.117-138
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• 2014

The main focus of the current study is to evaluate the dynamic behavior of a cantilever retaining wall considering backfill and soil/foundation interaction effects. For this purpose, a three-dimensional finite element model (FEM) with viscous boundary is developed to investigate the seismic response of the cantilever wall. To demonstrate the validity of the FEM, analytical examinations are carried out by using modal analysis technique. The model verification is accomplished by comparing its predictions to results from analytical method with satisfactory agreement. The method is then employed to further investigate parametrically the effects of not only backfill but also soil/foundation interactions. By means of changing the soil properties, some comparisons are made on lateral displacements and stress responses. It is concluded that the lateral displacements and stresses in the wall are remarkably affected by backfill and subsoil interactions, and the dynamic behavior of the cantilever retaining wall is highly sensitive to mechanical properties of the soil material.

• Nuclear Engineering and Technology
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• v.51 no.7
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• pp.1822-1827
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• 2019

Mechanical responses and failure behaviors of advanced C/C composite tube are very important for structural component design in nuclear reactor. In this study, an experimental investigation was conducted to study mechanical properties of C/C composite tube. Quasi-static compression loading was applied to a type of advanced composite tube to determine the response of the quasi-static load displacement curve during progressive damage. Acoustic emissions (AE) signals were captured and analyzed to characterize the crack formation and crack development. In addition, the crack propagation of the specimens was monitored by imaging technique and failure mode of the specimen was analyzed. FEM is appled to simulate the stress distribution. Results show that advanced C/C composite tube exhibits considerable energy absorption capability and stability in load-carrying capacity.

• Clinics in Shoulder and Elbow
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• v.22 no.2
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• pp.106-109
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• 2019

Acromial fractures are well-documented complications subsequent to reverse shoulder arthroplasty (RSA), and most appear as stress fractures with no history of single trauma. To date, no study has reported the occurrence of acute displaced acromial fracture due to sudden strong deltoid contraction during heavy work. Displacement of the fracture results in a challenging surgery since it is difficult to obtain adequate fixation in thin and osteoporotic bones. We report a rare case of acute displaced acromial fracture after successful RSA treatment, using a novel technique of open reduction and internal fixation, applying two 4.5 mm cannulated screws and lateral clavicle precontoured plate.

• Proceedings of the Korean Society of Computer Information Conference
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• 2021.07a
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• pp.691-694
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• 2021

The malalignment of the trunk causes abnormal stress in a specific area and lead to trunk instability. The purpose of this study was to investigate the correlation between the angle between the infrasternal angle and the trunk side shift distance. The participants in this study 22 subjects were participated. The infrasternal angle and trunk side shift distance were measured using a camera and analyzed using the Image J program. The correlation between the asymmetry of the infrasternal angle and trunk side shift distance was moderate (r=-0.413; p=0.028). According to the asymmetry of the infrasternal angle, it was confirmed that trunk lateral shift appeared in a specific direction. Based on result, it suggests that infrasternal angle and trunk side shift should be considered in the intervention plan of patients with asymmetry of the infrasternal angle.

• Biomolecules & Therapeutics
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• v.28 no.3
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• pp.230-239
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• 2020

Previous studies have shown disrupted synaptic plasticity and neural activity in depression. Such alteration is strongly associated with disrupted synaptic structures. Chronic stress has been known to induce changes in dendritic structure in the basolateral amygdala (BLA) and medial prefrontal cortex (mPFC), but antidepressant effect on structure of these brain areas has been unclear. Here, the effects of imipramine on dendritic spine density and morphology in BLA and mPFC subregions of stressed mice were examined. Chronic restraint stress caused depressive-like behaviors such as enhanced social avoidance and despair level coincident with differential changes in dendritic spine structure. Chronic stress enhanced dendritic spine density in the lateral nucleus of BLA with no significant change in the basal nucleus of BLA, and altered the proportion of stubby or mushroom spines in both subregions. Conversely, in the apical and basal mPFC, chronic stress caused a significant reduction in spine density. The proportion of stubby or mushroom spines in these subregions overall reduced while the proportion of thin spines increased after repeated stress. Interestingly, most of these structural alterations by chronic stress were reversed by imipramine. In addition, structural changes caused by stress and blocking the changes by imipramine were corelated well with altered activation and expression of synaptic plasticity-promoting molecules such as phospho-CREB, phospho-CAMKII, and PSD-95. Collectively, our data suggest that imipramine modulates stress-induced changes in synaptic structure and synaptic plasticity-promoting molecules in a coordinated manner although structural and molecular alterations induced by stress are distinct in the BLA and mPFC.