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Minimal Stimulation using rhFSH and GnRH Antagonist for IVF Treated Patients of Advanced Age (고령 불임여성의 체외수정술시 최소자극법의 효용성)

  • Kim, So-Ra;Kim, Chung-Hoon;Lee, Jin-Kyoung;Jeon, Gyun-Ho;Kim, Sung-Hoon;Chae, Hee-Dong;Kang, Byung-Moon
    • Clinical and Experimental Reproductive Medicine
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    • v.36 no.1
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    • pp.63-70
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    • 2009
  • Objective: This study was performed to investigate the effectiveness of minimal stimulation using rhFSH and GnRH antagonist compared with GnRH antagonist multidose protocol (MDP) in IVF treated patients with aged 40 and above. Methods: Seventy-five patients with aged 40 and above were equally randomized to minimal stimulation group (n=37) or GnRH antagonist MDP group (n=38). For minimal stimulation group, ultrasound monitoring was started on cycle day 7 or 8. Daily injections of 0.25 mg cetrorelix together with 150 IU rhFSH were started from the day at 13${\sim}$14 mm of a leading follicle diameter. For GnRH antagonist MDP group, daily injections of 225 IU rhFSH were initiated from cycle day 2 and GnRH antagonist was started at a dose of 0.25 mg/day on rhFSH stimulation day 6 or the day at 13${\sim}$14 mm of leading follicle diameter. In both groups, transvaginal ultrasound-guided oocyte retrieval was performed. According to cleavage and morphologic characteristics of embryos, embryos were transferred 3 to 5 days after oocyte retrieval. Results: There were no differences in patients' characteristics and cycle cancellation rate between the two groups. Total dose and duration of rhFSH used were significantly fewer and shorter in minimal stimulation group than those in GnRH antagonist MDP group. The numbers of oocytes retrieved, mature oocytes and transferred embryos were also lower in minimal stimulation group. However, there were no significant differences in the clinical pregnancy rate and miscarriage rate between the two groups. Conclusions: This study demonstrates that minimal stimulation protocol provides comparable pregnancy rates to GnRH antagonist MDP with fewer dose and days of rhFSH used, and thus can be a cost-effective alternative in women aged 40 and above.

Midwives' Perceptions of the Importance of Teaching the Lamaze Method of Childbirth Preparation, Their Practice of it and Inhibiting Factors. (조산사의 라마즈 산전교육에 대한 중요성 인식과 수행정도 및 저해요인에 관한 연구)

  • Yoon, Gui-Nam;Cho, Mi-Young
    • 모자간호학회지
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    • v.2 no.1
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    • pp.21-33
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    • 1992
  • This study was done to investigate how importantly midwives thought of Lamaze Method of Childbirth, how satisfactorily they performed their Lamaze Method of Childbirth and what inhibited their activities from being performed if not done satisfactorily. The subjects of this study were 76midwives at midwifery in Pusan, Deagu, Kyungnam and Kyungbok. Data were collected by using questionaire from Sep. 1 to Sep.30, 1991. The measurement tools was maded by the researcher based on Kim's scale for prenatal nursing activities. The statistical analysis was done with based statistical values likes frequencies, means, standard deviations and advanced methods such as Pearson's correlation coefficient, 1-test, F-test, F-test by using SPSS package program. The results of this study can be summarized as follows ; 1. The results of Investigating perception according to importance degree and performance degree of Lamaze Method of Childbring showed that midwives were slightly below both perception according to importance(2.17) and performance(2.16) of Lamaze Method of Childbirth 2. Inhibiting factors of Lamaze Method of Childbirth were abscence of husband(3.08), lack of teaching room(2.71), and lack of books or literature of Lamaze Method (2.58). 3. There appears to be a positive relation between perception according to importance degree and performance degree of Lamaze Method of Childbirth (r=0.69, P<0.01). There appears to be a negative relation between perception according to importance degree and inhibit factors of performance (r=-0.38, P<0.01). There appears to be a negative relation between performance and inhibit factors of performance (r=-0.22. P<0.01). 4. The item of highest perception defree in prenatal education is 1st, Consultation about sexual life (2.53), End, illustration of the importance of a bath and perinal cleanliness and Avoidance of excessive respiration method and also its comfortable application during uterine contractility(2.45). The item of lowest perception degree is about pregnant symptom sign and predicted date of birth (E.D.C.). On the other hand, The item of highest performance degree is education about nurtrition during pregnacy. 2nd, Illustration of the Importance of a bath and perineal cleanness(2.45). The lowest one is leaching the pregnant woman and her family about the role of husband and her family and also teaching the couple to learn exercise and respiration method (1.84). Though importance perception degree and performance degree is low. Midwives who wert subject in this research shoves that they perform general items concerning prenatal education well. 5. In the relationship between perception according to importance degree of Lamaze Method of Childbirth and the general characteristics of subjects, the differences in mean number of visiting pregnacies for 1 month. 6. In the relationship between performance degree of Lamaze Method of Childbirth and the general characteristics of subjects, the differences in age, marriage, and mean number of visiting pregnancies for 1 month. With the above information we see the importance of midwife prenatal care education and high correlation between performance degree and perception degree. When Lamaze prenatal education is well performed the number of pregnant woman who have follow-up, check-ups increase. Therefore in this research we can validity that there is a relation between Lamaze prenatal education and patient follow-up. This research showes in a situation where if one does not maximally perform a prenatal education there is a possibility that the popular use of midwife activities may encounter obstacles so the education to save new knowledge and training for prenatal education is needed as a function of Lamaze prenatal education, when a special Lamaze education is well performed for the pregnant woman, who follows-up at amidwife clinic. With the above conclusion we can suggest : 1. Continued research which minimized obstacles to Lamaze prenatal education is needed. 2. The official method of midwives is necessary.

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Development of the Bittering, Acanthorhodeus(=Acheilognathus) gracilis (Cyprinidae), with a Note on Minute Tubercles on the Skin Surface (가시납지리의 난발생(卵發生)과 자어(仔魚)의 발육(發育) 및 자어(仔魚)의 표피상돌기(表皮上突起))

  • Suzuki, Nobuhiro;Jeon, Sang-Rin
    • Korean Journal of Ichthyology
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    • v.2 no.2
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    • pp.169-181
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    • 1990
  • The development of eggs and larvae, and minute scale-like tubercles on the skin surface of larval Acantlaorhodeus gracilis from Korea were observed. They spawned from late March through the middle of June. A fish spawned at least 5 times and the number of eggs averaged 304 per oviposition. Unfertilized eggs are nearly ovoid-shaped(mean$\pm$SD=$2.09{\pm}0.04\;mm$ in length with range of 2.05 to 2.13 mm and mean$\pm$SD=$1.26{\pm}0.02\;mm$ in breadth with range of 1.24 to 1.30 mm measured for the 50 eggs) and opaque yellow color. The tip of egg membrane at the animal pole side swelled and formed a few hilly projections. The shape of the eggs was just like a loquat. Most of embryos began to hatch out in thirty-eight hours after insemination at $22{\pm}1^{\circ}C$ in water temperature. As regards the morphological characters of the eggs and larval development, Acan. gracilis was similar to Acan. asmussi, Acheilognathus rhombeus, A. longipinnis and Pseudoperilampus typus. The larvae of this species is unique particularly in the following two characters, i.e., 1) scale-like tubercles ellipsoided in a diagonal cross section on the whole body and 2) incessant wiggly movement pattern as that of fly maggot, with the larvae of the above mentioned species. These characters seem to reflect the phylogenetic relationships among acheilognathine fishes. On the other hand, this species and Acan. asmussi are spring-summer spawning bitterlings. And also these species never retard the larval growth in such larval stage as the duration from Stage B to Stage D.

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The Effect of Orthodontic Resin Cements Containing Fluoride on Fluoride-releasing and the Resistance to Enamel Decalcification (불소 함유 교정용 레진 시멘트의 불소 유리 및 법랑질 탈회 저항성에 대한 효과)

  • Kim, Myung-Eun;Kang, Jae-Kyoung;Kim, Soo-Wha;Lee, Min-Young;Lee, Joo-Hye;Kim, Hyoung-Sik;Kim, Kwang-Mahn
    • Journal of dental hygiene science
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    • v.11 no.5
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    • pp.445-453
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    • 2011
  • Objectives : The purpose of this study was to determine of fluoride-releasing of orthodontic resin cements containing fluoride and compare decalcification of tooth attached fluoride and non-fluoride resin cements. Methods : Total eighty premolar tooth were used in this study. Forty tooth were used for fluoride releasing measurement and forty tooth were used for decalcification measurement. Each forty tooth were randomly divided into four groups, and brackets were attached on tooth surface with Blugloo, Light Bond, Orthofolw(experimental groups) and Transbond cement(control group). After brackets were attached on tooth surface, forty tooth were immersed in artificial salival and then the quantity of fluoride releasing was measured ever day for 8days and then three-days intervals for 3 weeks. Forty tooth were immersed in decalcification solution for 48hours and then degree of decalcification was measured as lesion area, ${\Delta}F$, and ${\Delta}Q$ using QLF. The data were analysed by one-way ANOVA and Pearson's correlation coefficient using SPSS 12.0 program. Results : Fluoride release of experimental groups was higher than control group(p<0.05). Cumulative fluoride release of experimental groups was also higher than control group(p<0.05). There were the highest release during first day. ${\Delta}F$, and ${\Delta}Q$ was high TB > BG > OF > LB (p<0.05). Change of ${\Delta}F$, and ${\Delta}Q$ was also high TB > BG > OF > LB (p<0.05). As for correlation between fluoride release and lesion area, ${\Delta}F$, and ${\Delta}Q$ showed negative correlation but there was no significant difference. Conclusions : This study shows that orthodontic reins cements containing fluoride release fluoride and prevent initial enamel decalcification caused by orthodontic treatment.

A Study on the Impact of General Characteristics on Achievement Motivation in Dental Hygiene Students (치위생과 학생들의 일반적인 특성이 성취동기에 미치는 영향 연구)

  • Youn, Hye-Jeong;Lim, Sun-A;Kim, Soo-kyung
    • Journal of dental hygiene science
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    • v.11 no.5
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    • pp.389-395
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    • 2011
  • The purpose of this study was to examine dental hygiene students' achievement motivation and factors affecting dental hygiene students' achievement motivation by the general characteristics of subjects in this study. The subjects in this study were 450 who were selected by convenience sampling from three different three-year-course colleges. After a survey was conducted, the answer sheets from 421 respondents were analyzed. The collected data were analyzed, which made use of t-test, ANOVA and Kruscal-Wallis test. The findings of the study were as follows. 1. The dental hygiene students investigated got 3.34 in achievement motivation. They got the highest score of 3.78 in the item 'I perform what I have to do with a sense of responsibility.' and they got the lowest score of 2.67 in the item 'I like to do something risky.' 2. Concerning links between their general characteristics and achievement motivation, the students whose academic year was higher(p<0.001) and who had more clinical practice experiences (p<0.01) were better motivated than their counterparts. As to connections between achievement motivation and expected post-graduation length of service, those who replied that they planned to find another job after getting married were better motivated(p<0.05). Regarding relationship between achievement motivation and a will to work abroad, the students who had a stronger will to work abroad were better motivated. 3. As a result of checking the influence of their general characteristics on achievement motivation, stronger motivation was found among the students whose academic year was higher(p<0.01), who intended to work until marriage(p<0.01) and who didn't plan to keep working after marriage(p<0.05) when the other variables were controlled. Therefore dental hygiene students should be taught to look at things positively when they enter college, and they should also be educated to become progressive to keep working for their lifetime instead of just getting a temporary job after graduation.

A Study on Effective Smoking Cessation Policy of Smoker Patients (흡연환자의 효과적인 금연정책에 대한 연구)

  • Hwang, Ji-Min;Kim, Eung-Gwon;Park, Yong-Duk;Han, Ji-Hyoung
    • Journal of dental hygiene science
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    • v.13 no.1
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    • pp.77-82
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    • 2013
  • The purpose of this study was to examine the subjective awareness of smoker patients about the preparation of smoking cessation plans in an effort to lay the foundation for smoking cessation policy setting. The subjects were the selected patients at a dental clinic. A self-administered survey was conducted to grasp their personal characteristics, and the selected answer sheets from 236 respondents were analyzed. The findings of the study were as follows: 1. As for the extension of existing smoking cessation plans, the largest group (32.6%) preferred smoking cessation education, followed by smoking cessation counseling (28.8%), prescription of an smoking cessation aid (18.6%). 2. Concerning the necessity of a smoking cessation law, the men and the women respectively gave 2.37 and 3.00 to that, and the gender gap was significant. The patients had a significantly different opinion on the necessity of a rise in tobacco price according to their occupation and monthly mean household income, and their took a significantly different view of the necessity of smoking cessation counseling according to their residential area. 3. As a result of analyzing the correlation between their on effective smoking cessation policies and the related variables, all the variables had a statistically significant correlation to each other. 4. As a result of analyzing their opinions on what institution should be in charge of smoking cessation plans, the biggest group answered that dental clinics should be responsible for smoking cessation-aid prescription (50.0%), and the largest group replied that smoking cessation education and smoking cessation counseling should respectively be provided by public dental clinics (37.3%) and dental clinics (44.1%).The above-mentioned findings suggest that the preparation of new smoking cessation measures and the extension of existing smoking cessation plans are urgently required, and that dentists and dental hygienists should make a concerted effort to offer counseling and education to stimulate dental patients to abstain from smoking.

The Associated Factors with Scaling Experience among Some Workers in Small and Medium-Sized Companies (중소 사업장 근로자의 치석제거 경험 관련요인)

  • Lee, Jae Ra;Han, Mi Ah;Park, Jong;Ryu, So Yeon;Lee, Chul Gab;Moon, Sang Eun
    • Journal of dental hygiene science
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    • v.17 no.4
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    • pp.333-340
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    • 2017
  • The prevalence of periodontal disease was steadily increased. The best prevention methods for periodontal disease are teeth brushing and scaling. The purpose of this study was to investigate the status of scaling experience and related factors among some workers. Total 455 workers in 5 manufacturing companies in Gwangju were selected using convenience sampling method. General characteristics, work-related characteristics, oral health-related characteristics and scaling experience were collected by self-reported questionnaires. Chi-square tests, t-tests and multiple logistic regression analysis were performed to investigate the factors influencing the scaling experience using SPSS software. Statistical significance was defined as a p-value<0.05. The proportion of scaling experience during the past year was 47.0%. In simple analysis, age, current working position, number of oral disease, interest in oral health, use of secondary oral products, oral health screening use, oral health education experience and awareness of scaling inclusion in the National Health Insurance (NHI) coverage were associated with scaling experience. Finally, the odds ratios (ORs) for scaling experience were significantly higher in younger subjects (adjusted OR [aOR], 3.09; 95% confidence internal [CI], 1.60~5.96), assistant manager (aOR, 2.68; 95% CI, 1.55~4.63), subjects with high interest in oral health (aOR, 2.15; 95% CI, 1.02~4.52), subjects with oral health screening use (aOR, 2.76; 95% CI, 1.50~5.11) and awareness of scaling inclusion in the NHI coverage (aOR; 2.91, 95% CI, 1.80~4.72) in multiple logistic regression analysis. Scaling experience was relatively low (47.0%). The related factors with scaling experience were age, working position, use of screening and awareness of scaling inclusion in the NHI coverage. Considering these factors will increase the utilization rate of scaling.

Historical Investigation on Development of Produce and Packages or Physical Analysis of Packaging's Materials of Cheese in Korea since 1967-2 (1967년 이후 한국(韓國)에서 치즈제품(製品)의 개발(開發)과 포장(包裝)의 변화(變化) 및 그 포장재(包裝材)의 생물학적(生物學的) 조사연구(調査硏究)-2)

  • Kim, Duck-Woong
    • KOREAN JOURNAL OF PACKAGING SCIENCE & TECHNOLOGY
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    • v.5 no.1
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    • pp.30-36
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    • 1999
  • Physical analysis of some composite films of outer packaging at process cheeses in Korea is as following. In comparison with four composite films, tensile strength is $72.2{\mu}PET/PVDC/PE/AL-vac/PE\;film\;MD9.55kg/15mm,\;TD8.95kg/15mm>79.3{\mu}PET/PVDC/L-LDPE\;film\;MD5.37kg/15mm,\;TD5.01kg/15mm>96.9{\mu}PE/PVDC/PE\;film\;MD5.42kg/15mm,\;TD4.73kg/15mm>61.6{\mu}PVDC/PE/AL-vac/CPS\;film\;MD4.65kg/15mm,\;TD4.22kg/15mm$. Water vapor transmission is $72.2{\mu}PET/PVDC/PE/AL-vac/PE\;film\;0.41g/m^2{\cdot}24hr>79.3{\mu}PET/PVDC/L-LDPE\;film\;3.77g/m^2{\cdot}24hr>96.9{\mu}PE/PVDC/PE\;film\;3.81g/m^2{\cdot}24hr>61.6{\mu}PVDC/PE/AL-vac/4.91g/m^2{\cdot}24hr$. Gas transmission $O_2:N_2:CO_2$ is $72.2{\mu}PET/PVDC/PE/AL-vac/PE\;film\;1.81:0.74:4.2cc/m^2{\cdot}24hr{\cdot}atm>79.3{\mu}PET/PVDC/L-LDPE\;film\;13.4:6.4:34.2cc/m^2{\cdot}24hr{\cdot}atm>96.9{\mu}PE/PVDC/PE\;film\;15.3:7.1:42.0cc/m^2{\cdot}24hr{\cdot}atm>61.6{\mu}PVDC/PE/AL-vac/CPS\;film\;25.3:12.5:59.3cc/m^2{\cdot}24hr{\cdot}atm$ each other. And for preservation this were sealed to filths $N_2,\;CO_2$ gas or defilling ai (vacuum type) in the packaging and reserved less than $10^{\circ}C$ at refrigerator.

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Association of Bone Mineral Density with the Metabolic Syndrome (건강검진 수진자들에서 골밀도와 대사증후군의 연관성)

  • Kang, Yeong-Han;Kam, Shin
    • Journal of radiological science and technology
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    • v.31 no.3
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    • pp.259-266
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    • 2008
  • Objective : The purpose of this study was to examine the relationship between bone mineral density (BMD) and the metabolic syndrome. Method : We conducted a cross-sectional study of 1204 adults(males: 364 females: 840) in a general hospital health promotion center. They were grouped into the normal and lower BMD group according to bone loss(osteopenia, osteoporosis), as determined by duel energy X-ray absorptiometery(DEXA). We analyzed the association between BMD and metabolic syndrome by multiple logistic regression analysis. After adjustment for age, weight, alcohol intake, smoking, regular exercise, regular intake of meals, and menopausal status, odds ratios for the prevalence of the metabolic syndrome by gender were calculated for lower BMD. Results : After adjustment for the effect of potential covariates, the prevalence of metabolic syndrome was associated with bone loss in men(p<0.001). If the odds ratio of normal group is 1.00, then that of the lower BMD group is 3.07(95% CI=1.83-5.16). The prevalence of metabolic alterations fitting the criteria of metabolic syndrome was significantly decreased in High BMI, Low HDL in men and in High BMI in women(p<0.05). Conclusions : This study shows that BMD was associated with metabolic syndrome. Further studies needed to obtain evidence concerning the association between BMD and metabolic syndrome.

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Analysis of Immunogenicity after Hepatitis B Vaccination in Korea by Literature Review (문헌 분석에 의한 B형 간염 백신의 항체 양전률의 비교)

  • Roh, Hye Ok;Lee, Woo Gill;Sohn, Young Mo
    • Pediatric Infection and Vaccine
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    • v.5 no.2
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    • pp.245-257
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    • 1998
  • Purpose : Although hepatitis B vaccine has been available to general population in Korea since 1983, it was difficult to compare various types of hepatitis B virus(HBV) vaccines primarily due to the differences in vaccination schedule, dosage, test methods and seropositive antibody level. In this study we reviewed the results of previous studies published in Korea, which include antibody positive rates and antibody titers of various vaccines, and examined the immunogenicity of these HBV vaccines. Methods : Studies published in medical journals, university journals concerning antibody positive rates following hepatitis B vaccination were reviewed. Inclusion criteria were those studies in which seroprotective antibody rate of 10mIU/mL or the sample ratio unit of 10 RU were used as the cut-off value and in which the test methods were RIA or ELISA. Exclusion criteria were; 1) unclear or inconsistent vaccine dosage, 2) no record of antibody titers or seroconversion rate, 3) no defined antibody rate or ratio for positive rating and 4) the vaccination schedule other than 0-1-2 months or 0-1-6 months. Results : 23 out of 52 studies were subjected for the review for seroconversion rates. 1) As for the immunogenicity in each age group, the seroconversion rates of Hepaccine(Cheil Jedang) were 85.1% in infants, 83.3% in children and 62.7% in adults, indicating higher rates in infants and children compared to adults(P<0.01). The seroconversion rates of Hepavax(Korea Green Cross) were 84.7%, 81.1% and 90.8%, indicating higher rates in infants and adults compared to children(P<0.01). 2) The seroconversion rate of Hepavax was 85.6% with 0-1-6 mo. schedule, 78.5% with 0-1-2 mo. schedule with a statistically significant difference(P<0.01). 4) There was no difference of seroconversion rates between the two doses of Hepavax, $5{\mu}g$ and $10{\mu}g$ in infants and children. 5) In adults the seroconversion rates were 62.7% with Hepaccine, 90.8% with Hepavax, and 94.8% with Engerix-B(SmithKline Beecham). Conclusion : In Korea, the incidence of chronic hepatitis B is high and changing the schedule in vaccination cannot contribute to the increase of the serocoversion rate. And in order to maximize immunogenicity, more effective vaccines as well as more proper vaccination methods should be used.

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