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Fumonisin $B_1$-induced Alteration of Sphingolipid Metabolism in $LLC-PK_1$ Cells ($LLC-PK_1$ 세포에서의 퓨모너신 $B_1$에 의해 유도된 스핑고리피드 대사)

  • Yoo, Hwan-Soo;Yun, Yeo-Pyo
    • YAKHAK HOEJI
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    • v.41 no.6
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    • pp.789-796
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    • 1997
  • The purpose of this study was to determine the effect of sulfinpyrazone on fumonisin $B_1$-induced elevation of free sphingoid bases in LLC-$PK_1$ cells. Fumonis ins are a family of mycotoxins produced by the fungi Fusarium moniliforme which is common contaminant in corn. Fumonisins are also potent inhibiors of sphingosine and sphinganine N-acyltransferases (ceramide synthases), key enzymes in sphingolipid metabolism resulting in the elevation of free sphinganine. The cytosolic concentration of fumonisin B1 was known to be closely proportional to the elevation of free sphinganine in LLC-PK1 cells [Yoo, H.-S., Norred, W.P., Wang, E., Merrill, A.H., Jr., and Riley, R.T. (1992) Toxicol. Appl.Pharmacol. 114. 9-15]. Sulfinpyrazone, an anion transport inhibitor, reduced the elevated level of free sphinganine resulting from fumonisin B1 inhibition of de novo sphingolipid biosynthesis. Fumonisin B1 at a concentration of 20${\mu}$M showed approximately 120pmol/$10^6$ cells relative to 3-10pmol/$10^6$ cells in control cultures, and sulfinpyrazone at a concentration of 200${\mu}$M partially reversed the increased level of free sphinganine induced by fumonisin $B_1$ down to normal level after exposure to fumonisin $B_1$ for 8 to 24hr. However, the reduced effect of sulfinpyrazone on the fumonisin $B_1$-induced elevation of intracellular sphinganine was not shown after 24hr. Fumonisin $B_1$ exposure to LLC-PK1 cells for 36 and 48hr showed approximately 74 and 80pmol per $10^6$ cells relative to 82 and 76pmol,respectively, in fumonisin $B_1$ plus sulfinpyrazone-treated cultures. Sulfinpyrazone-induced less elevation of free sphinganine in confluent cells after exposure to fumonisin $B_1$ suggested that either sulfinpyrazone may block the availability of fumonisin $B_1$ to cells or act on the fumonisin $B_1$ interaction with ceramide synthase.

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Influences of Forest Fire on Forest Floor and Litterfall in Bhoramdeo Wildlife Sanctuary (C.G.), India

  • Jhariya, Manoj Kumar
    • Journal of Forest and Environmental Science
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    • v.33 no.4
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    • pp.330-341
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    • 2017
  • Tropical forests play a key role for functioning of the planet and maintenance of life. These forests support more than half of the world's species, serve as regulators of global and regional climate, act as carbon sinks and provide valuable ecosystem services. Forest floor biomass and litterfall dynamics was measured in different sites influenced by fire in a seasonally dry tropical forest of Bhoramdeo wildlife sanctuary of Chhattisgarh, India. The forest floor biomass was collected randomly placed quadrats while the litterfall measured by placing stone-block lined denuded quadrat technique. The seasonal mean total forest floor biomass across the fire regimes varied from $2.00-3.65t\;ha^{-1}$. The total litterfall of the study sites varied from $4.75-7.56t\;ha^{-1}\;yr^{-1}$. Annual turnover of litter varied from 70-74% and the turnover time between 1.35-1.43 years. Monthly pattern of forest floor biomass indicated that partially decayed litter, wood litter and total forest floor were differed significantly. The seasonal variation showed that leaf fall differed significantly in winter season only among the fire regimes while the wood litter was found non significant in all the season. This study shows that significant variation among the site due to the forest fire. Decomposition is one of the ecological processes critical to the functioning of forest ecosystems. The decomposing wood serves as a saving account of nutrients and organic materials in the forest floor. Across the site, high fire zone was facing much of the deleterious effects on forest floor biomass and litter production. Control on such type of wildfire and anthropogenic ignition could allow the natural recovery processes to enhance biological diversity. Chronic disturbances do not provide time for ecosystem recovery; it needs to be reduced for ecosystem health and maintaining of the high floral and faunal biodiversity.

3X Serial GF($2^m$) Multiplier Architecture on Polynomial Basis Finite Field (Polynomial basis 방식의 3배속 직렬 유한체 곱셈기)

  • Moon, Sang-Ook
    • Journal of the Korea Institute of Information and Communication Engineering
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    • v.10 no.2
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    • pp.328-332
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    • 2006
  • Efficient finite field operation in the elliptic curve (EC) public key cryptography algorithm, which attracts much of latest issues in the applications in information security, is very important. Traditional serial finite multipliers root from Mastrovito's serial multiplication architecture. In this paper, we adopt the polynomial basis and propose a new finite field multiplier, inducing numerical expressions which can be applied to exhibit 3 times as much performance as the Mastrovito's. We described the proposed multiplier with HDL to verify and evaluate as a proper hardware IP. HDL-implemented serial GF (Galois field) multiplier showed 3 times as fast speed as the traditional serial multiplier's adding only partial-sum block in the hardware. So far, there have been grossly 3 types of studies on GF($2^m$) multiplier architecture, such as serial multiplication, array multiplication, and hybrid multiplication. In this paper, we propose a novel approach on developing serial multiplier architecture based on Mastrovito's, by modifying the numerical formula of the polynomial-basis serial multiplication. The proposed multiplier architecture was described and implemented in HDL so that the novel architecture was simulated and verified in the level of hardware as well as software.

VLIS Design of OCB-AES Cryptographic Processor (OCB-AES 암호 프로세서의 VLSI 설계)

  • Choi Byeong-Yoon;Lee Jong-Hyoung
    • Journal of the Korea Institute of Information and Communication Engineering
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    • v.9 no.8
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    • pp.1741-1748
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    • 2005
  • In this paper, we describe VLSI design and performance evaluation of OCB-AES crytographic algorithm that simulataneously provides privacy and authenticity. The OCB-AES crytographic algorithm sovles the problems such as long operation time and large hardware of conventional crytographic system, because the conventional system must implement the privancy and authenticity sequentially with seqarated algorithms and hardware. The OCB-AES processor with area-efficient modular offset generator and tag generator is designed using IDEC Samsung 0.35um standard cell library and consists of about 55,700 gates. Its cipher rate is about 930Mbps and the number of clock cycles needed to generate the 128-bit tags for authenticity and integrity is (m+2)${\times}$(Nr+1), where m and Nr represent the number of block for message and number of rounds for AES encryption, respectively. The OCB-AES processor can be applicable to soft cryptographic IP of IEEE 802.11i wireless LAN and Mobile SoC.

Hardware Design of AES Cryptography Module Operating as Coprocessor of Core-A Microprocessor (Core-A 마이크로프로세서의 코프로세서로 동작하는 AES 암호모듈의 하드웨어 설계)

  • Ha, Chang-Soo;Choi, Byeong-Yoon
    • Journal of the Korea Institute of Information and Communication Engineering
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    • v.13 no.12
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    • pp.2569-2578
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    • 2009
  • Core-A microprocessor is the all-Korean product designed as 32-bit embedded RISC microprocessor developed by KAIST and supported by the Industrial Property Office. This paper analyze Core-A microprocessor architecture and proposes efficient method to interface Core-A microprocessor with coprocessor. To verify proposed interfacing method, the AES cryptography processor that has 128-bit key and block size is used as a coprocessor. Coprocessor and AES are written in Verilog-HDL and verified using Modelsim simulator. It except AES module consists of about 3,743 gates and its maximum operating frequency is about 90Mhz under 0.35um CMOS technology. The proposed coprocessor interface architecture is efficiency to send data or to receive data from Core-A to coprocessor.

Requirement analysis and architecture establishment for ship production monitoring system (조선소 생산공정모니터링 시스템 개발을 위한 요구사항 분석 및 아키텍처 수립)

  • Lee, Kwangkook
    • Journal of the Korea Institute of Information and Communication Engineering
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    • v.18 no.9
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    • pp.2079-2086
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    • 2014
  • Shipbuilding production management is one of the most significant activities in productivity improvement. Shop-floor managers and production planners still do not have enough production information for shop-floor scheduling due to shortage of information sharing among them. In this research, main issues were derived from requirement analysis between production planning and shop-floor control to establish a software system architecture for ship production monitoring system(SPMS), which is developed with component based design(CBD). The proposed system's key functions cover from block shop assembly to quay outfitting stage to visualize production progress as well as to maximize production information sharing. The system will allow more reliable and accurate production information to permeate down to members of the workforce just in time.

An Improved Side Channel Attack Using Event Information of Subtraction (뺄셈연산의 이벤트 정보를 활용한 향상된 RSA-CRT 부채널분석공격 방법)

  • Park, Jong-Yeon;Han, Dong-Guk;Yi, Okyeon;Kim, Jung-Nyeo
    • KIPS Transactions on Computer and Communication Systems
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    • v.2 no.2
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    • pp.83-92
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    • 2013
  • RSA-CRT is a widely used algorithm that provides high performance implementation of the RSA-signature algorithm. Many previous studies on each operation step have been published to verify the physical leakages of RSA-CRT when used in smart devices. This paper proposes SAED (subtraction algorithm analysis on equidistant data), which extracts sensitive information using the event information of the subtraction operation in a reduction algorithm. SAED is an attack method that uses algorithm-dependent power signal changes. An adversary can extract a key using differential power analysis (DPA) of the subtraction operation. This paper indicates the theoretical rationality of SAED, and shows that its results are better than those of other methods. According to our experiments, only 256 power traces are sufficient to acquire one block of data. We verify that this method is more efficient than those proposed in previously published studies.

Design and Implementation of a Improved Cipher Web Mail System using a Chaos Cipher (카오스 암호를 이용한 개선된 암호화 웹 메일 시스템의 설계와 구현)

  • Kim Dae-Young;Kim Tae-Sik
    • The KIPS Transactions:PartD
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    • v.13D no.3 s.106
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    • pp.437-444
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    • 2006
  • A chaos cipher system that focuses on the stream cipher system has a demerit that the longer the text is, the slower the speed of the encryption and description and the transmission and reception. On this study, we designed the cipher web mail system showing much better capabilities than the existing web mail system as the text is longer. In the embodiment of the cipher web mail system, we developed the key stream, the encryption and description of the text and the inside and outside mail viewer and so on. After the efficiency test, it was valued high in the respect of the speed of the encryption and description and the transmission and reception. And it made up for the defect of the stream cipher system. We expect that we can use it through the persistent applied study in the server system security, the file security, the security of the internet information, the protection of the e-commerce system information and other fields based on the cipher technique as the wide use cipher system that can replace the block cipher system.

Replantation of Multi-level Amputated Digit (다중절단수지의 재접합술)

  • Kwon, Soon-Beom;Park, Ji-Ung;Cho, Sang-Hun;Seo, Hyung-Kyo;Whang, Jong-Ick
    • Archives of Plastic Surgery
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    • v.38 no.5
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    • pp.642-648
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    • 2011
  • Purpose: The recent advances in microsurgical techniques and their refinement over the past decade have greatly expanded the indications for digital replantations and have enabled us to salvage severed fingers more often. Many studies have reported greater than 80% viability rates in replantation surgery with functional results. However, replantation of multi-level amputations still remain a challenging problem and the decision of whether or not to replant an amputated part is difficult even for an experienced reconstructive surgeon because the ultimate functional result is unpredictable. Methods: Between January of 2002 and May of 2008, we treated 10 multi-level amputated digits of 7 patients. After brachial plexus block, meticulous replantation procedure was performed under microscopic magnification. Postoperatively, hand elevation, heat lamp, drug therapy and hyperbaric oxygen therapy were applied with careful observation of digital circulation. Early rehabilitation protocol was performed for functional improvement. Results: Among the 19 amputated segments of 10 digits, 16 segments survived completely without any complications. Overall survival rate was 84%. Complete necrosis of one finger tip segment and partial necrosis of two distal amputated segments developed and subsequent surgical interventions such as groin flap, local advancement flap and skin graft were performed. The overall result was functionally and aesthetically satisfactory. Conclusion: We experienced successful replantations of multi-level amputated digits. When we encounter a multi-level amputation, the key question is whether or not it is a contraindication to replantation. Despite the demand for skillful microsurgical technique and longer operative time, the authors' results prove it is worth attempting replantations in multi-level amputation because of the superiority in aesthetic and functional results.

Evaluation of Risk Factors to Detect Anomaly in Water Supply Networks Based on the PROMETHEE and ANP (상수도관망의 이상징후 판정을 위한 위험요소 평가 - PROMETHEE와 ANP 기법 중심으로)

  • Hong, Sung-Jun;Lee, Yong-Dae;Kim, Sheung-Kown;Kim, Joong-Hoon
    • Journal of Korea Water Resources Association
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    • v.39 no.1 s.162
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    • pp.35-46
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    • 2006
  • In this study, we proposed a layout of the integrated decision support system in order to prevent the contamination and to manage risk in water supply networks for safe and smooth water supply. We evaluated the priority of risk factors to detect anomaly in water supply networks using PROMETHEE and ANP techniques, which are applied to various Multi-Criteria Decision Making area in Europe and America. To develop the model, we selected pH, residual chlorine concentration, discharge, hydraulic pressure, electrical conductivity, turbidity, block leakage and water temperature as the key data item. We also chose pipe corrosion, pipe burst and water pollution in pipe as the criteria and then we present the results of PROMETHEE and ANP analysis. The evaluation results of the priority of risk factors in water supply networks will provide basic data to establish a contingency plan for accidents so that we can establish the specific emergency response procedures.