• Archives of Pharmacal Research
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• v.27 no.10
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• pp.1053-1059
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• 2004

$N^1$-Benzyl-4-methylbenzene-1,2-diamine (JSH-21) and its analogs were chemically synthesized and their anti-inflammatory potentials investigated. JSH-21 inhibited nitric oxide (NO) production in lipopolysaccharide (LPS)-stimulated macrophages RAW 264.7 in a dose-dependent manner, with an $IC_{50}$ value of 9.2 ${\mu}M$, where pyrrolidine dithiocarbamate and parthenolide as positive controls exhibited $IC_{50}$ values of 29.3 and 3.6 ${\mu}M$, respectively. The inhibitory effect of JSH-21 on the NO production was attributable to its down-regulatory action on LPS-inducible NO synthase (iNOS), which was documented by iNOS promoter activity. In the mechanism of the anti-inflammatory action, JSH-21 exhibited inhibitory effects on LPS-induced DNA binding activity and transcriptional activity of nuclear factor-kappa B (NF-$_KB$). Structural analogs of JSH-21 also inhibited both the LPS-induced NO production and NF-$_KB$). transcriptional activity, where diamine substitution at positions 1 and 2 of JSH-21 seems to play an important role in the anti-inflammatory activity.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.16 no.9
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• pp.6254-6259
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• 2015

On the optical system and the system itself of the noise of the noise from the outside always present. This noise is to function as reducing performance of the optical system. Therefore, the probability of error, thereby changing the system. In this paper, the error probability of the optical system due to changes in various values by introducing the characteristic variable the value of the optical system was calculated using the ${\kappa}$-square method. Was confirmed also in accordance with the calculation result is an error probability of the optical system changes, it was confirmed that when the value of the holding case for holding the standard about 400 Lux on the probability of the optical system. This case was found to be an optical system using a light source with a low output, so that means the smaller output is no problem to maintain the error probability value of the optical system is large. This means that more effective and less expensive to implement because it means that the optical system does not require the use of pre-amplifier for amplifying the signal at the receiving end of an optical system using a light source with a low output when the normal case.

• Clinical and Experimental Reproductive Medicine
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• v.48 no.3
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• pp.211-220
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• 2021

Objective: The present study aimed to investigate the possibility that curcumin (CMN) protects against methotrexate (MTX)-induced testicular damage by affecting the phospho-p38 (p-p38) mitogen-activated protein kinase (MAPK) and nuclear factor-kappa B (NF-κB) signaling pathways. Methods: Eighteen male Wistar albino rats were randomly divided into three groups. The control group was given an intragastric administration of dimethyl sulfoxide (DMSO) daily for 14 days, the MTX group was given a single intraperitoneal dose of MTX (20 mg/kg) on the 11th day, and the MTX+CMN group was given intragastric CMN (100 mg/kg/day, dissolved in DMSO) for 14 days and a single intraperitoneal dose of MTX (20 mg/kg) on the 11th day. At the end of the experiment, all animals were sacrificed and the testicular tissues were removed for morphometry, histology, and immunohistochemistry. Body and testicular weights were measured. Results: Body weights, seminiferous tubule diameter, and germinal epithelium height significantly decreased in the MTX group compared to the control group. Whereas, the number of histologically damaged seminiferous tubules and interstitial space width significantly increased in the MTX group. In addition, the number of p-p38 MAPK immunopositive cells and the immunoreactivity of NF-κB also increased in the MTX group compared to the control group. CMN improved loss of body weight, morphometric values, and histological damage due to MTX. CMN also reduced the number of p-p38 MAPK immunopositive cells and the NF-κB immunoreactivity. Conclusion: CMN may reduce MTX-induced testicular damage by suppressing the p38 MAPK and NF-κB signaling pathways.

• International Journal of Computer Science & Network Security
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• v.22 no.4
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• pp.193-202
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• 2022

The classification of hyperspectral imagery (HSI) is essential in the surface of earth observation. Due to the continuous large number of bands, HSI data provide rich information about the object of study; however, it suffers from the curse of dimensionality. Dimensionality reduction is an essential aspect of Machine learning classification. The algorithms based on feature extraction can overcome the data dimensionality issue, thereby allowing the classifiers to utilize comprehensive models to reduce computational costs. This paper assesses and compares two HSI classification techniques. The first is based on the Joint Spatial-Spectral Stacked Autoencoder (JSSSA) method, the second is based on a shallow Artificial Neural Network (SNN), and the third is used the SVM model. The performance of the JSSSA technique is better than the SNN classification technique based on the overall accuracy and Kappa coefficient values. We observed that the JSSSA based method surpasses the SNN technique with an overall accuracy of 96.13% and Kappa coefficient value of 0.95. SNN also achieved a good accuracy of 92.40% and a Kappa coefficient value of 0.90, and SVM achieved an accuracy of 82.87%. The current study suggests that both JSSSA and SNN based techniques prove to be efficient methods for hyperspectral classification of snow features. This work classified the labeled/ground-truth datasets of snow in multiple classes. The labeled/ground-truth data can be valuable for applying deep neural networks such as CNN, hybrid CNN, RNN for glaciology, and snow-related hazard applications.

• Korean Journal of Remote Sensing
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• v.39 no.5_2
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• pp.837-847
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• 2023

In this study, we explored a method for assessing the extent of damage caused by chemical substances at an accident site through the use of a vegetation index. Data collection involved the deployment of two different drone types, and the damaged area was determined using photogrammetry technology from the 3D point cloud data. To create a vegetation index image, we utilized spectral band data from a multi-spectral sensor to generate an orthoimage. Subsequently, we conducted statistical analyses of the accident site with respect to the damaged area using a predefined threshold value. The Kappa values for the vegetation index, based on the near-infrared band and the green band, were found to be 0.79 and 0.76, respectively. These results suggest that the vegetation index-based approach for analyzing damage areas can be effectively applied in investigations of chemical accidents.

• Journal of Korean Academy of Fundamentals of Nursing
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• v.24 no.3
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• pp.189-199
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• 2017

Purpose: This study was conducted to examine the level of agreement between a standardized patient (SP) and a faculty member in the evaluation of nursing students' assessment and communication skills. Methods: Participants were 51 third year nursing students in a simulation practice of 'nursing care for a patient admitted with chest pain'. Using a 30-item checklist and a 16-item communication tool, a SP and faculty member evaluated the students' assessment and communication skills during the simulation. Results: The average values for percent agreement and kappa statistic for nursing assessment between the two evaluators were 85.3% and .48 respectively. Twenty of thirty items evaluating assessment skill had above moderate agreement (${\geq}.41$) by kappa between the evaluators. Seven of sixteen items evaluating communication and interpersonal skills showed above fair agreement (${\geq}.40$) between the two evaluators, which was measured by intraclass correlation coefficient. Conclusion: The findings show that the evaluation of the SP was consistent with those of the faculty member to a moderate degree. Clear guidelines for evaluating criteria and optimal time and effort for SP training are necessary to increase the reliability of standardized patients as evaluators in simulation-based nursing education.

• Physical Therapy Korea
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• v.15 no.4
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• pp.87-96
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• 2008

The purpose of this study was to establish the reliability of the Trunk Impairment Scale (TIS) translated into Korea in patients with stroke. It also aims to score the quality of trunk movement and to be a tool for the treatment. The TIS consists of three subscales that static sitting balance, dynamic sitting balance and co-ordination. The TIS score ranges from a minimum of 0 to a maximum of 23. Twenty-five stroke patients (13 males, 12 females) were examined by two physiotherapists. Interrater and test-retest reliability were assessed. Kappa and weighted kappa values for the items of the trunk assessment of the TIS ranged from .67 to 1.00. Intraclass correlation coefficients for interrater and test-retest agreement were .95 and .97. Cronbach alpha coefficients for internal consistency range from .87 to .97. The TIS provide reliable assessments for the trunk and are valid scales for measuring trunk performance in patients with stroke. TIS can be used as a guideline for treatment and the assessment of quality of trunk activity.

• Preventive Nutrition and Food Science
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• v.19 no.2
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• pp.89-97
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• 2014

Broccoli (Brassica oleracea var. italia) florets were extracted with 80% methanol and the extract was sequentially fractionated with n-hexane, ethyl acetate, n-butanol, and distilled water. The extract and the fractions were evaluated for total phenolic content, sulforaphane content, antioxidant activity, and anti-inflammatory activity in lipopolysaccharide (LPS)-stimulated RAW 264.7 cells. The total phenolic content and sulforaphane content of the ethyl acetate fraction (EF) were 35.5 mg gallic acid equivalents/g and $620.2{\mu}g/g$, respectively. These values were higher than those of the 80% methanol extract and organic solvent fractions. The oxygen radical absorbance capacity of the EF [$1,588.7{\mu}M$ Trolox equivalents (TE)/mg] was 11-fold higher than that of the distilled water fraction ($143.7{\mu}M\;TE/mg$). The EF inhibited nitric oxide release from LPS-stimulated RAW 264.7 cells in a dose-dependent manner and inhibited $I{\kappa}B-{\alpha}$ degradation and nuclear factor-${\kappa}B$ activation in LPS-stimulated RAW 264.7 cells. In conclusion, the EF of broccoli florets exerted potent antioxidant and anti-inflammatory effects.

• Journal of the East Asian Society of Dietary Life
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• v.10 no.3
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• pp.245-251
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• 2000

This study was conducted to investigate the influence of different nutrient databases in estimating nutrient intake. A nutrient survey with Food Frequency Questionnaire containing 65 food items was conducted with 2,426 subjects over 30 years of age living in Yeonchon-gun, Kyungki province. The nutrient intakes were first estimated by using one (A) nutrient database which was based on the Korean Food Composition Table, 4th edition. With the other (B) nutrient database which was based on the Korean RDA(Recommended Dietary Allowances) 6th edition, it was reestimated and two resu1ts were compared. For most nutrients except carbohydrate, calcium, vitamin C and $eta$-carotene, mean nutrient intake level estimated from database B was significantly higher than that from database A(p<0.05). Mean intake level of most nutrients from two databases were significantly correlated by Pearson's correlation coefficients(p<0.001). Results from the ranking of nutrient intake levels of the subjects by two databases were highly correlated ( P >0.9, p<0.001). Weighted kappa values representing measures of agreement ranged from 0.55 databases ranged from 45% for vitamin C to 96% for carbohydrate. This result implies that different nutrient database may produce substantial differences in estimating the absolute nutrient intake but may not be crucial in ranking or classifying individuals with regard to specific nutrient intake.

• Ocean and Polar Research
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• v.34 no.2
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• pp.265-273
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• 2012

A new algorithm was developed, not only to detect the existence of a thermocline, but also to extract the thermocline parameters (such as thermocline thickness, mixed layer thickness, maximum temperature gradient, and temperature difference of thermocline), using the vertical profile of water temperature. According to Kappa analysis, in order to find adequate threshold values of vertical water temperature gradients ${\Delta}T$ ($^{\circ}C/m$), agreement and reliability were 87% and 0.74 respectively, in the conditions of maximum ${\Delta}T{\geq}0.5$ and surface and bottom layers ${\Delta}T<{\mid}0.2{\mid}$. Also, three different kinds of methods, viz. 1. Gradient method, 2. Hyperbolic tangent method, and 3. Differential hyperbolic tangent method, were tested to extract the key parameters of a thermocline. Comparing the results of three different methods, the differential hyperbolic tangent method was the most appropriate to extract the start and end point of a thermocline curve.