• Molecules and Cells
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• v.39 no.4
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• pp.286-291
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• 2016

Epstein-Barr virus (EBV) is the prototypical ${\gamma}$-herpesvirus and an obligate human pathogen that infects mainly epithelial cells and B cells, which can result in malignancies. EBV infects these target cells by fusing with the viral and cellular lipid bilayer membranes using multiple viral factors and host receptor(s) thus exhibiting a unique complexity in its entry machinery. To enter epithelial cells, EBV requires minimally the conserved core fusion machinery comprised of the glycoproteins gH/gL acting as the receptor-binding complex and gB as the fusogen. EBV can enter B cells using gp42, which binds tightly to gH/gL and interacts with host HLA class II, activating fusion. Previously, we published the individual crystal structures of EBV entry factors, such as gH/gL and gp42, the EBV/host receptor complex, gp42/HLA-DR1, and the fusion protein EBV gB in a postfusion conformation, which allowed us to identify structural determinants and regions critical for receptor-binding and membrane fusion. Recently, we reported different low resolution models of the EBV B cell entry triggering complex (gHgL/gp42/HLA class II) in "open" and "closed" states based on negative-stain single particle electron microscopy, which provide further mechanistic insights. This review summarizes the current knowledge of these key players in EBV entry and how their structures impact receptor-binding and the triggering of gB-mediated fusion.

• Molecules and Cells
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• v.39 no.6
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• pp.447-459
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• 2016

Many studies have been conducted to understand plant stress responses to salinity because irrigation-dependent salt accumulation compromises crop productivity and also to understand the mechanism through which some plants thrive under saline conditions. As mechanistic understanding has increased during the last decades, discovery-oriented approaches have begun to identify genetic determinants of salt tolerance. In addition to osmolytes, osmoprotectants, radical detoxification, ion transport systems, and changes in hormone levels and hormone-guided communications, the Salt Overly Sensitive (SOS) pathway has emerged to be a major defense mechanism. However, the mechanism by which the components of the SOS pathway are integrated to ultimately orchestrate plant-wide tolerance to salinity stress remains unclear. A higher-level control mechanism has recently emerged as a result of recognizing the involvement of GIGANTEA (GI), a protein involved in maintaining the plant circadian clock and control switch in flowering. The loss of GI function confers high tolerance to salt stress via its interaction with the components of the SOS pathway. The mechanism underlying this observation indicates the association between GI and the SOS pathway and thus, given the key influence of the circadian clock and the pathway on photoperiodic flowering, the association between GI and SOS can regulate growth and stress tolerance. In this review, we will analyze the components of the SOS pathways, with emphasis on the integration of components recognized as hallmarks of a halophytic lifestyle.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.16 no.11
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• pp.7690-7697
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• 2015

This study is to reveal structural causal relationship of individual factors influencing association member's substantive payment in the economic view which is a critical factor of project implementation and identify its influence through simulation and actual proof analysis. As the results of analysis, the first, association member's substantive payment is decided to allow for the difference between special price for association members and general price and the profit arising between the time of approval of disposal plan and moving in. The second, on analysis of sensitivity of individual factors influencing association member's substantive payment, floor area ratio applied to project has the biggest influence. Association member's payment is also greatly influenced by the subject of cost allocation for establishing infrastructure in project area. The third, this study set up a structure model based on causal relationship among the factors deciding association member's payment and empirically examined influence and path of influence which the individual factors exercise. The result indicates that control elements and regional characteristic elements influence association member's payment through the medium of plan elements.

• The Journal of the Korea Contents Association
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• v.15 no.8
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• pp.481-494
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• 2015

Recently mobile application providers and telecommunication companies went through a difficult time in a highly competitive mobile and its application market where we've seen a huge trend for diverse mobile applications occurring on smart phone. If there were a time when those of companies need to analyze factors affecting users' intention to download or recommend others applications more than ever, it is now. Based on UTAUT model, this research is to provide them with strategic implications by analyzing those factors according to application types with utilization and hedonic values. As a result, firstly trust and personalization have positive impact on Performance Expectancy and users' intention to use have been significantly affected by Performance Expectancy and Effort Expectancy. Secondly the result of path analysis has a different outcome according to application types with utilization and hedonic values. Therefore it is expected that the research gives practical and strategic implication for application developer, mobile companies and others helping application development, new service launch and marketing implementation.

• Journal of Information Science Theory and Practice
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• v.4 no.4
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• pp.49-63
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• 2016

The emergence of the World Wide Web (WWW) has changed the scholarly publishing system. Today, Open Access (OA) scholarly publishing offers free access and wide dissemination for research findings anytime and anywhere as an additional value for scholarly content. Despite the potentials of OA publishing, its adoption and use is still low.This paper determines factors influencing the adoption and use of OA publishing by academic staff in universities in Nigeria using an adapted Unified Theory of Acceptance and Use Technology (UTAUT). The study applies methodological triangulation by combining quantitative and qualitative approaches. The empirical data were collected from 317 academic staff in universities in southwest Nigeria. The questionnaire forms were analyzed using the Statistical Package for Social Sciences (IBM-SPSS) 19.0 version to generate descriptive statistics, Analysis of Variance, and Hierarchical Multiple Regression. Thematically, analysis also applies to the interviews. The results show that awareness, attitude, performance expectancy, Internet self-efficacy, and facilitating conditions significantly influenced the adoption and use of OA publishing. The study also reveals that due to lack of OA policy, most of the respondents did not know about OA. The findings further establish that all predictors and moderating variables jointly contributed 64.4% total variance towards the adoption and use of OA publishing. One of the implications of this study is that there is a need for adequate facilities to support adoption and use of OA publishing. The findings inform the proposed framework for improving and evaluating the adoption and use of OA publishing. The findings also have theoretical, societal, and methodological significance to all stakeholders.

• Journal of Korean Society of Rural Planning
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• v.26 no.4
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• pp.15-26
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• 2020

Although the demand and awareness of public regarding social-cultural functions of agriculture and rural areas would increase recently, the sustainability of them has continuously decreased. To derive policy directions for improvements of social-cultural functions of agriculture and rural areas, This study analyzed willingness to pay for social-cultural functions of agriculture and rural areas and its determinants by uisng contigent valuation method. The results show that the willingness to pay for social-cultural functions of agriculture and rural areas is positively affected by awareness of the importance of agriculture, interest in problems regarding agriculture in Korea, awareness of social functions of agriculture, and experience in rural life. These results would imply that policies for the improvement of public awareness and experiences increase the value of social-cultural functions of agriculture and rural areas. In addition, the results imply that more diverse education programs and activities are required in order to change awareness of future generations in response to decreases in population having experiences in agriculture and rural life due to urbanization. Lastly, the results show that the average willingness to pay for social-cultural functions of agriculture and rural areas is about 35,600 won, and total willingness to pay for social-cultural functions of agriculture and rural areas is about 998.3 billion won. This is much larger than the government budget on enhancement of social-cultural functions of agriculture and rural areas in 2019. This difference between government budget and the total willingness to pay implies that Korean government would be required more positive policies to maintain and enhance social-cultural functions of agriculture and rural areas.

• Korea journal of population studies
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• v.17 no.2
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• pp.77-97
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• 1994

Despite the fact that the national family planning program in korea has accomplished its primary goals of fertility reduction and universal contraceptive use, the induced abortion is still high and there has been an increasing trend in the population sex ratio at birth. It seems that the changes in the imbalance of sex ratio have originated from traditonal boy preference. This indicates that much of the current family planning program can be overhauled, so that the program quality could be better controlled, by preventing the number of unwanted pregnancies and the imbalance of sex ratios. This paper aims, therefore, to examine the determinants of induced abortion through the investigation of pregnancy outcomes and their changes over time and to study the interaction between induced abortion, boy preference and the imbalance of sex ratio in Korea. The abortion rate had increased rapidly until the mid-1980s when there were about the same number of abortions as live births. Thereafter, the abortion rate has been maintained at this high level. By parity it shows a much higher abortion rate for a higher parity at all time. From the first parity, the sex composition of previous children stands out as the most important factor in deciding the pregnancy outcome at all time. The probability of a pregnancy ending in an abortion increases substantially when parents already had a son. The decline of the desired family size and the sustained strong son preference has made the sex of children a more important factor in the determination of the pregnancy outcome. Women's education has had consistently positive effects on the probability of a pregnancy ending in an abortion, but the effect shows a steady decline over time. The premarital pregnancy and urban residence also increase the abortion probability. This study suggests that the main concerns of the family planning program should be to strengthen the social support policies so as to weaken the son preference value leading to a balanced sex ratio and prevention of induced abortions.

• Journal of Korea Society of Industrial Information Systems
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• v.5 no.3
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• pp.1-9
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• 2000

Computer-based systems operating between two or more co-operating organizations as part of their business relationship are genera11y referred to as inter-organizational systems(IOS). IOS automate aspects of transactional work between organizations and coordinate other activities. Consequently, the design, construction and maintenance of IOS require substantial planning and sensitivity to these broader issues. This paper demonstrates that IOS planning is still in its infancy, though there is widespread agreement as to the desired results from IOS planning and how it should be conducted. In general, there is an over-reliance on traditional information systems planning approaches and the majority of organizations experience difficulties with IOS planning.

• The Journal of the Korea Contents Association
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• v.15 no.10
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• pp.481-494
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• 2015

The objective of this study is to verify the correlations among design quality of domestic internet fashion shopping mall and relations to specific shopping malls, and shopping mall users' intention to continue the relations. The main results were withdrawn as follows. First, it was found that some factors of internet fashion shopping mall design quality had significant positive influences on the qualities of relationship to users such as reliability, satisfaction and devotion. Second, it was found that all components of quality of customer relationship to internet fashion shopping mall such as reliability, satisfaction and devotion had significant positive influence on their intention to continue relations to the internet shopping mall. Third, graphic and multimedia quality of internet fashion shopping mall design components had significant positive influences on internet fashion shopping mall users' intention to continue relationship to the shopping mall. Empirical study of qualities on the relationship between internet fashion shopping mall design quality and its users, their intention to repurchase or recommend goods from the mall would be very valuable in a management point of view of small internet fashion shopping mall.

• Proceedings of the Korea Water Resources Association Conference
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• 2017.05a
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• pp.518-518
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• 2017

Since Korea lunched the 4 Major River Restoration Project, the hydrological regime which is one of the major determinants for riverine condition have actually changed. It also important to connect hydrological characteristics and vegetation. The objective of this study is to investigate the influence of hydrological regime on riverine vegetations and its successions. Iunundated exceedance probability concept are suggested to estimate rehabilitated and succession on the Binae island in the Han River. The result shows that the P=0.08 or lower IEPs should have the disturbance for vegetations, or should be changed to a hydrophilic ones. Therefore, agency which is mainly responsible for river and flow may have to be changed and considered flow regulation standard to conserve riverine zone.