• 생명과학회지
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• 제18권1호
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• pp.96-102
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• 2008

이상의 연구 결과에 의하면 piceatannol의 처리에 의한 U937 세포의 증식억제는 세포주기 S기 arrest 및 apoptosis 유발과 뚜렷한 연관성이 있었다. 또한 piceatannol은 hTERT 및 TEP-1 유전자의 발현 저하와 연관된 telomerase 활성의 저하 효과도 나타내었으나, COXs의 발현 및 PGE2의 생성에는 큰 변화를 주지 못하였다. 따라서 본 연구의 결과는 암세포에서 높게 발현되는 telomerase 활성 조절제로서 piceatannol의 적용이 가능함을 보여주며, 이는 piceatannol의 항암작용을 이해하는데 매우 유용한 자료라 생각한다.

• 미생물학회지
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• 제36권2호
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• pp.136-141
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• 2000

소양호에서 수온, 엽록소$\alpha$, pH 그리고 DOC의 농도가 세균군집에 미치는 영향을 파악하였다. 이 연구에서는 fluorescent in situ hybridization(FISH) 방법을 사용하기 1998년 4월부터 5월까지 세균군집구조를 조사하였고 이 시기 환경요인과 세균군집간의 상관성 분석을 실시하기 위해 수온, 엽록체$\alpha$, pH, DOC의 측정도 함께 수행하였다. 또한 환경요인과 세균군집간의 상관성 분석을 실시하기 위해 통계프로그램(SPSS)을 이용하였다. 그 결과 소양호에서 DOC, 엽록체$\alpha$, pH와 온도가 다중선형희귀직선상 설명가능정도가 약 43~58%정도로 나타났으며, 세균군집변화의 약 50%정도가 본 조사 이외의 환경요인에 영향을 받은 것으로 나타났다. $\alpha$-group은 DOC가 증가할수록 감소하여 DOC와 음의 상관관계를 보였고 , ${\gamma}$-group은 엽록소 $\alpha$농도와 음의 상관관계를 나타내었다. $\beta$-Cytophaga-Flavobacterium group 의 경우 수온과 뚜렷한 양의 상관성이 있는 것으로 나타났다. 또한 $\alpha$-group과 Cytophaga-Flavobacterium group은 pH와 양의 상관관계를 보였다. 이처럼 소양호의 세균군집은 계절에 따른 여러 가지 수 환경요인의 변화에 의해 다양하게 변화하였다.

• 한국언론정보학보
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• 제46권
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• pp.9-36
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• 2009

본 연구는 IPTV-VOD 서비스의 선택에 영향을 주는 요인들을 밝히고, 기존 다채널 유료TV와 IPTV-VOD 서비스 간에 대체 혹은 보완 관계가 있는지의 여부를 분석하였다. 연구결과, VOD 형식으로 제공되는 IPTV-VOD 서비스는 기존의 유료방송서비스와 콘텐츠에 있어서 큰 차별성을 보이고 있지 않으나, IPTV-VOD 서비스의 이용자들은 IPTV-VOD 서비스가 가지고 있는 양방향 서비스 특성들 - 능동적으로 선택할 수 있고, 시청시 중단, 되돌리기, 다시보기 등 - 을 이용하여 이용시간을 스스로 선택하여 기존 유료방송과는 다른 양방향적 특성들을 즐기면서 시청하고 있는 것으로 나타났다. 또한 이미 케이블/위성 서비스에 가입한 이용자와 가입하지 않은 이용자 간에 IPTV를 선택할 확률이 실시간 지상파방송 등 다른 요인들이 통제된 상태에서 차이가 나타났기 때문에 두 서비스가 어느 정도의 대체성을 가지고 있음을 예측할 수 있다.

• 산업경영시스템학회지
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• 제43권3호
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• pp.29-40
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• 2020

Korean firms have been vigorously searching and exploring overseas market opportunities through export and overseas investment. As of end of 2019, there were more than 80,000 Korean overseas subsidiaries all over the world. With Korean overseas direct investment increasing recently, it became one of the important issues for overseas investors to be successful in the global market. There are a lot of studies on factors influencing the performance of overseas subsidiaries such as 'firm' and 'country' factors. This study empirically examines subsidiary performance determinants with 'industry architectures' by using a sample of 292 overseas Korean firm subsidiaries. Industry architectures are the stable but evolving sets of rules and roles through which labor is divided within a sector. This article considers how industry architectures shape success in international expansion. Industry architectures differ between countries, are not necessarily technologically determined, shape firms' capabilities and their competitive environment, and constitute a distinct level of analysis. We extract antecedents of related theory and empirically test its impact with a survey of Korean firms expanding in emerging economies. We would say this is the first study which tries to focus on industry architectures with the performance of Korean overseas subsidiaries. We find that separability and similarity of industry architectures across countries and localization of subsidiaries are robust and important predictors of success in international expansion. Our results suggest that industry architectures should be added to firm and country as an intermediate level of analysis that helps explain success in international expansion. While we established a pattern, much more remains to be done. We focus on the success of foreign operations, but we do not consider the broader benefits of going abroad, such as the learning or network effects that accrue at the level of the entire firm. The next obvious question is whether the results would differ in the developed market context. These we leave for future research to consider.

• 한국병원경영학회지
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• 제14권2호
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• pp.1-20
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• 2009

The purpose of this study is to find the determinant variables to make profitability in regional public hospitals. The data come from financial statements and annual reports of 34 regional public hospitals for five years (from year 2003 to year 2007). The T or F-test and hierarchical multiple regression analysis are used. The dependant variables are the profitability indicators, ordinary income to total asset and operating margin to gross revenue, and the independent variables are general characteristics, diagnosis and treatment patterns, financial and public benefits. The findings of this study are summarized as follows. First, Variables affecting the profitability indexes revealed from DEA results is the bed occupancy rate, number of hospitalized patients to outpatients, ratio of first medical examination for outpatients, number of daily patients per medical specialist, labor cost per patient and managerial expenses per patient. Second, the ordinary income to total asset representing the asset usage performance is affected by the average hospitalized days, bed occupancy rate, labor cost per patient and ratio of patients with medical insurance coverage. Third, the operating martin to gross revenue obtained from the actual operations of hospitals has its significance with the bed occupancy rate, number of hospitalized patients to outpatients, managerial expenses per patient and public benefit indicator. This study has some restriction not to use pannel data analysis, although it used data for five years. Accordingly, various additional studies should be done to supplement such problems.

• 보건교육건강증진학회지
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• 제30권5호
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• pp.61-77
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• 2013

Objectives: The purpose of this study was to evaluate program methods for effective smoking cessation and prevention through systematic review of studies published during recent 3 years in Korea. Methods: Electronic searches were conducted in DBPIA, RISS, KISS and other databases looking for studies published from 2010 to 2012 that dealt with the effects of intervention on smoking prevention and cessation. A total of 25 studies were included in the final analysis. Three independent reviewers critically evaluated the study quality and evidence of effectiveness based on The Community Guide methodology. Results: Multi-component intervention showed strong evidence of effectiveness for adolescents and sufficient evidence for patient smokers. Cognitive-behavioral intervention for adolescents and child-parent interaction program for adults demonstrated sufficient evidence of effectiveness on the smoking cessation and its determinants. There was insufficient evidence showing effectiveness of smoking prevention programs. Conclusion: Improving the quality and quantity of the intervention studies on smoking could help to expand evidence base for effective intervention methods and strategies on smoking.

• 농업과학연구
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• 제39권4호
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• pp.477-482
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• 2012

Low-temperature germination is one of the major determinants for stable stand establishment in the rice direct seeding method in temperate regions and at high altitude areas. Quantitative trait loci (QTL) controlling low-temperature germinability in rice were identified using 96 introgression lines (ILs) derived from a cross between Oryza rufipogon and the Korean japonica cultivar, 'Hwaseongbyeo'. The germination rate at $15^{\circ}C$ was measured to represent low-temperature germination and used for QTL analysis. The germination rate at $15^{\circ}C$ for 7 days of Oryza rufipogon and Hwaseongbyeo was 93.3 and 28.7%, respectively, and that of progenies ranged from 0 to 48%. A linkage map was constructed using 135 simple sequence repeat (SSR) markers. Five putative QTLs associated with low-temperature germination were detected on chromosomes 1, 3, 4, 10 and 11. The QTL, qltg10 on chromosome 10 accounted for 19.2% of the total phenotypic variation for low-temperature germinability. Four additional QTL, accounted for 10.4 - 15.1% of the total phenotypic variation. The O. rufipogon alleles in all detected QTLs loci increased the low-temperature germination rate. No QTL associated with low temperature germinability has been detected near the qltg10 QTL in this study suggesting that qltg10 is a new QTL. The locus, qltg10 is of particular interest because of its independence from undesirable height and maturity effects. The DNA markers linked to the QTL for low temperature germinability would be useful in selecting lines with enhanced low temperature germinability in rice breeding program.

• Investigative Magnetic Resonance Imaging
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• 제22권2호
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• pp.79-85
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• 2018

Purpose: To determine the impact of pseudoglandular formation on apparent diffusion coefficient (ADC) values of hepatocellular carcinoma (HCC) in diffusion-weighted imaging (DWI), and to validate the results using histopathological grades. Materials and Methods: We assessed 182 HCCs surgically resected from 169 consecutive patients. Each type of tumor pseudoglandular formation was categorized into "non-," "mixed-," or "pure-," based on official histopathology reports. The ADC for each tumor was independently measured, using the largest region of interest on the ADC map. Data were assessed using the analysis of variance test, with Bonferroni correction for post hoc analysis to stratify the relationship of ADCs with pseudoglandular formation, followed by subgroup analysis according to the histopathological tumor grades. Results: The mean ADC was significantly higher in pure pseudoglandular lesions (n = 5, $1.29{\pm}0.08{\times}10^{-3}mm^2/s$) than in non-pseudoglandular lesions (n = 132, $1.08{\pm}0.17{\times}10^{-3}mm^2/s$; P = 0.003) or mixed-pseudoglandular lesions (n = 45, $1.16{\pm}0.24{\times}10^{-3}mm^2/s$; P = 0.034). The ADC values and pseudoglandular formation were significantly correlated in moderately differentiated HCCs (n = 103; r = 0.307, P = 0.007), while well- (n = 19) and poorly-differentiated HCCs (n = 60) did not show significant correlation (r = 0.105 and 0.068, respectively; P = 0.600 and 0.685, respectively). Conclusion: The degree of pseudoglandular formation could be one of the determinants of ADC in DWI of HCCs-especially moderately differentiated HCCs-while its influence does not appear to be significant in well- or poorly differentiated HCCs.

• 대한간호학회지
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• 제43권1호
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• pp.39-49
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• 2013

Purpose: To analyze the structure of Korean nurse labor market and examine its effect on hospital nurse staffing. Methods: Secondary data were obtained from Statistics Korea, Education Statistics, and Health Insurance Review & Assessment Service and Patient Survey. Intensity of monopsony in the nurse labor market was measured by Herfindahl Hirshman Index (HHI). Hospital nurse staffing level was divided into high and low. While controlling for confounding factors such as inpatient days and severity mix of patients, effects of characteristics of nurse labor markets on nurse staffing levels were examined using multi-level logistic regressions. Results: For characteristics of nurse labor markets, metropolitan areas had high intensity of monopsony, while the capital area had competitive labor market and the unemployed nurse rate was higher than other areas. Among hospital characteristics, bed occupancy rate was significantly associated with nurse staffing levels. Among characteristics of nurse labor markets, the effect of HHI was indeterminable. Conclusion: The Korean nurse labor market has different structure between the capital and other metropolitan areas. But the effect of the structure of nurse labor market on nurse staffing levels is indeterminable. Characteristics such as occupancy rate and number of beds are significantly associated with nurse staffing levels. Further study in support of the effect of nurse labor market is needed.

• 한국간호교육학회지
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• 제10권1호
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• pp.139-148
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• 2004

Purpose of this study was determining predictor variables of Korean nurses' intention to educate clients and their significant others using the theory of planned behavior (TPB). Nurses working in health institutions (N=221) were conveniently selected from 2 RN-BSN programs and 2 hospitals in Seoul and Kyunggi-Do. A packet of questionnaires was developed according to the guidelines of the TPB. Multiple regression and Pearson product coefficients were used to analyze the data. Korean nurses showed positive intention to education their patients. They also showed positive attitude toward the patients education while perceived strong social pressure of teaching the patients. Attitude, subjective norms and perceived behavioral control were the predictors of the intention as the theory proposed. Especially the perceived behavioral control was the best predictors among them. Time to prepare themselves for the patient education; high self-esteem as a teacher; a perception that patients want nurses as a resource person; and the quality of information that nurse perceived they had were the predictors among the perceived behavioral control variables. Three recommendation were identified for the effective patient education. Nurses should be prepared to teach patients in their nursing school so that they have self-esteem as a competent teacher. The professional patient educators who are well-prepared for educating patients and their family are strongly recommended. Finally, development of a patient education center in the health institution were also recommended for its quality control.