• Asia-Pacific Journal of Business Venturing and Entrepreneurship
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• v.8 no.1
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• pp.111-125
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• 2013

This study is to find out that how the personal, collective, and organizational learning method three learning organization affect the job satisfaction, organizational commitment, and innovative action through the questionnaire of company members, and to verify the moderating effects of shared values in this relation. The results show that three learning organization have a positive effect on the job satisfaction, and a partial effect on organizational commitment and innovative action, and shared values influence positively on the job satisfaction, organizational commitment, and innovative action. The moderating effects of shared values in the relation between three learning organization and Organizational Effectiveness are as follows : First, shared values can moderating the influence of collective and organizational learning organization on the job satisfaction, but can't moderating the relation between a personal learning method and the job satisfaction. Second, shared values can moderating the influence of collective and organizational learning organization on the organizational commitment, but can't moderating the relation between a personal learning method and the organization commitment. Third, shared values can moderating the influence of personal and organizational learning organization on the innovative action, but can't moderating the relation between the collective learning method and the innovative action.

• The Journal of the Korea Contents Association
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• v.15 no.1
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• pp.451-461
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• 2015

The objective of this research is investigating the mediating effect of job engagement on the relationship between job autonomy and innovative behavior in public organizations. Major findings from Structural Equation Model analysis demonstrates that the variable 'job engagement' took a positive role between job autonomy and innovative behavior. From theoretical point, this result provides the empirical evidence of causal relationship in the three components of attitude-cognition, emotion, and action, which contributes to the advancement of action theory. Some policy implications can be drawn from the empirical findings. Firstly, job autonomy need to be seriously considered as a strategic instrument for the encouragement of innovative behavior. Secondly, job engagement of employees need to be more carefully monitored to stimulate the innovative behavior in the public organizations. In public organizations, enhancement of innovative behavior can not be achieved from institutional arrangements. Provision of job autonomy is more effective method of behavior change than performance management approach.

• Journal of Distribution Science
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• v.19 no.9
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• pp.53-64
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• 2021

Purpose: The current study aims and reviews the current state of research in green awareness' distribution structure using the ecological theory of Ted Hughes who was regarded as one of the best English poets of the 20 century. Ted poetry has innovated ecological distribution. It has inspired so many young people to have a positive energy impact on the environment. Research design, data and methodology: Action research design is an approach used extensively in qualitative content analysis. This design starts by adopting an exploratory claim that develops the research objectives, hence instigating the action process, which involves several strategies. This type of design involves a cyclic process of stance then action. Results: According to the investigation, there are nine solutions that can deal with the green distribution based on previous literature review, applying an ecological approach of Ted Hughes to green awareness distribution. The solutions figured out that Ted's novels had an innovative impact on the environment as it is clear that information is given to society. Conclusions: It is observed that having a highly professional environment is good enough for a structure to go green. But, on the other hand, polluting our environment can endanger species by causing health diseases and environmental problems.

• Asia-Pacific Journal of Business Venturing and Entrepreneurship
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• v.11 no.3
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• pp.199-208
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• 2016

In this study, We tried to investigate the relationship between the Caregiver's Autonomy of duty and the Their innovation action at the present situation of awareness diffusion of caregiver's job autonomy and rapid aging increasing. We analyzed the factors effected to the innovative action by the caregiver's job autonomy and demographic factor, to the caregivers who work in Seoul. As a result of the analysis, it was found the factors that effect to innovation action statistically and significantly are job autonomy, work schedule, decision-making, methodology, age, education, type of facility, scale of facility and job title. In other words, the organization tries to invest enough job autonomy to caregiver in their environment and the organizational culture tries to encourage new idea is induct positive effect to the innovative action. In this regards, the principal requires ability to create environment that the caregivers can suggest new idea, and develop the management strategy to improve caregiver's job autonomy.

• Biomolecules & Therapeutics
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• v.31 no.3
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• pp.241-252
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• 2023

The era of innovative RNA therapies using antisense oligonucleotides (ASOs), siRNAs, and mRNAs is beginning. Since the emergence of the concept of ASOs in 1978, it took more than 20 years before they were developed into drugs for commercial use. Nine ASO drugs have been approved to date. However, they target only rare genetic diseases, and the number of chemistries and mechanisms of action of ASOs are limited. Nevertheless, ASOs are accepted as a powerful modality for next-generation medicines as they can theoretically target all disease-related RNAs, including (undruggable) protein-coding RNAs and non-coding RNAs. In addition, ASOs can not only downregulate but also upregulate gene expression through diverse mechanisms of action. This review summarizes the achievements in medicinal chemistry that enabled the translation of the ASO concept into real drugs, the molecular mechanisms of action of ASOs, the structure-activity relationship of ASO-protein binding, and the pharmacology, pharmacokinetics, and toxicology of ASOs. In addition, it discusses recent advances in medicinal chemistry in improving the therapeutic potential of ASOs by reducing their toxicity and enhancing their cellular uptake.

• Integrative Medicine Research
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• v.3 no.4
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• pp.204-210
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• 2014

The aim of this review was to understand the effects of ${\beta}$-adrenergic stimulation on oxidative stress, structural remodeling, and functional alterations in the heart and cerebral artery. Diverse stimuli activate the sympathetic nervous system, leading to increased levels of catecholamines. Long-term overstimulation of the ${\beta}$-adrenergic receptor (${\beta}AR$) in response to catecholamines causes cardiovascular diseases, including cardiac hypertrophy, stroke, coronary artery disease, and heartfailure. Although catecholamines have identical sites of action in the heart and cerebral artery, the structural and functional modifications differentially activate intracellular signaling cascades. ${\beta}AR$-stimulation can increase oxidative stress in the heart and cerebral artery, but has also been shown to induce different cytoskeletal and functional modifications by modulating various components of the ${\beta}AR$ signal transduction pathways. Stimulation of ${\beta}AR$ leads to cardiac dysfunction due to an overload of intracellular $Ca^{2+}$ in cardiomyocytes. However, this stimulation induces vascular dysfunction through disruption of actin cytoskeleton in vascular smooth muscle cells. Many studies have shown that excessive concentrations of catecholamines during stressful conditions can produce coronary spasms or arrhythmias by inducing $Ca^{2+}$-handling abnormalities and impairing energy production in mitochondria, In this article, we highlight the different fates caused by excessive oxidative stress and disruptions in the cytoskeletal proteome network in the heart and the cerebral artery in responsed to prolonged ${\beta}AR$-stimulation.

• International Journal of Computer Science & Network Security
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• v.21 no.11
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• pp.111-118
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• 2021

The authors of the study highlight the conceptual foundations of the investment mechanism of innovation of enterprises in the context of strategic development. Such indicators of investment attraction for the enterprise as investment attractiveness, investment activity of the enterprise, critical mass of investments, minimum sufficiency of investments and others are singled out. It is proved that the balance of investment resources is facilitated by the action of the investment mechanism of innovation activity at the enterprise in the context of achievements of strategic development tasks. Investment processes and their intensification have an impact on the expansion of production capacity of economic entities in strategic development and on improving the efficiency of existing capacities. The investment mechanism of innovative activity at the enterprise in the context of achievement of tasks of strategic development contains system of complex actions which provides: definition of the clear purpose and tasks for the mechanism and achievement of the purposes of the enterprise; assessment of the investment potential of the enterprise; definition of tasks of innovative development of enterprises and investment resources necessary for this purpose, etc. The tasks of the investment mechanism of innovative activity at the enterprise in the context of achievements of tasks of strategic development and its economic, organizational and information components are singled out, as well as levers of influence and regulators of the investment mechanism of innovation in the enterprise.

• Journal of Microbiology and Biotechnology
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• v.33 no.3
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• pp.288-298
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• 2023

Host defense peptides are expressed in various immune cells, including phagocytic cells and epithelial cells. These peptides selectively alter innate immune pathways in response to infections by pathogens, such as bacteria, fungi, and viruses, and modify the subsequent adaptive immune environment. Consequently, they play a wide range of roles in both innate and adaptive immune responses. These peptides are of increasing importance due to their broad-spectrum antimicrobial activity and their functions as mediators linking innate and adaptive immune responses. This review focuses on the pleiotropic biological functions and related mechanisms of action of human host defense peptides and discusses their potential clinical applications.

• Asia-Pacific Journal of Business Venturing and Entrepreneurship
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• v.11 no.2
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• pp.89-100
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• 2016

This article analyzes two different strategies that both aim at creating innovative design or problem solving: design thinking and action learning. User-driven innovation strategy that has become more and more popular during the last decades is "design thinking". Based on designerly methods and principles, this strategy was developed by the design consultancy IDEO in the late 90s. Action learning is a pragmatic and moral philosophy based on a deeply humanistic view of human potential that commits us, via experiential learning, to address the intractable problems of organizations and societies. This paper provides a structured analysis and comparison of the two innovation strategies-design thinking and action learning-with the goal to identify potentials to enrich either of the two by merging or adapting specific parts or aspects. Although there are significant differences in both strategies, there are also several similarities in methodology and process design. This article compares process models for action learning and design thinking and highlights the specific differences and similarities. As a result, we suggested a union model of action learning and design thinking, and verified a this model through a case study. We complemented the process of team building and reflection of action learning for union model. Also, we statistically verified through a case study to validate the superiority of the design thinking model which complemented action learning. This article contributes to a better understanding of both-design thinking and action learning, and it may help to improve either of the two strategies to foster social innovation.

• Journal of Agricultural Extension & Community Development
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• v.19 no.3
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• pp.551-579
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• 2012

This case study aims to explore how RDA PLA model affects the agri-SMEs' empowerment. As an agri-business management renovation program from main workshop it was conducted on March to December 2011 with agri-SMEs and extension officials nationwide by RDA. Especially, as a packaged action learning process in the model used participatory action research. This study collected data with participants observation, interviews, situational analysis and systematic review of discourse in qualitative method. For the validity and identifying empirical results, this study used statistic analysis as a mixed method. Further including various pedagogic methods and business coaching skills, this model was conducted from workshop in RDA, in turn, on-farm business coaching as follow-up, CoPs' activities, and local ATCs extension services by each actors. The dynamic process and effects of each process led some change for farmers' innovative knowledge, skills, attitude, practice and aspiration on their farm business. RDA PLA model development based on the previous practices and research, which provided a configurated picture in the holistic action learning process. In statistic research, this study focused on 279 farmers as respondents who had participated in the program. It shows that their income and benefits increased from their renovative practices on farm business. Following the sampling group, it was surveyed by four indicators - products, customer, quality and cost. The level of contribution of education on economic impact 15% is quoted from previous paper. Even in some limitations of public sector, RDA PLA model actively suggests the paradigm shift of agricultural HRD and development of alternative extension-service system.