• Korean Journal of Clinical Laboratory Science
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• v.56 no.1
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• pp.1-9
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• 2024

Exosomes are nano-sized membrane-bound extracellular vesicles containing various biological molecules, such as nucleic acids, proteins, and lipids, which can be used to modulate physiological processes. The exosomal molecules secreted by cells can be extensively used as tools for diagnosis and therapy. Exosomes carry specific molecules released by the cells they originate from, which can be transferred to surrounding cells or tissues by the exosome. For these reasons, exosomes can be exploited as biomarkers for diagnosis, carriers for drug delivery, as well as therapeutics. In stem cell technology, exosomes have been an attractive option because they can be used as safer therapeutic agents for stem cell-based cell-free therapy. Recently, studies have demonstrated the safety and efficacy of mesenchymal stem cell-derived exosomes in alleviating symptoms associated with coronavirus disease 2019 as they have anti-inflammatory and immunomodulatory potential. Performing multiple studies on exosomes would provide innovative next-generation options for clinical diagnostics and therapy. This review summarizes the use of exosomes focusing on their diverse roles. In addition, the potential of exosomes is illustrated with a focus on how exosomes can be exploited as powerful tools in the days to come.

• Spatial Information Research
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• v.2 no.1
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• pp.15-25
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• 1994

Geographical Informal ion Systems have become useful tools for improving the administrative management of local governments. Despite its innovative aspects, GIS implementation in local governments has yet to be actively carried out, utilized in only a few occasions in establishing comprehensive plans or conduct ins model system developments. This can be basically attributed to technological, institutional, and economic difficulties, that is, a lack of understanding of GIS technology, database development, and the required institutional support. Using Seoul as a case study, this study analyses the potential and effectiveness of GIS and examines strategies of implementation, thereby suggesting basic policy direct ions for GIS investment in local governments.

• Journal of the Korean Geographical Society
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• v.32 no.4
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• pp.543-548
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• 1997

New technologie of information and interaction create ambiguous, multifaceted relationships between concepts and realities that once seemed clear and simple. The acvent of cyberspace implies the existence of cyberplaces and relationships among cyberspace and places that could be as or more complex then those that exist among the spaces and places of the non-digital world. Virtual reality-the current uses of infomation technologies to create replicas of places and processes in the world-offers a point of exploring such relationships. But more penetrating insights become evident in the examination of real virtuality-the uses of information technologies to enhance the experience of places in the world. Real virtuality offers geographers a variety of innovative and powerful tools for augmenting the effectiveness and domain of their craft. Widespread use of real virtuality by geograpgers will alter their use of data, methods, and theory in research, teaching, and practice.

• Interdisciplinary Bio Central
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• v.3 no.1
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• pp.2.1-2.4
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• 2011

Arabidopsis is well-known to the world's plant research community as a model plant. Many significant resources and innovative research tools, as well as large bodies of genomic information, have been created and shared by the research community, partly explaining why so many researchers use this small plant for their research. The genome sequence of Arabidopsis was fully characterized by the end of the $20^{th}$ century. Soon afterwards, the Arabidopsis research community began a 10-year international project on the functional genomics of the species. In 2001, at the beginning of the project, the RIKEN BioResource Center (BRC) started its Arabidopsis resource project. The following year, the National BioResource Project was launched, funded by the Japanese government, and the RIKEN BRC was chosen as a core facility for Arabidopsis resource. Seeds of RIKEN Arabidopsis transposon-tagged mutant lines, activation-tagged lines, full-length cDNA over-expresser lines, and natural accessions, as well as RIKEN Arabidopsis full-length cDNA clones and T87 cells, are preserved at RIKEN BRC and distributed around the world. The major resources provided to the research community have been full-length cDNA clones and insertion mutants that are suitable for use in reverse-genetics studies. This paper provides an overview of the Arabidopsis resources made available by RIKEN BRC and examples of research that has been done by users and developers of these resources.

• Proceedings of the Korean Society for Noise and Vibration Engineering Conference
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• 2008.11a
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• pp.561-562
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• 2008

The numerical analysis of sound radiation by vibrating structure is a well known and mature technology used in many industries. Accurate methods based on the boundary or finite element method have been successfully developed over the last two decades and are now available in standard CAE tools. These methods are however known to require significant computational resources which, furthermore, very quickly increase with the frequency of interest. The low speed of most current methods is a main obstacle for a systematic use of acoustic CAE in industrial design processes. In this paper we are going to present a set of innovative techniques that significantly speed-up the calculation of acoustic radiation indicators (acoustic pressure, velocity, intensity and power; contribution vectors). The modeling is based on the well known combination of finite elements and infinite elements but also combines the following ingredients to obtain a very high performance: o a multi-frontal massively parallel sparse direct solver; o a multi-frequency solver based on the Krylov method; o the use of pellicular acoustic modes as a vector basis for representing acoustic excitations; o the numerical evaluation of Green functions related to the specific geometry of the problem under investigation. All these ingredients are embedded in the ACTRAN/AR CAE tool which provides unprecedented performance for acoustic radiation analysis. The method will be demonstrated on several applications taken from various industries.

• Journal of the Korean Society for Library and Information Science
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• v.20
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• pp.35-63
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• 1991

DDC, LCC, and CC can be said as the major schemes for mordern general library classification. Among these, DDC, since its publication in 1876, has been continuously studies and revised by many scholars and practitioners to publish 20th edition in 1989: LCC also has been studied and revised by the specialists in each subject, since 1904; and CC(first edition 1933) is now on the stage of 7th edition(1987). Even though studied, revised and developed by many classificationists, all these schemes maintain the general framework of the beginning, only with the partial revision and expansion to reflect the developments of the subjects. and antioipated tremendous amount of works resulted from reclassification also can be a reason that disturbs the full innovative revision of the scheme, because these are used in many libraries as a basic tools for the classification. But all these schemes mainly based on the state of the discipline at the time of their creation, the beginning of 20the century, and so in some aspect it is natural for them to have many problems. This study aims to investigate the problems in these major schemes, to find some ways to solve the problems, and to suggest the ideas for the basic design of a new modern library classification scheme. This plan is prepared to be applied to the situation of all countries equally without any revision. And in its notation, it uses two digits of Arabic numerals as centesimal, and so it is named provisionally to Plan for Centesimal Classification (PCC).

• Korean Institute of Interior Design Journal
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• v.26 no.2
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• pp.55-63
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• 2017

Recent projects of Japanese architect, Ito Toyo have been evolved into innovative and experimental stages that are unique and different from other contemporary architects. Since Ito established his own office in 1971, there were several critical changes and developments in terms of architectural philosophy as well as design methods. Particularly, after Sendai Mediatheque, Ito has tended to focus on creating three-dimensional organic body in which architectural form, space, structure, facilities, images are merged all together. With this new type of three-dimensional structure, Ito aims to generate a new notion of architecture as 'living organism'. This paper tried to analyze Ito's new concept of architecture, design process of three-dimensional organic body and its ultimate characteristics and meanings. For the analysis, three projects were selected: Taichung Metropolitan Opera House(2005), Berkeley Art Museum and Pacific Film Archive(2007), The New Deichman Library in Oslo(2008). These projects clearly represent several types of three-dimensional organic body. After the comparative studies, it is found that, in Ito's design process and method, there are unique characters: ambivalent relationship between plan and three-dimensional form, aiming new/hyper reality through complicated collaboration of analogue and digital design tools, and contradictory relationship with surrounding urban context. Although there are some limitations and restrictions, ever-evolving Ito's design concept and methods are very much valid and meaningful in contemporary spatial design in various perspectives.

• Journal of the Korean Society for Aviation and Aeronautics
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• v.25 no.3
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• pp.1-8
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• 2017

As many people all over the world increasingly take more time in exchanging with other people or acquiring information on the internet, use of social media becomes a part of their daily lives. A lot of changes of consumer culture, which have been occurring through social media, have significant effects on corporate marketing activities. Since social media's importance to airlines has been continuously increased, this study attempts to examine effects of passengers' uses of social media, who plan to select an airline, on dependence on reliance of electronic word-of mouth(EWOM) and EWOM acceptance. To this end, a questionnaire survey of passengers who use airlines and the airline's social media was conducted, and then effective data of 302 copies were analyzed by using the structural equation modeling. The findings show that social media use intensity has a significant effect on Acceptance of EWOM via reliance of EWOM, while a direct effect of social media use intensity on Acceptance of EWOM is not significant. From this study, it is found that control and management of social media and only EWOM are effective tools for marketing of airline businesses, suggesting that innovative strategies are required to preemptively cope with changes in consumers' behaviors and markets, which continue to evolve.

• KIEAE Journal
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• v.15 no.3
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• pp.15-20
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• 2015

Purpose: Suggesting a working prototype of a kinetic light shelf unit and revealing its energy efficiency by a series of building performance simulations were presented. Recently, kinetic building envelope has been an emerging technology as an innovative way to control exterior building environment, but products from many researches about the facade could not been reached to the industrialization so far. That is because its initial installation, operation and maintenance costs are still too high to use for the practical field, although buildings using kinetic envelopes could decrease their energy consumption significantly. This narrow point of view needs to be reconsidered, since buildings require great amount of energies to run their functions through the whole life and using better building components can lead to achieve much more benefits in aspects of the lifecycle cost (LCC). Method: A series of certified simulation tools like Ecotect and Green Building Studio that are normally used for researches and developments in the field of architecture were utilized. Result: Based on simulation analyses, the result of the study has showed that the proposed system definitely has adaptability to the professions and positively shows practicability as advanced integrative building envelopes with renewable energy association.

• International Journal of Naval Architecture and Ocean Engineering
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• v.9 no.3
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• pp.339-349
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• 2017

This paper is related to structural design evaluation of 19,000 TEU ultra large container ship, dealing with hydroelastic response, i.e. springing and whipping. It illustrates application of direct calculation tools and methodologies to both fatigue and ultimate strength assessment, simultaneously taking into account ship motions and her elastic deformations. Methodology for springing and whipping assessment within so called WhiSp notation is elaborated in details, and in order to evaluate innovative container ship design with increased loading capacity, a series of independent hydroelastic computations for container ship with mobile deckhouse and conventional one are performed with the same calculation setup. Fully coupled 3D FEM - 3D BEM model is applied, while the ultimate bending capacity of hull girder is determined by means of MARS software. Beside comparative analysis of representative quantities for considered ships, relative influence of hydroelasticity on ship response is addressed.