• Annual Conference of KIPS
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• 2008.11a
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• pp.722-725
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• 2008

복합질환(complex disease)의 원인과 작용 모델을 찾기 위해 여러 가지 통계적인 방법들과 기계 학습(machine learning)의 방법 등이 사용되고 있다. 소수 SNP의 작용모델을 찾는 방법은 많이 알려져 있지만 다수 SNP의 작용 모델을 효과적으로 찾는 방법은 거의 연구되어 있지 않다. 본 연구에서는 원인 SNP들의 작용을 부울 식(boolean expression)으로 나타내고, 유전 알고리즘(genetic algorithm)을 이용하여 예측 정확도가 높은 부울 식을 구성하였으며 실제 자료와 생성된 자료에 대하여 제안한 모델의 성능을 측정하였다.

• Annual Conference of KIPS
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• 2008.11a
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• pp.649-651
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• 2008

상황인식 컴퓨팅 기술은 넓게 보면 유비쿼터스 컴퓨팅 기술의 일부분으로 볼 수 있다. 그러나 상황인식 컴퓨팅 기술의 적용측면에 대한 접근 방법이 유비쿼터스 컴퓨팅과는 다르다고 할 수 있다. 지금까지 연구된 상황인식 컴퓨팅 기술은 지정된 공간에서 상황을 발생시키는 객체를 식별하는 일과 식별된 객체가 발생하는 상황의 인식에 주된 초점을 두고 있다. 또한, 상황정보로는 객체의 위치 정보만을 주로 사용하고 있다. 그러나 본 논문에서는 객체의 얼굴표정을 상황정보로 사용하여 감성을 인식할 수 있는 상황인식 미들웨어로서 CM-FEIP의 구조를 제안한다. CM-FEIP의 가상공간 모델링은 상황 모델링과 서비스 모델링으로 구성된다. 또한, 얼굴표정의 인식기술을 기반으로 온톨로지를 구축하여 객체의 감성을 인식한다. 객체의 얼굴표정을 상황정보로 사용하고, 무표정일 경우에는 여러 가지 환경정보(온도, 습도, 날씨 등)를 이용한다. 온톨로지를 구축하기 위하여 OWL 언어를 사용하여 객체의 감성을 표현하고, 감성추론 엔진은 Jena를 사용한다.

• KSII Transactions on Internet and Information Systems (TIIS)
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• v.17 no.11
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• pp.2903-2923
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• 2023

Knowledge recommendation is a type of recommendation system that recommends knowledge content to users in order to satisfy their needs. Although using graph neural networks to extract data features is an effective method for solving the recommendation problem, there is information loss when modeling real-world problems because an edge in a graph structure can only be associated with two nodes. Because one super-edge in the hypergraph structure can be connected with several nodes and the effectiveness of knowledge graph for knowledge expression, a dual-channel hypergraph convolutional neural network model (DCHC) based on hypergraph structure and knowledge graph is proposed. The model divides user data and knowledge data into user subhypergraph and knowledge subhypergraph, respectively, and extracts user data features by dual-channel hypergraph convolution and knowledge data features by combining with knowledge graph technology, and finally generates recommendation results based on the obtained user embedding and knowledge embedding. The performance of DCHC model is higher than the comparative model under AUC and F1 evaluation indicators, comparative experiments with the baseline also demonstrate the validity of DCHC model.

• Proceedings of the Korean Society for Bioinformatics Conference
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• 2003.10a
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• pp.66-72
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• 2003

Toxicogenomics is now emerging as one of the most important genomics application because the toxicity test based on gene expression profiles is expected more precise and efficient than current histopathological approach in pre-clinical phase. One of the challenging points in Toxicogenomics is the construction of intelligent database management system which can deal with very heterogeneous and complex data from many different experimental and information sources. Here we present a new Toxicogenomics database developed as a part of 'Toxicogenomics for Efficient Safety Test (TEST) project'. The TEST database is especially focused on the connectivity of heterogeneous data and intelligent query system which enables users to get inspiration from the complex data sets. The database deals with four kinds of information; compound information, histopathological information, gene expression information, and annotation information. Currently, TEST database has Toxicogenomics information fer 12 molecules with 4 efficacy classes; anti cancer, antibiotic, hypotension, and gastric ulcer. Users can easily access all kinds of detailed information about there compounds and simultaneously, users can also check the confidence of retrieved information by browsing the quality of experimental data and toxicity grade of gene generated from our toxicology annotation system. Intelligent query system is designed for multiple comparisons of experimental data because the comparison of experimental data according to histopathological toxicity, compounds, efficacy, and individual variation is crucial to find common genetic characteristics .Our presented system can be a good information source for the study of toxicology mechanism in the genome-wide level and also can be utilized fur the design of toxicity test chip.

• Journal of KIISE:Software and Applications
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• v.35 no.6
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• pp.366-373
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• 2008

The web ontology language(OWL) has been used by ontology designers to construct ontology. In order to derive hidden information(concept subsumption, concept satisfiability and realization) of OWL ontology, a number of OWL reasoners have been introduced. But most reasoners simply report these information without process for any arbitrary entailment and unsatisfiable concept derived from a OWL ontologies. In this paper, we propose Minimum Expression Axiom Set(MEXS) detection and storing for debugging unsatisfiable concepts in ontology. In order to detect MEXS, we need to find axiom to cause inconsistency in ontology. Therefore, our work focused on two key aspects: given a inconsistency ontology, identifying the roots of axioms to occur unsatisfiable and derived axioms from among them; and extracting MEXS. Our results can be applicable to all application, which is at the basis of the description logic.

• Journal of the Korean Institute of Intelligent Systems
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• v.17 no.2
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• pp.202-207
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• 2007

Ontology has many merits such as high expression power and extensibility etc. and there are some suggestion on development of ubiquitous environment using ontology. For collecting and analysing the context information in ubiquitous environment, we need a context-awareness system. For these reason, some context-awareness systems have been developed using ontology, but they have insufficient representation power of context information and are independent to domain. In this paper, we define the context type to improve the extensibility of context framework, and develop the context ontology adopting the defined contort type to represent or inference various context information. We define the ontology to be easily adopted the and domain. Also, we use SWRL to represent numerical formulas and Horn-Logic expression.

• Genomics & Informatics
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• v.10 no.1
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• pp.33-39
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• 2012

High-throughput genomic technologies (HGTs), including next-generation DNA sequencing (NGS), microarray, and serial analysis of gene expression (SAGE), have become effective experimental tools for cancer genomics to identify cancer-associated somatic genomic alterations and genes. The main hurdle in cancer genomics is to identify the real causative mutations or genes out of many candidates from an HGT-based cancer genomic analysis. One useful approach is to refer to known cancer genes and associated information. The list of known cancer genes can be used to determine candidates of cancer driver mutations, while cancer gene-related information, including gene expression, protein-protein interaction, and pathways, can be useful for scoring novel candidates. Some cancer gene or mutation databases exist for this purpose, but few specialized tools exist for an automated analysis of a long gene list from an HGT-based cancer genomic analysis. This report presents a new web-accessible bioinformatic tool, called CaGe, a cancer genome annotation system for the assessment of candidates of cancer genes from HGT-based cancer genomics. The tool provides users with information on cancer-related genes, mutations, pathways, and associated annotations through annotation and browsing functions. With this tool, researchers can classify their candidate genes from cancer genome studies into either previously reported or novel categories of cancer genes and gain insight into underlying carcinogenic mechanisms through a pathway analysis. We show the usefulness of CaGe by assessing its performance in annotating somatic mutations from a published small cell lung cancer study.

• Nutrition Research and Practice
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• v.3 no.3
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• pp.180-184
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• 2009

The apoptotic effect of bacteria-derived $\beta$-glucan was investigated in human colon cancer cells SNU-C4 using terminal deoxynucleotidyl transferase (TdT)-mediated dUTP nick end labeling (TUNEL) assay, reverse transcription-polymerase chain reaction (RT-PCR) expressions of Bcl-2, Bax, and Caspase-3 genes, and assay of caspase-3 enzyme activity. $\beta$-Glucan of 10, 50, and $100{\mu}g$/mL decreased cell viability in a dose-dependent manner with typical apoptotic characteristics, such as morphological changes of chromatin condensation and apoptotic body formation from TUNEL assay. In addition, $\beta$-glucan ($100{\mu}g$/mL) decreased the expression of Bc1-2 by 0.6 times, whereas the expression of Bax and Caspase-3 were increased by 3.1 and 2.3 times, respectively, compared to untreated control group. Furthermore, the caspase-3 activity in the $\beta$-glucan-treated group was significantly increased compared to those in control group (P < 0.05). Bacterial derived $\beta$-glucan could be used as an effective compound inducing apoptosis in human colon cancer.

• The Journal of the Korea institute of electronic communication sciences
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• v.7 no.3
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• pp.597-606
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• 2012

The description of this paper was made putting the emphasis on CIM Interface configuration with a college policy program as the center whether it is suitable or not for a college promotion. CIM Interface technique for a college promotion is an expression method by visual requirements. Alternatives to a college promotion turned up which are depending on Contents, Image, Marketing strategies by visual elements. The application of consumer contents to give users information did the role of a channel inducing the users to join. Besides, an information designing enabled the information structure to be a visual expression by being grafted on content consistency. First above all, the implementation policy of such systematical formation could be found through University Identity Program-IMC useful as a branding strategy of a college promotion. Like this, a methodology which is able to increase the efficiency of college promotion through a process and a connection was established.

• KSII Transactions on Internet and Information Systems (TIIS)
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• v.12 no.3
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• pp.1098-1112
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• 2018

Achievable sum rate and energy efficiency (EE) are investigated for the massive multiple-input multiple-output (Massive MIMO) downlink with channel aging in the time varying Ricean fading channel. Specifically, the expression of the achievable sum rate of the system for the maximum ratio transmission (MRT) precoder with aged channel state information (CSI) in the time varying Ricean fading channel is first presented. Based on the expression, the effect of both channel aging and the Ricean factor on the power scaling law are studied. It is found that the transmit power of base station (BS) is scaled down by $1/{\sqrt{M}}$(where M is the number of the BS antennas) when the Ricean factor K is equal to zero (i.e., time varying Rayleigh fading channel), indicating that aged CSI does not affect the power scaling law. However, the transmit power of the BS is scaled down by 1/M for the time varying Ricean fading channel (where $K{\neq}0$) indicating that the Ricean factor affects the power scaling law and sum rate, and channel aging only leads to a reduction of the sum rate. Second, the EE of the system is analyzed based on the general power consumption model. Both the theoretical analysis and the simulations show that the channel aging could degrade the sum rate and the EE of the system, and it does not affect the power scaling law.