• 대한가정학회지
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• 제38권4호
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• pp.99-114
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• 2000

The purpose of this study was to investigate foodservice management of snacks as will as to evaluate nutrient intakes of young children from the snacks serried in early childhood educational institute. Two hundred and twenty-three snack items from 14 kindergartens and daycare centers were measured sewing size and analyzed for the nutritional values in addition to the general evaluation of the snack service management practice by the trained personnel. The results were as follow: The contents of most nutrients supplied from the snacks amounted to 10-15% of RDA (recommended dietary allowances for Koreans) except iron and niacin. And there were not any significant differences in the contents of energy, protein, fat and carbohydrate between the morning and afternoon snacks. The energy and protein contents (as the % of RDA) of snacks sewed to children of 1-3 years old were turned out to be significantly higher than that sewed to the children of 4-6 years old since the portion amount of snacks per child was about the same regardless of the age and individual variation. There were significant differences in the contents of nutrient serried from the snacks among 14 kindergartens. Therefore, nutritional guidence including the standard portion amount for the kindergarten snacks considering the age, activities and individual variation should be developed for kindergarten teachers so that they can effectively manage snack service and provide good nutrition for young children.

• 한국환경성돌연변이발암원학회:학술대회논문집
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• 한국환경성돌연변이발암원학회 2004년도 춘계학술대회
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• pp.27-29
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• 2004

Drug transporters play an essential role in the absorption, distribution and elimination of clinical drugs, nutrients and toxicants. The importance of the transporters is exampled by therapeutic failure in cancer chemotherapy that is mainly caused by the overexpression of multidrug resistance (MDR)-related transporters. In addition, the transporters may involve in drug-drug interactions that lead to serious adverse drug responses and some transporters also contribute to inter-individual variation in drug responses. As an effort to understand the mechanism underlying the inter-individual variation of transporters activity, genetic and environmental factors influencing the expression or function of the transporters have extensively explored through last decade. Among them, genetic polymorphism of drug transporter encoding genes has generated much interest since the discovery of functional single nucleotide polymorphisms (SNP) of MDR1 gene. Besides drug transporters, xenobiotic receptors also modulate drug disposition by regulating the transcription of drug metabolizing enzymes and drug transporters. Among many xenobiotic receptors, pregnane X receptor (PXR) and constitutive androstane receptor (CAR) are two most well characterized since these receptors show wide substrate specificities and regulate the expression of various enzymes involved in drug disposition. Recently, several functional genetic polymorphisms were reported in PXR coding gene. In the present study, genetic polymorphisms of two drug transporters, MDR1 and BCRP, and two xenobiotic receptors, PXR and CAR, were investigated in Korean population.

• 한국독성학회:학술대회논문집
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• 한국독성학회 2004년도 춘계학술대회
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• pp.27-29
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• 2004

Drug transporters play an essential role in the absorption, distribution and elimination of clinical drugs, nutrients and toxicants. The importance of the transporters is exampled by therapeutic failure in cancer chemotherapy that is mainly caused by the overexpression of multidrug resistance (MDR)-related transporters. In addition, the transporters may involve in drug-drug interactions that lead to serious adverse drug responses and some transporters also contribute to inter-individual variation in drug responses. As an effort to understand the mechanism underlying the inter-individual variation of transporters activity, genetic and environmental factors influencing the expression or function of the transporters have extensively explored through last decade. Among them, genetic polymorphism of drug transporter encoding genes has generated much interest since the discovery of functional single nucleotide polymorphisms (SNP) of MDRl gene. Besides drug transporters, xenobiotic receptors also modulate drug disposition by regulating the transcription of drug metabolizing enzymes and drug transporters. Among many xenobiotic receptors, pregnane X receptor (PXR) and constitutive androstane receptor (CAR) are two most well characterized since these receptors show wide substrate specificities and regulate the expression of various enzymes involved in drug disposition. Recently, several functional genetic polymorphisms were reported in PXR coding gene. In the present study, genetic polymorph isms of two drug transporters, MDR1 and BCRP, and two xenobiotic receptors, PXR and CAR, were investigated in Korean population.

• 보건행정학회지
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• 제3권1호
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• pp.25-52
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• 1993

Variation in the utilization of medical services is a very important issue in cost containment and quality assurance of health care. Practice variation directly affects health care expenditure especially in fee-for-service system, which is the payment system of health insurance in Korea. In addition to cost issue it is generally accepted that variations in medical practice and the cost of inpatient care suggest the possibility of inappropriate quality of care. This study is to closely examine the patterne and degrees of variation in cost structure of inpatient care among types of hospital and individual hospitals in some tracer diseases, and also to inquire into the service items which contribute much to the variation of total medical care cost. Foru common diseases, i.e. Cesarean Section, appendectomy, cataract extraction and pediatric pneumonia, were selected as tracer diseases. In most tracer diseases there were statistically significant differences in total medical care cost among hospitals in same type of hospital as well as among types of hospital(p<0.01). When total medical care cost were subdivided into the types of service, cost of medication and diagnostic examination varied the most prominenly. When the cost of medication were subdivided again, cost of parenteral antibiotics showed the most prominent variation. Of total medical care cost, medication was most contributory to the variation of total medical care cost(58.1~82.3%), and cost of antibiotics was most contributory to the variation of medication cost(63.9~92.2%). The results of study implicated that reducing the variation of medication may plays a significant role in containing the cost of inpatient care. In order to sort out the factors affecting practice variations including drug prescription pattes further researches are required.

• 원예과학기술지
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• 제30권6호
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• pp.743-750
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• 2012

본 연구는 UPLC를 이용하여 국내 브로콜리 육성계통 95점의 화구 내 desulfo-glucosinolate를 표준물질과 비교하여 정량 분석하고 그 함량변이를 평가하여, 궁극적으로 고기능성 국내 브로콜리 품종 육성의 기초자료로 이용하고자 수행되었다. 브로콜리 화구에서 9종의 표준물질과 비교하여 progoitrin, glucoraphanin, sinigrin, gluconapin, glucobrassicanapin 및 glucobrassicin 등 6종의 glucosinolate가 동정되었다. 전체 브로콜리 육성계통 95점에 대해서 총 glucosinolate 함량은 $4.2-29.0{\mu}mol{\cdot}g^{-1}$ DW의 변이를 보였다. 총 glucosinolate 중 glucoraphanin의 함량은 $1.6-13.9{\mu}mol{\cdot}g^{-1}$ DW로 가장 높은 비율을 차지하였고 progoitrin은 제한적인 13개의 계통에서만 특이적으로 함유되어 있었으며 glucoraphanin의 함량과는 부의 상관관계를 보였다. 동정된 glucosinolate 중 glucobrassicanapin, glucoraphanin, glucobrassicin 및 gluconapin의 4종 물질이 전체 브로콜리 계통의 함량변이에 크게 영향하였고 이들 4종 물질 상호 간에는 높은 정의 상관관계가 있음이 확인되었다. 본 연구결과에서 선발된 브로콜리 유망계통에 대해서는, 향후 재배 작형 및 연차간 물질함량의 안정성 평가와 유전자원 간 추가적인 비교평가 연구를 통하여 고기능성 육종소재로의 개발이 가능할 것으로 판단된다.

• 한국산림과학회지
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• 제34권1호
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• pp.1-14
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• 1977

지리산(智異山) 일대(一帶)에 생육(生育)되고 있는 잣나무집단(集團)의 변이(變異)를 구명(究明)하기 위해 수형(樹形), 침엽(針葉), 자엽(子葉), 종자(種子), 묘목성장(苗木成長)의 특성(特性)을 조사하였다. 두개 집단(集團)을 비교(比較) 검토(檢討)하였던 바 그 결과(結果)를 요약(要約)하면 다음과 같다. 1. 침엽(針葉)의 엽장(葉長), 거치밀도(鋸齒密度), 종자충실율(種子充實率), 종자장(種子長), 종자후(種子厚), 자엽장(子葉長), 자엽폭(子葉幅), 자엽(子葉)의 기공선수(氣孔線數)와 묘고성장(苗高成長)에 있어서는 집단(集團), 개체간(個體間)에 유의차(有意差)를 인정(認定)할 수 있었다. 2. 수목(樹木)의 역지각(力枝角)과 목재(木材)의 비중(比重), 자엽(子葉)의 수지구수(樹脂溝數)의 형질(形質)에 있어서는 집단간(集團間)에 유의차(有意差)가 인정(認定)되었다. 3. 침엽(針葉)의 기공선수(氣孔線數), 종자폭(種子幅), 종자중량(種子重量), 자엽(子葉)의 거치밀도(鋸齒密度), 자엽수(子葉數)의 형질(形質)은 개체간(個體間)에 유의차(有意差)를 인정(認定)할 수 있었다. 4. 침엽(針葉)의 수지구(樹脂溝)는 집단(集團), 개체간(個體間) 모두 3개(個)의 주수지구(主樹脂溝)만 발달(發達)하여 변이폭(變異幅)은 인정(認定)할 수 없었다. 그리고 수간형(樹幹型)은 두 집단(集團) 모두 통직성(通直性)을 나타내었다. 5. 침엽(針葉)과 자엽(子葉) 형질(形質)의 변이계수(變異係數)는 대체로 자엽(子葉)의 것이 큰 경향(傾向)을 나타내었다.

• 한국초지조사료학회지
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• 제9권3호
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• pp.179-186
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• 1989

사초용유채의 품종선별선급실험과 유채용유채와 사초용유채품종들 간에 있어서 생산성과 영양가치를 비교한 실험에서 사초용유채 도인품종중 우리나라 남부지역의 특성에 적합한 품종으로 Velox가 사초생산성 및 영양가치면에서 가장 유망하다고 생각되었다. 따라서 Velox를 공시하여 고립적배와 실행群落培 사이에 생산성과 영양가치에 있어서 어떤 차이가 있는가를 비교하였으며 또한 생육과정중의 영양가치의 변화를 조사하였는데 그 결과를 요약하면 다음과 같다. 1. 수당 생산성에 있어서 생체중과 건물중의 개체간 변이가 매우 컸으나 고립적배가 군락적배보다 1%수준의 유의차로 우수하였다. 孤립적배에 있어서 생체중과 건물중의 구성은 분지에 크게 의존되었으며 군락적배에 있어서는 분치와 주경이 비슷한 영향을 주었다. 건물율은 고리적배와 군락적배사이에 큰 차이가 없었으며 부위별로는 주경이 가장 높았다. 2. 粗蛋白質含量은 生育期間이 經過됨에 따라 점차 저하되었으며, 播種後 90일부터 120일까지에는 孤立적배가 群落적배보다 높은 반면 180일以後 개화기까지는 군락적배가 고립적배보다 높았다. NDF, ADF, cellulose 및 lignin등의 鐵維含量은 生育초기에는 낮은 水준이었으며 생育期間이 經過됨에 따라 점차 높아지면서 생育後期에는 孤立적배가 군락적배보다 높게 變化되었다. 3. In vitro 乾物소화率은 줄기나 잎 모두 生育기간이 경과됨에 따라 점차 저하되었으며, 줄기는 군락적배가 고립적배보다 높았으나 잎은 고립적배와 군락적배간에 유의차가 인정되지 않았다.

• Journal of Biosystems Engineering
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• 제24권3호
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• pp.225-234
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• 1999

This study was performed as a basic research for establishing an objective quality evaluation method on whole bulbs of garlic. The size of a whole bulb of garlic, the number and the uniformity of complete individual garlics, and the existence of bad individual garlics in the whole bulb of garlic were selected as quality grading factors. Quality discrimination algorithms with machine vision techniques were developed and verified for the four factors based on morphological and physical features of whole bulbs of garlic. Based on the results, the size discrimination by the projected area of a whole bulbs of garlic suggested four grading levels and the algorithm for predicting the number of complete individual garlics based on the peaks on its projected boundary showed ${\pm}$0.78 prediction error. In addition, the uniformity represented by coefficient of variation could be divided into four levels, but the algorithm for discriminating the existence of bad individual garlics in a whole bulb of garlic was not effective.

• 한국의류산업학회지
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• 제2권5호
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• pp.398-404
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• 2000

We examined the effect of individual sweating responses on thermoregulatory responses induced by heat of sorption, immediately after the onset of sweating. The present study consists of two experiments. In experiment 1, made of 100% cotton (C) and 100% polyester (P) clothing were exposed in the chamber at ambient temperature (Ta) of $27.2^{\circ}C$ and relative humidity (rh) raised from 50% to 95% at five different increase rates of environmental vapor pressure (VP). The increase rate of clothing surface temperature (Tcs), peak Tcs and peak time showed significant correlation with the increase rate of environmental VP in C-clothing (p<0.05). In experiment 2, seven female subjects were studied during leg water immersion ($35-41^{\circ}C$) for 70min in Ta of 27.2 and 50%rh. There were significant positive correlations in the increase rate of clothing microclimate VP vs. changes in Tcs, skin blood flow, mean skin temperature and mean body temperature (p<0.05). The present results showed that individual clothing microclimate VP had significant effects on thermoregulatory responses induced by heat of sorption wearing C ensembles.

• Asian-Australasian Journal of Animal Sciences
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• 제19권4호
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• pp.463-467
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• 2006

Genetic profiles of Iranian Holstein young bulls at the national artificial insemination station were determined on the basis of individual genotypes at 13 ISAG's recommended microsatellites, the most useful markers of choice for parentage identification. In the present study a total of 119 individuals were genotyped at 13 microsatellite loci and for possible parent-offspring combinations. A high level of genetic variation was evident within the investigated individuals as assessed from various genetic diversity measures. The mean number of observed alleles per microsatellite marker was 9.15 and the number of effective alleles as usual was less than the observed values (4.03). The average observed and expected heterozygosity values were 0.612 and 0.898, respectively. The mean polymorphic information content (PIC) value (0.694) further reflected a high level of genetic variability. The average exclusion of probability (PE) of the 13 markers was 0.520, ranging from 0.389 to 0.788. The combined exclusion of probability was 0.999, when 13 microsatellite loci were used for analysis in the individual identification system. Inbreeding was calculated as the difference between observed and expected heterozygosity. Observed homozygosity was less than expected which reflects inbreeding of -3.7% indicating that there are genetic differences between bull-sires and bull-dams used to produce young bulls. The results obtained from this study demonstrate that the microsatellite DNA markers used in the present DNA typing are useful and sufficient for individual identification and parentage verification without accurate pedigree information.