• Asian Pacific Journal of Cancer Prevention
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• v.17 no.5
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• pp.2389-2394
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• 2016

Background: Multiple myeloma (MM) is influenced by genetic and micro-environmental changes. Malignant plasma cells produce an abnormal monoclonal immunoglobulin, as well as cytokines, such as IL-10 and IL-6 which stimulate cells of the bone marrow microenvironment (BMM) and cause dysfunction and failure of many organs. B cell activating factor (BAFF), IL6, IL10 are known to influence the growth & survival of the malignant clone. Aim: The objectives of the present study were to investigate the circulating levels of BAFF, IL-10 and IL-6, correlate them with well-known parameters of disease activity in patients with MM, and to detect their impact on the patients' survival. Materials and Methods: This study was conducted on 89 newly diagnosed MM patients and seventy apparently healthy volunteers as a normal control group. BAFF, IL6, IL10 were measured by ELISA for both groups. Survival analysis was performed for all patients. Results: Studied markers were higher in the MM patients compared to the normal control subjects. Patients' survival was improved by high serum BAFF levels. Conclusions: High levels of BAFF were found to improve patients' survival. BAFF and IL-6 can be considered probable diagnostic markers for MM.

• 한국전산유체공학회:학술대회논문집
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• 2009.04a
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• pp.215-222
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• 2009

In the present study, a numerical analysis on the sloshing in a tank with the harmonic motion was investigated. A VOF method was used for two-phase flows inside the sloshing tank and a source term of the momentum equation was applied for the harmonic motion. This numerical method was verified by comparing its results with the available experimental data. The sloshing in a tank causes the instability of the fluid flows and the fluctuation of the impact pressure on the tank. By these phenomena of the tank sloshing, the sloshing problems such as the failure and the noise of system can be generated. For the reduction of these sloshing problems, the various baffles such as the horizontal/vertical plate baffles and the porous baffles inside the tank are installed. With the installations of these baffles, the characteristics of the liquid behavior in the sloshing tank, the impact pressure on the wall, the amplitude of the free surface near the wall and the sloshing noise were numerically analyzed.

• International Journal of Aeronautical and Space Sciences
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• v.12 no.2
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• pp.115-133
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• 2011

Fiber reinforced polymer composites (FRPs) are being increasingly used for a wide range of engineering applications owing to their high specific strength and stiffness. However, their through-the-thickness performance lacks some of the most demanding physical and mechanical property requirements for structural applications, such as aerospace vehicles and military components. Carbon nanotubes (CNTs) and carbon nanofibers (CNFs), due to their excellent mechanical, thermal and electrical properties, offer great promise to improve the weak properties in the thickness direction and impart multi-functionality without substantial weight addition to FRPs. This paper reviews the progress made to date on i) the techniques developed for integration of CNTs/ CNFs into FRPs, and ii) the effects of the addition of these nanofillers on the interlaminar properties, such as such interlaminar shear strength, interlaminar fracture toughness and impact damage resistance and tolerance, of FRPs. The key challenges and future prospects in the development of multiscale CNT-FRP composites for advanced applications are also highlighted.

• Journal of Korean Society for Quality Management
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• v.46 no.3
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• pp.441-452
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• 2018

Purpose: The purpose of this paper is to study quantitative risk grade assessment for objective government quality assurance activities based on risk management in initial mass production for weapon systems. Methods: The Defense quality management regulations and foreign risk assessment documents are referred to analyze problems performing quality assurance actives. The failure rate data, maintainability and cost of products have been studied to quantify the risk Likelihood and impact. The analyzed data were classified as risk grade assessment through K-means Cluster Analysis method. Results: Results show that a proposed method can objectively evaluate risk grade. The analyzed results are clustered into three levels such as high, middle and low. Two products are allocated high, eleven low and seven middle. Conclusion: In this paper, quantitative risk grade assessment methods were presented by analyzing risk ratings based on objective data. The findings showed that the methods would be effective for initial mass production for weapon systems.

• Macromolecular Research
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• v.15 no.1
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• pp.44-50
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• 2007

This study investigated the effect of ultrasound irradiation on the blend of poly(lactic acid) (PLA) and poly(butylene adipate-co-terephthalate) (PBAT). The blends of PLA/PBAT(50/50) (PBAT50) were prepared in a melt mixer with an ultrasonic device attached. Thermal, rheological, and mechanical properties, morphology, and biodegradability of the sonicated blends were analysed. The viscosity of the sonicated blends was increased by the ultrasound irradiation owing to the strong interaction. The morphology of the sonicated blends was significantly dependent on the duration o the ultrasound irradiation. For PBAT50, the phase size reduction was maximized when the blends were ultrasonically irradiated for 30 sec. At longer duration of ultrasound irradiation, the PBAT phase underwent flocculation. Measurement of the tensile properties showed an increased breakage tensile stress and an enhanced Young's modulus when the blends were properly irradiated. This improvement was ascribed to better adhesion between the PLA matrix and the PBAT domain and to better dispersion of the PBAT phase. However, the tensile properties were maximized after excessive energy irradiation, which was ascribed to an emulsifying effect leading to coalescence of the PBAT phase. Impact strength was increased to reach a peak with the ultrasound irradiation, and was higher than the untreated sample for all sonicated samples due to the difference of failure mechanism between the tensile test and the impact test.

• Journal of Sensor Science and Technology
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• v.28 no.6
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• pp.371-376
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• 2019

We have developed an acoustic resonance inspection system to inspect the welding defects in the mechanical parts fabricated using friction stir welding method. The inspection system was consisted of a DAQ board, a microphone sensor, an impact hammer, and controlled by a PC software. The system was developed to collect and analyze the sound signal generated by hitting the sample with an impact hammer to determine whether it is defective. In this study, 100% welded good samples were compared with 95%, 90%, and 85% welded samples, respectively. The variation of the completeness in welding did not affect the visual appearance in the samples. As a result of analyzing the natural frequencies of the good samples, the five natural frequency peaks were identified. In the case of the defective samples, the frequency change was observed. The welding failure detection time was fast enough to be only 0.7 seconds. Employing our welding defect inspection system to the actual industrial field will maximize the efficiency of quality inspection and thus improve the productivity.

• Journal of the Microelectronics and Packaging Society
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• v.18 no.2
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• pp.35-41
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• 2011

Recently, board level solder joint reliability performance of IC packages during drop impact becomes a great concern to semiconductor and electronic product manufacturers. The handheld electronic products are prone to being dropped during their useful service life because of their size and weight. The IC packages are susceptible to solder joint failures, induced by a combination of printed circuit board (PCB) bending and mechanical shock during impact. The board level drop testing is an effective method to characterize the solder joint reliability performance of miniature handheld products. In this paper, applying the JEDEC (JESD22-B111) standard present a finite element modeling of the FBGA. The simulation results revealed that maximum stress was located at the outermost solder ball in the PCB or IC package side, which consisted well with the location of crack initiation observed in the failure analysis after drop reliability tests.

• KOREAN JOURNAL OF PACKAGING SCIENCE & TECHNOLOGY
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• v.23 no.2
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• pp.103-108
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• 2017

The amount of delivered parcels have been increasing according to the change and expansion of consumption pattern through e-commerce, and they are required to minimize breakout or failure under the delivery. In this study, we measured and analyzed the distribution environment data (vibration and impact) occurred in the packaging, which were prepared with 5 types by the weight and dimension, distributed from Seoul to Busan in Korea by 2 parcel delivery service companies through e-commerce order. Date showed the parcels had 3-5 times of drop impact and 0.3-0.7 m of drop height on average, and 0.8 Grms of vibration acceleration from equivalent equation to the vertical direction. The significant gap in service quality was not found between 2 parcel delivery service companies. This study is expected to be useful for designing the suitable packaging in order to enhance safe transportation of the delivered packaging, and furthermore useful for developing Korean testing method for Field-to-Lab simulation.

• Journal of the Korean Society for Aviation and Aeronautics
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• v.25 no.1
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• pp.11-22
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• 2017

Aviation/tourism industry has a unique characteristic of high inter-dependance between customer and service-provider. It is the mental condition of service-provider that could influence on the attitude of the service-provider. Thus, it is important to manage the mental condition of the service employees to enhance a company's financial performance. This paper tries to analyze the combined model of both policy acceptance and service profit chain(SPC) models. First, service policy acceptance model tells how the service policy acceptance, which consists of policy compliance, trust, participation and policy failure, would influence on SPC model. According to empirical research, it was found that both the employees' policy compliance and the policy trust have a positive significant impact on their participation on service policy. In the policy acceptance model, the employee's voluntary participation based on their trust and compliance of the policy was proven to have a positive effect on increasing job satisfaction and customer orientation. Regarding SPC model, their participation in the policy had the strongest impact among variables on customer orientation. Such results implies the employees' participation on the policy could become the starting point to enhance the customer value.

• Transactions of the Korean Society of Automotive Engineers
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• v.19 no.5
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• pp.67-75
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• 2011

A new energy absorbing mechanism for car seat was developed to reduce the neck injury in rear impacts. Energy absorbing principle is based on the shear-bolt behavior of thin-walled cast components subjected to static and dynamic loads. Results of shear bolt test using AM60 of Mg alloys showed robust behavior giving an approximately constant mean force during failure processes. Simply designed energy absorbing mechanism was assembled with the recliner between seat backs and seat rails. We have simulated the sled test of seat with dummy under the rear end impact using the finite element method. Results of simulation show that the new seat mechanism reduces thorax acceleration to a considerable extent, but it is not sufficient to mitigate neck injury indices e.g. neck shear force, neck tension force and NIC. With heightened headrest and narrowed backset, the energy absorbing mechanism resulted in good performance of protecting the neck injuries.