• Proceedings of the Korea Contents Association Conference
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• 2010.05a
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• pp.520-523
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• 2010

I investigated the styles of progress bar in the top 8 China's websites. According to the authoritative literature, I calculated the time which each kind of operation needed. I investigated 400 examples which were used the progress bar. The statistical result confirmed my idea - progress bar's style and user's waiting time has the relations. Finally, I gave the revision comment which the progress bar's style improvement.

• Education of Primary School Mathematics
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• v.9 no.1 s.17
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• pp.59-64
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• 2005

The purpose of this study is to find out how to use dynamic geometry software such as the Geometer's Sketchpad in elementary math classroom. Fist of all, I reviewed dynamic geometry software's property. Then I considered methods to improve geometry education using this software. Some researchers proposed three types of using the software. But I think using the software and developing instructional materials is different. So, I proposed two types of developing instructional materials using the software and two representative examples.

• International Journal of Computer Science & Network Security
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• v.21 no.12
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• pp.137-142
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• 2021

Distance learning universities provide online course content. The main methods of providing class contents are on-demand and live-streaming. This means that students are not restricted by time or space. The advantage is that students can take the course anytime and anywhere. Therefore, unlike commuting students, there is no commuting time to the campus, and there is no natural process required to take classes. However, despite this convenient situation, the attendance rate and graduation rate of distance learning universities tend to be lower than that of commuting universities. Although the course environment is not the only factor, students cannot obtain a bachelor's degree unless they fulfill the graduation requirements. In both commuter and distance learning universities, taking classes is an important factor in earning credits. There are fewer time and space constraints for distance learning students than for commuting students. It is also easy for distance learning students to take classes at their own timing. There should be more ease of learning than for students who commute to school with restrictions. However, it is easier to take a course at a commuter university that conducts face-to-face classes. I thought that the reason for this was that commuting to school was a part of the process of taking classes for commuting students. Commuting to school was thought to increase the willingness and motivation to take classes. Therefore, I thought that the inconvenient constraints might encourage students to take the course. In this research, I focused on the act of commuting to school by students. These situations are also applied to the distance learning environment. The students have physical time constraints. To achieve this goal, I will implement a course restriction method that aims to promote the willingness and attitude of students. Therefore, in this paper, I have implemented a virtual school system called "virtual go to school (VG2S)" that reflects the actual route to school.

• Biomolecules & Therapeutics
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• v.22 no.4
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• pp.282-287
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• 2014

We show that silymarin, a polyphenolic flavonoid isolated from milk thistle (Silybum marianum), inhibits cytokine mixture (CM: TNF-${\alpha}$, IFN-${\gamma}$, and IL-$1{\beta}$)-induced production of nitric oxide (NO) in the pancreatic beta cell line MIN6N8a. Immunostaining and Western blot analysis showed that silymarin inhibits iNOS gene expression. RT-PCR showed that silymarin inhibits iNOS gene expression in a dose-dependent manner. We also showed that silymarin inhibits extracellular signal-regulated protein kinase-1 and 2 (ERK1/2) phosphorylation. A MEK1 inhibitor abrogated CM-induced nitrite production, similar to silymarin. Treatment of MIN6N8a cells with silymarin also inhibited CM-stimulated activation of NF-${\kappa}B$, which is important for iNOS transcription. Collectively, we demonstrate that silymarin inhibits NO production in pancreatic beta cells, and silymarin may represent a useful anti-diabetic agent.

• BMB Reports
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• v.38 no.4
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• pp.486-490
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• 2005

Genetic factors are important in the pathogenesis of coronary artery disease (CAD). Angiotensin converting enzyme (ACE) gene insertion(I)/deletion(D) polymorphism is one of the genetic factor found to be related with CAD. We investigated the association between I/D polymorphism of the ACE gene and the presence of CAD. Threehundred and seven patients (187 males and 120 females, aged between 35-80, mean $54.3{\pm}9.8$ years) who underwent diagnostic coronary angiography were included in the study. ACE I/D polymorphism was detected by polymerase chain reaction. Of the 307, 176 had CAD. The most frequently observed genotype in all subjects was ID (47.9 %). However, in patients with CAD the frequency of II genotype was lower whereas DD genotype was higher compared to the controls (p < 0.05). The number of D allele carrying subjects were also higher (p < 0.05) in CAD patients. The logistic regression analysis indicated that the ACE D allele is an independent risk factor (odds ratio = 1.48, 95% CI = 1.01-2.18, p < 0.05). In conclusion, the I/D polymorphism of ACE gene (carrying D allele) is an independent risk factor for CAD in the studied Turkish population.

• The Korean Journal of Physiology and Pharmacology
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• v.17 no.5
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• pp.455-461
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• 2013

Retinoids regulate not only various cell functions including proliferation and differentiation but also glucose and lipid metabolism. After we observed a marked up-regulation of cellular retinol-binding protein-I (CRBP-I) in the liver of hepatitis B virus x antigen (HBx)-transgenic (HBx Tg) mice which are prone to hepatocellular carcinoma (HCC) and fatty liver, we aimed to evaluate retinoid pathway, including genes for the retinoid physiology, CRBP-I protein expression, and retinoid levels, in the liver of HBx Tg mice. We also assessed the effect of chronic metformin treatment on HCC development in the mice. Many genes involved in hepatic retinoid physiology, including CRBP-I, were altered and the tissue levels of retinol and all-trans retinoic acid (ATRA) were elevated in the liver of HBx Tg mice compared to those of wild type (WT) control mice. CRBP-I protein expression in liver, but not in white adipose tissue, of HBx Tg mice was significantly elevated compared to WT control mice while CRBP-I protein expressions in the liver and WAT of high-fat fed obese and db/db mice were comparable to WT control mice. Chronic treatment of HBx Tg mice with metformin did not affect the incidence of HCC, but slightly increased hepatic CRBP-I level. In conclusion, hepatic CRBP-I level was markedly up-regulated in HCC-prone HBx Tg mice and neither hepatic CRBP-I nor the development of HCC was suppressed by metformin treatment.

• Asian-Australasian Journal of Animal Sciences
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• v.15 no.3
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• pp.406-409
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• 2002

The effect of refeeding with various single essential amino acids on the recovery of plasma insulin-like growth factor-I (IGF-I) concentration in fasted young chickens was examined. Young chickens (29 days of age) were divided into 15 experimental groups. Chickens in one group were fed on the commercial diet ad libitum for 4 days. The remaining 56 chickens in 14 experimental groups were fasted. After 2 days of fasting, 52 chicks in 13 fasted groups were refed with one of the following experimental diets for 2 days. Eleven experimental diets were protein-free diets supplemented with one of 11 essential amino acids (Arg, Gly, His, Ileu, Leu, Met, Phe, Lys, Thr, Trp, Val). The remaining 2 experimental diets were a protein-free diet containing 11 essential amino acids and a protein-free diet not supplemented with amino acids. Birds in the remaining fasted group continued to be fasted for 2 days. Fasting for 2 days markedly reduced plasma IGF-I concentration. When fasted chickens were refed the protein-free diet containing either Gly alone or all essential amino acids, plasma IGF-I concentration was recovered to the level similar to that of fed chickens. Protein-free diet alone, however, failed to restore the reduced IGF-I concentration in plasma. Body weight loss modulated by feeding with protein-free diets supplemented with various single essential amino acids was associated with changes in plasma IGF-I concentrations. We concluded that body weight loss by feeding with a protein-free diet was lower than that of fasted chickens and that body weight loss associated with the decrease in plasma IGF-I concentration was modulated by feeding with protein-free diets containing various single essential amino acids.

• The Journal of the Korea Contents Association
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• v.12 no.5
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• pp.199-205
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• 2012

The purpose of this article is to study on the public administration in the perspective of I Ching(周易) which is the original philosophy and science of East Asia. I Ching is divided into two different schools, namely, the school of Image- Number I(象數易) and the school of Right Theory I(義理易). The school of Image- Number I are five science and technology(名 卜 醫 相 山) and astronomy, and so forth. And the school of Right Theory I are a Confucanist, a Taoist, a Mukist and all other thoughts. The meaning of Eastern Public Administration in mordern society is newer and better advanced concept, theory, and thoughts than western science and technology.

• Journal of Environmental Health Sciences
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• v.50 no.4
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• pp.257-266
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• 2024

Background: Exposure to fine particulate matter (PM_2.5) and ozone (O₃) poses potential health risks. The Indoor-to-Outdoor ratio (I/O ratio) is a valuable tool for understanding indoor air quality and identifying potential indoor sources. Objectives: The objective of this study was to determine I/O ratios of PM_2.5 and O₃ by different microenvironments and seasons in Korea. Methods: From December 2021 to November 2023, indoor concentrations of PM_2.5 and O₃ were monitored every hour in 13 microenvironments (residential indoor, office, school, restaurant, pub, café, study café, private educational institute, PC room, billiard room, screen golf center, supermarket, and shopping mall) in Korea. Hourly outdoor concentrations of PM_2.5 and O₃ were obtained from local air quality monitoring stations, provided by airkorea.or.kr. The hourly I/O ratio was calculated by the indoor and outdoor concentrations. Results: At the pub, billiard room, and PC room, the median PM_2.5 I/O ratio exceeded 1 in all seasons, except in spring at the PC room (0.9), suggesting indoor smoking as a potential cause. The median PM_2.5 I/O ratio at the restaurant exceeded 1 in winter, autumn, and summer, except for spring (0.9), indicating significant PM_2.5 emission sources in the restaurant. The median O₃ I/O ratio was below 0.5 in all seasons and microenvironments. Conclusions: This study provided useful data on relationships between indoor and outdoor pollution in various microenvironments by seasons. These I/O ratios could be applied for more accurate exposure assessment to protect health of human.

• Bulletin of the Korean Mathematical Society
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• v.59 no.1
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• pp.73-82
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• 2022

Let K be a field of characteristic zero. We first show that images of the linear derivations and the linear 𝓔-derivations of the polynomial algebra K[x] = K[x₁, x₂, …, x_n] are ideals if the products of any power of eigenvalues of the matrices according to the linear derivations and the linear 𝓔-derivations are not unity. In addition, we prove that the images of D and 𝛿 are Mathieu-Zhao spaces of the polynomial algebra K[x] if D = ∑ⁿ_i=1 (a_ix_i + b_i)∂_i and 𝛿 = I - 𝜙, 𝜙(x_i) = λ_ix_i + 𝜇_i for a_i, b_i, λ_i, 𝜇_i ∈ K for 1 ≤ i ≤ n. Finally, we prove that the image of an affine 𝓔-derivation of the polynomial algebra K[x₁, x₂] is a Mathieu-Zhao space of the polynomial algebra K[x₁, x₂]. Hence we give an affirmative answer to the LFED Conjecture for the affine 𝓔-derivations of the polynomial algebra K[x₁, x₂].