• The Korean Journal of Food And Nutrition
• /
• v.31 no.6
• /
• pp.836-843
• /
• 2018

The objective of this study was to determine the effect of high hydrostatic pressure (HHP) treatment on proliferation of human cancer cell lines (MCF-7, HCT-116, PC-3 and AGS) of crude soyasaponin extracts in germinated black soybean. Black soybean was germinated and subjected to HHP, followed by preparation of crude soyasaponin extracts. Cell treatments done with extracts less than $400{\mu}g/mL$ concentrations had no significant effect on 3T3-L1 adipocyte cell viability. The inhibitory effect of crude soyasaponin extracts with germination periods and applied pressure on breast cancer cell (MCF-7), human colon cancer cell (HCT-116), human gastriccancer cell (AGS) and prostate cancer cell (PC-3) growth were investigated using MTT assay. The highest anti-proliferation of human cancer cell line of crude soyasaponin extracts was observed at 150 MPa treatment after germination for 4 days (150 MPa-Day 4). The cell viability on MCF-7, HCT-116, PC-3 and AGS cell lines of crude soyasaponin extract in 150 MPa-Day4 was 48.82%, 57.37%, 39.89% and 23.94% at $400{\mu}g/mL$, respectively. These results suggest that soyasaponin extracts from black soybean subjected to HHP after germination may mediate physiological activity.

• Journal of Biomedical Engineering Research
• /
• v.28 no.4
• /
• pp.577-584
• /
• 2007

Uroflowmetry is non-invasive and easily performed to diagnose benign prostatic hypertrophy(BPH) frequent in aged men. Weight change during urination is usually measured to estimate the urinary flow rate by a load cell, but sensitive to any impacts against the bottom of the container, leading to unnecessary noise generation. Moreover, load cells are relatively expensive raising the production cost. The present study proposed a new technique, measuring hydraulic pressure on the bottom of the urine container to evaluate the urinary volume. Low cost pressure transducer enabled almost perfectly linear relationship between the urine volume and the hydraulic pressure. During both the simulated and human urination experiments, variance of the pressure signal was more than 50% smaller than the weight signal acquired by a load cell, which demonstrated that the impact noise was decreased to a great degree by pressure compared to weight measurement.

• Korean Journal of Medicinal Crop Science
• /
• v.22 no.2
• /
• pp.134-139
• /
• 2014

This study was to investigate the improvement of immune activities of the extracts from Codonopsis lanceolata by stepwise steaming process and high pressure process. The phenol contents was $8.742{\mu}g/mg$ which was higher than that from conventional extraction using 70% ethyl alcohol at $80^{\circ}C$ for 24 hours. All of extracts at a concentration of $1.0mg/m{\ell}$ showed relatively low cytotoxicity on human normal kidney cell (HEK293) in range of 16 19%. The immune B and T cell growth was improved by extracts using the steamed and high pressure precess of C. lanceolata up to $180{\times}10^4cells/m{\ell}$ and $96{\times}10^4cells/m{\ell}$, respectively. The extract prepared also greatly increased the secretion of both IL-6 and TNF-${\alpha}$ from the stepwise steamed and high pressure process. This results can conclude that stepwise steamed and high pressure process effectively released active biomaterials which could important role in enhancing immune activity in the body.

• Journal of the Korean Institute of Electrical and Electronic Material Engineers
• /
• v.26 no.3
• /
• pp.171-176
• /
• 2013

In this paper, we present a MEMS (micro-electro-mechanical system) implantable blood pressure sensor which has designed and fabricated with consideration of size, design flexibility, and wireless detection. Mechanical and electrical characterizations of the sensor were obtained by mathematical analysis and computer aided simulation. The sensor is composed of two coils and a air gap capacitor formed by separation of the coils. Therefore, the sensor produces its resonant frequency which is changed by external pressure variation. This frequency movement is detected by inductive coupling between the sensor and an external antenna coil. Theoretically analyzed resonant frequency of the sensor under 760 mmHg was calculated to 269.556 MHz. Fused silica was selected as sensor material with consideration of chemical and electrical reaction of human body to the material. $2mm{\times}5mm{\times}0.5mm$ pressure sensors fitted to radial artery were fabricated on the substrates by consecutive microfabrication processes: sputtering, etching, photolithography, direct bonding and laser welding. Resonant frequencies of the fabricated sensors were in the range of 269~284 MHz under 760 mmHg pressure.

• Proceedings of the Korea Water Resources Association Conference
• /
• 2022.05a
• /
• pp.458-458
• /
• 2022

It is essential to reduce global carbon emissions, mainly from energy use. The water supply and distribution sector is a vital part of human society and is one of the primary energy consumers. The procurement and distribution of water require electricity to operate the pump to deliver water to users with sufficient pressure. As the water users are spatially distributed over a wide area, the energy required to deliver water to each user differs depending on the corresponding supplying element (reservoir, tank, pipe, pump, and valve). This difference in energy required for each user also comes with a difference in pressure availability which affects the level of service for individual users and the whole network. Typically, there is a disproportion where users close to the source experience excessively high pressure with low energy consumption. In contrast, remote users need more energy to get the minimum pressure. This study proposes the Energy Return Index (ERI) to quantify the pressure return from particular energy consumption to supply water to each node. The disproportionality can be quantified and identified in the network using the proposed ERI. The index can be applied to optimize the network elements such as pump operation and tank location/size to reach a balanced energy consumption with the appropriate level of service.

• Journal of the korean Society of Automotive Engineers
• /
• v.8 no.3
• /
• pp.55-67
• /
• 1986

The safety and comfort of car seats wee studied by utilization of engineering analysis/ experiment and human engineering data. As important factors of the static seating comfort, static spring constant, body pressure distribution, driving posture were discussed. In connection with the dynamic seating comfort, vibrational characteristics of domestic car seats(natural frequencies, damping, frequency spectrum, transmission ratio)were measured and discussed. Finally, the safety of the seat was analyzed and evaluated through calculation and experiments.

• 제어로봇시스템학회:학술대회논문집
• /
• 2002.10a
• /
• pp.84.1-84
• /
• 2002

A Human-Robot-Interface(HRI) for the disabled Person is developed. $\textbullet$ HRI consists of the laser pointer '||'&'||' USB camera and pressure sensor. $\textbullet$ HRI makes three degree of freedom. $\textbullet$ Three robot position control method with the Interface is presented. $\textbullet$ Experimental results show that user control the 6 DOF robot with the interface and control method.

• Composites Research
• /
• v.34 no.3
• /
• pp.161-166
• /
• 2021

In this study, we present a research method to develop a shoe that prevents foot injury by inducing the foot pressure. An orthogonal grid sensor was used to check the foot pressure in the upright standing position, and the change in the foot pressure distribution for various conditions was compared. We checked the conditions for distributing foot pressure efficiently by changing the spring constant of the spring inserted into the sole of the shoe and the foot pressure generated with or without the arch of the insole. In order to minimize the experimental error from the randomness of the human body's behavior, it is possible to predict through foot pressure under certain conditions through finite element analysis that simulates the pressure distribution. By checking the change of foot pressure according to the number and arrangement of springs through finite element analysis, conditions were established to provide more efficient foot pressure. The result can be used for designing footwear for patients with diabetic feet.

• Transactions of the Korean Society for Noise and Vibration Engineering
• /
• v.21 no.9
• /
• pp.842-849
• /
• 2011

The human ear canal amplifies the sound pressure level at specific frequency bands. The characteristics of the ear canal are very similar to those of curved cylindrical tube. In this study, the characteristics of sound transfer in human ear canal were measured and the acoustical space of ear canal was reproduced from the canal cavity geometry. For the measurement of sound transfer function in ear canal, a probe microphone and a reference microphone were used. The sound transfer functions were measured for 5 human subjects. To reproduce the acoustical space of the ear canal, two kinds of ear simulator were designed. The first one is a straight cylindrical tube type and the other is a real-shape ear of which geometry was taken from a micro-CT scanning of a human ear. The characteristics of the reproduced apparatus were compared with those of the human and a commercial ear simulator, RA0045 of G.R.A.S. Inc. The comparison results show that the developed apparatus well represent the ear canal characteristics in the low frequency, but have limited coincidence in level over high frequency range.

• Journal of Fisheries and Marine Sciences Education
• /
• v.19 no.3
• /
• pp.502-509
• /
• 2007

This study evaluates thermal comfort by air conditioner temperature raising at the point of time that human body begins to adapt. Thermal comfort according to change of time enters by uncomfortable area gradually at general cold room temperature that magnetic pole is in human body. However, can know that keep continuous thermal comfort in case raise temperature in human body adaptation visual point. Experiments were performed in environmental chamber. Subjects were selected 4 men and 4 women whose life cycle were proved that are similar. The subjects stay in the pretesting room during the 30 minutes and enter the testing room under each experiment conditions. During the experiment, brain wave, electrocardiogram, blood pressure and thermal comfort and sensation responses were measured. In this study, physiological and psychological responses correspond under temperature raising at human body adaptation.