• 한국임상약학회지
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• 제26권2호
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• pp.150-162
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• 2016

Objective: First-in-human dose estimation is an essential approach for successful clinical trials for drug development. In this study, we systematically compared first-in-human dose and human pharmacokinetic parameter estimation approaches. Methods: First-in-human dose estimation approaches divided into similar drug comparison approaches, regulatory guidance based approaches, and pharmacokinetic based approaches. Human clearance, volume of distribution and bioavailability were classified for human pharmacokinetic parameter estimation approaches. Results: Similar drug comparison approaches is simple and appropriate me-too drug. Regulatory guidance based approaches is recommended from US Food and Drug Administration (FDA) and European Medicines Agency (EMA) regarding no-observed-adverse-effect level (NOAEL) or minimum anticipated biological effect level (MABEL). Pharmacokinetic based approaches are 8 approaches for human clearance estimation, 5 approaches for human volume of distribution, and 4 approaches for human bioavailability. Conclusion: This study introduced and compared all methods for first-in-human dose estimation. It would be useful practically to estimate first-in-human dose for drug development.

• 한국신재생에너지학회:학술대회논문집
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• 한국신재생에너지학회 2008년도 추계학술대회 논문집
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• pp.163-163
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• 2008

• 한국생활과학회지
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• 제21권1호
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• pp.71-82
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• 2012

The purpose of this study is to examine perceptive change in attitude toward infancy and early childhood among university students' who were exposed to a human development lecture on infancy and early childhood. This study aims to investigate the significance of education in shaping attitudes related to child development and the importance of infancy and early childhood as developmental stages. This study also seeks to provide basic data for expanding and systematizing relevant educational programs. Fifteen university students who attended a lecture on human development were divided into four groups with three groups containing 4 members and one group containing 3 members. The following results were obtained: 1) Before attending the lecture on human development, students perceived infancy as a period dominated by feelings of helpless, indifference, and a general lack of knowledge or ability to interact with their environment; 2) Before attending the lecture on human development, students perceived early childhood as an initial period of transition that can potentially influence one's future; 3) After attending the lecture, students were better able to rationalize the developmental importance of infancy and early childhood. 4) After attending the lecture, students displayed broader understanding of the importance of early childhood on human development. This study also discusses the necessity for continuous and systematic provision of programs to help adults develop a positive perception of infancy and early childhood as a developmental process related to parenting skills.

• 가정과삶의질연구
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• 제26권1호
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• pp.107-120
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• 2008

The purpose of this study was to analyze the effects of human resource development on the job satisfaction and wage among employed workers. A sample of 3,578 employed workers was selected from Korea Labor Panel Data. For data analysis, t-test and multiple regression were used. The major findings were as follows: First, the employed workers who had experiences of human resource development had more certificates of job-related qualification, more employed in government-invested organization or foreign company regularly than the counterpart. Second, the employed workers' wage was affected by gender, age, educational attainment, as well as whether they had experiences of human resource development. Third, the factors that influence employed workers' job satisfaction were gender, age, educational attainment, job regularity, having certificate of job-related qualification or not, and having experiences of human resource development or not. From the findings, it can be concluded that the employed workers' wage and job satisfaction were improved by the human resource development.

• 대한간호학회지
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• 제33권1호
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• pp.130-137
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• 2003

Purpose: The purpose of this study was to examine the effects of Self-Development training on the Human Relationship and Intrinsic Motivation for first-line nurse managers. Method: This was an empirical study on the Human Relationship and Intrinsic Motivation of Self Development Training. The researcher developed a new Self-Development Training Program, and the two-hour long training session was performed twice a week for each group. The program was performed for 4 session in two weeks. The subjects consisted with 24 nurse managers from C University Hospital in Seoul, Korea. The subjects were divided into two groups for the training. Two weeks before and 4 weeks after the training, subjects completed questionnaires that measured Human Relationship and Intrinsic Motivation. Analysis was completed by using SPSS PC 10.0 for percentile, mean, standard deviation and paired t-test. Result: The results of this study showed that Self-Development Training Program resulted in a significant effects on the Human Relationship. But the Intrinsic Motivation was not significantly affected by the program. Conclusion: This Self-Development training program had a positive effect on the Human Relationship and Intrinsic Motivation.

• Nuclear Engineering and Technology
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• 제54권9호
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• pp.3299-3309
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• 2022

Nuclear energy has the potential to play an influential role in energy transition efforts than is now anticipated by many countries. Realizing sustainable human development and reducing global climate crises will become more difficult without significantly increasing nuclear power. This paper aims to probe the role of nuclear energy, external debt, and financial globalization in sustaining human development and environmental conditions simultaneously in BRICS (Brazil, Russia, India, China, and South Africa) countries. This study applied a battery of second-generation estimation approaches over the period from 1990 to 2019. These methods are useful and robust to cross-countries dependencies, slope heterogeneity, parameters endogeneity, and serial correlation that are ignored in conventional approaches to generate more comprehensive and reliable estimates. The empirical findings indicate that nuclear energy and financial globalization contribute to human development, whereas external debt inhibits it. Similarly, financial globalization accelerates ecological deterioration, but nuclear energy and external debt promote environmental sustainability. Moreover, the study reveals bidirectional feedback causalities between human development, carbon emissions and nuclear energy consumption. The study offers useful policy guidance on accomplishing sustainable and inclusive development in BRICS countries.

• 수산경영론집
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• 제54권2호
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• pp.15-29
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• 2023

This study aims to establish a development strategy for higher education in Indonesia's marine and fisheries sector and to present a direction for international development cooperation through evaluating policies and current problems related to higher education in marine and fisheries sector. To achieve the goals of human resources development in marine and fisheries sector, Indonesian government needs to secure non-salary expenditures to strengthen support for areas directly related to the effects of education, such as improving educational facilities, expanding scholarships, and so on. Education institution needs to develop effective teaching methods and systematic practice-based curriculum that reflects the needs of the local fishermen community and fisheries industry. In addition, it is necessary to support the supply of manpower throughout the fisheries industry. Fisheries industry needs to stop relying on the government or education institutions to secure excellent human resources and actively participate and cooperate in the education field so that excellent human resources can flow into the industry. Based on this strategy, international development cooperation for human resources development in Indonesia's marine and fisheries sector should focus on qualitative rather than quantitative expansion of higher education institutions.

• 인간식물환경학회지
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• 제22권6호
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• pp.593-600
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• 2019

We identified how plants affected by the human behavior of crushing plants respond and what kind of plants responded sensitively. We investigated Lactuca sativa "Gaesebadak", Syneilesis palmata and Peucedanum japonicum as plants that humans use for edible purposes, and Achyranthes japonica and Bidens bipinnata as wild plants that stick to people's clothes and disperse seed. Plants exposed to human breathing air were compared with those exposed to human breathing air after being crushed. Methyl jasmonate (MeJA), a chemical word, was measured using Syft/MS, which detects real-time VOC, and related genes were analyzed. The amount of MeJA of Syneilesis palmata and Peucedanum japonicum as edible plants was greater than that of non-edible plants that disperse seeds using humans. The amount of MeJA ranged from 0.20 ppb to 0.35 ppb when the control group were not exposed to human breathing air. On the other hand, MeJA decreased after increasing for the first hour in human breathing air. Also, MeJA affected by human breathing after crushing plants was higher than that affected by just human breathing air. Peucedanum japonicum showed the most distinctive difference between the treatment with human breathing after crushing plants and the treatment with just human breathing. In addition, the gene activity of JAR1 and JMT increased 3 hours after the treatment with human breathing after crushing plants. Therefore, in the treatment with human breathing after crushing plants, the concentration of MeJA and the activity of related genes showed the same tendency to increase. As a result, the plant that responded sensitively to human behavior was Peucedanum japonicum. Plants released MeJA as a chemical word in the treatment with human breathing air after crushing plants.

• The Journal of Asian Finance, Economics and Business
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• 제6권1호
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• pp.321-328
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• 2019

The purpose of the study is to analyze the main approaches to assessing human capital and develop proposals for its most objective assessment of it at the different levels of manifestation - individual, microeconomic and macroeconomic. The article considers the basic approaches to the evaluation of human capital, used in practice: retrospective (costly) and prospective (income based). Cost based methods involve measuring the value of human capital based on the total costs associated with its formation. The proposed additional evaluation criteria, in particular, the use of the expert approach and the developed indicators of a qualitative assessment of the human capital of the enterprise will allow development that is more efficient and use of available human resources. Human capital is becoming a major factor in the formation and development of an innovative economy and knowledge economy. Accordingly, the proposed additions to the assessment of human capital at the country level are aimed at assessing it from a new angle, taking into account the current global trends in the formation of an innovative economy and digitalization. They meet qualitatively new requirements for human capital as the main productive factor in the creation of new highly efficient technologies that promote the active development of the social sphere, science, education, health, etc.

• 통상정보연구
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• 제4권2호
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• pp.233-252
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• 2002

This thesis is designed to draw up scheme for human resources development of the Korean software industry. Its concrete scheme is as follows. That is, IT professionals with international competitiveness should be cultivated, and a human resource development system, which can flexibly meet the market demands, has to be built. Pool of specialized programmers is necessary condition for achieving competitiveness in Korean software industry. Reeducation is also desirable to embody the agile productive capability into the existing human resources for new challenges in the industry. Well-organized human resources database will also make it easy to match new demand and to lower the transaction cost in switching jobs. To cope with the rapidly changing environment actively, human resource development and training system improvement through the cooperation with the concerned industries, universities, research centers and the government must be settled immediately.