• Title/Summary/Keyword: hepatoma

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Inhibitory Effect of Artemisia princeps Pampan.. Extract on Growth of Cancer Cell Lines (쑥(Artemisia princeps Pampan) 추출 성분의 암세포증식 억제효과)

  • 황윤경
    • Journal of Nutrition and Health
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    • v.31 no.4
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    • pp.799-808
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    • 1998
  • To investigate the antitumor activity of mugwort (Artemisia princeps Pampan), petroleum ether extract of mugwork was partially purified by a silica gel chromatography. Among several fractions, the fraction which was obtained under the elution with acetone, showed potent cytotoxicity against mouse leukemia cell line(Ll210), human colon cancer cell line (HCT-48) and human hepatoma cell line (Hep G2) , but was less effective with normal cell line(mouse embryo cell). Acetone fraction appeared to be glycolipid by Benedict test and the major fatty acids of the lipid were C16 ; 0 , C 18: 3by GC/MS analysis.

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Arachidonic Acid Liberated through Activation of $iPLA_2$ Mediates the Production of Reactive Oxygen Species and Apoptosis Induced by N-Ethylmaleimide in HepG2 Human Hepatoma Cells

  • Lee, Yong-Soo
    • Proceedings of the PSK Conference
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    • 2002.10a
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    • pp.242.2-243
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    • 2002
  • We have previously reported that activation of $K^{+}$-$Cl^{-}$-cotransport (KCC) by N-ethylmaleimide (NEM) induces apoptosis through generation of reactive oxygen species (ROS) in HepG2 human hepatoblastoma cells. In this study we investigated the possible role of phospholipase $A_2$($PLA_2$)-arachidonic acid (AA) signals in the mechanism of the NEM actions. (omitted)

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Effect of Acidic Polysaccharides of White Ginseng on Lipolytic Action of Toxohormone-L from Cancerous Ascites Fluid (고려백삼의 산성다당체 성분이 암독소호르몬-L의 지방질분해에 미치는 영향에 관하여)

  • Lee, Seong-Dong;Jeon, Jung-Chi
    • The Korean Journal of Food And Nutrition
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    • v.3 no.1
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    • pp.9-12
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    • 1990
  • Toxohormone-L is a lipolytic factor, found in ascites fluid of sarcoma 180-bearing mice and of patients with hepatoma. A substance that inhibited the lipolytic action of toxohormone-L was isolated from white ginseng powder. This substance was an acidic polysaccharides It inhibited toxohormone-L-induced lipolysis in a dose dependent manner at concentrations higher than 100g/ml.

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Effect of KEUMSUNYEON on Lipolytic Action of Toxohormone-L from Cancerous Ascites Fluid (Toxohormone-L의 지방질분해 작용에 미치는 금선연의 영향)

  • 이성동;취전척도
    • The Korean Journal of Food And Nutrition
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    • v.2 no.2
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    • pp.27-30
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    • 1989
  • This study was devised to observe an inhibitory reaction toward an lipolytic action of toxohormone-L from KEUMSUNYEON powder. Toxohormone-L is known to be a lipolytic factor that was purified from the ascites fluid of sarcoma 180-bearing mice and of patients with hepatoma. KEUMSUNYEON powder was found to inhibit toxohormone-L induced lipolysis at its concentration of 0.5 mg/ml.

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EXPERIMENTAL AND EPIDEMIOLOGICAL EVIDENCE FOR NON-ORGAN SPECIFIC CANCER PREVENTIVE EFFECT OF KOREAN GINSENG AND IDENTIFICATION OF ACTIVE COMPOUNDS

  • Yun, Taik-Koo
    • Proceedings of the Korean Society of Toxicology Conference
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    • 2001.10a
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    • pp.17-18
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    • 2001
  • Panax ginseng C. A. Meyer has been the most highly recognized medicinal herb in the Orient. The prolonged administration of red ginseng extract significantly inhibited the incidence of hepatoma and also proliferation of pulmonary tumors induced by aflatoxin B$_1$and urethane. Statistically significant anticarcinogenic effects were observed in powders and extract of 6 year-dried fresh ginseng, 5 and 6 year-white ginseng and 4, 5 and 6 year-red ginseng by 9 week medium-term anticarcinogenicity test using benzo[a]pyrene (Yun's model).(omitted)

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ANTIMUTAGENICITY OF DIETARY AND MEDICINAL FLAVONOLS IN HUMAN DERIVED METABOLICALLY COMPETENT HEPATOMA CELLS

  • Sundermann, Volker-Mersch;Alessandro Naher;Richard Gminski
    • Proceedings of the Korean Society of Toxicology Conference
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    • 2001.10a
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    • pp.91-92
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    • 2001
  • Flavonols are polyphenolic compounds that are present in dietary plant-based foodstuffs and beverages (e. g. apple, onion, grape fruit, tea) and medicinal plants (e. g. Crategus, Ruta graveolens, Silybum marianum, Fagopyrum species) in high concentrations. They have been reported to exhibit a wide variety of biological effects, including anti-inflammatory, antiviral, antioxidant and free-radical-scavenging activities.(omitted)

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