• Nutrition Research and Practice
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• 제17권5호
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• pp.883-898
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• 2023

BACKGROUND/OBJECTIVES: Probiotics have been suggested as potent modulators of age-related disorders in immunological functions, yet little is known about sex-dependent effects of probiotic supplements. Therefore, we aimed to investigate sex-dependent effects of probiotics on profiles of the gut microbiota and peripheral immune cells in healthy older adults. SUBJECTS/METHODS: In a randomized, double-blind, placebo-controlled, multicenter trial, healthy elderly individuals ≥ 65 yrs old were administered probiotic capsules (or placebo) for 12 wk. Gut microbiota was analyzed using 16S rRNA gene sequencing and bioinformatic analyses. Peripheral immune cells were profiled using flow cytometry for lymphocytes (natural killer, B, CD4⁺ T, and CD8⁺ T cells), dendritic cells, monocytes, and their subpopulations. RESULTS: Compared with placebo, phylum Firmicutes was significantly reduced in the probiotic group in women, but not in men. At the genus level, sex-specific responses included reductions in the relative abundances of pro-inflammatory gut microbes, including Catabacter and unclassified_Coriobacteriales, and Burkholderia and unclassified Enterobacteriaceae, in men and women, respectively. Peripheral immune cell profiling analysis revealed that in men, probiotics significantly reduced the proportions of dendritic cells and CD14⁺ CD16^- monocytes; however, these effects were not observed in women. In contrast, the proportion of total CD4⁺ T cells was significantly reduced in women in the probiotic group. Additionally, serum lipopolysaccharide-binding protein levels showed a decreasing tendency that were positively associated with changes in gut bacteria, including Catabacter (ρ = 0.678, P < 0.05) and Burkholderia (ρ = 0.673, P < 0.05) in men and women, respectively. CONCLUSIONS: These results suggest that probiotic supplementation may reduce the incidence of inflammation-related diseases by regulating the profiles of the gut microbiota and peripheral immune cells in healthy elders in a sex-specific manner.

• 대한간호학회지
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• 제17권2호
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• pp.116-121
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• 1987

This study was undertaken to elucidate effects of ingesting small or large amount of tap or iced water on circulation of normal healthy men with the purpose of furnishing basic data for nursing intervention of myocardial infarction patients. The subjects for this study were normal healthy men consisting of 30men and 30women in age from 22 to 30 years. One group consisting of 30men drank 240m1 tap water on day l and 240m1 iced water 24hours later. The other group drank 960m1 tap water on day 1 and 960m1 iced water 24hours later. Blood pressure and heart rate were taken in a sitting position before ingesting water, and immediately after ingesting it and at 2,5,10,15,30 minute intervals thereafter. Changes of heart rate, systolic and diastolic blood pressure after ingesting water were compared with those of preingestive period. The results obtained were as follows : 1. There were no significant changes in blood pressure and heart rater after ingesting small amount of water regardless of its temperature. 2. No significant decrease in blood pressure after ingesting large amount of tap water at all time peroids was noted. 3. A strongly significant interaction effect bet-ween temperature and volume was demonstrated, that is, there was a highly significant decrease in blood pressure and heart rate at all time periods after ingesting large amount of iced water.

• 운동영양학회지
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• 제23권2호
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• pp.7-12
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• 2019

[Purpose] Eccentric exercise induces a decrease in vascular endothelial function. Curcumin, a major component of turmeric, has potent antioxidant and anti-inflammatory properties that are associated with vascular protective effects. The present study examined the effect of acute supplementation of curcumin on eccentric exercise-induced endothelial dysfunction in healthy young men. [Methods] Fourteen healthy sedentary young men (range, 21-29 years) were assigned to either the curcumin (n = 6) or placebo (n = 8) group. All subjects consumed either curcumin or placebo before exercise, and eccentric exercise of the elbow flexors was performed with their nondominant arm. Before and 60 min after exercise, brachial artery flow-mediated dilation (FMD), as an indicator of endothelial function, was measured in the non-exercised arm. [Results] Brachial artery FMD significantly decreased following eccentric exercise (p < 0.05) in the placebo group, but acute supplementation with curcumin before exercise nullified this change. The change in FMD before and after eccentric exercise between the placebo and curcumin groups was significantly different (p < 0.05). [Conclusion] The present study found that acute curcumin supplementation could attenuate the decrease in endothelial function, as measured by FMD, following eccentric exercise in healthy young men.

• Nutrition Research and Practice
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• 제17권2호
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• pp.316-329
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• 2023

BACKGROUND/OBJECTIVES: This study investigated the association between dietary quality based on the Korean Healthy Eating Index (KHEI), and the prevalence of chronic conditions among middle-aged individuals (40-60 yrs of age) living alone. MATERIALS/METHODS: The participants were selected (1,517 men and 2,596 women) from the Korea National Health and Nutrition Examination Survey (KNHANES) 2016-2018 and classified into single-person households (SPH) and multi-person households (MPH). Nutrient intake, KHEI, and the prevalence of chronic conditions were compared according to household size. The odds ratios (ORs) of chronic conditions were analyzed according to the tertile levels of KHEI by gender within each household size category. RESULTS: Men in SPH had a significantly lower total KHEI score (P < 0.0001) and a lower prevalence of obesity (OR, 0.576) than those in MPH. For men, the adjusted ORs for obesity, hypertension, and hypertriglyceridemia in the first tertile (T1) of KHEI scores within SPH compared with the third tertile (T3) were 4.625, 3.790, and 4.333, respectively. Moreover, the adjusted OR for hypertriglyceridemia in the T1 group compared to the T3 group within the MPH was 1.556. For women, the adjusted ORs for obesity and hypertriglyceridemia in T1 compared to T3 within the SPH were 3.223 and 7.134, respectively, and 1.573 and 1.373 for obesity and hypertension, respectively, within MPH. CONCLUSIONS: A healthy eating index was associated with a reduced risk of chronic conditions in middle-aged adults. Greater adherence to a healthy eating index could lower the risk of chronic conditions in middle-aged adults living alone.

• Nutrition Research and Practice
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• 제12권1호
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• pp.47-51
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• 2018

BACKGROUND/OBJECTTIVES: The purposes of the study were to investigate folate intakes and plasma folate concentrations as well as estimate folate status in Korean healthy adults. SUBJECTS/METHODS: A total of 254 healthy 19- to 64-year-old adults (68 men and 186 women) living in Seoul metropolitan area, Gumi, and Kwangju, Korea participated. Three consecutive 24-hour dietary recalls, information on folate supplementation, and fasting blood samples were collected from the subjects. RESULTS: The mean dietary folate intakes were 587.4 and $499.2{\mu}g$ dietary folate equivalent (DFE)/day for men and women, respectively. The median dietary intakes of men and women were 566.6 and $474.6{\mu}g\;DFE/day$, respectively. Forty subjects (16.7% of total) less total folate than the estimated average requirement (EAR). Folate intakes of 23.3% of men and 34.8% of women aged 19-29 years did not meet the EAR for folate. Major food sources consumed for dietary folate were baechukimchi (Chinese cabbage kimchi), rice, spinach, eggs, and laver, which provided 44% of dietary folate intake for the subjects. Plasma folate concentrations were 23.4 nmol/L for men and 28.3 nmol/L for women, and this level was significantly lower in men than in women. Approximately 13% of men and 3% of women were folate-deficient, and the percentages of subjects showing folate concentrations lower than 10 nmol/L were 27.9% of men and 6.4% of women. CONCLUSIONS: Folate intakes of Korean adults in this study were generally adequate. However, one-third of young adults had inadequate folate intakes.

• 한국전문물리치료학회지
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• 제3권1호
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• pp.40-47
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• 1996

Body position is known to have an effect on vital capacity(VC). The purpose of this study was to examine effect on VC of posture, sex and smoking, and the difference between predicted and measured values of VC. VC was measured in the standing and the $30^{\circ}$ head-down position in 40 healthy subjects (20 men and 20 women) in a random order of testing. When subjects changed from standing to head-down position, this VC decreased by 19.9%. In both positions, VC changes in men were significantly larger than in women. No statistically significant difference was found in men who smoked. There was no difference between the predicted and measured values in men. But measured values were larger than predicted values in women. Because VC can decrease by 19.9% in the head-down position due to the effect of gravity, attention should be paid especially to patients who are placed in the head-down position for postural drainage since they already have a decreased VC.

• 대한지역사회영양학회지
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• 제10권3호
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• pp.281-289
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• 2005

Hyperlipidemia and related heart disease will be growing public health problems as the population ages. It is therefore of great importance to identify modifiable risk factors. So this research investigated associations among life style, nutrient intake, and blood lipids in middle-aged men with borderline hyperlipidemia. Dietary intakes were assessed by food-frequency questionnaire and convenient method. The subject's histories of alcohol use and smoking were assessed via a questionnaire. Current smokers were classified as smokers, whereas past smokers and subjects who never smoked were classified as nonsmokers. With regard to alcohol intake, the subjects were stratified into drinkers and nondrinkers. In drinkers the frequency were measured. Frequency of alcohol intake and weight were associated with high blood lipids and blood pressure. The highest quartile of calcium intake had lower triglyceride concentration than did those in the lower three quartiles. High calcium intake was associated with low blood triglyceride concentration. These results suggest that healthy weight and high calcium intake and less alcohol intake can contribute to maintenance of healthy blood lipids in men.

• 대한한방부인과학회지
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• 제21권1호
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• pp.199-205
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• 2008

Purpose: This study was conducted for evaluating whether the postpartum women has lower threshold than healthy non delivered women and men. Methods: We divided the groups by three. Group I is consist of postpartum women who have delivered within 7days. Group II is nonparous women, and the Group III is consist of men. Pain threshold in 6 specific points was measured using the digital algometer from each groups. Results: Pain threshold was obviously higher in Group III than Group I, II, And group II’s threshold was significantly higher than group I’s Conclusion: This study shows the postpartum women had lower pressure pain threshold than non delivered women and men. So clinicians should consider the physiologic and psychologic aspects for the pain control if they meet postpartum women.

• Journal of Nutrition and Health
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• 제30권3호
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• pp.277-285
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• 1997

The purpose of this study was to investigate the relationship among nutrient intake, life style, and serum lipids level in 108 healthy middle-aged men in Taegu. A convenient method was to assess nutritional intake. Anthropometric measuement of body weight and hight were measured and average energy expenditure was calculated. The mean body mass index(BMI) was 22.8$\pm$2.4 and it was in the middle of the mean BMI of Korean men. Obesity rate of study subject were 13.2%. Daily energy intake was not sufficient as 88.4% of recommended dietary allowances and the energy percentage of carboydrate, fat protein was 65 : 21 : 14. Mean intake of vitamin A, B1, C and Ca were lower than RDA. There was a highly significant negative correlation between the systolic blood pressure and calcium intake(r=-0.28, p<0.05). Smokers showed significantly higher blood glucose than non-smokers. Skipping meals and uneven diurnal distribution(no breakfast and large evening meals) are associated with high triglyceride level in this population. There was a highly significant correlation between body weight and plasma lipids. Energy expenditure was negatively correlated with plasma triglyceride level. Especially, atherogenic index was significantly lower in job-time physically active worker than that in sedentary worker. Above data provides valuable imformation to the community for program planning as well as to health providers who work individual male adults to meet their nutrition needs and to control blood lipids.

• Nutritional Sciences
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• 제5권2호
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• pp.91-102
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• 2002

A survey of how dietary patterns and living habits were related to individual health status was undertaken amongst the elderly in Jeon-ju the results were analyzed in order to collect information which would be useful in preventing chronic diseases and promoting health in the general population. Two hundred and thirty elderly people, 73 min (31.7%) and 157 women (68.3%) from the colleges and households in the Jeon-ju area, were studied in truly and August, 1999. Average scores for men and women, respectively, in nutrition-related questions were as follows: 4.98 $\pm$ 0.24 and 5.24 $\pm$ 0.13 in a nutrition knowledge test (maximum score= 10), 25.92 $\pm$ 0.39 and 26.04 $\pm$ 0.26 for nutrition attitudes (maximum=50), and 11.25 $\pm$ 0.15 and 10.70 $\pm$ 0.12 for dietary habits (maximum= 15). The percentages of smokers and drinkers in the sample were 23.3% and 31.5% among men, and 3.2% and 10.8% among women, respectively, while those who took regular exercise were 67.1% among men and 34.8% among women. Average scores of clinical symptoms for men and women were 27.62 $\pm$ 0.62 and 33.36 $\pm$ 0.47, respectively. Analysis was carried out on the effects of individual dietary patterns and lifestyles on current health status in a healthy group (below the 25 percentile in clinical symptom scores) and an unhealthy group (above the 75 percentile in clinical symptom scores). The results show that the healthy elderly group had relatively good nutrition knowledge, nutrition attitudes, and dietary patterns, ate with family, took nutrition supplements and snacks, and did not smoke. The most healthy group ate out once a month, drank small quantities of alcohol occasionally, and exercised once or twice a week. We believe that the results of this study will be helpful in developing or coordinating plans or programs f)r improving the health of elderly people.