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Folate food source, usual intake, and folate status in Korean adults

  • Kim, Young-Nam (Department of Food and Nutrition, Songwon University) ;
  • Cho, Youn-Ok (Department of Food and Nutrition, Duksung Women's University)
  • Received : 2017.10.12
  • Accepted : 2017.12.15
  • Published : 2018.02.01

Abstract

BACKGROUND/OBJECTTIVES: The purposes of the study were to investigate folate intakes and plasma folate concentrations as well as estimate folate status in Korean healthy adults. SUBJECTS/METHODS: A total of 254 healthy 19- to 64-year-old adults (68 men and 186 women) living in Seoul metropolitan area, Gumi, and Kwangju, Korea participated. Three consecutive 24-hour dietary recalls, information on folate supplementation, and fasting blood samples were collected from the subjects. RESULTS: The mean dietary folate intakes were 587.4 and $499.2{\mu}g$ dietary folate equivalent (DFE)/day for men and women, respectively. The median dietary intakes of men and women were 566.6 and $474.6{\mu}g\;DFE/day$, respectively. Forty subjects (16.7% of total) less total folate than the estimated average requirement (EAR). Folate intakes of 23.3% of men and 34.8% of women aged 19-29 years did not meet the EAR for folate. Major food sources consumed for dietary folate were baechukimchi (Chinese cabbage kimchi), rice, spinach, eggs, and laver, which provided 44% of dietary folate intake for the subjects. Plasma folate concentrations were 23.4 nmol/L for men and 28.3 nmol/L for women, and this level was significantly lower in men than in women. Approximately 13% of men and 3% of women were folate-deficient, and the percentages of subjects showing folate concentrations lower than 10 nmol/L were 27.9% of men and 6.4% of women. CONCLUSIONS: Folate intakes of Korean adults in this study were generally adequate. However, one-third of young adults had inadequate folate intakes.

Keywords

References

  1. Institute of Medicine (US) Standing Committee on the Scientific Evaluation of Dietary Reference Intakes and its Panel on Folate, Other B Vitamins, and Choline. Dietary Reference Intakes for Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and Choline. Washington, D.C.: National Academies Press; 1998.
  2. Gibson RS. Principles of Nutritional Assessment. 2nd ed. New York (NY): Oxford University Press; 2005.
  3. EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA). Scientific opinion on dietary reference values for folate. EFSA J 2014;12:3893.
  4. Chan YM, Bailey R, O'Connor DL. Folate. Adv Nutr 2013;4:123-5. https://doi.org/10.3945/an.112.003392
  5. Han YH, Yon M, Hyun TH. Folate intake estimated with an updated database and its association to blood folate and homocysteine in Korean college students. Eur J Clin Nutr 2005;59:246-54. https://doi.org/10.1038/sj.ejcn.1602065
  6. Kim JH, Lee E, Hyun T. Dietary folate intake and food sources of children and adolescents in Chungcheong area: using nutrient database revised by measured folate in selected foods. J Nutr Health 2015;48:94-104. https://doi.org/10.4163/jnh.2015.48.1.94
  7. Ministry of Health and Welfare (KR); The Korean Nutrition Society. Dietary Reference Intakes for Koreans 2015. Sejong: Ministry of Health and Welfare; 2016.
  8. World Health Organization. Nutritional anaemias: report of a WHO scientific group [Internet]. Geneva: World Health Organization; 1968 [cited 2017 June 7]. Available from: http://apps.who.int/iris/bitstream/10665/40707/1/WHO_TRS_405.pdf.
  9. World Health Organization (WHO). Serum and red blood cell folate concentrations for assessing folate status in populations [Internet]. Geneva: World Health Organization; 2012 [cited 2016 July 19]. Available from: http://apps.who.int/iris/bitstream/10665/75584/1/WHO_NMH_NHD_EPG_12.1_eng.pdf.
  10. de Benoist B. Conclusions of a WHO Technical Consultation on folate and vitamin B12 deficiencies. Food Nutr Bull 2008;29:S238-44. https://doi.org/10.1177/15648265080292S129
  11. Lim HS, Jin HO, Lee JA. Dietary intakes and status of folate in Korean women of child-bearing potential. Korean J Nutr 2000;33:296-303.
  12. Kang MH, Chang N. Effect of dietary folate intakes on serum folate levels of pregnant and lactating women. Korean J Nutr 1993;26:433-42.
  13. Lee GJ, Jang HM, Ahn HS. A change of serum folate and vitamin B12 concentrations of maternal and umbilical cord blood during pregnancy. Korean J Community Nutr 2005;10:615-22.
  14. Kim H, Kim KN, Hwang JY, Ha EH, Park H, Ha M, Kim Y, Hong YC, Chang N. Relation between serum folate status and blood mercury concentrations in pregnant women. Nutrition 2013;29:514-8. https://doi.org/10.1016/j.nut.2012.08.012
  15. Jang HB, Han YH, Piyathilake CJ, Kim H, Hyun T. Intake and blood concentrations of folate and their association with health-related behaviors in Korean college students. Nutr Res Pract 2013;7:216-23. https://doi.org/10.4162/nrp.2013.7.3.216
  16. Kim HJ, Kim H, Kim KN, Kim G, Son JI, Kim SY, Chang N. Relationship among plasma homocysteine, folate, vitamin B12 and nutrient intake and neurocognitive function in the elderly. Korean J Nutr 2011;44:498-506. https://doi.org/10.4163/kjn.2011.44.6.498
  17. Min H. Folate status and plasma homocysteine concentration of Korean adults. Korean J Nutr 2001;34:393-400.
  18. The Korean Nutrition Society. CAN-Pro 4.0 for professionals. Seoul: The Korean Nutrition Society; 2011.
  19. The Korean Nutrition Society. Dietary Reference Intakes for Koreans. 1st rev. ed. Seoul: The Korean Nutrition Society; 2010.
  20. Kim YN, Cho YO. Vitamin E status of 20- to 59-year-old adults living in the Seoul metropolitan area of South Korea. Nutr Res Pract 2015;9:192-8. https://doi.org/10.4162/nrp.2015.9.2.192
  21. Hyun T, Han YH, Lim EY. Blood folate level determined by a microplate reader and folate intake measured by a weighted food record. Korean J Community Nutr 1999;4:512-20.
  22. Selhub J, Jacques PF, Dallal G, Choumenkovitch S, Rogers G. The use of blood concentrations of vitamins and their respective functional indicators to define folate and vitamin B12 status. Food Nutr Bull 2008;29:S67-73. https://doi.org/10.1177/156482650802900108
  23. O'Keefe CA, Bailey LB, Thomas EA, Hofler SA, Davis BA, Cerda JJ, Gregory JF 3rd. Controlled dietary folate affects folate status in nonpregnant women. J Nutr 1995;125:2717-25.
  24. Takata Y, Cai Q, Beeghly-Fadiel A, Li H, Shrubsole MJ, Ji BT, Yang G, Chow WH, Gao YT, Zheng W, Shu XO. Dietary B vitamin and methionine intakes and lung cancer risk among female never smokers in China. Cancer Causes Control 2012;23:1965-75. https://doi.org/10.1007/s10552-012-0074-z
  25. Buttriss JL. Folate status in the UK. Nutr Bull 2015;40:153-7. https://doi.org/10.1111/nbu.12148
  26. U.S. Department of Agriculture, Agricultural Research Service. Total nutrient intakes: percent reporting and mean amounts of selected vitamins and minerals from food and beverages and dietary supplements, by gender and age, what we eat in America, NHANES 2011-2012 [Internet]. Washington, D.C.: U.S. Department of Agriculture; 2017 [cited 2017 May 29]. Available from: http://www.ars.usda.gov/ba/bhnrc/fsrg.
  27. Halsted CH, Villanueva JA, Devlin AM, Chandler CJ. Metabolic interactions of alcohol and folate. J Nutr 2002;132:2367S-2372S. https://doi.org/10.1093/jn/132.8.2367S
  28. McKillop DJ, Pentieva K, Daly D, McPartlin JM, Hughes J, Strain JJ, Scott JM, McNulty H. The effect of different cooking methods on folate retention in various foods that are amongst the major contributors to folate intake in the UK diet. Br J Nutr 2002;88:681-8. https://doi.org/10.1079/BJN2002733
  29. Gropper SA, Smith JL. Advanced Nutrition and Human Metabolism. 6th ed. Belmont (CA): Wadsworth/Cengage Learning; 2013.
  30. Ganguly P, Alam SF. Role of homocysteine in the development of cardiovascular disease. Nutr J 2015;14:6. https://doi.org/10.1186/1475-2891-14-6
  31. Winkels RM, Brouwer IA, Verhoef P, van Oort FV, Durga J, Katan MB. Gender and body size affect the response of erythrocyte folate to folic acid treatment. J Nutr 2008;138:1456-61. https://doi.org/10.1093/jn/138.8.1456
  32. van der Griend R, Haas FJ, Biesma DH, Duran M, Meuwissen OJ, Banga JD. Combination of low-dose folic acid and pyridoxine for treatment of hyperhomocysteinaemia in patients with premature arterial disease and their relatives. Atherosclerosis 1999;143:177-83. https://doi.org/10.1016/S0021-9150(98)00273-1
  33. Hopkins SM, Gibney MJ, Nugent AP, McNulty H, Molloy AM, Scott JM, Flynn A, Strain JJ, Ward M, Walton J, McNulty BA. Impact of voluntary fortification and supplement use on dietary intakes and biomarker status of folate and vitamin B-12 in Irish adults. Am J Clin Nutr 2015;101:1163-72. https://doi.org/10.3945/ajcn.115.107151
  34. Ganji V, Kafai MR. Trends in serum folate, RBC folate, and circulating total homocysteine concentrations in the United States: analysis of data from National Health and Nutrition Examination Surveys, 1988-1994, 1999-2000, and 2001-2002. J Nutr 2006;136:153-8. https://doi.org/10.1093/jn/136.1.153
  35. Green R. Indicators for assessing folate and vitamin B-12 status and for monitoring the efficacy of intervention strategies. Am J Clin Nutr 2011;94:666S-672S. https://doi.org/10.3945/ajcn.110.009613

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