• Title/Summary/Keyword: health science

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The Effects of MRI on Mouse Embryos During Fetal Stage

  • Nakamura, Takashi;Ryu, Myung-Sun;Sakazaki, Takahiko;Itokawa, Yuka;Maenaka, Toshihiro;Masubuchi, Takashi;Sekimoto, Hiroyuki;Kanehara, Masayuki;Kang, Young-Nam;Gu, Yeun-Hwa
    • Journal of Radiation Protection and Research
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    • v.31 no.2
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    • pp.91-96
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    • 2006
  • The effects of Magnetic resonance imaging (MRI) on mouse embryos at the early stage of organogenesis were investigated. Pregnant ICR mice were exposed on day 8 of gestation to MRI at 0.5 T for 0.5 hour to 3 hours. The mortality rates of embryos or fetuses, the incidence of external malformations, fetal body weight and sex ratio were observed at day 18 of gestation. A significant increase in embryonic mortality was observed after exposure to either 0.5 T MRI for 0.5 hour or 2 hours. However, the exposure to MRI for 1 hour or 3 hours did not induce any significant increase in embryonic mortality when compared with control. External malformations such as exencephaly, cleft palate and anomalies of tail were observed in all experimental groups exposed to each MRI. A statistically significant increase of external malformations was observed in all groups treated with 0.5 T MRI for 0.5 hour and 3 hours. The incidence of external malformations in the mice group exposed to 0.5 T MRI for 0.5-hour was found to be higher than those of mice group exposed to 0.5 T MRI for 2 hours. The effects of MRI on the external malformations might not to be dose-dependent. There was no statistically significant difference in fetal body weight and sex ratio among each MRI exposure groups.

Mammographic Screening of Women Attending a Reference Service Center in Southern Brazil

  • Lopes, Tiara Cristina Romeiro;Gravena, Angela Andreia Franca;de Oliveira Demitto, Marcela;Brischiliari, Sheila Cristina Rocha;Borghesan, Deise Helena Pelloso;Agnolo, Catia Millene Dell;de Barros Carvalho, Maria Dalva;Pelloso, Sandra Marisa
    • Asian Pacific Journal of Cancer Prevention
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    • v.17 no.3
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    • pp.1385-1391
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    • 2016
  • Background: To investigate the prevalence of and factors associated with performance of annual mammography by women above 40 years of age. Materials and Methods: This cross-sectional retrospective study was conducted at an oncology reference service in Southern Brazil from October 2013 to October 2014 with 525 women aged 40 years or older. Results: The prevalence of annual mammography was 54.1%; annual mammographic screening was performed for women without private medical insurance, who were under hormone replacement therapy and who had used contraception in the past. An association was found between non-performance of breast clinical and self-examination and non-performance of mammographic screening. Conclusions: Use of mammography for breast cancer screening in the public health care setting proved to be accessible; nevertheless, the proportion of screened women was low, and they exhibited poor adherence to the basic measures of care recommended for breast assessment. Thus, control of breast cancer requires implementing actions targeting the population most vulnerable to non-adherence to screening in addition to continuously monitoring and assessing that population to reduce the prevalence of this disease.

Genome-wide Association Study Identified TIMP2 Genetic Variant with Susceptibility to Osteoarthritis

  • Keam, Bhum-Suk;Hwang, Joo-Yeon;Go, Min-Jin;Heo, Jee-Yeon;Park, Mi-Sun;Lee, Ji-Young;Kim, Nam-Hee;Park, Miey;Oh, Ji-Hee;Kim, Dong-Hyun;Jeong, Jin-Young;Lee, Jong-Young;Han, Bok-Ghee;Lee, Ju-Young
    • Genomics & Informatics
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    • v.9 no.3
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    • pp.121-126
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    • 2011
  • Osteoarthritis (OA) is the most common degenerative joint disorder in the elderly population. To identify OA-associated genetic variants and candidate genes, we conducted a genome-wide association study (GWAS). A total 3,793 samples (476 cases: wrist + knee and 3317 controls) from a community-based epidemiological study were genotyped using the Affymetrix SNP 5.0. An intronic SNP (rs4789934) in the TIMP2 (tissue inhibitor of metalloproteinase-2) showed the most significance with OA (odd ratio [OR] = 2.06, 95% confidence interval [CI] = 1.52-2.81, p = $4.01{\times}10^{-6}$). Furthermore, a poly-morphism (rs1352677) in the NKAIN2 ($Na^+/K^+$ transporting ATPase interacting 2) was suggestively associated with OA (OR = 1.43, CI = 1.22-1.66, p = $7.01{\times}10^{-6}$). The present study provides new insights into the identification of genetic predisposing factors for OA.

A Study on the Health Science College Student's Pattern and Interest of Oral Health Care According to Smoking or not and Health - Related and Health-Unrelated Majors (일부 대학생들의 흡연유무 및 계열에 따른 구강관리 행태 및 관심도에 관한 조사)

  • Lee, Jung-Hwa;Jeon, Eun-Suk
    • The Korean Journal of Health Service Management
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    • v.5 no.3
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    • pp.169-177
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    • 2011
  • The purpose of this study were to investigate smoking status and management and knowledge of oral health, to provide basic data of giving up smoking policy for oral health management and oral health educational program. 268 self-reporting questionnaire were collected from March 3, 2010 to March 10, 2010. The results were as follows; (1) As to compare department, the answers of that in health science department were 38.3% and the other department were 44.3%, however it was shown statistically significant correlation(p>0.001). (2) As to compare department, the answers of that in health science department were 50.8% and the other department were 68.6%(p<0.007). (3) As to compare department(p<0.00), the answers of that in health science department were 36.7% and the other department were 55.0%, smoker group and non-health science department group were higher than that of the others(p<0.014).

The Determination of Ethyl Isocyanate and Propyl Isocyanate by GC/FID (에틸 이소시아네이트와 프로필 이소시아네이트의 GC/FID 분석)

  • Lee, Eun-Jung;Yoo, Chul;Choi, Hong-Soon;Park, Jun-Ho;Yoon, Ju-Song;Cho, Young-Bong
    • Environmental Analysis Health and Toxicology
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    • v.15 no.1_2
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    • pp.53-59
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    • 2000
  • The purpose of this study is the development of the simple and precise determination method of ethyl isocyanate (EIC) and propyl isocyanate (PIC) through derivatization using secondary aliphatic amines by gas chromatography with flame ionization detector. The urea derivatives are quantitatively and simultaneously derived from EIC and PIC with secondary aliphatic amines such as dipropylamine, dibutylamine. and dipentylamine in methylene chloride, and confirmed by thin layer chromatography and gas chromatography with mass selective detector. For GC/FID, according to the increasing carbon atom of the amines, the retention time and peak area of the urea derivatives are increased. The instrumental detection limits for EIC and PIC were about 23.3∼34.8 $\mu\textrm{g}$ and 21.6∼28.9 $\mu\textrm{g}$, respectively.

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Susceptibility of several strains of mice to Echinostoma hortense infection

  • Lee, Kyu-Jae;Park, Seung-Kyu;Im, Jee-Aee;Kim, Soo-Kie;Kim, Geun-Ha;Kim, Gwang-Young;Yang, Eun-Ju;Ryang, Yong-Suk
    • Parasites, Hosts and Diseases
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    • v.42 no.2
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    • pp.51-56
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    • 2004
  • Susceptibilities of 5 different mice strains, including C3H/HeN, BALB/c, C57BL6, FvB and ICR, to Echinostoma hortense infection, was evaluated. The worm expulsion rate, worm size and egg production were observed from 1 to 8 weeks after infection with 30 metacercariae. C3H/HeN and ICR mice showed the highest worm maturation rates. The worm recovery rate and the number of eggs per gram (EPG) of feces was also higher in C3H/HeN and ICR mice than in BALB/c, C57BL6, and FvB mice. It is suggested that E. hortense is highly infectious to ICR and C3H/HeN mice, but not to the other strains of mice. Based on the results obtained, we believe that the susceptibility of different mouse strains to E. hortense infection is dependent on the genetic and immunologic back-ground of mice.