• Title/Summary/Keyword: hazard exposure

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Application of Mathematical Modeling to Extraplate from High Dose to Low Dose for Risk Assessment of Vinyl Chloride (화학물질의 건강 위해성 평가를 위한 수학 통계적 추계 모델링의 응용)

  • 이영조;이석호;이승진;정진호
    • Journal of Food Hygiene and Safety
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    • v.15 no.3
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    • pp.267-270
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    • 2000
  • This study was designed to predict the risk of a hazard chemical, vinyl chloride, by applying dose-response assessment that are one of the major process in practicing risk assessment. After extrapolating from the high dose exposure of vinyl chloride based upon animal carcinogenic data to the low dose exposed to human using several mathematical models, we calculated the cancer potency factors as well as virtually safe dose and the resulted values were compared. This process will provide the new insight to assess the risk of a chemical accurately imposed to human in the future.

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Dietitians' Perceptions of Safety Supervision in Institutional Foodservices (I) - Status of Accidents and Assessment of Hazards - (단체급식 안전관리에 대한 영양사 인식 조사(I) - 사고 현황 및 위해 평가 -)

  • Park, Hye-Ran;Moon, Hye-Kyung
    • Journal of the Korean Dietetic Association
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    • v.16 no.4
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    • pp.318-331
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    • 2010
  • The objectives of this study were to investigate the status of accidents and to assess hazards in institutional foodservices in the Changwon and Masan areas. A survey was conducted from February 1 to March 31, 2009 using questionnaires, and 142 dietitians participated. The dietitians' perception of accident risks in workplace averaged 3.11 points. Forty-five percent of the respondents responded that accidents had occurred more than once between 2006 and 2008. In addition, 28.2% of the respondents experienced employee absences or turnover due to accidents during Year 2008. 'Musculoskelectal injuries or disorders (65.5%)', 'slips or falls (64.8%)', 'burns (57.7%)', and 'cuts and punctures (48.6%)' were the predominant accidents in foodservice. 'Knives (76 points)', 'steam kettles (41 points)', 'vegetable cutters (34 points)' and 'turn kettles (26 points)' were the equipment with severe accidents, such as burns or cut injuries. Among foodservice processes, 'carpal tunnel syndrome while washing (2.83 points)', 'burned by frying oil (2.64 points)', 'cut by sharp tools (2.55 points)', 'musculoskelectal injury by moving heavy weight food materials (2.41 points)', and 'injury by slipping on wet workplace floors and trenches (2.19 points)' were the most frequently occurring accidents at foodservice sites. To prevent safety accidents, dietitians' perceptions of safety supervision should be improved, and therefore, it is necessary they receive safety education.

Endocrine Disrupting Effects of Several Pharmaceuticals to Oryzias Latipes

  • Kang, Hee-Joo;Kim, Kyung-Tae;Kim, Hyun-Soo;Lee, Jeong-Joo;Choi, Kyung-Ho;Kim, Pan-Gyl
    • Proceedings of the Korean Environmental Health Society Conference
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    • 2005.06a
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    • pp.279-285
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    • 2005
  • Endocrine disrupting effects of four pharmaceutical products were evaluated with fish. The test pharmaceuticals, i.e., sulfamethoxazole, sulfamethazine, oxytetracycline and tetracycline have been often detected in aquatic environment, but their ecological hazard on receptors of various trophic levels has seldom been evaluated. In the present study, we conducted acute toxicity assays with a fish, Japanese medake (Oryziα lαtipes). The vitellogenin induced in female fish normally, but a endocrine disrupting chemical could give effects even male fish. We have tried 4 pharmaceutic chemicals to find out the endocrine disrupting effects. Sulfamethoxazole 1, 0.5 ppm induced vitellogenin even at male Japanese medaka. Sulfamethazine 10, 5, 1 ppm could induced vitellogenin at male fish. Oxytetracycline 10, 5, 1ppm could induced vitellogenin With the fish. Tetracycline 10, 5 ppm could induced vitellogenin at male fish. Some pharmaceuticals such as sulfamethoxazole, sulfamethazine, oxytetracycline and tetracycline could give effects to male Oryzias latipes. They could induced vitellogenin under exposure range 0.5 ${\sim}$ 10 ppm of chemicals at male Oryzias latipes.

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Assessment of toxic metals in vegetables with the health implications in Bangladesh

  • Islam, Md. S.;Ahmed, Md. K.;Proshad, Ram;Ahmed, Saad
    • Advances in environmental research
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    • v.6 no.4
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    • pp.241-254
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    • 2017
  • This study was conducted to investigate the levels of heavy metals in twelve species of vegetables and assessment of health risk. Samples were analyzed using inductively coupled plasma mass spectrometer (ICP-MS). The ranges of Cr, Ni, Cu, As, Cd and Pb in vegetables species were 0.37-5.4, 0.03-17, 0.35-45, 0.01-2.6, 0.001-2.2, and 0.04-8.8 [mg/kg, fresh weight (fw)], respectively. The concentrations of As, Cd and Pb in most vegetable species exceeded the maximum permissible levels, indicating unsafe for human consumption. Health risks associated with the intake of these metals were evaluated in terms of estimated daily intake (EDI), and carcinogenic and non-carcinogenic risks by target hazard quotient (THQ). Total THQ of the studied metals from most of the vegetables species were higher than 1, indicated that these types of vegetables might pose health risk due to metal exposure. The target carcinogenic risk (TR) for As ranged from 0.03 to 0.48 and 0.0004 to 0.025 for Pb which were higher than the USEPA acceptable risk limit (0.000001) indicating that the inhabitants consuming these vegetables are exposed to As and Pb with a lifetime cancer risk. The findings of this study reveal the health risks associated with the consumption of heavy metals through the intake of selected vegetables in adult population of Bangladesh.

Seismic Loading Requirements for Singapore Buildings

  • Pan, Tso-Chien
    • Journal of the Earthquake Engineering Society of Korea
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    • v.2 no.3
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    • pp.87-98
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    • 1998
  • In this paper, the potential ground motion in terms of the peak ground accelerations(PGAs) due to long-distance Sumatra earthquakes is investigated for Singapore, following the probabilistic seismic hazard assessment a, pp.oach. The case investigated differs from a conventional one, in that few attenuation equations for long-distance major earthquakes are readily available. The attenuation relationships developed for other regions of the world are thus reviewed. It is found that the existing attenuation equations, when extrapolated to distant major earthquakes, tend to underestimate the PGAs. By comparing with the PGAs recorded over long distances at stations of the Japanese Meteorological Agency for major earthquakes in Japan, an attenuation equation is chosen for this study. With the chosen attenuation equation, the probability of PGAs exceeding selected levels for various exposure periods of time is then computed. The results show that at Singapore there is a 10% probability in 50 years for the PGA at rock sites to exceed 1.1% g. In view of the results and the associated uncertainties, a base shear coefficient of 1.5% is being recommended as the tentative seismic loading in Singapore. The tentative seismic loading reflects the design value of the notional horizontal load, equal to 1.5% of the characteristic building weigh as specified in the BS code, which usualy governs the design of most buildings in Singapors.

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Actual Condition and Reliability Monitoring of Material Safety Data Sheets for the Organic Solvents (일부 유기용제의 물질안전보건자료의 실태와 신뢰성 조사)

  • 정규혁;김경례;김대현;오기석;유일재
    • Journal of Environmental Health Sciences
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    • v.27 no.4
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    • pp.85-91
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    • 2001
  • The regulation of Material safety data sheets(MSDS) was required for the chemicals in use in the workplace from July 1976. Under the provisions of the workplace hazardous materials information system, employers in Korea must be provided with accurate and comprehensive MSDS. To examine the reliability of MSDS for organic solvents, 63 organic solvents and MSDS were collected from the workplace of 39 companies located in Kyonggi province. Manufacture\`s MSDS were compared with the actual composition of the collected samples, and further examined the reliability by checking whether the chemicals analyzed were included in the MSDS correctly. 38 solvents were able to analyze their composition by gas chromatography-mass selective detector(GC-MSD). Among them, 28 solvents were incorrect in their composition and contents. In some case, health hazardous or carcinogenic chemicals which were not included in the MSDS were detected from samples. As a result of evaluating whether the MSDS correspond to the regulation required by Industrial Safety and Health Act (ISHA), the information in the MSDS including hazard classification, occupational exposure level, toxicity, regulatory information were incorrectly provided, and some MSDS did not disclose carcinogenic in their MSDS, and some MSDS were not written in the standard format. From this survey, continuous monitoring and promoting correct MSDS, and analyzing the components of the solvents were required to endure the reliability of MSDS for organic solvents.

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Inhibition of Oxidative Stress and Enhancement of Cellular Activity by Mushroom Lectins in Arsenic Induced Carcinogenesis

  • Rana, Tanmoy;Bera, Asit Kumar;Das, Subhashree;Bhattacharya, Debasis;Pan, Diganta;Das, Subrata Kumar
    • Asian Pacific Journal of Cancer Prevention
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    • v.17 no.9
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    • pp.4185-4197
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    • 2016
  • Chronic arsenicosis is a major environmental health hazard throughout the world, including India. Animals and human beings are affected due to drinking of arsenic contaminated ground water, due to natural mineral deposits, arsenical pesticides or improperly disposed arsenical chemicals. Arsenic causes cancer with production of free radicals and reactive oxygen species (ROS) that are neutralized by an elaborate antioxidant defense system consisting of enzymes and numerous non-enzymatic antioxidants. Dietary antioxidant supplements are useful to counteract the carcinogenesis effects of arsenic. Oyster mushroom lectins can be regarded as ingredients of popular foods with biopharmaceutical properties. A variety of compounds have been isolated from mushrooms, which include polysaccharides and polysaccharopeptides with immune-enhancing effects. Lectins are beneficial in reducing arsenic toxicity due to anticarcinogenetic roles and may have therapeutic application in people suffering from chronic exposure to arsenic from natural sources, a global problem that is especially relevant to millions of people on the Indian subcontinent.

The effect of computer using work hours on work-related symptom experiences (업무상 컴퓨터 사용 정도가 작업관련 불건강 증상 경험 여부 및 회수에 미치는 영향 분석)

  • Kim, Young Sun;Rhee, Kyung Yong
    • Journal of the Korea Safety Management & Science
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    • v.16 no.3
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    • pp.219-229
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    • 2014
  • Employees used computer significantly(IT employee) is increased by technological development in workplace. This study tried to find the magnitude of IT employees and the profile of their working conditions and ill health experiences in South Korea. Korean Working Conditions Survey was used with descriptive and mean difference test in order to find the difference working conditions and ill health status among the groups classified by the degree of using computer during work. Some of working conditions was positively correlated with the density of computer use such as work autonomy, the exposure of repetitive movement of hand and arms. The pain of upper extreme was also more frequently found in the highest user group of computer than lower user groups. Based on the result of hierarchical regression analysis, the effect of computer using on the experience of work-related symptoms after controlling other factors was shown as U shape. This study as heuristic one suggest that some of depth analysis with hypothesis will be done to identify the causes and pathway of impact of computer use.

Risk Assessment by Toluene Source Emission Model in Indoor Environments of New Houses (신축 주택의 톨루엔 발생량 모델을 이용한 건강위해성 평가)

  • Kim, Young-Hee;Yang, Won-Ho;Son, Bu-Soon
    • Journal of Environmental Health Sciences
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    • v.32 no.5 s.92
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    • pp.398-403
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    • 2006
  • Indoor air quality can be affected by indoor sources, ventilation, decay and outdoor levels. Understanding the effectiveness of indoor air quality control depends on knowledge of the characteristics of air pollutants in indoor air, especially their quantities and persistence, and the relevance of indoor sources to these factors. Toluene within new and established houses has been determined and factors significant to its presence have been identified. A total of 30 selected houses in Seoul, Asan and Daegu areas that were constructed within 4 years and over 4 years of construction were measured the concentration of toluene from July to September in 2004. Toluene emission decay of double-exponential model exhibited good fit of $Y=276.37e^{-1.21x}(R^{2}=0.34,\;P=0.06)$ for 2 years and then $Y=51.54e^{-0.11x}(R^{2}=0.40,\;P=0.0)$ from 23 years in new houses. In case of living in new houses, noncarcinogenic health effects of exposure to toluene was 1.38 of hazard quotient (HQ) comparing to toluene reference dose of 0.13 mg/kg-day.

The Research of Safety Effects by using a Hearing Protection(Ear Plug) in the Military (군대 청력 보호구(귀마개) 사용 및 착용 안전효과 실태조사)

  • Hwang, Sung Ho;Joo, Myo Kyoung;Park, Jae Bum
    • Journal of the Korean Society of Safety
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    • v.28 no.4
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    • pp.103-106
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    • 2013
  • During a military service, noise has unusual characteristics, and constitutes a serious hazard to hearing of military servicemen. The purpose of this study is to understand the use of hearing protection and to assess the safety effects of hearing protection by using a ear plug in military. A total of 208(the army : 101, an air force : 107) serviceman were studied utilizing a questionnaire to know how many serviceman use the hearing protection and a total of 202(the army : 110, an air force : 92) serviceman were also studied using a ear fit validation device to assess the safety effects of hearing protection by using a ear plug. The results showed that the army have low used of hearing protection than an air force because of the low frequency of the noise exposure in the army. Personal attenuation rate was increased with 8 dB after fitting education. Therefore, it is recommended that use of proper hearing protection and fitting education was more suitable for military servicemen who were being exposed of the noise in domestic military.