• 한국콘텐츠학회논문지
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• 제22권3호
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• pp.112-120
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• 2022

이 논문은 온라인 교육 콘텐츠에 나타난 젠더의 문화적 악순환 양상을 살펴보기 위하여 아동 전문 웹툰 플랫폼, 아이나무툰(EBS툰)의 인기 웹툰 상위 5위 작품에 재현된 젠더 양상을 검토하였다. 아동의 성별을 구분하는 외모 재현 양상, 성별에 따른 인물의 욕망과 문제 상황에서의 심리, 작품에서 수행하는 기능 등을 여성주의 시각에서 비판적으로 분석하였다. 여성과 남성의 외모 특질은 젠더 고정 관념을 답습하는 경우가 많았다. 대부분 여성은 긴 머리, 남성은 짧은 머리였으며 원피스를 입은 여성이 많았다. 그러나 심리적, 기능적 특질은 젠더의 상투성을 깬 측면이 있었다. 주인공의 성별 비중이 비슷하고, 양성 모두 해결사나 구원자로 기능하며 용감하고 지혜롭게 문제 상황을 극복해 나갔다. 그런데 주인공의 젠더 재현에서 젠더 고정 관념이 약하게 나타난 작품일수록 순위가 높았다. 이러한 사실은 아동 감상자들의 비판적 수용과 선택이 젠더의 문화적 악순환을 끊어내는 데 기여할 수 있음을 시사한다.

• Biomolecules & Therapeutics
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• 제25권4호
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• pp.417-426
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• 2017

4-O-methylhonokiol, a neolignan compound from Magnolia Officinalis, has been reported to have various biological activities including hair growth promoting effect. However, although transforming growth factor-${\beta}$ (TGF-${\beta}$) signal pathway has an essential role in the regression induction of hair growth, the effect of 4-O-methylhonokiol on the TGF-${\beta}$ signal pathway has not yet been elucidated. We thus examined the effect of 4-O-methylhonokiol on TGF-${\beta}$-induced canonical and noncanonical pathways in HaCaT human keratinocytes. When HaCaT cells were pretreated with 4-O-methylhonokiol, TGF-${\beta}1$-induced G1/G0 phase arrest and TGF-${\beta}1$-induced p21 expression were decreased. Moreover, 4-O-methylhonokiol inhibited nuclear translocation of Smad2/3, Smad4 and Sp1 in TGF-${\beta}1$-induced canonical pathway. We observed that ERK phosphorylation by TGF-${\beta}1$ was significantly attenuated by treatment with 4-O-methylhonokiol. 4-O-methylhonokiol inhibited TGF-${\beta}1$-induced reactive oxygen species (ROS) production and reduced the increase of NADPH oxidase 4 (NOX4) mRNA level in TGF-${\beta}1$-induced noncanonical pathway. These results indicate that 4-O-methylhonokiol could inhibit TGF-${\beta}1$-induced cell cycle arrest through inhibition of canonical and noncanonical pathways in human keratinocyte HaCaT cell and that 4-O-methylhonokiol might have protective action on TGF-${\beta}1$-induced cell cycle arrest.

• 기본간호학회지
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• 제25권3호
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• pp.185-196
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• 2018

Purpose: The purpose of this study was to investigate the alopecia experience in adults and to explain the process of their experiences. Methods: Using a grounded theory methodology, 18 interviews were performed with fourteen men and four women, 34~57 years of age, suffering from alopecia. Data were analyzed using the constant comparative analysis method. Results: The core category emerged as "inescapable fetters". adults with alopecia engaged in three stages: embarrassment, seeking solution, and acceptance phase. Causal conditions were a vicious cycle of stress, biological factors and poor life style. Contextual conditions were recognition of irreversibleness, negative social awareness, and marriage. The central phenomenon of the adaptation process among the adults with alopecia was withdrawn life due to negative body image. Action/Interaction strategies included rely on medical treatment, efforts to take good care of hair, research for information treatment, efforts to cover up hair loss, and mind control. Intervening conditions were time cost, economic cost, support of surrounding people. Consequences was burden of unfinished lifetime homework. Conclusion: When caring for these adults, it is important to identify needs, allow patients to express what they want at that moment and support them in maintaining a daily life.

• 한국임상수의학회지
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• 제33권6호
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• pp.395-399
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• 2016

In the present case, the effect and toxicity of carboplatin and cyclophosphamide chemotherapy combined with surgery of mammary tumors in a dog were examined. An 8-year old spayed female Beagle presented with a mammary tumor. Physical examination, radiography, ultrasonography, computed tomography (CT), and laboratory examination were performed. Metastasis of the mammary tumor was confirmed by CT scan. Chemotherapy using a combination of carboplatin and cyclophosphamide was initiated following surgery. The first cycle of chemotherapy was planned to last for 6 weeks; it was planned that carboplatin would be intravenously administered for the first week (1 day) and cyclophosphamide would be intravenously administered for the next 3 weeks (22 days). Between the end of cycle 1 and the beginning of cycle 2, based on CT, it was confirmed that the number and size of tumors were unchanged and the tumors had not spread to other organs. However, at the end of cycle 2 and the beginning of cycle 3, CT revealed an increase in the number and size of mass in the lung. Chemotherapy was associated with adverse effects such as lethargy, anorexia, leukopenia, and hair loss. In conclusion, this case showed that a combination of carboplatin and cyclophosphamide suppressed the development of new neoplasms as well as metastasis for a certain period of time but did not improve the survival time. Although more cases are required, this chemotherapeutic procedure remains challenging.

• 한국임상보건과학회지
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• 제5권1호
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• pp.816-824
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• 2017

Purpose. This study was classified into normal and demented elderly through K-MMSE. The purpose of this study was to analyze gait characteristics of normal elderly and demented peoples using GAITRite walking system. Methods. The subjects of this study were selected as elderly people receiving home visit physical therapy. An independent t-test was conducted to verify the statistical significance of the time-space variables of the elderly with dementia. Results. Step time(p=0.041), cycle time(p=0.037), distance(p=0.024), and cadence(p=0.048) were significantly shorter in the normal elderly than in the demented elderly on flat place. The mean age was significantly longer in normal elderly than in elderly persons with dementia. Step time(p=0.022), cycle time(p=0.023), distance(p=0.019), and cadence(p=0.015) were significantly shorter in the mat walking. The mean age was significantly longer in normal elderly than in elderly patients with dementia. Stretch time, cycle time, distance, and hair support time were significantly shorter in the mat walking. The mean age of the elderly was significantly longer than that of the elderly with dementia. The spinal support time, which is a spatial variable, was significantly shorter in the normal elderly than in the demented elderly. Conclusions. It compares the various gait characteristics of the normal and demented elderly people, thereby increasing the walking ability of the elderly person more effectively. This study should be utilized as basic data for preventing fall-down.

• ALGAE
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• 제25권4호
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• pp.187-195
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• 2010

The genus Rosenvingea is well known in the tropics. Four species have been reported from Pacific Mexico: R. floridana, R. antillarum, R. intricata and R. sanctae-crucis. We collected a plant (Boca del Cielo, Chiapas) that we identified as Rosenvingea orientalis, a species not previously reported from Pacific Mexico. We were able to characterize the life cycle of this species for the first time in laboratory culture. It reproduced exclusively by plurilocular sporangia (plurangia). The mature plants were up to 6 cm long with cylindrical to compressed fronds (to 2 mm wide) with dichotomous branches in the upper half of the thallus. The medulla was hollow with 2-3 layers of large inflated colourless cells at the periphery. The cortex was comprised of 1 layer of small cells, each with a single chloroplast and pyrenoid. Linear plurangial sori with phaeophycean hairs formed along the mature fronds. Zoospore germlings developed into prostrate filamentous systems, each with a single phaeophycean hair that gave rise to a single erect shoot with multiple hairs arising near the tip. Molecular phylogeny using the psaA gene placed this isolate within the Scytosiphonaceae. It does not confirm the exact identification of R. orientalis, although its placement close to other Rosenvingea sequences was confirmed and morphological evidence supports its placement in R. orientalis. Our culture investigations indicated that it has an asexual life cycle. Further collections are needed to resolve the full generic and specific relationships of Rosenvingea and related taxa, and their reproductive patterns.

• BMB Reports
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• 제45권8호
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• pp.427-432
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• 2012

Primary cilia, single hair-like appendage on the surface of the most mammalian cells, were once considered to be vestigial cellular organelles for a past century because of their tiny structure and unknown function. Although they lack ancestral motility function of cilia or flagella, they share common ground with multiciliated motile cilia and flagella on internal structure such as microtubule based nine outer doublets nucleated from the base of mother centrioles called basal body. Making cilia, ciliogenesis, in cells depends on the cell cycle stage due to reuse of centrioles for cell division forming mitotic spindle pole (M phase) and assembling cilia from basal body (starting G1 phase and maintaining most of interphase). Ciliary assembly required two conflicting processes such as assembly and disassembly and balance between these two processes determines the length of cilia. Both process required highly conserved transport system to supply needed substance to grow tip of cilia and bring ciliary turnover product back to the base of cilia using motor protein, kinesin and dynein, and transport protein complex, IFT particles. Disruption of ciliary structure or function causes multiple human disorder called ciliopathies affecting disease of diverse ciliated tissues ranging from eye, kidney, respiratory tract and brain. Recent explosion of research on the primary cilia and their involvement on animal development and disease attracts scientific interest on how extensively the function of cilia related to specific cell physiology and signaling pathway. In this review, I introduce general features of primary cilia and recent progress in understanding of the ciliary length control and signaling pathways transduced through primary cilia in vertebrates.

• Journal of Chest Surgery
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• 제22권3호
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• pp.436-447
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• 1989

The effect of Glutamate to myocardial toxicity induced by doxorubicin was studied with 20 male rats. 20 rats divided into 4 subgroups, 1st group was taken for normal control group without any treatment, 2nd group was injected with only doxorubicin, 3rd group was injected with L-glutamate and doxorubicin, and 4thd group was injected with only L-glutamate [all injections were done intraperitoneally]. Observations were made to each group on their gross findings, body weight, and electrocardiography, complete blood count and serum level of creatine phosphokinase. The results were as follows; l. In 1st group, we found no changes. 2. In 2nd group, there were many changes which were loss of body weight, dehydration, loss of body hair, diarrhea and death, in addition, elevation of CPK-MB isoenzyme and changes in EKG due to myocardial damage, leukopenia, thrombocytopenia were also found. 3. In 3rd group, there were more toxic effects containing 2 death cases, compared to 2nd group. 4. In 4th group, we found no specific changes except weight gain. These results suggest that L-glutamate which is intermediate of Krebs cycle may worsen the doxorubicin-induced myocardial toxicity.

• 생약학회지
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• 제52권1호
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• pp.34-40
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• 2021

Proliferation and maintain of dermal papilla during progression of hair-cycle are crucial to the duration of anagen and regulated by diverse signaling pathway such as PI3K/Akt/Wnt/β-catenin pathway. In this study, we investigated the effects and mechanisms of Viola verecunda on dermal papilla cells. Treatment of dermal papilla cells with whole plant extract of V. verecunda resulted in cell proliferation, which was accompanied by up-regulation of cyclin D1, phospho (ser780)-pRB and cdc2 p34, and down-regulation of p27kip1. V. verecunda extract also promoted the levels of phospho (ser473)-Akt and phospho (ser780)-pRB in a time-dependent manner. Inhibition of PI3K/Akt by Wortmannin suppressed progression of cell-cycle, thereby attenuated the increases in proliferation of dermal papilla cells by V. verecunda extract. We further investigated Wnt/β-catenin pathway with respect to the effects of V. verecunda extract on the proliferation of dermal papilla cells. Treatment with V. verecunda extract results in up-regulation of Wnt/β-catenin proteins such as phospho (ser9)-GSKβ, phospho (ser552)-β-catenin and phospho (ser675)-β-catenin. In addition, Wortmannin abrogated V. verecunda extract mediated up-regulation of cdc2 p34 and down-regulation of p27kip1. These finding reveal that the proliferative effect of V. verecunda mediated by alteration of cell-cycle via activating PI3K/Akt/Wnt pathway in dermal papilla cells.

• 수산해양기술연구
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• 제50권4호
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• pp.623-632
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• 2014

In this study, the stability of fishing vessels get some change in accordance with the installation of LED luring lamp in comparison with metal halide luring lamp were investigated. Inclining test for 9.77 ton class of squid jigging and hair-tail angling vessel was performed in order to make a stability evaluation. A performance analysis of the target vessels to the stability on the basis of KST-SHIP program was evaluated. The results were as follows in this study. The stability of the fishing vessel by a metal halide such as LED and the like according to the result obtained by the inclining test is a slightly present difference, and the stability is not affected. The fishing vessel with LED lamp installed satisfies all the stability criteria specified in law and IMO rule. Compared to the metal halide LED lamp the increase of the height of the center of gravity and the initial transverse metacenter was caused. Due to the LED installation, the somewhat wider wind area of the waterline, which appears as a result, does not lead to an actual increase in rolling period. But then it is necessary to be designed on that the LED lamp shape reduces wind pressure area. Because of LED lamp installation, the GM value of vessels is increasing faster rolling cycle so causes a decrease in the sense that the crew is aboard.