Journal of Veterinary Clinics (한국임상수의학회지)

The Korean Society of Veterinary Clinics (한국임상수의학회)
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Combination Chemotherapy of Carboplatin and Cyclophosphamide in a Dog with Mammary Tumors Metastasized to the Lungs

  • Ryu, Jae-June (Laboratory of Veterinary Theriogenology, Veterinary Medical Center and College of Veterinary Medicine, Chungbuk National University) ;
  • Kim, Ill-Hwa (Laboratory of Veterinary Theriogenology, Veterinary Medical Center and College of Veterinary Medicine, Chungbuk National University) ;
  • Hwang, Dae-Youn (Department of Biomaterials Science, Pusan National University) ;
  • Kang, Hyun-Gu (Laboratory of Veterinary Theriogenology, Veterinary Medical Center and College of Veterinary Medicine, Chungbuk National University)
  • Received : 2016.11.01
  • Accepted : 2016.12.23
  • Published : 2016.12.30
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Abstract

In the present case, the effect and toxicity of carboplatin and cyclophosphamide chemotherapy combined with surgery of mammary tumors in a dog were examined. An 8-year old spayed female Beagle presented with a mammary tumor. Physical examination, radiography, ultrasonography, computed tomography (CT), and laboratory examination were performed. Metastasis of the mammary tumor was confirmed by CT scan. Chemotherapy using a combination of carboplatin and cyclophosphamide was initiated following surgery. The first cycle of chemotherapy was planned to last for 6 weeks; it was planned that carboplatin would be intravenously administered for the first week (1 day) and cyclophosphamide would be intravenously administered for the next 3 weeks (22 days). Between the end of cycle 1 and the beginning of cycle 2, based on CT, it was confirmed that the number and size of tumors were unchanged and the tumors had not spread to other organs. However, at the end of cycle 2 and the beginning of cycle 3, CT revealed an increase in the number and size of mass in the lung. Chemotherapy was associated with adverse effects such as lethargy, anorexia, leukopenia, and hair loss. In conclusion, this case showed that a combination of carboplatin and cyclophosphamide suppressed the development of new neoplasms as well as metastasis for a certain period of time but did not improve the survival time. Although more cases are required, this chemotherapeutic procedure remains challenging.

Keywords

References

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