• Korean Parent-Child Health Journal
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• v.11 no.1
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• pp.49-60
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• 2008

This is an underlying study for expanding child growth and developmental screening program, which had been implemented as a part of maternal child health service in a certain public health center located in P City. This study attempted to develop system model to discover, consult and follow-up developmental disabilities in children in early stage. For the purpose of providing groundwork for further development of screening program, the system model was analyzed and evaluated. One of the focuses of this study was developing practical tool that can aid small number staffs of public health center to handle large number of patients. 9 types of developmental checklist by key month was developed to support understaffed public health center. These checklists were also supplied to other public health centers, greatly improving qualitative and quantitative development of screening project. Also, the 4-step program of operating and managing child growth and developmental screening was proved to be quite effective. Total 632 children were evaluated and 21 of them were suspected to have developmental problem. Among these children, 8 children were determined to receive regular supervision of public health center. Other 13 children were recommended to visit professional institution, but only 7 of them actually visited institution. Four of these children who visited professional institution are currently receiving treatment, while the other 3 children were determined to require close observation. Five times of screening education were provided to the staffs in public health center and personnel in charge of children in every district public center in P City. The purpose of this training was to improve individuals' capability to implement project and to establish basis for expanding child growth and developmental screening program. The participants were guided to have continuous attention for the project, and their knowledge, skill and recognition were greatly improved through educational training. Also, professional child consulting and education, including lecture for baby food and baby food menu exhibition, were given to parents. Through this opportunity, parents acquired higher understanding about baby food while the local residents' recognition for maternal child health service was greatly improved.

• Journal of Microbiology and Biotechnology
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• v.31 no.9
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• pp.1241-1255
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• 2021

This study was carried out to explore a non-chemical strategy for enhancing productivity by employing some antagonistic rhizobacteria. One hundred eighteen bacterial isolates were obtained from the rhizospheric zone of various crop fields of Gangwon-do, Korea, and screened for antifungal activity against Fusarium wilt (Fusarium oxysporum f. sp. lactucae) in lettuce crop under in vitro and in vivo conditions. In broth-based dual culture assay, fourteen bacterial isolates showed significant inhibition of mycelial growth of F. oxysporium f. sp. lactucae. All of the antagonistic isolates were further characterized for the antagonistic traits under in vitro conditions. The isolates were identified on the basis of biochemical characteristics and confirmed at their species level by 16S rRNA gene sequencing analysis. Arthrobacter sulfonivorans, Bacillus siamensis, Bacillus amyloliquefaciens, Pseudomonas proteolytica, four Paenibacillus peoriae strains, and Bacillus subtilis were identified from the biochemical characterization and 16S rRNA gene sequencing analysis. The isolates EN21 and EN23 showed significant decrease in disease severity on lettuce compared to infected control and other bacterial treatments under greenhouse conditions. Two bacterial isolates, EN4 and EN21, were evaluated to assess their disease reduction and growth promotion in lettuce in field conditions. The consortium of EN4 and EN21 showed significant enhancement of growth on lettuce by suppressing disease caused by F. oxysporum f. sp. lactucae respectively. This study clearly indicates that the promising isolates, EN4 (P. proteolytica) and EN21 (Bacillus siamensis), can be commercialized and used as biofertilizer and/or biopesticide for sustainable crop production.

• Journal of Life Science
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• v.21 no.10
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• pp.1443-1451
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• 2011

The purpose of this study was to observe self-reliance fitness and growth hormones in obese elderly women. Twenty-four females over the age of 65 years, who did not exercise regularly, were chosen as test subjects. All subjects were evaluated pre- and post-test. The results of this study were as follows; Results related to the experimental group revealed that there were statistically significant differences between the mean scores pre- and post-test in self-reliance fitness. Results related to the experimental group revealed that there were statistically significant differences between the mean scores pre- and post-test in growth hormone. Overall, participation in a 12-week combined exercise program had a positive impact on the self-reliance fitness and growth hormone in the obese elderly women. Based on the results of this study, obese elderly women are encouraged to participate in a combined exercises program on a regular basis.

• Current Industrial and Technological Trends in Aerospace
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• v.7 no.1
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• pp.3-10
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• 2009

In this paper the current statuses of world governments' funding for space program and space market were presented. Since 2001, governments' expenditures for space program have experienced strong growth, and are at a historical high, estimated $62.1 billion in 2008, as compared to $30-35 billion in 1990s. Following a peak growth of 9% in 2008, government budgets for space program are expected to continue their growing trend but at a slower pace during next five years, with 4.5%. Also world space market revenue reached a historical high $123 billion in 2007 with 11.5% annual growth rate during 2002-2007. In this paper the Korean government's budget and Korean space market revenue were presented too, and compared to those worldwide.

• Journal of Preventive Medicine and Public Health
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• v.10 no.1
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• pp.138-141
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• 1977

The total population of Korea in 1975 was 35,281,000 and population density was $357/km^2$, which is one of the highest rate of the countries in the world. In the early part of 1960's, prior to the initiation of national family planning program in 1962, the natural population increase rate in Korea was almost 3.0%. However, due to the positive support and activity of the national family planning program, the population growth rate has been dropped right below 2.0% in 1970, and decreased to 1.7% in 1975. The average number of children per woman was 5.8 in 1961 and has decreased steadily to 3.5 in 1975. However, traditional value like the 'boy-preference' concept may bring many difficulties of lowering the fertility rate, decreasing number of children less than three in the future. Rising marriage age which had much contributed to decrease the population growth showed preferably falling trends since 1970. There is a prospect that total number of birth will be continuously increased while the fertility rate may be fallen since the age group born during 'baby-boom' soon after the Korean war are becoming the reproductive age group at present time. Considering the above mentioned factors, family planning program should be much improved and strengthened and the government support is much required in order to meet the above mentioned objectives which maintain appropriate level of the population growth.

• Transactions of the Korean Society of Mechanical Engineers A
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• v.25 no.5
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• pp.823-833
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• 2001

In recent years, the subject of remaining life assessment has drawn considerable attention in chemical plants, where various structural components typically operate at high temperature an pressure. Thus a life prediction methodology accounting for high temperature creep fracture is increasingly needed for the components. Critical defects in such structures are generally found in the form of semi-elliptical surface crack, and the analysis of which is consequently an important problem in engineering fracture mechanics. On this background, we first develop an auto mesh generation program for detailed 3-D finite element analyses of axial and circumferential semi-elliptical surface cracks in a piping system. A high temperature creep fracture parameter C-integral is obtained from the finite element analyses of generated 3-D models. Post crack growth module is further appended here to calculate the amount of crack growth. Finally the remaining lives of surface cracked pipes for various analytical parameters are assessed using the developed life assessment program.

• Mycobiology
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• v.51 no.3
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• pp.178-185
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• 2023

The cell wall integrity (CWI) signaling pathway plays important roles in the dissemination and infection of several plant pathogenic fungi. However, its roles in the pepper fruit anthracnose fungus Colletotrichum scovillei remain uninvestigated. In this study, the major components of the CWI signaling pathway-CsMCK1 (MAPKKK), CsMKK1 (MAPKK), and CsMPS1 (MAPK)-were functionally characterized in C. scovillei via homology-dependent gene replacement. The ΔCsmck1, DCsmkk1, and ΔCsmps1 mutants showed impairments in fungal growth, conidiation, and tolerance to CWI and salt stresses. Moreover, ΔCsmck1, ΔCsmkk1, and ΔCsmps1 failed to develop anthracnose disease on pepper fruits due to defects in appressorium formation and invasive hyphae growth. These results suggest that CsMCK1, CsMKK1, and CsMPS1 play important roles in mycelial growth, conidiation, appressorium formation, plant infection, and stress adaption of C. scovillei. These findings will contribute to a better understanding of the roles of the CWI signaling pathway in the development of pepper fruit anthracnose disease.

• Journal of Microbiology and Biotechnology
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• v.22 no.6
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• pp.806-813
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• 2012

Adipocyte differentiation is strongly associated with obesity, which causes metabolic disorders. In this study, we investigated the inhibitory effects of widdrol on 3T3-L1 preadipocyte growth and differentiation. Widdrol decreased lipid droplet accumulation and down-regulated adipogenic transcription factors such as C/$EBP{\alpha}$, C/$EBP{\beta}$, and $PPAR{\gamma}$. Widdrol blocked preadipocyte proliferation and differentiation through the inhibition of mitotic clonal expansion, which was accompanied by the failure of degradation of p21, a cyclin-dependent kinase inhibitor. Cell-cycle analysis clearly indicated that widdrol actively induces cell-cycle arrest at the G1-S phage transition, causing cells to remain in the preadipocyte state. Moreover, widdrol increased p21 expression and inhibited Rb phosphorylation in preadipocyte incubated in a hormone medium. Therefore, these findings clearly suggest that widdrol blocks preadipocyte growth and differentiation through the inhibition of mitotic clonal expansion by p21-and Rb-dependent G1 arrest and can be developed as a potent anti-adipogenic agent for reducing obesity.

• Journal of Gifted/Talented Education
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• v.22 no.2
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• pp.467-482
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• 2012

In this research, the TRIZ program was developed for the growth of creativity of elementary school students. As for the TRIZ program that was developed in this research, it reconfigured the 40 of principles of the TRIZ within current curriculum, so that it would be possible for all elementary school students to receive their education in school for the growth of creativity. In order to adopt the 4-stages-class model that was developed, I made sample kit for utilizing TRIZ, and developed lesson plans along with materials 13-worksheet for lower-grade students, as well as lesson plans along with materials 12-worksheet, for higher-grade students. This program was applied to 2nd grade students of Y elementary school and 6th grade students of J elementary school, and according to the DESK theory, I subdivided the creativity into fluency, flexibility, originality, and exquisiteness, and it was shown that all of fluency, flexibility, originality, and exquisiteness were developed in elementary students who participated in TRIZ program compared with non-participated students. In conclusion, it was possible to understand that TRIZ program was effective for the growth of creativity of elementary school students.

• Molecules and Cells
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• v.27 no.5
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• pp.503-513
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• 2009

Proteoglycans located in basement membranes, the nanostructures underling epithelial and endothelial layers, are unique in several respects. They are usually large, elongated molecules with a collage of domains that share structural and functional homology with numerous extracellular matrix proteins, growth factors and surface receptors. They mainly carry heparan sulfate side chains and these contribute not only to storing and preserving the biological activity of various heparan sulfate-binding cytokines and growth factors, but also in presenting them in a more "active configuration" to their cognate receptors. Abnormal expression or deregulated function of these proteoglycans affect cancer and angiogenesis, and are critical for the evolution of the tumor microenvironment. This review will focus on the functional roles of the major heparan sulfate proteoglycans from basement membrane zones: perlecan, agrin and collagen XVIII, and on their roles in modulating cancer growth and angiogenesis.