• Korean Institute of Interior Design Journal
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• v.23 no.5
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• pp.183-191
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• 2014

Children stage is an important period the foundation of growth is accomplished. During the period, children are the most sensitive to environmental effects and experiences and interactions with surroundings can make lots of effects on their physical and cognitive development. Under the background of the above contents, a representative institution of the society, which is helpful to cultivate children's reading habit, will be children library. The purposes of this research are to analyze intensively reading room among the children library's spatial organization and compare/analyze cases of children library's reading room with the elements of interior environment. The methods of research are theory study and case study. Through the on-the-site visiting and shooting, interior environment design was investigated and then, it was arranged, analyzed and evaluated. Cases were analyzed by elements of interior environment design evaluation. As the result, comfort was the highest and variety was the lowest. Especially, Songpa children library showed various factors generally through the various designs. 7 evaluative elements of children library's reading room were mutually different, but there was a certain different in relation of them. Especially, variety and flexibility must be more strengthened. So, children can interests and joy in reading room various designs are requested by getting out of library's uniformed furniture and arrangement plan.

• Journal of the Korean Society of Food Culture
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• v.36 no.4
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• pp.412-420
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• 2021

This study aimed to assess the association between the weight status and dietary behavior of preschool children. The survey included 412 preschool children aged 2-5 years in 31 childcare facilities in Gwangju. General characteristics of children and their mothers, weight, height, feeding type, complementary feeding, food allergy, and dietary behavior of children based on the Nutrition Quotient for preschoolers (NQ-P) questionnaire were considered. Children were classified into 4 groups by weight status; underweight, normal, overweight, and obese, based on the 2017 Korean National Growth Charts. The percentage of children in the respective groups was 5.3, 70.9, 10.7, 13.1%. Weight status was not related to breast feeding duration nor the starting time of complementary feeding. The NQ-P scores of underweight, normal, overweight, and obese groups were 55.4, 60.0, 60.8, 60.0. Among the three factors covered by the NQ-P, 'balance' and 'environment' scores of the underweight group were lower than that of other groups. Underweight children consumed beans, fish, and white milk less frequently. The 'moderation' scores of the overweight/obese group were lower than those of the normal or obese groups. Obese children more frequently ate processed meat and fast foods. Proper nutrition education is thus needed for not only obese children but also underweight children based on their age, along with their parents, and caregivers.

• Neonatal Medicine
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• v.15 no.2
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• pp.123-133
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• 2008

Purpose: The purpose of this study was to determine the outcomes of extremely low birth weight infants (ELBWI) who were born at the Asan Medical Center and evaluate the recent status of neonatal intensive care and associated problems. Methods:We retrospectively evaluated 120 inborn ELBWI who were admitted to the NICU of the Asan Medical Center between 2003 and 2006. The survival rate, neurodevelopmental outcomes, maternal and infant factors, and infant mordibities were evaluated and the relationships with survival and catch-up growth were investigated. Results:The survival rate of the ELBWI was 82% at a mean gestational age of 27+2 weeks, and with a mean birth weight of 801.3${\pm}$129.0 g. The duration of hospitalization was 85.7${\pm}$27.2 days, the duration of O2 use was 43.9${\pm}$35.4 days, and the duration of ventilatory support was 20.9${\pm}$20.9 days among the survivors. The incidence of respiratory distress syndrome, chronic lung disease, severe intraventricular hemorrhage, and periventricular leukomalacia were 41.8%, 61.2%, 3%, and 4%, respectively. The mean mental developmental index and psychomotor development index of Bailey Scales of Infant Development (II) at follow-up were 83.4${\pm}$18.2 and 83.3${\pm}$20.3, respectively. Among the infants who had >18 months of follow-up, 50.8% had catch-up growth at 12 months. Conclusion:The survival rate of ELBWI has improved; however, the morbidities remain high, thus indicating further efforts must be implemented to reduce morbidity and improve neurodevelopmental outcomes.

• Human Ecology Research
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• v.56 no.5
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• pp.435-446
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• 2018

This study investigated relationships between primary caregivers' life satisfaction and abuse mediated by children's life satisfaction. We included term panel data for 3 years (2013-2015) from the 4th year to the 6th year of 2,067 children in the first grade of elementary school of the Korean Youth and Youth Panel(KCYPS)(2015); in addition, three years' longitudinal panel data (2013-2015) were analyzed utilizing SPSS 18.0 and AMOS 22.0 to measure Latent Growth Model(LGM) term relationships between variables. Analysis results were as follows. First, the life satisfaction of the primary caregiver, the life satisfaction of the child, and abuse gradually decreased from the fourth grade to the sixth grade. Second, the initial status of primary caregivers' life satisfaction influenced the initial status of the children's life satisfaction, and the initial status and change in the abuse rate. Third, the rate of change of life satisfaction of the primary caregiver did not have a significant effect on the change in the abuse rate and the rate of change of life satisfaction of the child. The initial value of the life satisfaction of the child played a partial mediating role in the relationship between the initial value of the life satisfaction of the primary caregiver, initial value of the abuse, and abuse change rate. The results suggest that a program to improve the life satisfaction of the 4th grade elementary school should be developed and applied.

• Pediatric Gastroenterology, Hepatology & Nutrition
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• v.22 no.1
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• pp.72-79
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• 2019

Purpose: The efficacy of exclusive enteral nutrition (EEN) with a polymeric diet has not been confirmed in Korean pediatric patients with Crohn's disease (CD). This study aimed to compare the effectiveness of EEN with a specific polymeric diet ($Encover^{(R)}$) and corticosteroids (CSs) for the induction of remission in Korean pediatric CD patients. Methods: We retrospectively compared data from 51 pediatric CD patients who underwent induction therapy with EEN (n=19) or CSs (n=32) at Severance Children's Hospital or Incheon St. Mary's Hospital in Korea. The primary endpoint of this study was the rate of clinical remission, defined as a Pediatric Crohn's Disease Activity Index (PCDAI) score <10, after 8 weeks of induction treatment. Clinical, laboratory, and growth data at post-induction as well as their changes from baseline were also compared between groups. Results: After 8 weeks of induction therapy, clinical remission rates were 78.9% (15/19) and 65.6% (21/32) in the EEN and CS groups, respectively (p=0.313). No significant differences in PCDAI scores, laboratory variables, and growth parameters were noted between the two groups at post-induction. However, significant changes in albumin levels at post-induction were observed in the EEN group compared to the CS group (p=0.038). Conclusion: Our results suggest that the effectiveness of EEN with a polymeric diet and CSs for induction therapy did not differ in Korean pediatric CD patients. EEN with a polymeric diet is a good first-line treatment option for the induction of remission in these patients.

• Journal of Genetic Medicine
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• v.19 no.1
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• pp.32-37
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• 2022

Mucopolysaccharidosis type VI (MPS VI) is an autosomal recessive lysosomal disorder caused by the deficiency of arylsulfatase B due to mutations in the ARSB gene. Here, we report the case of a Korean female with a novel variant of MPS VI. A Korean female aged 5 years and 8 months, who is the only child of a healthy non-consanguineous Korean couple, presented at our hospital for severe short stature. She had a medical history of umbilical hernia and recurrent otitis media. Her symptoms included snoring and mouth breathing. Subtle dysmorphic features, including mild coarse face, joint contracture, hepatomegaly, and limited range of joint motion, were identified. Radiography revealed deformities, suggesting skeletal dysplasia. Growth hormone (GH) provocation tests revealed complete GH deficiency. Targeted exome sequencing revealed compound heterozygous mutations in the ARSB genes c.512G>A (p.Gly171Asp; a pathogenic variant inherited from her father) and c.1157C>T (p.Ser386Phe; a novel variant inherited from her mother in familial genetic testing). Quantitative tests revealed increased urine glycosaminoglycan (GAG) levels and decreased enzyme activity of arylsulfatase B. While on enzyme replacement therapy and GH therapy, her height increased drastically; her coarse face, joint contracture, snoring, and obstructive sleep apnea improved; urine GAG decreased; and left ventricular mass index was remarkably decreased. We report a novel variant-c.1157C>T (p.Ser386Phe)-of the ARSB gene in a patient with MPS VI; these findings will expand our knowledge of its clinical spectrum and molecular mechanisms.

• Journal of Microbiology and Biotechnology
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• v.32 no.6
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• pp.699-708
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• 2022

Antibiotic exposure during pregnancy have an adversely effects on offspring behavior and development. However, its mechanism is still poorly understood. To uncover this, we added ceftriaxone sodium to the drinking water of rats during pregnancy and conducted three-chamber sociability test, open-field test, and Morris water maze test in 3- and 6-week-old offspring. The antibiotic group offspring showed lower sociability and spatial learning and memory than control. To determine the role of the gut microbiota and their metabolites in the changes in offspring behavior, fecal samples of 6-week-old offspring rats were sequenced. The composition of dominant gut microbial taxa differed between the control and antibiotic groups. KEGG pathway analysis showed that S24-7 exerted its effects through the metabolic pathways including mineral absorption, protein digestion and absorption, Valine, leucine, and isoleucine biosynthesis. Correlation analysis showed that S24-7 abundance was negatively correlated with the level of VEGF, and metabolites associated with S24-7-including 3-aminobutanoic acid, dacarbazine, L-leucine, 3-ketosphinganine, 1-methylnicotinamide, and N-acetyl-L-glutamate-were also significantly correlated with VEGF levels. The findings suggest that antibiotic exposure during pregnancy, specifically ceftriaxone sodium, will adversely affects the behavior of offspring rats due to the imbalance of gut microbiota, especially S24-7, via VEGF and various metabolic pathways.

• Journal of the Korean Society of Clothing and Textiles
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• v.31 no.3 s.162
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• pp.364-375
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• 2007

The propose of this study is to develop the optimal sizing system of ready-to-wear far elementary school boys using a newly invented statistical technique. The body measurements was classified by the method that equalizes the distribution of the subjects using the probability density function, to theoretically systemize a method to determine a size range of ready-to-wear for elementary school boys between 7 to 12 yeiws old. The results were as follows: 1. Height group includes 9 types of heights: 115, 120, 125, 130, 135, 140, 145, 150 and 155. 2. In the case of short children's groups, the variance in bust girth and waist girth is narrow. The people cluster together around the average. The size deviation of ready-to-wear is small. 3. In the case of tall children's groups, the variance in bust girth and waist girth is wide. The people spread widely around the average. The size deviation of ready-to-wear is large. 4. The optimal size system is suggested considering the weight of growth exponent of children according to their respective ages. Clothing companies can selectively choose sizes that meet the target of their brands. 5. It suggests the body sizes chart, which based on their means by the middle size children for each height group, so that clothing companies make use of it.

• Korean Journal of Clinical Pharmacy
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• v.10 no.2
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• pp.51-56
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• 2000

Deflazacort, an oxazoline derivative of prednisolone, has been claimed to have anti-inflammatory effects with fewer side effects compared to prednisone. The objectives of the study were to evaluate efficacy and safety of deflazacort in children with nephrotic syndrome. Eligible Patients were the children with nephrotic syndrome who were treated with deflazacort from October. 1994 to April. 1999. Nephrotic syndrome was defined as having albumin level of less than 2.5 mg/dL and 24-hour urinary protein excretion of greater than $40\;mg/m^2/hr$. The primary parameters evaluating the efficacy of deflazacort were response rate, time to respond and relapse frequency. The safety profiles were the impact on children's growth, calcium sparing effect, glucose metabolism, lipid profile and adverse drug reactions. As results, total of 60 children were evaluated (47 boys, 13 girls). Response rate was $95\%$ (57/60) for initial and late responders. Median time to respond was 12 days (range 7-110 days) and median relapse frequency was one time (range 0-6). Weight/height ratio increased from $22.05\pm3.47\;to\23.20\pm3.44\;kg/m$ (p<0.001) and plasma calcium level, from $7.55\pm3.86\;to\;9.98\pm3.77\;mg/dL$ after treatment (p<0.001). Change of fasting glucose level was not statistically significant $(91.92\pm3.53\;vs.\;98.19\pm4.78\;mg/dL,\;p=0.072)$, while change of total cholesterol was significant $(362.3\pm12.0\;vs\;251.4\pm11.5\;mg/dL$, p<0.001). In conclusion, patients on deflazacort showed similar efficacy in treatment of nephrotic syndrome as reported for prednisone with less impact on growth inhibition and metabolic side effects of hyperglycemia and hyperlipidemia.

• Hwankyungkyoyuk
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• v.23 no.4
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• pp.44-55
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• 2010

The purpose of this study is to develop an environmental report for children and to examine the learning effects of the environmental report on elementary school students. This study is carried out by the survey. The results of this study are as follows. First, the Environmental Report for children, which consists of 8 subjects related to the environmental policy in Korea. 1) Green Growth and Sustainable Policy, 2) Climate Change, 3) Water Supply and Sewage Policy, 4) Sustainable Watershed Management, 5) Conservation of Biodiversity, 6) Resource Recirculation, 7) Environmental Health for Children, and 8) Environmental Dictionary, was systematically developed. Second, the Environmental report developed was examined the effects to third and fourth grade elementary school students in Incheon and Daegu. By dividing elementary school students into two groups: A Control group and an Experimental group, the lessons were respectively executed. In conclusion, the Environmental Report leads to good effects when it is applied to both Environmental Education and the public relation of the Environmental Policy in Korea. Finally, it would be expected to be efficient in learning Sustainable Development and the Environmental Policy.