• Journal of Ginseng Research
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• 제43권3호
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• pp.475-481
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• 2019

Background: The ginsenoside Rg1 has been shown to exert various pharmacological activities with health benefits. Previously, we have reported that Rg1 promoted myogenic differentiation and myotube growth in C2C12 myoblasts. In this study, the in vivo effect of Rg1 on fiber-type composition and oxidative metabolism in skeletal muscle was examined. Methods: To examine the effect of Rg1 on skeletal muscle, 3-month-old mice were treated with Rg1 for 5 weeks. To assess muscle strength, grip strength tests were performed, and the lower hind limb muscles were harvested, followed by various detailed analysis, such as histological staining, immunoblotting, immunostaining, and real-time quantitative reverse transcription polymerase chain reaction. In addition, to verify the in vivo data, primary myoblasts isolated from mice were treated with Rg1, and the Rg1 effect on myotube growth was examined by immunoblotting and immunostaining analysis. Results: Rg1 treatment increased the expression of myosin heavy chain isoforms characteristic for both oxidative and glycolytic muscle fibers; increased myofiber sizes were accompanied by enhanced muscle strength. Rg1 treatment also enhanced oxidative muscle metabolism with elevated oxidative phosphorylation proteins. Furthermore, Rg1-treated muscles exhibited increased levels of anabolic S6 kinase signaling. Conclusion: Rg1 improves muscle functionality via enhancing muscle gene expression and oxidative muscle metabolism in mice.

• 원예과학기술지
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• 제16권3호
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• pp.358-360
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• 1998

본 실험은 자생나리인 땅나리의 기내 대량생산 체계를 확립하기 위한 기초 연구로서 배양환경중 광환경 및 배양 절편체의 분화 능력 조건을 유도하여 자구의 생장을 촉진시킬 수 있는 방법을 모색하기 위하여 실시하였다. 광조건은 24시간 지속적인 일장처리와 2,500~5,000 Lux 정도의 광도가 자구의 발달에 효과적이었다. 계대배양시 번무한 지상부를 자구의 연접부위까지 완전히 절단해 줌으로써 전반적인 식물체 생육을 촉진시킬 수 있었고, 절편체의 크기가 클수록 자구수가 많았으나, 자구의 비대는 모인편의 크기가 작은 처리구에서 약간 우수하였다. 광을 많이 필요로 하는 땅나리는 기내 인편 배양시 치상방법을 배지면 위에 노출시켜 치상하는 것이 자구생산면에 있어서 효율적이었다.

• Asian Pacific Journal of Cancer Prevention
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• 제13권12호
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• pp.6211-6216
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• 2012

Objective: To investigate the effects of gambogic acid (GA) on the growth of human malignant glioma cells. Methods: U251MG and U87MG human glioma cell lines were treated with GA and growth and proliferation were investigated by MTT and colony formation assays. Cell apoptosis was analyzed by annexin V FITC/PI flow cytometry, mitochondrial membrane potential assays and DAPI nuclear staining. Monodansylcadaverine (MDC) staining and GFP-LC3 localisation were used to detect autophagy. Western blotting was used to investigate the molecular changes that occurred in the course of GA treatment. Results: GA treatment significantly suppressed cell proliferation and colony formation, induced apoptosis in U251 and U87MG glioblastoma cells in a time- and dose-dependent manner. GA treatment also lead to the accumulation of monodansylcadaverine (MDC) in autophagic vacuoles, upregulated expressions of Atg5, Beclin 1 and LC3-II, and the increase of punctate fluorescent signals in glioblastoma cells pre-transfected with GFP-tagged LC3 plasmid. After the combination treatment of autophagy inhitors and GA, GA mediated growth inhibition and apoptotic cell death was further potentiated. Conclusion: Our results suggested that autophagic responses play roles as a self-protective mechanism in GA-treated glioblastoma cells, and autophagy inhibition could be a novel adjunctive strategy for enhancing chemotherapeutic effect of GA as an anti-malignant glioma agent.

• 한국식품과학회지
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• 제11권3호
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• pp.200-205
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• 1979

인산 염(monosodium phosphate, disodium phosphate, trisodium phosphate, ${\alpha}-polygel$ 및 sodium tripolyphosphate)이 Lactobacillus bulgaricus 단독 배양 및 Lactobacillus bulgari쳐s와 Streptococcus thermophilus의 혼합 배양(혼합비 1:1)에 미치는 영향을 검토하였다. 인산 염은 유산균의 생장을 촉진하였으며 특히 단독 배양의 경우 MSP와 STPP가, 혼합 배양의 경우 MSP와 DSP가 가장 효과적이었다. 산도도 유산균의 증식과 동일한 결과를 보였다. 배양액을 실온에서 저장하는 동안 생균 수의 감소는 인산 염 처리구가 대조구에 비하여 완만하였으며 단독 배양시 특히 DSP와 TSP가 효과적이었고 혼합 배양의 경우 TSP와 ${\alpha}-PG$가 가장 효과적이었다. 혼합 균주를 사용하여 제조된 발효유의 저장 중 안정성은 인산염 처리구가 대조구보다 좋았으며 특히 MSP가 가장 효과적이었다.

• Environmental Engineering Research
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• 제19권1호
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• pp.59-66
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• 2014

The aim of this study was to assess the effect of pre-aeration on sludge solubilization and the behaviors of nitrogen, dissolved sulfide, sulfate, and siloxane. The results of this study showed that soluble chemical oxygen demand in sewage sludge could be increased through pre-aeration. The pre-aeration process resulted in a higher methane yield compared to the anaerobic condition (blank). The pre-aeration of sewage sludge, therefore, was shown to be an effective method for enhancing the digestibility of the sewage sludge. In addition, this result confirms that the pre-aeration of sewage sludge prior to its anaerobic digestion accelerates the growth of methanogenic bacteria. Removal rates for $NH_3$-N and T-N increased simultaneously during pre-aeration, indicating simultaneous nitrification and denitrification. The siloxane concentration in sewage sludge decreased by 40% after 96 hr of pre-aeration; in contrast, the sulfide concentration in sewage sludge did not change. Therefore, pre-aeration can be employed as an efficient treatment option to achieve higher methane yield and lower siloxane concentration in sewage sludge. In addition, reduction of nitrogen loading by pre-aeration can reduce operating costs to achieve better effluent water quality in wastewater treatment plant and benefit the anaerobic process by minimizing the toxic effect of ammonia.

• 대한불안의학회지
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• 제10권1호
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• pp.52-58
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• 2014

Objective : The purpose of this study is to develop the one-session positive psychology based strength enhancing workshop and verify effect of this program. This program is composed of lecture based on positive psychology and activities for identifying and utilizing personal character strengths. Methods : Total 81 participants were participated in this study. Positive Resources Test was assessed the change of personal positive resources at pre-, post program and subjective satisfaction for the workshop was measured at the post program. Repeated-t test was performed to identify the effect of this program. Results : Among the positive resources, satisfaction with life, positive affect, gratitude, acceptance, personal growth, efficacy, flow, resilience, hope, spirituality are significantly increased after program. Conclusion : Although this study is a single-session program without control group for comparison, it is meaningful to try a short-term intervention concise the program consisting of more than 8 sessions. This study will be based on the future development a variety of positive interventions.

• 보건행정학회지
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• 제10권1호
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• pp.126-147
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• 2000

This paper empirically explores the nature of the medical service industry and its various propagation effects on the economy in the input-output model, as revealed by a comparative analysis between Korea and Japan. The main findings of the paper are as follows; First, the growth of medical industry induces above-average effect on employment. Second, the industry is of the characteristics of weak both backward and forward linkage effects implying a 'final demand dependency industry'. When compared with public service sectors, however, the medical services industry shows stronger backward linkage effect than those sectors. Furthermore, it has strong repercussion effects on the goods industries. Third, in order to produce per unit of services, the medical services industry of Korea uses relatively more drugs and medical devices than that of Japan. In general, it has been shown that production structure of medical service industry in Korea is 'hardware-oriented' one; on the other hand, 'software-oriented' in Japan which means that, as intermediate inputs, outsourcing and informatization has been used than those of Korea. From the findings of the paper it could be emphasized that the medical organizations in Korea should put more efforts on shifting the current hardware-oriented production structure to strengthen core competence by enhancing productivity and by outsourcing to improve efficiency of production process. However, the medical organizations in Korea would not have enough incentives for high value-added production structure because they enjoy high operating surplus. Therefore, it would be necessary that government policy should be taken into account of these environments.

• 신재생에너지
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• 제17권3호
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• pp.8-15
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• 2021

In this study, we assessed the effect of vitamin components (such as biotin, thiamine-HCl, and folic acid) on microorganism microbial growth and ethanol production was examined to enhance increase the ethanol concentration in the Clostridium autoethanogenum culture process using syngas as a sole carbon source. Biotin and folic acid concentrations of 0.2, 2, 20, and 100 ㎍/L were used in the culture experiments at 0.2, 2, 20, and 100 ㎍/L concentrations. The maximum ethanol concentrations of 2.81 g/L and 3.12 g/L were obtained by adding at 0.2 ㎍/L biotin and folic acid, respectively. Moreover, Thiaminethiamine--HCl at concentrations of 0.5, 5, 50, and 250 ㎍/L were was examined evaluated to in the culture experiments. The maximum ethanol concentration of 2.84 g/L was observed at 0.5 ㎍/L of thiamine--HCl. As a resultThus, the optimized concentrations of biotin, thiamine--HCl, and folic acid were determined at 0.2, 0.5, and 0.2 ㎍/L, respectively, for enhancing increasing the ethanol production. In conclusion, the maximum ethanol production was obtained by adding the minimal concentration of vitamins in C. autoethanogenum culture.

• 동아시아경상학회지
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• 제10권2호
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• pp.115-125
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• 2022

Purpose - The quality of the hotel depends on the Oriental arts established. Customers tend to believe that high prices reflect the offered services. This research expounds on the effects of Oriental interior designs in the hospitality industry in enhancing hotel profitability, opportunities for development, and the growth of urban hotels. Research design, Data, and methodology - This study conducted the comprehensive literature analysis to obtain suitable contents about the effect of Oriental Art for Urban Hotel Business Plan. the literature analysis method systematically assesses the value of qualitative data. Resources are organized into groups using a coding frame. Result - The adoption of the Oriental arts in the interior designs in the hotel industry will lead to customer attraction, improved competitive advantage, customer loyalty, and the preservation of the societal values of culture. Therefore, the marketing practitioners should adopt oriental arts as an integral aspect of interior designs to enhance customer satisfaction Conclusion - Marketing practitioners also use the oriental arts to enhance customers' willingness to pay. This is because oriental arts serve as the cues that enable the consumers to feel that the hotel's products are of quality. When oriental arts are used in interior hotel designs, the customer's willingness to pay increases. Thus the firm's relationships with customers are boosted.

• Asia pacific journal of information systems
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• 제32권1호
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• pp.125-150
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• 2022

Technology companies launched their intelligent personal assistants (IPAs). IPAs not only provide individuals with a convenient way to interact with technology but also offer them the opportunity to interact with AI in a useful and meaningful form. Therefore, the global IPAs have experienced tremendous growth over the past decade. But maintaining continuous usage intention is still a massive challenge for developers and marketers and previous technology adoption models are not enough to explain continuous usage intention of IPAs. Thus, we adopted the bi-dimensional perspectives of utilitarian and hedonic value in this research model, and investigated how three characteristics of IPAs - anthropomorphism, autonomy, and intelligence - affect utilitarian value and hedonic value, which in turn continuous usage intentions. 227 data were collected from IPA users. The results showed that IPAs' continuous usage intention is significantly determined by both utilitarian and hedonic value, with the hedonic value being more prominent. In addition, the results showed that anthropomorphism and intelligence are the most important antecedents of utilitarian and hedonistic value. The results also illustrated that autonomy is a crucial predictor of utilitarian value rather than hedonistic value. Our work contributes to current research by widening the theoretical understanding of the effect of IPA characteristics on continuous usage intention through bi-dimensional values. Our paper also provides IPAs' developer and marketer guidelines for enhancing continuous usage intention.