• Anatomy and Cell Biology
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• 제56권1호
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• pp.9-15
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• 2023

An accessory submandibular gland is a rare variation. As such, there is limited literature regarding the embryology, anatomy, variations, clinical imaging, and pathology of the accessory submandibular gland. In this article, we review the existing literature on the accessory submandibular gland from clinical and anatomical perspectives. The goal of this review is to provide comprehensive knowledge of this variation which can be useful for oral and maxillofacial/head and neck surgeons, radiologists, and anatomists. Within this review, the embryologic origin as well as the anatomy of the accessory submandibular gland is detailed. Several imaging modalities which can be used to visualize the accessory submandibular gland are outlined as well as its variations. Lastly, this review investigates several reported clinical considerations regarding the accessory submandibular gland including sialoliths, Wharton's duct obstruction, and pleomorphic adenoma.

• 한국콘텐츠학회논문지
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• 제16권4호
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• pp.144-152
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• 2016

본 연구는 의과대학을 포함하지 않은 보건의료대학에서 실물(시신)실습이 용이하지 않다는 사실에 근거하여, 인체해부학 수업에서 골학실습을 시행했을 때 맨눈해부학의 교육개선 효과가 있는지 살펴볼 목적으로 실시한 국내 최초의 연구이다. 연구방법은 임상병리학과 1학년 학생을 대상으로 인체해부학 수업에 골학실습을 실시하였고 실습 전 후에 자기보고식 설문과 실습 종료 후 지문평가 하였다. 설문지와 지문평가지의 각 문항은 고등교육 교과과정과 성별에 따라 분석하였다. 연구결과, 골학실습이 해부학수업의 흥미를 유발할 뿐만 아니라 해부학 수업을 이해하는데 도움이 되었고, 실습 후 대부분의 학생들은 뼈의 이름을 잘 알고 있었으나 이과보다는 문과출신 학생이 뼈의 해부학적 방향을 묻는 질문에 매우 취약했다. 그리고 대부분의 학생은 골학실습 후에도 대부분의 학생들은 실물실습을 하고자 하는 바람을 가지고 있었다. 결론으로 골학실습은 의과대학을 포함하지 않은 보건의료대학 임상병리학과 학생에게 해부학수업에 대한 기대 부응 및 학습효과의 증대를 가져왔다. 본 연구를 통해 맨눈해부학 교육은 이론뿐만 아니라 실습이 병행한다면 학습효과를 높일 수 있음을 제언한다.

• 대한견주관절학회:학술대회논문집
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• 대한견주관절학회 1995년도 Symposium and Workshop
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• pp.8-8
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• 1995

• 대한족부족관절학회지
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• 제16권1호
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• pp.1-8
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• 2012

Major technologic advances in fiberoptic light transmission, video cameras, and instrumentation have allowed great advances in small-joint arthroscopy. Arthroscopy in particular is now well established procedure for accurate diagnosis and operative management of certain ankle disorders. The small size of the ankle and significant periarticular soft tissue structures make placement and advancement of the arthroscope and instrumentation more difficult than in larger joints. Successful arthroscopy of the ankle requires knowledge of the regional anatomy and a familiarity with the available arthroscopic portals. This review article is going to describe the gross and arthroscopic anatomy of the ankle as it relates to current arthroscopic techniques. Particular emphasis is placed on the anatomic relations of the important osseous and soft tissue structures for a safe, reproducible approach to arthroscopic treatment of ankle pathology. Also, current arthroscopic equipment and instruments are included.

• Anatomy and Cell Biology
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• 제56권2호
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• pp.271-275
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• 2023

The abducens nerve (AN; cranial nerve VI) exits the brainstem at the inferior pontine sulcus, pierces the dura of the posterior cranial fossa, passes through the cavernous sinus in close contact to the internal carotid artery (ICA) and traverses the superior orbital fissure to reach the orbit to innervate the lateral rectus muscle. At its exit from the brainstem, the AN includes only axons from lower motor neurons in the abducens nucleus. However, as the AN crosses the ICA it receives a number of branches from the internal carotid sympathetic plexus. The arrangement, neurochemical profile and function of these sympathetic axons running along the AN remain unresolved. Herein, we use gross dissection and microscopic study of hematoxylin and eosin-stained sections and sections with tyrosine hydroxylase immunolabeling. Our results suggest the AN receives multiple bundles of unmyelinated axons that use norepinephrine as a neurotransmitter consistent with postganglionic sympathetic axons.

• Biomolecules & Therapeutics
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• 제17권3호
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• pp.325-331
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• 2009

The object of this study was to evaluate the single oral dose toxicity of Low Molecular Weight Fucoidan (LMF) in male and female rats. LMF was administered to female and male SD rats as an oral dose of 2,000, 1,000 and 500 mg/kg (body wt.). Animals were monitored for the mortality and changes in body weight, clinical signs and gross observation organ weight and histopathology of 14 principle organs were examined upon necropsy. As the results, no LMF treatment related mortalities, clinical signs, changes on the body and organ weights, gross and histopathological observations against 14 principle organs were detected up to 2,000 mg/kg in both female and male rats except for some sporadic findings not LMF treatment related toxicological signs. Therefore, $LD_{50}$ (50% lethal dose) and approximate LD of LMF after single oral treatment in female and male rats were considered over 2,000 mg/kg - the limited dosages recommended by KFDA Guidelines [2005-60, 2005], respectively.

• 대한본초학회지
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• 제28권3호
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• pp.17-24
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• 2013

Objectives : This study was to evaluate the single dose toxicity of Persicae Semen (PS) in ICR mice. Methods : Aqueous extracts of PS (Yield = 18.60%) were administered as an oral dose of 2,000, 1,000 and 500 mg/kg (body weight) according to the recommendation of Korea Food and Drug Administration (KFDA) guidelines (2009-116, 2009). Animals were monitored for the mortality and changes in body weight, clinical signs and gross observation during 14 days after dosing, upon necropsy; organ weight and histopathology of 12 principle organs were examined. Results : Amygdalin contents in PS aqueous extracts were detected as $32.50{\pm}5.96{\mu}g/ml$. We could not find any PS extracts treatment related mortalities, clinical signs, changes on the body and organ weights, gross and histopathological observations up to 2,000 mg/kg in both female and male mice, except for transient and slight loss of locomotion detected in female and male mice treated with 2,000 mg/kg. In addition, pharmacological immunomodulatory effects related findings were also demonstrated in 2,000mg/kg treated female and male mice as hypertrophy and hyperplasia of lymphoid cells in the submandibular lymph nodes. Conclusions : Based on the results of this experiment, the approximate lethal dose (ALD) of PS extracts after single oral treatment in female and male mice were considered above 2,000 mg/kg, respectively. It should be carefully used in clinics because the possibilities of respiratory or neurological disorders were observed when administered over 2,000 mg/kg of PS extract related to amygdalin.

• Anatomy and Cell Biology
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• 제56권4호
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• pp.435-440
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• 2023

Few studies have examined the basilar venous plexus (BVP) and to our knowledge, no previous study has described its histology. The present anatomical study was performed to better elucidate these structures. In ten cadavers, the BVP was dissected. The anatomical and histological evaluation of the intraluminal trabeculae within this sinus were evaluated. Once all gross measurements were made, the clivus and overlying BVP were harvested and submitted for histological analysis. A BVP was identified in all specimens and in each of these, intraluminal trabeculae were identified. The mean number of trabeculae per plexus was five. These were most concentrated in the upper half of the clivus and were more often centrally located. These septations traveled in a posterior to anterior direction and usually, from inferiorly to superiorly however some were noted to travel horizontally. In a few specimens the trabeculae had wider bases, especially on the posterior attachment to the meningeal layer of dura mater. More commonly, the trabeculae ended in a denticulate form at their two terminal ends. The trabeculae were on average were 0.85 mm in length. The mean width of the trabeculae was 0.35 mm. These septations were consistent with the cords of Willis as are found in the lumen of some of the other intradural venous sinuses. An understanding of the internal anatomy of the BVP can aid in our understanding of venous pathology. Furthermore, this knowledge will benefit patients undergoing interventional treatments that involve the BVP.

• Toxicological Research
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• 제26권1호
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• pp.53-59
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• 2010

This study was conducted to obtain acute information of the oral dose toxicity of DHU001, a polyherbal formula in male and female mice. In order to calculated 50% lethal dose ($LD_{50}$) and approximate lethal dose (LD), test material was once orally administered to male and female ICR mice at dose levels of 2000, 1000, 500, 250 and 0 (vehicle control) ml/kg (body weight). The mortality and changes on body weight, clinical signs, gross observation, organ weight and histopathology of principle organs were monitored 14 days after treatment with DHU001. We could not find any mortalities, DHU001 treatment-related clinical signs, changes on the body and organ weights, gross and histopathological findings. The results obtained in this study suggest that $LD_{50}$ and approximate LD in mice after single oral dose of DHU001 were considered over 2000 mg/kg in both female and male mice.

• 혜화의학회지
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• 제5권2호
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• pp.449-461
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• 1997

Anatomical terms is very important for the whole medical area. In the past, medical student have confused with the anatomical terms which were base on Japanish-Chinese. So they have to be made easily for reading and learning. Fortunately the anatomical terms in Korean had completely made through the fourth edition. According to the oriental law and customs human dissection was prohibited, therefore human anatomy naturally undeveloped. In this study, on the view of the Korean terms carried out the comparison between oriental and western anatomical terms in osteology and splanchnology. The oriental anatomical terms expressed with only looking at and touching the part of the human body. The gross structure of the osteology, is similar to oriental and western medicine but there's no detailed nomenclature of the bone. Instead of it, they expressed connection to acupuncture point or disease in the human body. So it's difficult to find out the anatomical terms of the splanchnology like recent ones.