• 대한방사선치료학회지
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• 제16권1호
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• pp.11-19
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• 2004

서론 및 목적 : 세기변조 방사선치료와 전신 정위적 방사선치료에서 5mm이내의 위치 정확성확인 (L-gram)은 환자치료 목적 달성을 위한 중요한 QA과정의 하나이다. 이에 본원에서 제작한 scale point를 이용하여 L-gram 영상을 얻어 환자치료의 정확성을 향상시키고자 한다. 대상 및 방법 : 본원의 MLC 부착장비인 CL2100C/D, CL21EX에서 치료중인 IMRT, SRS환자를 대상으로 기존의 상품화된 port film graticule과 본원에서 제작한 MLC scale pointer를 비교 분석하였다. 결과 : MLC를 이용한 scale pointer는 beam의 확산까지 고려한 정확한 위치를 나타내었고 MLC의 교차로 생기는 pixel 모양의 형성을 통해 어떠한 위치에서도 정확한 확인이 가능했다. 결론 및 고찰 : L-gram 확인시 약간의 시간적 투자($1{\sim}2$분)로서 정확한 위치를 나타냄으로서 L-gram 확인시간 단축과 치료부위의 정확한 위치 확인을 할 수 있었다.

• Journal of Microbiology and Biotechnology
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• 제27권9호
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• pp.1559-1565
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• 2017

Naturally occurring ginsenoside F1 (20-O-${\beta}$-$\text\tiny{D}$-glucopyranosyl-20(S)-protopanaxatriol) is rare. Here, we produced gram-scale quantities of ginsenoside F1 from a crude protopanaxatriol saponin mixture comprised mainly of Re and Rg1 through enzyme-mediated biotransformation using recombinant ${\beta}$-glucosidase (BgpA) cloned from a soil bacterium, Terrabacter ginsenosidimutans Gsoil $3082^T$. In a systematic step-by-step process, the concentrations of substrate, enzyme, and NaCl were determined for maximal production of F1. At an optimized NaCl concentration of 200 mM, the protopanaxatriol saponin mixture (25 mg/ml) was incubated with recombinant BgpA (20 mg/ml) for 3 days in a 2.4 L reaction. Following octadecylsilyl silica gel column chromatography, 9.6 g of F1 was obtained from 60 g of substrate mixture at 95% purity, as assessed by chromatography. These results represent the first report of gram-scale F1 production via recombinant enzyme-mediated biotransformation.

• 대한본초학회지
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• 제37권1호
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• pp.11-18
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• 2022

Objectives : Green gram (mung bean) has a cold nature and has been known to detoxify against various side effects that belong to hot in nature. In particular, since it has the effect of detoxifying fever and detoxification to treat swelling, it was also used externally to treat febrile dermatological diseases such as erysipelas and rubella. This study was designed to determine whether green gram exhibits anti-inflammatory effects on contact dermatitis in mice. Methods : We investigated the effects of green gram extract (70% ethanol extract) on skin lesion, skin thickness and weights, melanin and erythema index and spleen body weight ratio in mice with contact dermatitis induced by repeated application of 1-Fluoro-2,4-dinitrobenzene. Results : Topical application of green gram extract ameliorates skin lesions of contact dermatitis such as scale and roughness induces by 1-Fluoro-2,4-dinitrobenzene. green gram extract also suppressed enlargement of skin thicknesses and weights significantly. In addition, green gram extract treatment also lowered erythema index significantly compared to those in the control group. In the histopathological observation, green gram extract prevented epidermal hyperplasia and hyperkeratosis in inflamed tissues. Finally, green gram extract did not affect changes in body weights and the spleen body weight ratio, unlike dexamethasone, which significantly prevented body weight gain and lowered the spleen body weight ratio. Conclusions : These results imply that green gram, which is known to have a detoxifying effect in Korean medicine, can be used in the treatment of contact dermatitis.

• Journal of Electrical Engineering and Technology
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• 제13권4호
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• pp.1494-1503
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• 2018

This paper proposes a novel probabilistic load flow model for power systems integrated with large-scale wind power, which considers the multi-time scale dispatching features. The ramp limitations of the units and the steady-state security constraints of the network have been comprehensively considered for the entire duration of the study period; thus, the coupling of the system operation states at different time sections has been taken into account. For each time section, the automatic generation control (AGC) strategy is considered, and all variations associated with the wind power and loads are compensated by all AGC units. Cumulants and the Gram-Charlier expansion are used to solve the proposed model. The effectiveness of the proposed method is validated using the modified IEEE RTS 24-bus system and the modified IEEE 118-bus system.

• 한국산학기술학회논문지
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• 제4권2호
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• pp.96-101
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• 2003

최근, 새로운 영상 부호화로서 프랙탈 부호화가 높은 압축률의 가능성으로 폭넓게 연구되고 있다. 프랙탈 부호화는 초기에 흑백 영상과 선영상의 압축 방식으로서 검토되었다. 더욱이 Jacquin은 프랙탈 변환(LIFS)을 제안하여 프랙탈 부호화를 농담 영상으로 확장하였다. 현재, Gram-Schmidt 직교화 방식을 이용한 YTKT의 LIFS방식 등은 정지 영상 압축의 국제표준 방식인 JPEG와 경합이 가능할 정도의 압축률이 얻어졌다. 본 연구에서는 YTKT방식의 직교화 연산 알고리즘의 연산량을 크게 삭감할 수 있는 방법을 제안한다.

• 한국생물공학회:학술대회논문집
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• 한국생물공학회 2002년도 생물공학의 동향 (X)
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• pp.427-430
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• 2002

본 실험실에서는 음식폐기물을 이용하여 단시간내에 메탄을 생산할 수 있는 Pilot 규모 (2.5 톤 )의 3단계 메탄 발효 공정을 개발하여 운전하고 있다. 3단계 메탄 발효공정 가운데 첫 번째 단계인 반혐기성 가수분해/산발효조에서 유기물 분해균주를 11개 분리하여 그 특성을 조사하였다. 분리된 균주는 gram 양성균이 8 개 균주, gram 음성균이 3개 균주이며, catalase에 대해서는 모두 양성반응을 보였고 모두 간균의 형태이었다. 분리된 균주들 가운데 amylase 와 protease의 활성은 분리균주 K5이 다른 균주들에 비해 매우 우수하였다.

• 대한방사선치료학회지
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• 제8권1호
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• pp.131-133
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• 1996

• 약학회지
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• 제56권2호
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• pp.71-73
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• 2012

Cordyceps militaris, a caterpillar-grown traditional medicinal mushroom, produces important bioactive compounds, cordycepin (3'-deoxyadenosine) and militarin. Militarin is reported to possess anticancer activities against several tumor cells. An efficient synthetic method of militarin was developed to prepare muti-gram scale sample for bioassay. Militarin was successfully synthesized from commercial starting materials in 5 steps and 29.3% overall yields.

• International Journal of Fuzzy Logic and Intelligent Systems
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• 제12권1호
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• pp.94-100
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• 2012

In this paper, we propose a system which improves text catchphrases on the web using onomatopoeia and the Japanese Google N-grams. Onomatopoeia is regarded as a fundamental tool in daily communication for people. The proposed system inserts an onomatopoetic word into plain text catchphrases. Being based on a large catchphrase encyclopedia, the proposed system evaluates each catchphrase's candidates considering the words, structure and usage of onomatopoeia. That is, candidates are selected whether they contain onomatopoeia and they use specific catchphrase grammatical structures. Subjective experiments show that inserted onomatopoeia is effective for making attractive catchphrases.

• 대한간호학회지
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• 제36권3호
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• pp.457-467
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• 2006

Purpose: Community health practitioners (CHP) in Korea have a responsibility for delivering primary health care to remote or isolated communities. The aim of this paper is to analyze CHPs' level of depression and impacts of their Ego state and interpersonal attitude in transactional analysis on depression. This paper gives fundamental data for developing a the program for mental health promotion of CHPs. Method: The subjects Of this Study consisted of 459 Korean CHP who were conveniently selected from the target population. The data was collected through interviews using self-administered questionnaires, including the Korean Ego gram and life position inventory and depression scale. Results: The CHP's Ego gram showed the N type with the top point of NP. The type of interpersonal attitude was I'M OK - YOU'RE OK (I+U++). The level of depression was 35.4, normal range. There was a significant difference in depression according to the duration of the career. There was a significant negative correlation among NP, A, FC ego states, interpersonal OK and depression, and a significant positive correlation between interpersonal Not-OK and depression. The NP, A, FC ego states and interpersonal Not-OK were significant predictors (47.1%) of depression. Conclusion: This study showed that a program for CHPs to should include increasing the function of ego states and positive interpersonal attitude.