The Korea Journal of Herbology (대한본초학회지)

The Korea Association of Herbology (대한본초학회)
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Effects of Green Gram Extract on Skin Lesion and Histopathological Changes in Mice with Contact Dermatitis

녹두 추출물이 생쥐에 유발된 접촉피부염의 피부 증상과 조직병리학적 소견에 미치는 영향

  • Jang, Seonkyung (School of Korean medicine, Pusan National University) ;
  • Kang, Yoonhyoung (School of Korean medicine, Pusan National University) ;
  • Oh, Seongyeop (School of Korean medicine, Pusan National University) ;
  • Kang, Yuntae (School of Korean medicine, Pusan National University) ;
  • Kim, Soyeon (School of Korean medicine, Pusan National University) ;
  • Lyu, Ji-Hyo (School of Korean medicine, Pusan National University) ;
  • Kim, Hyungwoo (School of Korean medicine, Pusan National University)
  • 장선경 (부산대학교 한의학전문대학원) ;
  • 강윤형 (부산대학교 한의학전문대학원) ;
  • 오승엽 (부산대학교 한의학전문대학원) ;
  • 강윤태 (부산대학교 한의학전문대학원) ;
  • 김소연 (부산대학교 한의학전문대학원) ;
  • 류지효 (부산대학교 한의학전문대학원) ;
  • 김형우 (부산대학교 한의학전문대학원)
  • Received : 2021.12.13
  • Accepted : 2022.01.25
  • Published : 2022.01.30
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Abstract

Objectives : Green gram (mung bean) has a cold nature and has been known to detoxify against various side effects that belong to hot in nature. In particular, since it has the effect of detoxifying fever and detoxification to treat swelling, it was also used externally to treat febrile dermatological diseases such as erysipelas and rubella. This study was designed to determine whether green gram exhibits anti-inflammatory effects on contact dermatitis in mice. Methods : We investigated the effects of green gram extract (70% ethanol extract) on skin lesion, skin thickness and weights, melanin and erythema index and spleen body weight ratio in mice with contact dermatitis induced by repeated application of 1-Fluoro-2,4-dinitrobenzene. Results : Topical application of green gram extract ameliorates skin lesions of contact dermatitis such as scale and roughness induces by 1-Fluoro-2,4-dinitrobenzene. green gram extract also suppressed enlargement of skin thicknesses and weights significantly. In addition, green gram extract treatment also lowered erythema index significantly compared to those in the control group. In the histopathological observation, green gram extract prevented epidermal hyperplasia and hyperkeratosis in inflamed tissues. Finally, green gram extract did not affect changes in body weights and the spleen body weight ratio, unlike dexamethasone, which significantly prevented body weight gain and lowered the spleen body weight ratio. Conclusions : These results imply that green gram, which is known to have a detoxifying effect in Korean medicine, can be used in the treatment of contact dermatitis.

Keywords

Acknowledgement

본 연구는 한국연구재단의 지원을 받아 수행되었음 (grant no. 2018R1A2B6006031).

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