• Asian Pacific Journal of Cancer Prevention
• /
• v.14 no.1
• /
• pp.381-386
• /
• 2013

Aims: The aim of this study was to investigate the effects of adjuvant chemotherapy cycles on the prognosis of patients with post-operative stomach cancer through retrospective analysis. Methods: A total of 128 patients with gastric cancer who underwent gastrectomy, followed by adjuvant chemotherapy consisting of epirubicin, cisplatin or oxaliplatin, leucovorin, and 5-fluorouracil, according to a defined schedule, were divided into three groups according to the number of chemotherapy cycles: Group I (<6 cycles); Group II (6 cycles); and Group III (>6 cycles). Results: The 5-year overall survival (OS) was 20.8% in Group I, 45.0% in Group II, and 42.9% in Group III, with a median follow-up of 43 months. The 5-year relapse-free survival (RFS) was 15.1% in Group I, 40% in Group II, and 40% in Group III. The OS and RFS in Groups II and III were significantly better than in Group I (OS, p = 0.002 and p=0.003; RFS, P<0.001 and P=0.002). There was no difference in OS (p = 0.970) or in RFS (p = 0.722) between Groups II and III. Multivariate Cox hazard analysis determined that the number of adjuvant chemotherapy cycles was an independent factor that influenced OS and RFS. Conclusion: Six cycles of adjuvant chemotherapy gave encouraging outcomes in patients with resectable gastric cancer. Further prospective randomized controlled investigations are warranted in a multi-center setting.

• Journal of Korean Academy of Nursing
• /
• v.31 no.5
• /
• pp.808-817
• /
• 2001

To survey the present status of the gerontological nursing course at three year diploma programs, baccalaureate degree programs(BSN), and graduate programs in Korea, and to analyze the contents of the syllabus and gerontological nursing textbooks to provide the basic data in developing a standard model for gerontological nursing curriculum. Method: Data was collected from all the nursing programs in Korea from Nov. 2000 to Feb. 2001 by mail and fax. Result: The gerontological nursing courses has been offered 36 diploma program, 40 BSN, and 17 graduate programs. And the credits of the gerontological nursing course offered by the program were as follows : one credit (10 diploma and 8 BSN), two credits (22 diploma and 29 BSN), and three credits (1 BSN). The contents of curri- culum were analyzed by comparing the core curriculum of NGNA. The majority of the schools included Gerontological Nursing in General, Theory of Aging, Aging Processes, Care Plan Options, and Common Health Problems. The subjects which very few school cover are Legal/ Ethical Issues, Evaluation, Regulatory & Reimbursement Issues, Education Issues, Nursing Research in Gerontology, and Environmental Issues of Older Adults. There were some differences in these results among diploma courses, BSNs, and graduate schools. The gerontological nursing textbooks contained similar contents to those of the diploma and the baccalaureate programs.

• Women's Health Nursing
• /
• v.16 no.1
• /
• pp.47-59
• /
• 2010

Purpose: The purpose of this study was to develop a Korean version of Physical Activity Scale for the Elderly (K-PASE) from PASE and to evaluate the validity and reliability of the K-PASE. This scale was originally developed by Washburn et al. (1993). A valid and reliable physical activity scale for the elderly is needed to assess accurately physical activity of the elderly, because there has been no valid and reliable physical activity scale for the elderly in Korea. Methods: The K-PASE was developed from PASE through linguistic validation and cultural adaptation for use with this population. Convenient sampling was used to recruit participants. Reliability was evaluated by conducting the test-retest and convergent validity was evaluated by Pearson correlation. Results: Test-retest reliability, assessed over a 2 week interval, was r=.94. Convergent validity was established by correlating the KPASE scores between related variables which were the Tokyo Metropolitan Institute of Gerontology Index of Competence (TMIG-IC) and hand-grip strength. Scores of the K-PASE had a low significant correlation with TMIG-IC (r=.246, p<.001), and hand-grip strength (r=.251, p<.001). The mean score of physical activity of Korean elderly assessed by the K-PASE was 96.5. Conclusion: We conclude that the K-PASE is a reliable and valid instrument to assess physical activity for Korean elderly.

• Journal of the Korean Society of Food Science and Nutrition
• /
• v.46 no.9
• /
• pp.1053-1060
• /
• 2017

The present study examined the anti-inflammatory and anti-oxidative effects of Pinus koraiensis (PK) cone shell extracts in vitro. Anti-inflammatory and anti-oxidative effects of PK cone shell extracted with hot water, 20% ethanol (EtOH), or 50% EtOH were examined using 2,2'-azino-bis(3-ethylbenzothiazoline-6-sulphonic acid) (ABTS) radical scavenging assay, superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPx) activites, as well as nitric oxide (NO) and anti-inflammatory cytokine measurements. The 20% EtOH extract of the PK cone shell decreased the NO and inflammatory cytokines secretion, and increased the ABTS radical scavenging, SOD, CAT, and GPx activities. This indicates that the 20% EtOH extract of the PK cone shell would be helpful in inflammation and oxidation systems. Therefore, the 20% EtOH extract of PK cone shell has great potential as a useful health food.

• Asian Pacific Journal of Cancer Prevention
• /
• v.16 no.14
• /
• pp.6047-6053
• /
• 2015

Background: Hepatocellular carcinoma is one of the most common cancers worldwide. Its prevalence is increasing in many countries. Plant products can be used to protect against cancer due to natural anticancer and chemopreventive constituents. Strobilanthes crispus is one of plants with potential chemopreventive ability. Objective: This study aimed to evaluate the anticancer effects of Strobilanthes crispus juice on hepatocellular carcinoma cells. Materials and Methods: MTT assays, flow cytometry, comet assays and the reverse transcription-polymerase chain reaction (RT-PCR) were used to determine the effects of juice on DNA damage and cancer cell numbers. Results: This juice induced apoptosis after exposure of the HepG2 cell line for 72 h. High percentages of apoptotic cell death and DNA damage were seen at the juice concentrations above 0.1%. It was found that the juice was not toxic for normal cells. In addition, juice exposure increased the expression level of c-myc gene and reduced the expression level of c-fos and c-erbB2 genes in HepG2 cells. The cytotoxic effects of juice on abnormal cells were in dose dependent. Conclusions: It was concluded that the Strobilanthes crispus juice may have chemopreventive effects on hepatocellular carcinoma cells.

• The Journal of the Korea Contents Association
• /
• v.12 no.1
• /
• pp.254-264
• /
• 2012

The purpose of this study is to make proposal an oriented-market curriculum of related dance major through analyzing the current curriculum and graduates' employment rate and occupational category of ten universities for last 3 years. This study suggested that Employment rate of the related-dance department graduates decreased considerably last year, which frist asked health insurance for calculating employment rate compared with 2008, 2009 year. The occupational category which is related dance occupied over half of whole occupation and office and sport job were taken to scale. It was necessarily to set up subjects such as body structure and function, administration, management, IT, integration, performance project, pedologics, and gerontology to meet the demand of times. The development of new job market which is connected with related-job subjects will be needed to increase employment rate and variety of occupational category of graduates from dance department.

• Journal of Digital Convergence
• /
• v.12 no.11
• /
• pp.585-595
• /
• 2014

The purpose of this study is to examine the Baby Boom Generation's participation intention for and needs on the elderly education. The survey research was conducted with the 261 participants who were born in 1955 through 1974 years. The results of this study are as follows : First, 67.4% of the respondents have not experienced life-long education because the respondents have no time to learn. Second, the positive agreement of the participation intention is 64.3% because the elderly people want to cope with the social changes themselves. Third, the respondents want to have the need for the elderly education by taking a class about health education with the method of practical training in a welfare organization. In conclusion, as showed the survey research, the elderly have highly participation intention about elderly education, so this study indicates that the high quality programs of elderly education should develop and provide.

• Journal of Haehwa Medicine
• /
• v.8 no.1
• /
• pp.625-641
• /
• 1999

Aging occurs as a part of maturation as the time progresses which manifests in the human body causing morphological and functional degeneration, eventually leading to death. This experimental study was conducted to investigate a herbal formula to fortify the heart with easy clinical applications. Sungshimsan was chosen to study its effects in heart lipid peroxide and metabolic enzyme system in senescence induced rats. After pre-treatment of Sungshimsan for 2 weeks at the dosage of A (100mg/kg), B (250mg/kg), C (350mg/kg), and D (500mg/kg), a lipid peroxide and metabolic enzyme system changes of the heart were meaured in 32 weeks old rats. The following results were obtained in this study: 1. The contents of lipid peroxide was significantly reduced in the experimental groups treated with greater than 2 weeks at 250mg/kg. 2. The enzymatic activity of cytochrome P-450, cytochrome b5, and NADPH-cytochrome P450 reductase were significantly decreased in the 250mg/kg, 350mg/kg, and 500mg/kg experimental groups. 3. The activity of glutathione and glutathione S-transferase were significantly increased in the 250mg/kg, 350mg/kg, and 500mg/kg experimental groups. 4. The activity of glutathione reductase and glutathione peroxidase were not influenced compared to the control group. 5. The activity of ${\gamma}$-glutamylcystein synthetase was significantly increased in the 250mg/kg, 350mg/kg, and 500mg/kg experimental groups. 6. The activity of enzymes detoxificatioon superoxide dismutase and catalase were not influenced compared to the control group. Summarizing above results suggest that the Sungshimsan has profound effects in the heart lipid peroxide, free radicals, and delaying the heart aging process. Further clinical researches and application can be anticipated on the topic of senility and gerontology.

• YAKHAK HOEJI
• /
• v.58 no.2
• /
• pp.129-140
• /
• 2014

Background: As elderly population has been increasing, pharmacists need to possess special knowledge and skills to provide enhanced pharmaceutical care for senior patients. Purpose: This study aims to systematically review on (1) the certified geriatric pharmacists (CGP) system, (2) the curriculum related to geriatric pharmacy education, and (3) the CGP's performance in terms of clinical, economic and humanistic outcomes in the U.S. Method: The information related to CGP system and curriculum was obtained through the official websites of 'American Society of Consultant Pharmacists', 'Commission for Certification in Geriatric Pharmacy' and the selected pharmacy school samples. Articles about on the outcomes of pharmacist-provided cognitive services including Medication Therapy Management were searched through PubMed. Results: To gain the CGP credential, pharmacists need 2-year experience as pharmacist in advance and take the CGP examination. This certification must be renewed every 5 year. Most pharmacy schools provide geriatric-related curriculum through didactic or pharmacy practice classes for pharmacy students and certificate or dual degree in gerontology are given on completion. Most previous outcomes research reported that pharmacists have played a role in yielding favorable results regarding clinical, economic and humanistic outcomes for nursing facilities, hospitals and community pharmacy settings. Conclusion: Considering the organized CGP certification system and concrete educational courses established the basis for pharmacists to exert their ability for senior patients of the U.S., it is suggested to build a geriatric pharmacist credential model for pharmacists to provide the increasing elderly patients with the requisite safe and effective pharmacy care in Korea.

• Research in Community and Public Health Nursing
• /
• v.14 no.3
• /
• pp.385-396
• /
• 2003

Purpose: The purpose of this study is to examine the status of care-giving for the demented elderly and to find out the need of community in-house care services-day care services, short-term care services, home help services, and home care services. Method: It analyzed the data of 186 old people having dementia, and caregivers. Data were collected for five days, in September 2002. Results: The caregivers were mostly women and the burden for the care giving was high (87.5%). They used community care services, that is, day care services (26.5%), home care services (21.6%), home help services 00.8%), short-term care services (6.2%). Caregivers' age and education level were significant factors in the demand for day care services. Caregivers' education level was a statistically significant factor in the demand for short-term care services and home help services. Caregivers' age and education level were significant factors in the demand for home care services. Conclusions: It is necessary to expand the financial aid for the active implementation of daytime protection for dementia-patients under medical treatment at home and to promote patients' recovery. It is necessary to enhance home help services and home care services, and to establish many day care centers and short term care centers. Through this, it will prevent caregivers from becoming burnt out due to the burden of care giving.