Journal of the Korean Society of Food Science and Nutrition (한국식품영양과학회지)

The Korean Society of Food Science and Nutrition (한국식품영양과학회)
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Anti-Inflammatory and Anti-Oxidative Effect of Pinus koraiensis Cone Shell Extracts

잣피 추출물들의 항산화 및 항염증에 미치는 영향

  • Jin, Joong Hyun (Department of Gerontology, Kyung Hee University) ;
  • Kwon, Han Ol (Department of Medical Nutrition, Kyung Hee University) ;
  • Ha, Yejin (Department of Medical Nutrition, Kyung Hee University) ;
  • Heo, Seok Hyun (Korea Health Supplements Association) ;
  • Lee, Jeongmin (Department of Medical Nutrition, Kyung Hee University)
  • 진중현 (경희대학교 동서의학대학원 노인학과) ;
  • 권한올 (경희대학교 동서의학대학원 의학영양학과) ;
  • 하예진 (경희대학교 동서의학대학원 의학영양학과) ;
  • 허석현 (한국건강기능식품협회) ;
  • 이정민 (경희대학교 동서의학대학원 의학영양학과)
  • Received : 2017.06.20
  • Accepted : 2017.08.16
  • Published : 2017.09.30
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Abstract

The present study examined the anti-inflammatory and anti-oxidative effects of Pinus koraiensis (PK) cone shell extracts in vitro. Anti-inflammatory and anti-oxidative effects of PK cone shell extracted with hot water, 20% ethanol (EtOH), or 50% EtOH were examined using 2,2'-azino-bis(3-ethylbenzothiazoline-6-sulphonic acid) (ABTS) radical scavenging assay, superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPx) activites, as well as nitric oxide (NO) and anti-inflammatory cytokine measurements. The 20% EtOH extract of the PK cone shell decreased the NO and inflammatory cytokines secretion, and increased the ABTS radical scavenging, SOD, CAT, and GPx activities. This indicates that the 20% EtOH extract of the PK cone shell would be helpful in inflammation and oxidation systems. Therefore, the 20% EtOH extract of PK cone shell has great potential as a useful health food.

본 연구에서는 잣피 열수, 20% 주정, 50% 주정 추출물들이 항염증과 항산화에 미치는 영향을 확인하기 위하여 ABTS 항산화능과 SOD, CAT, GPx 항산화 효소, NO의 분비량, 염증성 cytokine의 분비량을 살펴보고자 하였다. 잣피 열수, 20% 주정, 50% 주정 추출물 중 20% 주정 추출물이 항산화능, 항산화 효소 활성 증가, NO의 분비량 감소, 염증성 cytokine 분비량을 감소시켜 염증반응과 항산화 반응에 도움을 주어 내부에서 생성된 활성산소종과 외부로부터 침입한 미생물, 감염된 세포나 종양세포 등을 효과적으로 제거할 수 있을 것이라 예상할 수 있었다. 이는 염증뿐만 아니라 면역반응에서도 영향을 미칠 것이라 생각되며 염증조절 및 항산화 반응에 긍정적인 변화를 보였으므로 추후 염증 조절제로서 기능성 식품의 상업화에 기초 자료가 되어 국내 기능성 소재로서의 개발 가능성을 기대할 수 있다.

Keywords

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