• Korean Journal of Air-Conditioning and Refrigeration Engineering
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• v.16 no.12
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• pp.1101-1106
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• 2004

Magnetic refrigeration is based on the magnetocaloric effect (MCE)-the ability of some materials to heat up when magnetized and cool down when demagnetized. A rotary magnetic refrigeration device using gadolinium (Gd) ribbon and permanent magnets was constructed for experimental study. Gd ribbon attached around a rotating wheel is cyclically magnetized and demagnetized by permanent magnets and exchanges heat with liquid in the surrounding container. Temperature of the liquid in each divided section of the container was measured and the experimental results obtained in this study were discussed.

• Journal of Radiopharmaceuticals and Molecular Probes
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• v.5 no.1
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• pp.61-68
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• 2019

Purine type compounds has been recently reported to cause the death for lung cancer cell, related to microtubules-targeting agents (MTAs). Therefore it can be used to develop as theranostic radiopharmceuticals in nuclear medicine or gadolinium-based MRI imaging agents by chelate chemistry. In the study, we tried to chemically bind a DOTA chelate on the end of purine compound and obtained a specific conjugate of DOTA-purine for metal coordination. In particular, radiometal like Cu-64, for the development of MRI imaging agents, can be utilized to choice good candidates before the synthesis of gadolinium complexes. By the screening of radioisotope technique, Gd-DOTA-purine type complex was successfully prepared and showed MRI imaging for lung cancer cell into the mouse model.

• Korean Journal of Radiology
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• v.20 no.1
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• pp.134-147
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• 2019

Gadolinium-based contrast agents (GBCAs) are commonly used for enhancement in MR imaging and have long been considered safe when administered at recommended doses. However, since the report that nephrogenic systemic fibrosis is linked to the use of GBCAs in subjects with severe renal diseases, accumulating evidence has suggested that GBCAs are not cleared entirely from our bodies; some GBCAs are deposited in our tissues, including the brain. GBCA deposition in the brain is mostly linked to the specific chelate structure of the GBCA: linear GBCAs were responsible for brain deposition in almost all reported studies. This review aimed to summarize the current knowledge about GBCA brain deposition and discuss its clinical implications.

• Proceedings of the Materials Research Society of Korea Conference
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• 2003.11a
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• pp.108-108
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• 2003

• Proceedings of the Korean Magnestics Society Conference
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• 2014.05a
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• pp.19-19
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• 2014

• Proceedings of the Korean Vacuum Society Conference
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• 1993.02a
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• pp.126-128
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• 1993

• Proceedings of the SAREK Conference
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• 2003.07a
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• pp.91-91
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• 2003

• Proceedings of the Korean Nuclear Society Conference
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• 2002.10a
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• pp.339.1-339
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• 2002

• Proceedings of the Korean Magnetic Resonance Society Conference
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• 2000.01a
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• pp.20-20
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• 2000

• Journal of the Korean Society of Radiology
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• v.8 no.6
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• pp.325-332
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• 2014

Metallic nanoparticles have attractive properties in biomedical applications such as diagnostics and therapeutics. Cross linked dextran coated iron oxide nanoparticles (SPIONs) and silica coated gadolinium oxide nanoparticles (SPGONs) have been synthesized as a radiosensitizer in the proton beam cancer therapy. The dextran and silicaused for the protective moieties on the SPIONs and SPGONs respectively. Size distributions of synthesized nanoparticles were confirmed 3~5 nm for SPIONs and 30~100 nm for SPGONs by transmission electron microscope (TEM). Cell survival fraction measurement and Western blot assay were performed to evaluate the radiosensitization effects of synthesized radiosensitizer. The calculated radiosensitization of SPIONs and SPGONs at 90 % cell death from the measured cell survival curves were 1.23 and 1.03 respectively. Western blotting results also show the same consistent results that the amount of released cytochrome c from mitochondria was considerably increased for the cancer cells taken up SPIONs.