Korean Journal of Radiology

The Korean Society of Radiology (대한영상의학회)
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Gadolinium Deposition in the Brain: Current Updates

  • Jin Woo Choi (Department of Radiology, Konkuk University Medical Center, Konkuk University School of Medicine) ;
  • Won-Jin Moon (Department of Radiology, Konkuk University Medical Center, Konkuk University School of Medicine)
  • Received : 2018.06.05
  • Accepted : 2018.09.21
  • Published : 2019.01.01
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Abstract

Gadolinium-based contrast agents (GBCAs) are commonly used for enhancement in MR imaging and have long been considered safe when administered at recommended doses. However, since the report that nephrogenic systemic fibrosis is linked to the use of GBCAs in subjects with severe renal diseases, accumulating evidence has suggested that GBCAs are not cleared entirely from our bodies; some GBCAs are deposited in our tissues, including the brain. GBCA deposition in the brain is mostly linked to the specific chelate structure of the GBCA: linear GBCAs were responsible for brain deposition in almost all reported studies. This review aimed to summarize the current knowledge about GBCA brain deposition and discuss its clinical implications.

Keywords

References

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