• Journal of Adhesion and Interface
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• v.2 no.2
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• pp.1-10
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• 2001

Silica for Epoxy Molding Compound (EMC) was coated via plasma-polymerization with RF plasma (13.56 MHz) as a function of treatment time, power and pressure. 1,3-diaminopropane, allylamine, pyrrole, 1,2-epoxy-5-hexene, allylmercaptan or allylalcohol were utilized for plasma polymerization coating and adhesion of coated silica was evaluated by measuring flexural strength. CTE and water absorption of EMC were also measured, and fracture surface of flexural specimen was analyzed by SEM in order to elucidate the failure mode. The plasma polymer coated silica was analyzed by FT-IR and reactivity of plasma polymer coating with epoxy resin was evaluated with DSC in order to investigate the adhesion mechanism. The EMC prepared from the silica coated with 1,3-diaminopropane or allylamine exhibited high flexural strength, low CTE, and low water absorption compared with the control sample, and also exhibited 100% cohesive failure mode. These results can be attributed to the chemical reaction between the functional groups in the plasma polymer coating and epoxy resin, and also consistent with the results from FT-IR and DSC analysis.

• Radiation Oncology Journal
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• v.9 no.1
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• pp.73-79
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• 1991

Between January 1980 and September 1988,08 patients with advanced T3 & T4 glottic carcinoma were treated with RT and surgery/RT in the Department of Radiation Oncology, Yonsei Cancer Center and ENT, Yonsei University College of Medicine. The mean age was 60 years old (range 33 to 79 years old). The 34 patients were treated with irradiation alone, and the remaining 34 patients with surgery and irradiation. Initial nodal presentation was $37\% (25/68);\;31\%$ (l1/34) in RT alone group and $41\%$ (14/34) in combined treatment group. The minimum follow-up was 2 years. The local control rate after treatment was $47\%$ in RT alone group and $65\%$ in combined treatment group; $57\%$ for node negative and $27\%$ for node positive patients treated with RT alone; $65\%$ for node negative and $54\%$ for node positive patients treated with combined treatment. The treatment failure was observed in 30 patients; 14 patients for primary local failure, 6 patients for regional nodal failure,5 patients for local and regional failure, 26 patients for primary failure and/or distant metastasis, and 2 patient for regional failure and/or distant metastasis. The overall 5-year suwival rate was $57\%;\;37\%$ in RT alone group and $70\%$ in combined treatment group; $55\%$ for node negative and $20\%$ for node positive patients treated with RT alone; $73\%$ for node negative and $77\%$ for node positive patients treated with combined treatment. In conclusion, the combined treatment groups in the treatment of advanced 73 and 74 glottic cancer showed the better results in local control rates and S-year actuarial survival rates than RT alone group. We suggest that total laryngectomy and postoperative RT in the most patients of advanced glottic cancer were performed. However, in cases of node negative patints, RT alone is prefer as a treatment modality over combined surgery and RT since the treatment results were comparable and furthermore functional preservation could be achieved.

• Maxillofacial Plastic and Reconstructive Surgery
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• v.32 no.2
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• pp.107-111
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• 2010

Purpose: The aim of this study is to compare the stability between Mg-incorporated implant, TiUnite and Machined implant. Materials and Methods: Premolars of 3 Mini pigs (24 months) were extracted. After 2 months later, total 27 fixtures of implants (9 of each design : Machined/ TiUnite/ Mg-incorporated) were inserted into the mandible of 3 mini-pig. Implant stability was estimated by RFA in installation to 2, 4 & 6 weeks. Statistical analysis of RFA values was performed with time and between groups using repeated measure ANOVA and turkey's multiple comparison test. Results: In analyzing the mean value for the observation periods, three types of implants yielded a slight decrease in RFA mean value after 2 week, followed by increase at 4-6 weeks. Mg incorporated oxidized implants demonstrated significantly higher RFA mean values at 6 weeks comparing other groups. The difference of RFA value with time and between groups was statistically significant. Conclusion: We concluded that Mg implants may reduce failure rates of clinical implants In the early period of bone healing and Mg implants may shorten the bone healing time from surgery to functional loading.

• Journal of Ginseng Research
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• v.44 no.3
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• pp.386-398
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• 2020

Tissue fibrosis is an eventual pathologic change of numerous chronic illnesses, which is characterized by resident fibroblasts differentiation into myofibroblasts during inflammation, coupled with excessive extracellular matrix deposition in tissues, ultimately leading to failure of normal organ function. Now, there are many mechanistic insights into the pathogenesis of tissue fibrosis, which facilitate the discovery of effective antifibrotic drugs. Moreover, many chronic diseases remain a significant clinical unmet need. For the past five years, many research works have undoubtedly addressed the functional dependency of ginsenosides in different types of fibrosis and the successful remission in various animal models treated with ginsenosides. Caveolin-1, interleukin, thrombospondin-1 (TSP-1), liver X receptors (LXRs), Nrf2, microRNA-27b, PPARδ-STAT3, liver kinase B1 (LKB1)-AMPK, and TGF-β1/Smads are potential therapy targeting using ginsenosides. Ginsenosides can play a targeting role and suppress chronic inflammatory response, collagen deposition, and epitheliale-mesenchymal transition (EMT), as well as myofibroblast activation to attenuate fibrosis. In this report, our aim was to focus on the therapeutic prospects of ginsenosides in fibrosis-related human diseases making use of results acquired from various animal models. These findings should provide important therapeutic clues and strategies for the exploration of new drugs for fibrosis treatment.

• Journal of Chest Surgery
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• v.51 no.2
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• pp.130-132
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• 2018

Coronary sinus ostial atresia (CSOA) with persistent left superior vena cava (LSVC) in the absence of an unroofed coronary sinus is a benign and rare anomaly that may be taken lightly in most instances. However, if overlooked in patients undergoing univentricular heart repair such as bidirectional Glenn or Fontan-type surgery, fatal surgical outcomes may occur due to coronary venous drainage failure. We report a case of CSOA with a persistent LSVC that was managed through coronary sinus rerouting during a total cavopulmonary connection, and provide a review of the literature regarding this rare anomaly.

• 한국생물공학회:학술대회논문집
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• 2003.10a
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• pp.305-306
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• 2003

To treat fulminant hepatic failure (FHF) patients, various extracorporeal bioartificial liver (BAL) systems have been developed. Several requirements should be met for the development of BAL systems: hepatocytes should be cultured in a sufficiently high density; their metabolic functions should be of a sufficiently high level and duration; and the BAL systems module should permit scaling-up and aseptic handling. Several investigators have found that freshly isolated primary hepatocytes can be cultured into three dimensional, tightly packed, freely suspended, multicellular aggregates, or spheroids. These specialized cell structures exhibited enhanced liver specific functions and a prolonged differentiated state compared to cells maintained in a monolayer culture. Cells in spheroids appear to mimic the morphology and ultrastructure of the in vivo liver lobule. The ability of hepatocytes to organize into three-dimensional structures was hypothesized to contribute to their enhanced liver-specific activities. In this study, the ammonia removal rate and urea secretion rate of pig hepatocytes spheroids encapsulated in Ca-alginate bead were determined. A packed-bed bioreactor with encapsulated pig hepatocytes was devised as BAL support system. The efficacy of the system was evaluated in vitro.

• Journal of Advanced Research in Ocean Engineering
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• v.3 no.1
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• pp.1-14
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• 2017

The safety analysis of an earthquake is carried out during the operation of a subsea pipeline and an onshore pipeline. Several cases are proposed for consideration. In the case of a buried pipeline, permanent ground deformation by the earthquake and an increase of internal pressure by the acceleration of the earthquake should be considered. In the case of a subsea pipeline, a bending moment is caused by liquefaction of the backfill material on a trenched seabed, etc., which results in a high bending moment of the buried pipeline. The bending moment causes the collapse of the subsea pipeline or a leak of crude oil or gas, which results in economic loss due to enormous environmental contamination and social economic loss owing to operation functional failure. Thus, in order to prevent economic loss and operation loss, structurally sensitive design with regard to seismic characteristics must be performed in the buried pipeline in advance, and the negative impact on the buried pipeline must be minimized by conducting a thorough analysis on the seabed and backfilling material selection. Moreover, it is proposed to consider the selection of material properties for the buried pipeline. A more economical review is also required for detailed study.

• 대한핵의학회:학술대회논문집
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• 2001.05a
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• pp.66-75
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• 2001

Although diverse mechanisms are involved in multidrug resistance for chemotherapeutic drugs, the development of cellular P-glycoprotein(Pgp) and multidrug-resistance associated protein (MRP) are important factors in the chemotherapy failure to cancer. Various detection assays provide information about the presence of drug efflux pumps at the mRNA and protein levels. However these methods do not yield information about dynamic function of Pgp and MRP un vivo. Single photon emission tomography (SPECT) and positron emission tomography (PET) are available for the detection of Pgp and MRP-mediated transport. $^{99m}Tc$-sestaMIBl and other $^{99m}Tc$-radiopharmaceuticals are substrates for Pgp and MRP, and have been used in clinical studies for tumor imaging, and to visualize blockade of Pgp-mediated transport after modulation of Pgp pump. Colchicine, verapamil and daunorubicin labeled with $^{11}C$ have been evaluated for the quantification of Pgp-mediated transport with PET in vivo and reported to be feasible substrates with which to image Pgp function in tumors. Leukotrienes are specific substrates for MRP and N-$[^{11}C]$acetyl-leukotriene E4 provides an opportunity to study MRP function non-invasively in vivo. Results obtained from recent publications are reviewed to confirm the feasibility of using SPECT and PET to study the functionality of MDR transporters in vivo.

• Proceedings of the KIEE Conference
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• 2011.07a
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• pp.2152-2153
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• 2011

According to a sharp increase in demand for electricity supply secure, and $CO_2$ regulation in accordance with global environmental problems and to solve problems, etc. These factor less pollution, higher energy conversion hyoyulin way that the new electrical equipment, nano-composites The rapid degeneration of the unit study utilizing the power that is required is Free. Accordingly, cables, transformers and switchgear (GIS)-capacity of power equipment, such as, high-voltage high-density along with the miniaturization of equipment have made angry the reliability of these devices is becoming a very important issue. Insulation materials used in electrical equipment for high voltage withstand, power equipment, power equipment due to aging and overloading caused by a weakening of the insulation failure and replacement in accordance with the age due to increased costs because of the reliability of electrical equipment should be secured should. Therefore, improved performance and longevity of insulation material is recognized as an important challenge. In this study, power isolation and degeneration of the unit for use in various parts of the molding epoxy resin to improve the insulation performance of the epoxy resin by varying the added amount of nano-SiO2 nanocomposites made epoxy/SiO2 analysis and breakdown properties of the experiment want to improve the electrical properties through the geometry.

• The Journal of Pediatrics of Korean Medicine
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• v.18 no.1
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• pp.139-152
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• 2004

Objective: The aim of this study was to find about relation between Chiljung(七情) and chronic recurrent abdominal pain in children. Methods: It was surveyed the oriental medical book concerning Chiljung(七情) and western medical book concerning Chronic recurrent abdominal pain. Results: Chronic recurrent abdominal pain which is common disorder in children is mostly functional abdominal pain due to stress. The Stress can be defined as spiritual factor which lead to imbalance of body homeostasis in medicine. In oriental medicine, it is considered as Chiljung(七情) disorder. The gastrointestinal disease due to stress are peptic ulcer, chronic gastritis, irritable bowel syndrome, chronic abdominal pain, vomitting etc. In oriental medicine pathology mechanism, it is considered as discord with liver and spleen, depression of spleen-energy. It comes within the category of depression. Children with chronic recurrent abdominal pain is dependent on parents and they have an introspective nature, compulsive idea which is intolerable for failure.