Functional Imaging of the Multidrug Resistance In Vivo
기능적 영상술을 이용한 다약제 내성의 체내 진단
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Lee, Jea-Tae
(Department of Nuclear Medicine, School of Medicine, Kyungpook National University)
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이재태
(경북대학교 의과대학 핵의학교실)
- Published : 2001.05.18
Abstract
Although diverse mechanisms are involved in multidrug resistance for chemotherapeutic drugs, the development of cellular P-glycoprotein(Pgp) and multidrug-resistance associated protein (MRP) are important factors in the chemotherapy failure to cancer. Various detection assays provide information about the presence of drug efflux pumps at the mRNA and protein levels. However these methods do not yield information about dynamic function of Pgp and MRP un vivo. Single photon emission tomography (SPECT) and positron emission tomography (PET) are available for the detection of Pgp and MRP-mediated transport.
Keywords