• YAKHAK HOEJI
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• v.41 no.1
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• pp.60-73
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• 1997

In order to design a 24 hr sustained release preparation of sulindac for oral administration, fast release pellet (FR), slow release pellet (SR) and two combined formulation (1 : 1 and 1 : 2) were prepared. The pharmacokinetic effect of such preparations has been evaluated using rabbits as a suitable in vivo model, and tested in man. Dose determination was carried out using curve fitting according to RSTPJP II program. In bioavailability test using rabbit, AUCs of sulindac in a few designed formulations were similar to each other. $C_{max}$- of RF and SR were 1.8 times and 1.2 times higher, respectively, compared to that of combined formulation (FR:SR=1:1). While plasma concentration of FR and SR decreased rapidly, that of combined formulation (FR:SR 1:1) lasted at the level close to $C_{max}$ for 24 hrs. Plasma concentration of sulfide form from the combined pellet(FR:SR=1:1) lasted for 24 hrs, and its AUC value was 1.4-fold, 2.7-fold. and 1.2-fold greater than FR pellet, SR pellet and combined pellet (FR:SR 1 : 2). Thus, the combined pellet of 1:1 ratio was found to be the most effective for oral sustained release formulation. Bioavailability test in human showed that AUC of sulfide from TSRP (1 : 1) was approximately 1.5 times greater than total AUC of Immbaron$^{\circledR}$ administered twice in a day. While $T_{max}$ of sulfide from lmmbaron$^{\circledR}$ was 4.33 +/- 1.37 hr (lst administration) and 3.33 ${pm}$ 0.82 hr (2nd administration), respectively, that of sulfide from TSRP increased to 7.17 ${pm}$ 2.86 hr. Plasma concentration of sulfide from TSRP was sustained at more, than 1.0 ${\mu}g{\cdot}$hr/ml until 24 hrs after one dose administration. In addition, TSRP may decrease local adverse reaction in the stomach, since plasma concentration of sulfide from the combined pellet was low within 2hrs in the stomach. In conclusion, it is suggested that TSRP formulation may be effective for oral 24 hr sustained release formulation of sulindac dosing 300 ~ 350mg once a day.

• Proceedings of the Computational Structural Engineering Institute Conference
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• 1992.04a
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• pp.79-84
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• 1992

An integrated design system has as its aim the incoporation of all the design processes, such as, planning, preliminary design, analysis, detailed design (mamber design), evaluation, and drafting into an unified software system. Successful implementation such a system could lead to major improvements in efficiency by eliminating duplication of data and efforts. reducing errors, saving design time, providing management support, and so on. This study presents a methodology for an computer-integrated design system for building structures, synthesizing algorithmic procedures and knowledge based expert systems on the network database. Network database, which was designed to store all information systematically during the design processes, provides centeral communication area between algorithms and expert systems. The conventional procedural codes automate the routine design phases such as structural analysis, whereas knowledge-based expert systems support designer's decisions at the creative design phases such as preliminary design etc. The user interface with interactive and batch modes controls the design phases and manages design information and activates the algorithms and the expert systems. The concept presented in this paper will contribute to the formulation of automated design systems for building structures.

• Journal of Theoretical and Applied Mechanics
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• v.3 no.1
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• pp.66-80
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• 2002

The bilinear formulation proposed earlier by Peters and Izadpanah to develop finite elements in time to solve undamped linear systems, Is extended (and found to be readily amenable) to develop time finite elements to obtain transient responses of both linear and nonlinear, and damped and undamped systems. The formulation Is used in the h-, p- and hp-versions. The resulting linear and nonlinear algebraic equations are differentiated to obtain the first- and second-order sensitivities of the transient response with respect to various system parameters. The present developments were tested on a series of linear and nonlinear examples and were found to yield, when compared with results obtained using other methods, excellent results for both the transient response and Its sensitivity to system parameters. Mostly. the results were obtained using the Legendre polynomials as basis functions, though. in some cases other orthogonal polynomials namely. the Hermite. the Chebyshev, and integrated Legendre polynomials were also employed (but to no great advantage). A key advantage of the time finite element method, and the one often overlooked in its past applications, is the ease In which the sensitivity of the transient response with respect to various system parameters can be obtained. The results of sensitivity analysis can be used for approximate schemes for efficient solution of design optimization problems. Also. the results can be applied to gradient-based parameter identification schemes.

• Journal of Mechanical Science and Technology
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• v.16 no.12
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• pp.1687-1692
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• 2002

The problem analyzed here is a sheet metal forming process which requires a drawbead. The drawbead provides the sheet metal enough tension to be deformed plastically along the punch face and consequently, ensures a proper shape of final products by fixing the sheet to the die. Therefore, the optimum design of drawbead is indispensable in obtaining the desired formability. A static-explicit finite element analysis is carried out to provide a perspective tool for designing the drawbead. The finite element formulation is constructed from static equilibrium equation and takes into account the boundary condition that involves a proper contact condition. The deformation behavior of sheet material is formulated by the elastic-plastic constitutive equation. The finite element formulation has been solved based on an existing method that is called the static-explicit method. The main features of the static-explicit method are first that there is no convergence problem. Second, the problem of contact and friction is easily solved by application of very small time interval. During the analysis of drawbead processes, the strain distribution and the drawing force on drawbead can be analyzed. And the effects of bead shape and number of beads on sheet forming processes were investigated. The results of the static explicit analysis of drawbead processes show no convergence problem and comparatively accurate results even though severe high geometric and contact-friction nonlinearity. Moreover, the computational results of a static-explicit finite element analysis can supply very valuable information for designing the drawbead process in which the defects of final sheet product can be removed.

• Journal of Pharmaceutical Investigation
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• v.41 no.4
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• pp.217-225
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• 2011

The aim of this work was to prepare porous osmotic pump tablets for controlled delivery of Aceclofenac. Aceclofenac solid dispersion was prepared to improve the solubility by using the drug - carrier (Mannitol) ratio of 1:1. The osmotic pump tablets were prepared using the solid dispersed product of Aceclofenac. The formulation contains potassium chloride as osmotic agent, cellulose acetate as semipermeable membrane, poly ethylene glycol (PEG 4000) as pore former and sodium lauryl sulphate (SLS) as solubility enhancer. The formulations were designed by the general factors such as osmotic agent and pore former. All formulations were evaluated for various physical parameters and, the in vitro release studies were conducted as per USP. The drug release kinetic studies such as zero order, first order, and Higuchi and Korsmeyer peppas were determined and compared. All the formulations gave more controlled release compared to the marketed tablet studied. Numerical optimization techniques were applied to found out the best formulation by considering the parameter of in vitro drug release kinetics and dissolution profile standards. It was concluded that the porous osmotic pump tablets (F7) composed of Aceclofenac solid dispersion/Potassium chloride/Lactose/Sodium lauryl sulphate/Magnesium Stearate (400/40/95/10/5, mg/tab) and coating composition with Cellulose acetate/ PEG 4000 (60/40 %w/w) is the most satisfactory formulation. The porous osmotic pump tablets provide prolonged, controlled, and gastrointestinal environment-independent drug release.

• Structural Engineering and Mechanics
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• v.68 no.1
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• pp.1-15
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• 2018

In ocean industry, free surface type ART (Anti Roll tank) system has been widely used to suppress the roll motion of floating structures. In those, various obstacles have been devised to obtain the sufficient damping and to enhance the controllability of freely rushing water inside the tank. Most of previous researches have paid on the development of simple mathematical formula for coupled ship-ARTs analysis although other numerical and experimental approaches exist. Little attention has been focused on the use of 3D panel method for preliminary design of free surface type ART despite its advantages in computational time and general capacity for hydrodynamic damping estimation. This study aims at developing a potential theory based hydrodynamic code for the analysis of floating structure with baffled ARTs. The sloshing in baffled tanks is modeled through the linear potential theory with FE discretization and it coupled with hydrodynamic equations of floating structures discretized by BEM and FEM, resulting in direct coupled FE-BE formulation. The general capacity of proposed formulation is emphasized through the coupled hydrodynamic analysis of floating structure and sloshing inside baffled ARTs. In addition, the numerical methods for natural sloshing frequency tuning and estimation of hydrodynamic damping ratio of liquid sloshing in baffled tanks undergoing wave exiting loads are developed through the proposed formulation. In numerical examples, effects of natural frequency tuning and baffle ratios on the maximum and significant roll motions are investigated.

• ETRI Journal
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• v.29 no.1
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• pp.8-17
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• 2007

In this paper, we present a time domain combined field integral equation formulation (TD-CFIE) to analyze the transient electromagnetic response from dielectric objects. The solution method is based on the method of moments which involves separate spatial and temporal testing procedures. A set of the RWG functions is used for spatial expansion of the equivalent electric and magnetic current densities, and a combination of RWG and its orthogonal component is used for spatial testing. The time domain unknowns are approximated by a set of orthonormal basis functions derived from the Laguerre polynomials. These basis functions are also used for temporal testing. Use of this temporal expansion function characterizing the time variable makes it possible to handle the time derivative terms in the integral equation and decouples the space-time continuum in an analytic fashion. Numerical results computed by the proposed formulation are compared with the solutions of the frequency domain combined field integral equation.

• Earthquakes and Structures
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• v.7 no.5
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• pp.647-665
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• 2014

Squat reinforced concrete walls require enough shear strength in order to promote flexural yielding, which creates the need for designers of an accurate method for strength prediction. In many cases, especially for existing buildings, strength estimates might be insufficient when more accurate analyses are needed, such as pushover analysis. In this case, estimates of load versus displacement are required for building modeling. A model is developed that predicts the shear load versus shear deformation of squat reinforced concrete walls by means of a panel formulation. In order to provide a simple, design-oriented tool, the formulation considers the wall as a single element, which presents an average strain and stress field for the entire wall. Simple material constitutive laws for concrete and steel are used. The developed models can be divided into two categories: (i) rotating-angle and (ii) fixed-angle models. In the first case, the principal stress/strain direction rotates for each drift increment. This situation is addressed by prescribing the average normal strain of the panel. The formation of a crack, which can be interpreted as a fixed principal strain direction is imposed on the second formulation via calibration of the principal stress/strain direction obtained from the rotating-angle model at a cracking stage. Two alternatives are selected for the cracking point: fcr and 0.5fcr (post-peak). In terms of shear capacity, the model results are compared with an experimental database indicating that the fixed-angle models yield good results. The overall response (load-displacement) is also reasonable well predicted for specimens with diagonal compression failure.

• Biotechnology and Bioprocess Engineering:BBE
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• v.6 no.6
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• pp.419-425
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• 2001

A dense pellicular solid matrix has been fabricated by coating 4% agarose gel on to dense zironia-silica(ZS) spheres by watr-in-oil emulsification . The agarose evenly laminated the ZS bead to a depth of 30㎛, and the resultin gpellicular assembly was characterised by densities up to 2.39g/mL and a mean particle dimeter of 136 ㎛. In comparative fluidisation tests, the pellicular solid phase exhibited a two-fold greater flow velocity than commercial benchmark ad-sorbents necessary to achieve common values of bed expansion. Furthermore, the perlicular parti-cles were characterised by improved qualities of chromatographic behaviour, particularly with re-spect to a three-fold increase in the apparent effective diffusivity of lysozyme within a pellicular assembly modified with Cibacron Blue 3GA. The properties of rapid protein adsorption/desorp-tion were attributed to the physical design and pellicular deployment of the reactive surface in the solid phase. When combined with enhanced feedstock throughput, such practical advantages recommend the pellicular assembly as a base matrix for the selective recovery of protein products from complex, particulate feedstocks(whole fermentation broths, cell disruptates and biological extracts).

• Progress in Superconductivity and Cryogenics
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• v.21 no.3
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• pp.32-37
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• 2019

In various types of large-scale electrical applications, the number of coil turns in such machines is usually large. Electromagnetic simulation of large-scale superconducting coils (tens to hundreds of turns) is indispensable in the design process of superconducting electrical equipment. However, due to the large scale of the coil and the large aspect ratio of super-conducting material layer in HTS coated conductor, it is usually difficult or even unable to perform 3-D transient electromagnetic simulation. This paper introduces an effective 3-D electromagnetic simulation method for large-scale HTS coated conductor coil based on T-A formulation. The simulation and experimental results show that the 3-D model based on the T-A formulation using homogeneous strategy is more accurate than the traditional 2-D models. The memory usage is not sensitive to the number of turns and this model will be even more superior as the number of turns becomes larger.